TCM Prescription: Bai Bu Wine



Prescription Description
Prescription IDTCMF3113
Pinyin NameBai Bu Jiu
Chinese Name百补酒
English NameBai Bu Wine
Function Description虚劳, 眩晕, 遗精
IndicationsInvoluntary ejaculation disorder, Vertigo disorder, Dizziness
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1344 Cornu cervi 鹿角 TCMH1344
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1663 Semen euryales 芡实 TCMH1663
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH269 Fructus broussonetiae 楮实子 TCMH269
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1329 Arillus longan 龙眼肉 TCMH1329
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 13.0543
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1, TYR 10.7118
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 10.6418
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 10.0776
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 9.37093
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 9.36308
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 9.16814
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.16814
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.14657
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM1, GRM3, GRM5, GRM8 9.10394
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 8.59779
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 8.40491
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SRC, TEK, XDH 8.21619
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.21619
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.21619
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MAOB, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 8.18626
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.10235
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, MAOB, NR3C1, RORC, SRC, TEK, TRPV1, TYR 8.00534
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FDPS, FUT7, GLO1, HMGCR, HSPA1A, PDE5A, PIM1, PPARA, TYR, XDH 7.8285
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.71544
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 7.71544
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.6583
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.6583
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PDE5A, PIM1, SMAD3, SRC, TEK, XDH 7.64261
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.64261
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 7.59359
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 7.58781
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 7.46088
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.46088
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MAOB, MMP9, SRC 7.46088
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 7.36101
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 7.25476
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.24759
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, HMGCR, MAOB, TYR 7.17042
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 7.16694
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 7.0005
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 6.96577
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.87057
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.87057
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.69067
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 6.67623
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.67519
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC, TRPV1 6.51157
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.51157
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.33277
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 6.30363
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, MAOB, NR3C1, PPARA, SRC, TEK, TRPV1 6.29469
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.29334
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 6.20455
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 6.1874
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.15642
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, XDH 6.10812
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 6.08564
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 6.0634
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 6.0634
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.04592
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.04592
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOB, TYR, XDH 5.9941
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.9933
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.98413
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.98413
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.97545
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 5.96434
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 5.89254
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 5.8625
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.83584
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, XDH 5.75675
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.74022
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.69562
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, GRIK5, INSR, MAOB, SLC1A1, SMAD3, TRPV1 5.69023
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.69023
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, TRPV1 5.69023
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, EGFR, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.58445
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.58204
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.53399
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.53194
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.43594
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 5.41582
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, MAOB, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 5.41467
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.32702
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 5.31656
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, RORC, SRC, TRPV1 5.31656
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.31656
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.28253
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR, GPR35, GRM1, HCAR2, PDE5A, SLC1A1, SMAD3, TRPV1 5.24101
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.2114
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, TEK, XDH 5.2114
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 5.20399
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.18467
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK 5.18467
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.11939
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, MAOB, NR3C1, RORC, SRC, TYR 5.11648
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS, HMGCR 5.02638
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.00561
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, KDR, MAOB, NR3C1, SRC, TRPV1 5.00561
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 5.00495
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MAOB, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.96548
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 4.94384
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.93932
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRM5 4.89966
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.8901
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.87321
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.85541
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.8372
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.82309
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 4.81522
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, MAOB, SRC 4.78134
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 4.77009
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, DRD2, EGFR, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 4.72984
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.69627
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 4.66248
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PDE5A, PTPN1, SRC 4.65751
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 4.62077
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 4.62077
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.62077
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PDE5A, PTPN1, SRC 4.60632
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 4.57546
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.53123
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 4.51662
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CHRM3, CYP1B1, DRD2, EGFR, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP9, PDE5A, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 4.51662
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 4.5092
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.5092
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.47995
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.44037
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.42807
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, SRC, TEK 4.42807
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, HSPA1A, MAOB 4.42807
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC, TRPV1 4.42807
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.39906
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 4.39906
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS 4.37421
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.35425
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.35425
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 4.31636
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 4.30475
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.26599
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 4.25473
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.22921
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.20882
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK, TRPV1 4.17797
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.17797
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.17713
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 4.11686
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2, HMGCR, KDR, SRC, TRPV1 4.11126
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.10935
