TCM Prescription: Clear the Lung Decoction



Prescription Description
Prescription IDTCMF2704
Pinyin NameQing Fei Tang
Chinese Name清肺汤
English NameClear the Lung Decoction
Function Description治一切咳嗽, 上焦痰盛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH145 Bulbus fritillariae 贝母 TCMH145
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH2092 Asparagus cochinchinensis 天门冬 TCMH2092 ITSAJ4142-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2322 Prunus armeniaca 杏仁 TCMH2322 ITSAJ4486-14
TCMH1428 Ophiopogon japonicus 麦门冬 TCMH1428 ITSAJ4140-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH2681 Caulis bambusae in taeniam 竹茹 TCMH2681
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGES, TBXAS1, TRPV1 14.1846
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 13.489
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGES, RORC, SRC, TEK, TRPV1, TYR 12.6002
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 12.4292
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, PTGES, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 11.4812
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 11.4058
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TYR, XDH 11.1927
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, MTNR1B, PPARA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 11.0426
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGES, RORC, SRC, TEK, TRPV1, TYR 10.8975
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8064
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 10.8064
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 10.2228
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.1996
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.1144
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0002
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, TERT, XDH 9.97746
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 9.97746
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, DRD5, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 9.97746
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.21655
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 9.2012
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.19454
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 8.82078
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 8.77673
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA, PTGES, TBXAS1 8.57517
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MMP9, PTGES, SRC, TERT 8.24608
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TERT, TRPV1 8.21959
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 8.10905
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, GBA2, MAOA, TYR 8.04313
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1B, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.02342
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1B, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.85199
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 7.83713
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PTGES, RORC, SRC, TYR 7.7716
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.73315
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, KIT, NR3C1, PPARA, SRC, TEK, TRPV1 7.62141
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.58849
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 7.45042
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 7.35552
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DYRK1A, EGFR, ESR1, KIT, MTNR1A, MTNR1B, PPARA, RORC, SRC 7.34973
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.29724
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 7.19458
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 7.15069
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 7.14355
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.10688
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 7.06567
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 7.03
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.01107
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.83666
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.81424
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 6.6374
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.6374
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 6.63312
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.47956
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 6.47631
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, MTNR1B, SMAD3, SRC, TERT, TRPV1 6.46595
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2, TRPV1 6.44368
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.40033
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIM1, TEK, TERT 6.39087
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.33285
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.31762
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.31762
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.29298
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 6.27804
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.26475
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HSPA1A, KIT, MMP2, PPARA, SMAD3, SRC, TEK, TERT, TRPV1, TYR 6.21852
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.21076
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HSD11B2, KDR, NR3C1, SRC, TRPV1 6.21076
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.174
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B 6.09937
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 6.01989
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.9923
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, MTNR1B, SMAD3, TRPV1 5.96829
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 5.9677
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CDK6, CYP19A1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.92919
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MMP9, PTGES, TERT 5.92919
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 5.92919
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.84934
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, KIT, MET, SRC, TEK, XDH 5.83033
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.79943
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.76145
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PTPN1, SRC, TEK, XDH 5.75278
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.74268
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.6905
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1 5.64388
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES, TBXAS1 5.64026
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.62606
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.58461
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 5.58461
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD5, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 5.58461
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.56719
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 5.54785
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 5.53666
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 5.51581
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.4864
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.48368
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.48368
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.4749
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.40127
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 5.3947
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.3947
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TYR 5.36098
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.34642
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, KIT 5.3419
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, KIT 5.3419
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 5.17632
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.14788
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.14788
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.13619
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.12939
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.12001
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 5.0473
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.04451
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH 5.02949
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC, TRPV1 4.94307
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.928
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, NQO2, RORC 4.87573
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, MAOA, TYR 4.7945
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 4.67382
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.67382
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 4.63875
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, TNKS, TNKS2 4.63491
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.59751
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.58494
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 4.5848
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.56715
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, NR3C1, SMAD3, SRC, TRPV1 4.55289
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.47525
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.46393
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.429
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.40441
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.39038
[BP] GO:0007623 circadian rhythm DRD2, DRD3, DYRK1A, EGFR, MTNR1A, MTNR1B, PPARA, RORC 4.34025
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MTNR1A, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 4.30269
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24044
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, MAOA, SMAD3, TRPV1 4.19827
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP2, MMP9, SRC, XDH 4.19751
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, F3, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.13288
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, SRC 4.10938
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TERT, TRPV1 4.10355
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 4.07796
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.07017
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.06607
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.05759
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 4.05572
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, KIT, MET, SRC, TEK 4.01563
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 3.98422
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 3.98087
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, SMAD3, SRC, TERT, TRPV1 3.96713
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.9612
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.9612
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.95713
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MTNR1A, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 3.92541
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, KDR, KIT, MET, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TRPV1 3.9244
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, PPARA, PTPRS, SMAD3, TEK 3.90079
