TCM Prescription: Goupi Plaster, Dog-skin Plaster



Prescription Description
Prescription IDTCMF2631
Pinyin NameGou Pi Gao
Chinese Name狗皮膏
English NameGoupi Plaster, Dog-skin Plaster
Function Description筋骨疼痛, 手足麻木, 跌打损伤, 小肠疝气, 腹胀腹痛
IndicationsAbdominal pain disorder, Lower abdominal colic disorder, Numbness disorder
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
SB07 [Lower abdominal colic disorder (TM1), 疝气 (TM1) ];
SC62 [Numbness disorder (TM1), 麻木 (TM1) ];
Human Tissues Associated with IndicationSkeletalMuscle
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1680 Sinomenium acutum 青风藤 TCMH1680 ITSAJ4218-14
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH2112 Radix smilacis 铁丝威灵仙 TCMH2112
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGES, TBXAS1 10.773
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PTGES, SMAD3, SRC, TEK, TYR 10.7205
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, POLA1, POLB, PPARA, SMAD3, SRC, TEK, XDH 10.7205
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 9.75609
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HSD17B2, IGF1R, INSR, POLB, PPARA, PTGES, SRC, TEK, TYR 9.75609
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PTGES, SMAD3, SRC, TEK, TYR 9.42192
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, SMAD3, SRC, TEK, XDH 9.34807
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, SMAD3, SRC, TEK, XDH 9.34656
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 9.32797
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH 8.62974
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, PTGES, SRC, TEK, TYR 8.5553
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 8.555
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.555
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.35911
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 7.90205
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 7.64536
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES, TBXAS1 7.6383
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.31643
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 7.29465
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 7.29465
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, NUAK1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TEK, TYR 7.25213
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 7.14085
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, NUAK1, SRC, TEK, XDH 7.09494
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 7.04188
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, SMAD3, SRC, TEK, XDH 7.00936
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 6.97745
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 6.83778
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, SRC, TEK, XDH 6.80315
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 6.76683
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.76683
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 6.50557
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 6.48547
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, TBXAS1 6.39107
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, PTGES, SRC 6.39107
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.31601
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, TBXAS1 6.30106
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK 6.21523
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 6.21523
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, POLB, SRC 6.04563
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KDR, POLB, SRC 5.91384
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.91384
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.86032
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.80671
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.79895
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 5.76526
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.76031
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.66015
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 5.61978
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PPARA, SMAD3, SRC, TEK 5.37793
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.3775
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 5.37146
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.32907
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 5.23902
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 5.23902
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 5.23902
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 5.23902
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, PTGES, SRC, TYR 5.23121
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, SMAD3, SRC, TEK, XDH 5.16133
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.14828
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, TYR 5.14786
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, PPARA, SMAD3, SRC, TEK, XDH 5.12657
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, SMAD3, SRC, TEK 5.12657
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, XDH 5.09226
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, POLA1, POLB, SMAD3, SRC 5.00814
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.00518
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.96175
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 4.96021
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HSPA1A, IGF1R, KDR, MET, MIF, PIM1, SMAD3, SRC, TEK, XDH 4.93519
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 4.85569
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.85213
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.84384
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, NUAK1, SMAD3, SRC, TEK, XDH 4.80668
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.80668
[BP] GO:0050801 ion homeostasis ABCG2, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, GPR35, SMAD3 4.80263
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 4.78852
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.78852
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.74367
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.68189
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.68119
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, INSR, MIF, MMP12, SMAD3, SRC 4.64496
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.64394
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.57495
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, SMAD3, SRC, XDH 4.57495
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, SMAD3, SRC, XDH 4.56003
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SMAD3, TEK 4.56003
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.56003
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, KDR, MIF, SRC 4.5544
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, TBXAS1 4.52175
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH 4.51508
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.51508
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MIF, PIM1, SMAD3, SRC, TEK 4.49454
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.45599
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 4.45323
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 4.45323
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 4.42722
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD5, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, SRC 4.42026
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.39681
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HSPA1A, IGF1R, KDR, MIF, PIM1, SMAD3, SRC, TEK, XDH 4.38846
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.37188
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.37188
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MIF, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.3687
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, DRD3, EGFR, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP12, PIM1, TEK 4.35895
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.31768
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, EGFR, FLT3, INSR, KDR, MIF, SRC, TEK, XDH 4.30588
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.30404
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 4.24576
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, SMAD3 4.22793
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC 4.22513
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 4.21623
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, MIF, NUAK1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TEK 4.21571
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, PIM1, PPARA, PTGES, SMAD3, SRC, TEK, XDH 4.21571
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, MIF, PIM1, POLA1, SRC, TEK, TYR 4.16135
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.15694
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.07614
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MIF, SMAD3, SRC, TEK, XDH 4.04493
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MIF, SMAD3, SRC, TEK, XDH 4.04493
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.96449