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, EGFR, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 4.08158
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 4.05475
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 4.0502
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PDE5A, SRC, TEK, TRPV1, TYR 4.02484
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.01745
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.01745
[BP] GO:0042391 None ADORA1, APP, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.00953
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, EGFR, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 4.00953
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MAOB, MMP9 4.00883
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 3.9967
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.99031
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.9772
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.96316
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.92508
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 3.91345
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.86845
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.82308
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.80793
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.79573
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.79461
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 3.77787
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 3.76272
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HMGCR, KDR, SRC, TEK 3.75089
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, EGFR, GRM5, HMGCR, INSR 3.682
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 3.67877
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.67877
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, SRC, TEK 3.63593
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.62782
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.62782
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, HMGCR, PPARA, SMAD3, TEK 3.60537
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC, TRPV1 3.59682
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 3.57889
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.56014
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.56014
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PDE5A, PTPN1, SRC, TEK 3.56014
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR, PDE5A, SLC1A1 3.54704
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.54032
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 3.53518
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 3.50357
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PDE5A, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.46121
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.44486
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.44486
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.44327
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.4414
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.4414
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, TRPV1, TYR 3.4414
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.43682
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.42619
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, EGFR, F3, FABP4, HMGCR, KDR, MET, PPARA, SMAD3, TEK 3.4163
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.4163
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.41269
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.40601
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.38982
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.35781
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, SRC 3.35536
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PDE5A, PTPN1, SRC, TEK 3.35231
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, F10, F3, MET, XDH 3.25749
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.22078
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.20927
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PDE5A, PTPN1, SRC 3.18972
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.16875
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.1687
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1687
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.16854
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.16578
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.15774
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.12183
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.11882
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, PDE5A, PTPN1, SRC 3.11756
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, NR3C1, SRC 3.10927
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 3.09944
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.08967
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.08967
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, MAOB 3.05575
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.01451
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.00649
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.00428
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.99426
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR 2.99362
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR 2.99362
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.99362
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.97054
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PDE5A, PTPN1, SRC 2.9607
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 2.9415
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.93615
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.92968
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.91671
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.90658
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.90658
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.90658
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.90478
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.87625
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, MAOB, TYR 2.87302
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.87003
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR 2.86748
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.86408
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.86287
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR 2.85305
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.84883
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.81788
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, INSR 2.80364
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.78876
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, PPARA, RORC, SRC, TOP2A 2.77084
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.76327
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.76327
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.76235
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, SRC 2.74842
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.70342
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 2.68939
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.68939
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.68939
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.68939
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 2.68483
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.66569
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.65543
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.64406
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.62568
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, MAOB, NR3C1, SRC 2.62239
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.61569
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.61474
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH 2.54547
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, HCAR2 2.54193
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CHRM1, DRD1, DRD2, GPR35, GRM5, MAOB, MMP9 2.54153
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, MAOB, NR3C1, SRC 2.52466
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR 2.52265
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.52265
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH 2.5169
[BP] GO:0099566 None GRM1, GRM5 2.50265
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50265
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.50143
[BP] GO:1900542 None DRD1, DRD2, GRM3, GRM8, INSR, PDE5A, PPARA 2.46844
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.46633
[BP] GO:0007611 None APP, DRD1, DRD2, EGFR, GRM5, HMGCR, INSR 2.45914
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.45586
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, DRD1, DRD2, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.44187
[BP] GO:0072507 divalent inorganic cation homeostasis APP, DRD1, DRD2, EGFR, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.43168
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 2.42355
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.4201
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.4201
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.4201
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.4201
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.41799
[BP] GO:0006140 None DRD1, DRD2, GRM3, GRM8, INSR, PDE5A, PPARA 2.40769
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR 2.38757
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 2.37158
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.36129
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.36129
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.36129
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DUSP3, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 2.36129
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.33596
[BP] GO:0007610 None APP, DRD1, DRD2, EGFR, GRM1, GRM5, HMGCR, INSR, PPARA, TRPV1 2.32634
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.32531
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD1, DRD2, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 2.31928
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.30695
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.30181
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR 2.30072
