TCM Prescription: Feng Shi Han Tong Tablets



Prescription Description
Prescription IDTCMF3424
Pinyin NameFeng Shi Han Tong Pian
Chinese Name风湿寒痛片
English NameFeng Shi Han Tong Tablets
Function Description痹病, 腰痛, 痿病
IndicationsLumbago disorder, Arthritis, Rheumatoid arthritis
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), è…°ç—› (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1680 Sinomenium acutum 青风藤 TCMH1680 ITSAJ4218-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1370 Prevotella melaninogenica
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 14.4587
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 14.4587
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 14.3547
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 13.9928
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.9377
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 12.9333
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.1467
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9822
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.9699
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.3359
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.3267
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.3267
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.2453
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.2148
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 10.2148
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2095
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 10.2053
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 10.2053
[BP] GO:0007200 None ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, GRM5, HTR2A, HTR2B 9.59901
[BP] GO:0003018 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 9.45225
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 9.39136
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, PPARA, SMAD3, SRC, TEK, TYR 9.25456
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TYR 9.21661
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TYR 9.12569
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 9.00057
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.80026
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.77777
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.72378
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 8.43877
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.40891
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.37324
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 8.35143
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 8.34862
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 8.33693
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 8.09103
[BP] GO:0003013 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 8.07274
[BP] GO:0097746 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.07274
[BP] GO:0035296 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7 8.07274
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.87885
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 7.8615
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, FABP3, FLT3, GRM5, HTR5A, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 7.82954
[BP] GO:0050880 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7 7.81574
[BP] GO:0035150 None ADORA1, ADRA1A, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7 7.78633
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.68355
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, HTR2B, PIM1, PPARA, TYR, XDH 7.66361
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3 7.42072
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 7.36198
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 7.31747
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2 7.28396
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 7.25584
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.2245
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.13417
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HTR5A, SRC, TEK, TYR 7.09558
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.92076
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.92076
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.87365
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 6.87087
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 6.81966
[BP] GO:0097756 None ADORA1, ADRA1A, DRD5, HTR1A, HTR2A, HTR2B, HTR7 6.73512
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 6.67968
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.66762
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.57246
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 6.53386
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4827
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4827
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 6.48138
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH 6.34487
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.34437
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 6.29646
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR 6.28385
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HTR2A, HTR2B, KDR, SRC 6.26759
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.26255
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.26255
[BP] GO:0006939 None ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 6.16266
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 6.14272
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 6.12492
[BP] GO:0042310 None ADRA1A, DRD5, HTR1A, HTR2A, HTR2B, HTR7 6.00052
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.97614
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 5.9422
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.9422
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 5.89193
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.836
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, INSR, SRC, TEK, TYR 5.80702
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 5.80166
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK 5.76468
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.73271
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 5.7103
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 5.67696
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.6373
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, SMAD3, SRC, TEK, TYR 5.6373
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.63161
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.57451
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.57373
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.53285
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 5.53252
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.53252
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.53252
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 5.50439
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, INSR, PPARA, SRC, TEK 5.50439
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 5.37436
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.37397
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.33918
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.31933
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.31407
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, HTR2A, SLC1A1, SMAD3 5.30199
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 5.29932
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.29888
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD17B1, HSD17B2 5.28697
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.28376
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.27648
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.26607
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.21471
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 5.21102
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.20846
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 5.20205
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.17455
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, SLC1A1, SMAD3 5.17034
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.1613
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 5.10766
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.0794
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.0794
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.07273
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.06108
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.05817
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.03947
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.03195
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.02424
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 4.99232
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, SRC 4.98132
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.9581
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 4.93461
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HTR2A, INSR 4.93141
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.88228
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 4.87848
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.87457
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.87457
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.87168
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 4.865
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.8599
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.83509
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR 4.77771
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.76658
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.72666
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, TNKS, TNKS2 4.72231
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.68509
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.68391
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.66258
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, MMP12, SMAD3, SRC 4.66258
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.65786
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 4.64437
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 4.62449
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, SRC, TEK 4.62449
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA 4.61209
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HTR2B, HTR5A, KDR 4.58922
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, CHRM1, CHRM3, DRD1, DRD5, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.55825
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 4.55825
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.55744
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, GPR35, GRM5, HTR1A, HTR2A, MMP9 4.546
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK 4.546
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.53069
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.51998
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.46353
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, INSR, PPARA 4.41089
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.41089
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.36845