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC, TRPV1 3.86098
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, EGFR, FLT3, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.85752
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, PPARA, PTPRS, SMAD3, TEK 3.85463
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP9, PIM1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 3.85167
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, DRD5, KIT 3.85027
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, DYRK1A, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.81188
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOA 3.80849
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.80849
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, KIT, PPARA, RORC, SRC, TEK 3.75953
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.75953
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 3.71599
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 3.71235
[BP] GO:0007617 None APP, DRD1, DRD5, MTNR1A 3.6991
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC, TERT 3.68446
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, MTNR1A, SRC 3.68018
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.68018
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.68018
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.68018
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.67438
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 3.6686
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.66386
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.66386
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.59311
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.58926
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.56802
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.56347
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 3.55589
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 3.5507
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, MAOA 3.53268
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.51452
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 3.50336
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.49864
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 3.48229
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 3.47916
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3, KIT 3.47916
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 3.4732
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.45952
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.45874
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.42243
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 3.42172
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KIT, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.41638
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, DRD5, INSR, KIT 3.38312
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.34665
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.33879
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS 3.32125
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.29079
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, KIT, NUAK1, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 3.28903
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3, KIT 3.28903
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.28158
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.28158
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 3.27017
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.23932
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TNKS, TNKS2, TRPV1 3.23932
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.22438
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.21361
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.20452
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, KIT 3.20407
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.18979
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 3.18942
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.18579
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.17798
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, HSD11B2, PPARA, SMAD3 3.16111
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.10079
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.10079
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.09565
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.09565
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT, TNKS 3.07681
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 3.0767
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, KIT, TYR 3.06888
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.06583
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.05584
[BP] GO:0019098 None APP, DRD1, DRD5, MTNR1A 3.05459
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 3.04023
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.03394
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.02048
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, KIT, MTNR1A, PPARA, TRPV1 3.00921
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.00921
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.00921
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.00921
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.00577
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TERT, TNKS 3.00491
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.99654
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.98411
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.96436
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.96109
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 2.9574
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 2.9565
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 2.92677
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, KIT, MET, MMP2, MMP9, PTPRS, RORC, SMAD3, SRC, TEK, TERT 2.92227
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, PTPRS, TERT, XDH 2.91545
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, XDH 2.91251
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.90942
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.90395
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.89639
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.89639
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 2.88975
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 2.87272
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.86586
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.86586
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.86586
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, ESRRB, INSR, MTNR1A, PPARA 2.8656
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, KIT 2.85364
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.83796
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSD11B2, HSPA1A, KIT, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 2.83421
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.83367
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.81063
[BP] GO:0046960 None DRD1, DRD5 2.81063
[BP] GO:0009115 None AOX1, XDH 2.81063
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.81063
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.81063
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.81063
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.80708
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.80343
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.80343
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, ESRRB, INSR, MTNR1A, PPARA 2.79785
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, TEK, TERT 2.79746
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.79077
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.78136
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.76125
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 2.75667
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.75513
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.73186
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 2.72444
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.72109
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.71052
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.71052
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.71052
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.71052
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.71052
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 2.71052
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC, TEK 2.70823
[BP] GO:0007187 None ADORA1, DRD1, DRD2, DRD3, DRD5, MTNR1A, MTNR1B 2.69407
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK, TNKS 2.68515
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.66868
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.66226
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 2.65602
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, INSR, KDR, KIT, PIM1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.64999
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, SRC 2.64955
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 2.63954
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.62895
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, PTGES, SMAD3, TERT, XDH 2.62785
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.62575
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.62575
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 2.57693
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, KIT, MMP2, PTPN1, PTPRS, SMAD3, SRC 2.57418
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.56303
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.55435
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.55435
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.55435
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.55435
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.54212
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, KDR, SRC, TEK 2.51743
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.49908
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.48039
[BP] GO:0045934 None AURKB, DNMT1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 2.46824
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 2.46545
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46456
[BP] GO:0070920 None EGFR, ESR1, TERT 2.46456
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.46456
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.46456
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.46323
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.44996
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.42068
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK 2.42006
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, MMP9 2.41877
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.41687
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.41687
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.41687
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.41687
[BP] GO:0046110 None AOX1, XDH 2.41687
[BP] GO:0060160 None DRD2, DRD3 2.41687
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41687
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.40028
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 2.39969