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 2.29762
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.28418
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.28418
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, SMAD3, SRC, TOP2A, TRPV1, XDH 2.28124
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.28124
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25871
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25871
[BP] GO:0019725 cellular homeostasis APEX1, APP, CA2, CA7, DRD1, DRD2, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 2.25871
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, HSPA1A, MMP9, SLC1A1, TRPV1, XDH 2.25871
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.25482
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 2.24681
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.23927
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PDE5A, PTPN1, SRC 2.2334
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.2242
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.21519
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2129
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.2004
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.19298
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.19226
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, DRD1, DRD2, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.18841
[BP] GO:0051894 None KDR, SMAD3, TEK 2.16439
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.16439
[BP] GO:0061900 None APP, EGFR, TRPV1 2.16439
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, EGFR, HCAR2, HMGCR, PTPN1, SMAD3, SRC 2.14682
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.1226
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.12076
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, INSR 2.11747
[BP] GO:0050927 None F3, KDR, SMAD3 2.11722
[BP] GO:0048169 None APP, DRD2, GRM5 2.11722
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, DRD1, DRD2, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.11323
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, FDPS, HMGCR 2.102
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.10152
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, TRPV1, TYR 2.10123
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, SRC, TEK, TRPV1 2.08667
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.08571
[BP] GO:0021853 None DRD1, DRD2 2.08571
[BP] GO:0046541 None CHRM1, CHRM3 2.08571
[BP] GO:0010641 None F3, SRC 2.08571
[BP] GO:0007598 None F10, F3 2.08571
[BP] GO:1904936 None DRD1, DRD2 2.08571
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.08571
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.08571
[BP] GO:0042321 None ADORA1, DRD2 2.08571
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.08571
[BP] GO:0050926 None F3, KDR, SMAD3 2.08571
[BP] GO:1903393 None KDR, SMAD3, TEK 2.08571
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.06494
[BP] GO:0045936 None DRD2, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.06268
[BP] GO:0010563 None DRD2, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.05772
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.04339
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.04339
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, EGFR, HMGCR, TYR 2.04339
[BP] GO:0006874 cellular calcium ion homeostasis APP, DRD1, DRD2, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.0408
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, EGFR, HCAR2, SRC, TRPV1 2.034
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, FDPS, HMGCR 2.02809
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.02809
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.0072
[BP] GO:0051482 None DRD1, GPR35, GRM1 2.00383
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.00383
[BP] GO:0046683 response to organophosphorus APEX1, APP, TEK, TRPV1, TYR 2.00223
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 9.02138
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 7.84915
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, EGFR, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 7.65066
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK, TRPV1 7.31274
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 6.28154
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 6.11991
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 6.02841
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1, TYR 5.45325
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, PTPN1, SLC1A1, SRC, TEK, TRPV1, TYR 5.00561
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.474
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 3.80793
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 3.80793
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.73852
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.73852
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 3.36117
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.28378
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5 3.28007
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, SLC1A1, TEK, TRPV1, TYR 3.25508
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.17733
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.09518
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.058
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.00204
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.99521
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC, TEK 2.77004
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, KDR, TEK, TRPV1 2.64337
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.56585
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC, TEK 2.50265
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC, TRPV1 2.50143
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, SRC, TRPV1 2.45636
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, EGFR, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, SLC1A1, TEK, TRPV1, TYR 2.42408
[CC] GO:0031233 None CA4, F10, F3 2.36129
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.33423
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MMP2, MMP9, NR3C1, PDE5A, PIM1, PTPN1, SMAD3, SRC, TOP2A, TRPV1, TYR, XDH 2.2004
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 2.14682
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.0072
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FDPS, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 10.445
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 10.378
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 10.378
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 9.99332
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.57669
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 9.29163
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 9.15821
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 9.15821
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 9.1535
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 9.13504
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 9.02138
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.99144
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOB, TYR, XDH 7.25476
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A, TRPV1 7.20016
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.11815
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.51157
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.33613
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.33277
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.07409
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F10, FDPS, GLO1, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TRPV1, TYR, XDH 5.92326
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.33454
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.18149
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.95202
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.95202
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.93932
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.90386
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.80363
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, FDPS, GLO1, MMP1, MMP2, MMP9, NR3C1, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TRPV1, TYR, XDH 4.36257
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.09913
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.01745
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.87684
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3 3.87642
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 3.64619
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.55685
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 3.55685
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1 3.54704
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.54032
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.4414
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.30239
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30239
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.22078
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 3.01549
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.99362
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1 2.97054
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2 2.97054
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.92784
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.90658
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.87302
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.81788
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.78542
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.7732
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.7732
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, MAOB, SRC, XDH 2.66467
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.52466
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.52265
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50265
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.50265
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.50265
[MF] GO:0099583 None GRM1, GRM5 2.50265
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.47911
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.4201
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.4201