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 4.364
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.34624
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34624
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.33913
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TOP2A 4.2906
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.2906
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.28398
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.27602
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP12, MMP9, PIM1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS2, XDH 4.26789
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, HTR5A, INSR, KDR, MMP9, PIM1, PPARA, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TYR 4.25488
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 4.24386
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.24193
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5, HTR2A 4.18193
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.18193
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.18193
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.18193
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.17719
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.17565
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.17051
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 4.16769
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 4.16332
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.15323
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.13417
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 4.10587
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.07999
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.05007
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.04504
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 4.03735
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.02252
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK, TNKS 3.98431
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A 3.98272
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 3.95116
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HTR7, PPARA, SRC, TOP2A 3.94506
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.94345
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, CHRM3, DRD2, EGFR, HTR2A, SLC1A1 3.93463
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.9275
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.92563
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.91159
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.89849
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 3.88571
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.8587
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.82925
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 3.82506
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 3.8165
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.7782
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, HTR2A, INSR, PPARA 3.74061
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 3.74061
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.74061
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HTR2A, INSR 3.72911
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 3.72002
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TNKS, XDH 3.71568
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 3.71401
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.71363
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 3.66906
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.65171
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8, HTR2A, INSR, PPARA 3.65171
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.61065
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.5937
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TNKS, XDH 3.57841
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.55688
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.54736
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 3.54589
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.54567
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, DRD5, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, SRC 3.5329
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PPARA 3.5322
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.48061
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.48061
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, DRD5, GRM5, INSR 3.45225
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.4262
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.4207
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41145
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.41145
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.40511
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, XDH 3.39677
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 3.39677
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, DRD5, HTR5A 3.39139
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.37153
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, PTPN1, SRC 3.36771
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, HTR2A, MMP9 3.36717
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.35711
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.35711
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.35711
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.3364
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, TYR 3.31947
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 3.3166
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.30783
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS 3.30783
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.2944
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.2944
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.28002
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PTPN1, SRC 3.26464
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, SRC 3.26464
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 3.25137
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.24206
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 3.23664
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.23664
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, DRD5, PPARA, SMAD3 3.23664
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, FLT3, SRC 3.2363
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.21048
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, PTPRS, SMAD3, TEK 3.20822
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, DRD5, HTR5A 3.19343
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.19064
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17494
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17494
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17494
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17494
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 3.1516
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 3.14454
[BP] GO:0019229 None ADRA1A, CHRM1, CHRM3, EGFR, HTR2A 3.14252
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.0762
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.07615
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.07615
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS, TOP2A 3.0713
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.04484
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.02418
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.02418
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.0203
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.99027
[BP] GO:0006940 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM3 2.98734
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.96758
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, PTPN1, SRC 2.95524
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.95524
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.95524
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.94961
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 2.93241
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 2.92267
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.91499
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.89499
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.87121
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 2.86768
[BP] GO:0046960 None DRD1, DRD5 2.85587
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.83022
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9 2.8281
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.82733
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 2.8257
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, DRD5 2.8257
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 2.8152
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 2.79954
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3, DRD5 2.79954
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 2.79016
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.78326
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, DRD5, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, SMAD3, SRC 2.77787
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 2.76909
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.75395
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.75395
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.75395
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.75395
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.75324
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.75324
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.72939
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.71245
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.70985
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.7086
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.70449
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.70449
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.69526
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 2.68233
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.68233
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.67519
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.66809
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.66809
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 2.64954
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.64527
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 2.63284
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.62452
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.61207
[BP] GO:0003012 None ADORA1, ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.60149
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS 2.57987
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.56323
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.52397
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, PTPN1, SRC 2.52278
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.52127
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.52127
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.52019
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, MMP9 2.51313