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.39748
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.39748
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.39748
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, DRD1, DRD5, EGFR, ESR1, KIT, MTNR1A, SRC 2.36863
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.36651
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, NR3C1 2.35524
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.34643
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 2.33494
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.33316
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.32882
[BP] GO:0045596 None APP, BCL2, CDK6, DRD3, EGFR, ESRRB, PPARA, PTPRS, SMAD3, TERT, TRPV1, XDH 2.28524
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.26729
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.26729
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.26729
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.25871
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC, TRPV1 2.2498
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.2498
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.2498
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, TEK, TERT 2.24496
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, DRD5, KIT 2.24496
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.23153
[BP] GO:0003018 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.23153
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.21386
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.21386
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.21386
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.21386
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.21386
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.21386
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 2.19591
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 2.1901
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, MMP9 2.18727
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK, TERT 2.18727
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.18727
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK, TNKS 2.18451
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.18197
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.17595
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.17444
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.17444
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.17444
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.17444
[BP] GO:0070213 None TNKS, TNKS2 2.17444
[BP] GO:0006145 None AOX1, XDH 2.17444
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17444
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTPN1, SRC, TEK 2.17444
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.17444
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.17444
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.17444
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.17314
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.16274
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, DRD3, INSR, PIM1, PTPRS, TNKS2 2.16274
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.1479
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, GBA2, HSPA1A, MAOA, SRC, XDH 2.14753
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.12321
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.12178
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.12178
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET 2.1157
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.09928
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.09825
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.09825
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.09825
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.07073
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.07073
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.067
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, MMP9 2.067
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.06661
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.06661
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, PPARA, TRPV1 2.0665
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, MMP9 2.05855
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.05596
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.05061
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.05061
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.04487
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.02748
[BP] GO:0051894 None KDR, SMAD3, TEK 2.02748
[BP] GO:0061900 None APP, EGFR, TRPV1 2.02748
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.02748
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.02748
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, TEK, TERT, XDH 2.00703
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, KIT, TYR 2.00236
[BP] GO:0044057 None ADORA1, ADORA3, DRD2, DRD3, EGFR, GPR35, HCAR2, KIT, SMAD3, TRPV1 2.00236
[BP] GO:0021853 None DRD1, DRD2 2.00236
[BP] GO:0043696 None CDK6, ESRRB 2.00236
[BP] GO:0043697 None CDK6, ESRRB 2.00236
[BP] GO:0010641 None F3, SRC 2.00236
[BP] GO:0090325 None DRD2, DRD3 2.00236
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.00236
[BP] GO:1904936 None DRD1, DRD2 2.00236
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.00236
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.00236
[BP] GO:0042321 None ADORA1, DRD2 2.00236
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR 4.24044
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 3.9612
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GBA2, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TRPV1 3.77404
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK, TRPV1 3.70414
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 3.66463
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MMP2, MMP9, NQO2, NR3C1, PIM1, PTGES, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 3.61043
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TEK, TRPV1, TYR 3.48229
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.28158
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PTPRS, SRC, TEK, TRPV1 3.20407
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 3.07167
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK, TRPV1 3.00491
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 2.79785
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.6119
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 2.16274
[CC] GO:0044422 organelle part AKR1B1, ALDH2, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSPA1A, INSR, MAOA, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TUBB3, TYR 2.09825
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 21.6123
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 16.4307
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.9642
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 15.9387
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 10.8889
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 10.2288
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 9.97746
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.97746
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.52745
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, SMAD3, TNKS 9.21655
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 8.72522
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.69472
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.14658
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.02342
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 7.7716
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 7.64248
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 7.48935
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.17679
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 7.15862
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 6.93801
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 6.9025
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.65096
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 6.60708
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.40663
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.39348
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 6.36648
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.27564
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 5.98511
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2, NR3C1 5.74771
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.5721
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.55363
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.40887
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.3947
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.99464
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.78349
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.69373
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.69373
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.59965
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.46107
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.3159
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 4.14369
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 4.14369
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ALDH2, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MTNR1A, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TUBB3, XDH 4.12169
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, ALDH2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TRPV1, TUBB3, XDH 3.94223
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.94142
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.85167
[MF] GO:0000166 nucleotide binding ABCB1, ALDH2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TRPV1, TUBB3, XDH 3.70502
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ALDH2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TRPV1, TUBB3, XDH 3.70414
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.70147
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.64096
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 3.62699
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, PTGES, PTPRS, SRC, TEK, TRPV1, TUBB3, XDH 3.45306
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.4424
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT 3.18979
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.16111
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13259
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, SMAD3, TERT, TRPV1, TYR, XDH 3.09882
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.05459
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81063
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.81063
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81063
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81063
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5 2.73128
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KIT, MET, NR3C1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2 2.54212
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, ALDH2, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TUBB3, XDH 2.54212
[MF] GO:0008502 None MTNR1A, MTNR1B 2.41687
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.41687