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.4201
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.35106
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.30181
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25871
[MF] GO:0004971 None GRIA2, GRIA4 2.25871
[MF] GO:0051425 None APP, INSR 2.25871
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25871
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, DRD2, EGFR, FLT3, GRIK5, HMGCR, IGF1R, KDR, MAOB, MET, MMP9, SMAD3, TOP2A, TRPV1, TYR, XDH 2.22507
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.22507
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.2242
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.10152
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08571
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08571
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.08571
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.04339
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.04339
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.04339
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.00223


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 14.1755
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.9027
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6906
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.4861
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.7102
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.2833
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOB, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.7773
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD1, DRD2, PPARA, GRIA4 5.6546
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, DRD1, GRM1, EGFR 5.0122
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.0554
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.6284
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0122
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1, EGFR 4.745
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1, EGFR, HSPA1A 4.5232
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.8798
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.7662
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 4.745
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.6629
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.2468
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1996
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.1996
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5, ALOX15, ALOX12 3.1996
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 2.9642
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 3.7467
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, GRIA4 2.9961
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 3.0102
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.9393
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.8153
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.1153
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.9642
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.4665
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9961
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.2549
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.4665
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.2424
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4468
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 1.8336
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0655
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2106
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1351
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7359
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0392
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0479
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7378
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.6788
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0054
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.0567
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0307
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, CYP3A4 2.0222
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5777
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.2752
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.0054
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.266
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.4414
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.1052
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0014
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.9893
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2466
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9527
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0324
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8202
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8277
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.261
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.764
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2677
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7617
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8277
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8008
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.969
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7525
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9834
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.289
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2762
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7547
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2674
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9662
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7547
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.289
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9863
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7525
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3039
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.311
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7525
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.724
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1052
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5782
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6474
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3 0.4634
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0696
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9634
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.702
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3508
Influenza A_Homo sapiens_hsa05164 FDPS, HSPA1A 0.6474
Platelet activation_Homo sapiens_hsa04611 SRC 0.3732
Axon guidance_Homo sapiens_hsa04360 MET 0.3655
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1903
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3732
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0654
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3813
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4024
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1842
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2289
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9566
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4188
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4261
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4261
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4261
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.266
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4385
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.443
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1903
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4525
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4525
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4572
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4525
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4562
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4525
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4516
Peroxisome_Homo sapiens_hsa04146 XDH 0.4582
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2493
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4955
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4973
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4791
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5045
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5232
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5278
Shigellosis_Homo sapiens_hsa05131 SRC 0.5253
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5363
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5719
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5753
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5897
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4193
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5936
Malaria_Homo sapiens_hsa05144 MET 0.6017
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.5976
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6061
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5211
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.669
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7176
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.6108
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7044
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6668
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6668
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5947
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6788
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7627
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7411
Base excision repair_Homo sapiens_hsa03410 APEX1 0.724
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7642
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9115
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7503
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7627
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.7926
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.9412
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9119
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.969
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0102


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)