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.50281
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.50281
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.50203
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.50203
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.48864
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.47273
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 2.46167
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.46167
[BP] GO:0045761 None DRD2, DRD3, DRD5, GRM3 2.45486
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.45486
[BP] GO:0099566 None GRM1, GRM5 2.44974
[BP] GO:0060160 None DRD2, DRD3 2.44974
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44974
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD5, GRM3, GRM8 2.44749
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43405
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, SRC 2.43097
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.42898
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.42588
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.42102
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.41865
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, TYR 2.40184
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.40176
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.38083
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.37606
[BP] GO:0019226 None CHRM5, DRD1, DRD5 2.36904
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.36904
[BP] GO:0006936 None ADRA1A, CHRM3, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.36621
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.36541
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.36541
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.36541
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.33369
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.33369
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.33369
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.31007
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31007
[BP] GO:0007617 None APP, DRD1, DRD5 2.31007
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.30998
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.30843
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2 2.29027
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, DRD5, GRM5 2.28465
[BP] GO:0032412 None ABCB1, APP, DRD2, DRD3, GPR35, GRM5, MMP9 2.28465
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, TOP2A 2.25157
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.2493
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SMAD3, SRC 2.23774
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.22486
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.21994
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.21994
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.21969
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.20025
[BP] GO:0001994 None ADRA1A, DRD5 2.19872
[BP] GO:0070213 None TNKS, TNKS2 2.19872
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19872
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.19792
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.19792
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.19792
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.19188
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, DRD3, INSR, PIM1, PTPRS, TNKS2 2.18428
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.17027
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.17018
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, F3, MET, XDH 2.16664
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.16607
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.16057
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.15842
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.11752
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.11377
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.09577
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.09162
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.09162
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.08696
[BP] GO:0070201 None ACHE, APP, BCL2, CHRM1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTPN1, SMAD3, SRC 2.07559
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.07559
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.07559
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.06774
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.06774
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.06197
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 2.05718
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.05002
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.04526
[BP] GO:0051894 None KDR, SMAD3, TEK 2.04526
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.04526
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.04525
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, TYR 2.03758
[BP] GO:0050678 None EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.03447
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, GRM1, HTR2A, HTR2B 2.03447
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.02967
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.02318
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.02318
[BP] GO:0031279 None DRD2, DRD3, DRD5, GRM3 2.02318
[BP] GO:0021853 None DRD1, DRD2 2.01958
[BP] GO:0046541 None CHRM1, CHRM3 2.01958
[BP] GO:0010641 None F3, SRC 2.01958
[BP] GO:0090325 None DRD2, DRD3 2.01958
[BP] GO:0007598 None F10, F3 2.01958
[BP] GO:1904936 None DRD1, DRD2 2.01958
[BP] GO:0042321 None ADORA1, DRD2 2.01958
[BP] GO:0010513 None HTR2A, HTR2B 2.01958
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.01109
[BP] GO:0050927 None F3, KDR, SMAD3 2.00759
[BP] GO:0048169 None APP, DRD2, GRM5 2.00759
[BP] GO:0051339 None DRD2, DRD3, DRD5, GRM3 2.00715
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.00715
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.0032
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, SLC1A1, TEK 13.6117
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, SLC1A1, SRC, TEK 12.1465
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, SLC1A1, TEK 11.8454
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, SIGMAR1, SLC1A1, SRC, TEK 10.913
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK 10.0295
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 7.75533
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MPEG1, PTPN1, PTPRS, SIGMAR1, SLC1A1, SRC, TEK, TYR 7.66361
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SIGMAR1, SRC 5.89734
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTPRS, SRC, TEK, TUBB3 5.81605
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTPRS, SRC, TUBB3 5.80382
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTPRS, SRC, TEK, TUBB3 5.64185
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 5.57373
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MPEG1, PTPRS, SIGMAR1, SLC1A1, TEK, TYR 4.47008
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.26617
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.26617
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 4.15323
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, SIGMAR1, SRC 4.15323
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PTPRS, SIGMAR1, SRC, TUBB3 4.10587
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, SIGMAR1 4.07497
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MPEG1, PTPRS, SIGMAR1, SLC1A1, TEK, TYR 3.5972
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, HTR2B 3.41145
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.07615
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5 2.96631
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, HTR2B, KDR, PTPRS, SIGMAR1, TEK 2.90051
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.83022
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.79805
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.77787
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 2.69692
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1, HTR5A, TUBB3 2.67478
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSPA1A, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.54426
[CC] GO:0045121 membrane raft ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.33174
[CC] GO:0098857 membrane microdomain ADRA1A, APP, EGFR, HTR2A, INSR, KDR, SRC, TEK 2.31224
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.31007
[CC] GO:0031233 None CA4, F10, F3 2.2493
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.17027
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 2.15413
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, FLT3, GRIA2, HSD17B2, PTPN1, SIGMAR1 2.12647
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 19.5962
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7881
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 14.5371
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 14.5371
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 14.4032
[MF] GO:0008227 None ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.9431
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 12.9377
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 12.5542
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, SMAD3, TEK 12.5077
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 12.5077
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 12.2402
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 11.6523
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3, DRD5, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 10.3267
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2247
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1364
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 9.92033
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP2A 9.56393
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 8.80026
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 8.37324
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.93141
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.82954
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.50211
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.768
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.57246
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.57246
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.57246
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4827
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.4827
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.26255
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.01883
[MF] GO:0042165 neurotransmitter binding ACHE, CHRM3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.94073
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.93617
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.48368
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS 5.02424
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 4.98132
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 4.96316
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.61551
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.55694