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.41687
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.41687
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.33237
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD1, DRD2, DRD3, DRD5, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TUBB3, TYR, XDH 2.32974
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.31615
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.21437
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.21386
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.18727
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.18197
[MF] GO:0001588 None DRD1, DRD5 2.17444
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17444
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17444
[MF] GO:0051425 None APP, INSR 2.17444
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17444
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.13667
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.11409
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK 2.06009
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.00236
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.00236
[MF] GO:0043559 insulin binding IGF1R, INSR 2.00236


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.9454
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.2123
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4375
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.4538
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, ALOX15, AKR1B1, ALOX12, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, ALDH2, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, CBR1, TYR, CYP2A6, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL, PTGES 7.8567
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.2057
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.9122
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.1621
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 MTNR1A, GPR35, MTNR1B, ADORA3, ADORA1, TRPV1, DRD1, NR3C1, DRD2, DRD3, DRD5 5.8162
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.1323
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.9918
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 5.1323
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, EGFR, IGF1R 4.5484
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 4.8085
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1, CYP3A4 4.9263
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.2842
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.8085
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.5693
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.5855
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5, ALOX15, ALOX12 3.8844
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.8996
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.1371
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.0954
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, DRD2, EGFR 3.3438
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.0722
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA, DRD5 2.7071
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.6872
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2, DRD3, DRD5 2.7071
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 2.7445
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.7071
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.5129
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7111
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.8489
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.5519
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.8489
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 1.9884
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8554
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 1.9776
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 1.8477
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4959
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7696
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.5519
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 1.9454
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5399
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.476
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8207
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3672
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 1.7775
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.2834
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.1441
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2714
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.1581
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.099
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2413
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.1207
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1298
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.2122
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0497
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.0017
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR, DRD5 0.9446
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 0.945
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8623
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7071
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2286
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2397
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5245
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2283
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2397
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.8867
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.71
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2726
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2726
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.7647
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.2791
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2932
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8425
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.304
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7293
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.7084
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7293
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8687
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8356
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8592
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6611
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.8867
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 0.9897
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6788
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8722
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6682
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5779
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 0.8564
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8841
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6269
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6682
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6061
Axon guidance_Homo sapiens_hsa04360 MET 0.3181
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6611
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.945
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3256
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3307
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8623
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4098
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.5779
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4987
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4852
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5624
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3563
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3722
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3793
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3793
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.096
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.0456
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3917
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3909
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.5129
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.1392
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.0892
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0577
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4098
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4229
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4098
Peroxisome_Homo sapiens_hsa04146 XDH 0.4241
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4387
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4449
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4562
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4734
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.2107
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4852
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4756
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.237
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4876
Shigellosis_Homo sapiens_hsa05131 SRC 0.4852
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5053
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4833
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.3716
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5349
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5496
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5349
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5496
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5504
Malaria_Homo sapiens_hsa05144 MET 0.5624
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5635
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5682
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5519
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5682
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5779
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5779
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5779
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5136
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6061
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.644
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.6061
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7084
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6731
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7438
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6731
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6836
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7084
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6782
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.716
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7084
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7084
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8456
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9101
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8356
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8867
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1471


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)