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.55135
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.41534
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.39968
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.22297
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.07687
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.88619
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 3.71363
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR 3.54392
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.37904
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 3.35592
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.30076
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.21048
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 3.09508
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.07252
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.9544
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85587
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.53057
[MF] GO:0099583 None GRM1, GRM5 2.44974
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 2.40199
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.38083
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31007
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31007
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.25354
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, SRC, XDH 2.22486
[MF] GO:0001588 None DRD1, DRD5 2.19872
[MF] GO:0004971 None GRIA2, GRIA4 2.19872
[MF] GO:0051425 None APP, INSR 2.19872
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.16068
[MF] GO:0043559 insulin binding IGF1R, INSR 2.01958


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, HTR2B, HTR2A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD5, GRIA4, GPR35, HTR1A, HTR5A 22.3643
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.2648
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, HTR2B, HTR2A, HTR5A, ADRA1A, GRM1, EGFR, HTR6, GRM5, HTR7, DRD1, DRD5 12.4448
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4561
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, HTR6, CHRM1, ADORA1, HTR1A, DRD1, DRD2, PPARA, DRD5, GRIA4 8.3205
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 8.3588
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, HTR2B, HTR2A, DRD1, DRD2, GRM1, EGFR 8.0959
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3492
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.9512
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.0096
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.3258
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.1141
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 3.8548
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.1141
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7565
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5331
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.5242
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.381
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, DRD5, GRIA4 3.5242
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.309
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 3.1368
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.2235
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.1557
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.131
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.87
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.1072
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.6643
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 2.4599
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.5599
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.6509
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.2235
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.2027
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.745
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 1.7535
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 1.9722
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.8986
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8419
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 1.5824
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.8283
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.8283
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 1.8697
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8283
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 1.8339
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.7867
Taste transduction_Homo sapiens_hsa04742 CHRM3, HTR1A, GRM1 1.6256
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5146
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.5704
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8199
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5585
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.4946
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 1.8119
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3858
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.3092
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.105
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2971
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.2737
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.3716
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0719
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8608
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.149
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2013
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2143
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2202
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6404
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2311
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.8841
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6494
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.22
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2311
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6392
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6392
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.6847
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2385
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7106
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6392
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2609
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2609
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8419
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.6392
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8668
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6392
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2837
Salivary secretion_Homo sapiens_hsa04970 CHRM3, ADRA1A 0.8729
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8579
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6139
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.6234
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5624
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8697
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.5977
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2944
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.8551
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5402
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.5977
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5402
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8608
Platelet activation_Homo sapiens_hsa04611 SRC 0.3156
Axon guidance_Homo sapiens_hsa04360 MET 0.3083
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3176
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 0.9863
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3156
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9516
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3176
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8523
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.337
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3176
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3526
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3593
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3593
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3593
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9473
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1022
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3709
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.0703
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.0643
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.0129
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.137
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3879
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.391
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3879
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.3902
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3871
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.3893
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.0956
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3864
Peroxisome_Homo sapiens_hsa04146 XDH 0.3919
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.116
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4312
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4153
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4329
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4397
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4579
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.46
Shigellosis_Homo sapiens_hsa05131 SRC 0.46
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.46
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.22
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5053
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5085
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5224
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5085
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.2903
Malaria_Homo sapiens_hsa05144 MET 0.5402
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5402
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.384
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5643
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.5977
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5704
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.5824
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6265
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5977
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5322
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4567
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6404
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6826
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6392
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6265
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7535
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6847
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6826
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8617
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8841


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)