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.96398
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.94894
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.91217
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.90006
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.90006
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 3.90006
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, FLT3, SRC 3.87842
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK, XDH 3.84312
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.84312
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HSPA1A, INSR, MIF, MMP12, PPARA, SMAD3, SRC 3.83707
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.83707
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.8006
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.788
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.76105
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.74769
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.73658
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.73658
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, INSR 3.72999
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, POLB, SRC, TEK 3.71529
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, DUSP3, EGFR, KDR, MIF, SRC, TEK 3.71381
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, HSPA1A, KDR, MET, MIF, MMP12, PIM1, SMAD3, SRC, TEK 3.6955
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, MIF, MMP12, SRC 3.62736
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, EGFR, KDR, MIF, SRC, TEK 3.60948
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR, XDH 3.60678
[BP] GO:0055080 cation homeostasis ABCG2, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, SMAD3 3.56468
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, DRD5 3.5622
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, POLB, PPARA, SMAD3, SRC, TEK 3.54353
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.53506
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, HSD17B1, HSD17B2 3.53506
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, PIM1, PPARA, PTGES, SMAD3, SRC, TEK, XDH 3.46059
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.46059
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.46059
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, DRD5, INSR 3.43333
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.39665
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, TYR 3.38921
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.3878
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 3.3088
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, PTGES 3.28735
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR 3.27033
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 3.26797
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK, XDH 3.23979
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, SMAD3 3.23082
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, PPARA, SRC, TEK, XDH 3.20401
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, INSR 3.18018
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 3.1794
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.15964
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC 3.15964
[BP] GO:0003018 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 3.15249
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.14361
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.14361
[BP] GO:0060158 None DRD1, DRD2, DRD5 3.14361
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, SRC 3.12399
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC, TEK 3.1165
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 3.10465
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 3.09451
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 3.09451
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.09451
[BP] GO:0046960 None DRD1, DRD5 3.06866
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.05882
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.05882
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.04242
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH 3.0341
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 3.028
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK, XDH 3.01943
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, SMAD3, SRC, TEK 3.01943
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.00503
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK, XDH 2.99916
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, MIF, MMP12, SRC 2.99754
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, SRC, TEK, XDH 2.9913
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, PPARA, SMAD3, SRC, TEK 2.95917
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, PPARA, SRC, TEK 2.95917
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIM1, POLB, PPARA, PTGES, SMAD3, SRC, TEK 2.95917
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.94044
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.94044
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.94044
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.94044
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.94044
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, PIM1, SMAD3, SRC, TEK, XDH 2.92869
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 2.92311
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, DRD2, DRD5, EGFR, F3, FLT3, HSPA1A, INSR, MIF, SMAD3, SRC, TEK, XDH 2.91579
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.91579
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, PPARA, SMAD3, SRC, TEK 2.89667
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.86706
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.84991
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.83414
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.83224
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 2.82866
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.81961
[BP] GO:0019725 cellular homeostasis ABCG2, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, POLA1, SMAD3 2.79535
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.79535
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, PPARA, SMAD3, SRC, TEK 2.79337
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.79216
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, SRC 2.78813
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.77277
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.77277
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.77211
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MIF, SRC, XDH 2.75723
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, PPARA, SRC 2.75723
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 2.7522
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, DRD5, EGFR, IGF1R, INSR, SRC 2.7522
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, EGFR, TYR 2.7522
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.7248
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.7248
[BP] GO:0007617 None APP, DRD1, DRD5 2.7248
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.71997
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.71286
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.7013
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, DRD3, EGFR, MIF, MMP12, SMAD3, SRC 2.70019
[BP] GO:0060160 None DRD2, DRD3 2.69311
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.69311
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.67832
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.6735
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.6735
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.66201
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.65839
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, DRD5, EGFR, FLT3, IGF1R, INSR, SMAD3, SRC 2.61903
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.61667
[BP] GO:0055065 metal ion homeostasis ABCG2, APP, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, SMAD3 2.61667
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP12, SRC, TEK 2.61337
[BP] GO:0072507 divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD5, EGFR, GPR35, SMAD3 2.61337
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.61265
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.61231
[BP] GO:0003013 None ADORA1, DRD1, DRD5, EGFR, SRC, TEK 2.61119
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.5948
[BP] GO:0009314 response to radiation APP, AURKB, DRD1, DRD2, DRD3, EGFR, POLB, TYR 2.59123
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.58442
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PTGES 2.5803
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, DRD2, DRD5, EGFR, F3, FLT3, HSPA1A, INSR, MET, MIF, SMAD3, SRC, TEK, XDH 2.5662
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, PPARA, SMAD3, SRC, TEK, XDH 2.55908
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, DRD5, EGFR, IGF1R, INSR, SRC 2.5549
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, DRD2, FABP3, HSPA1A, PTGES, SMAD3, XDH 2.53599
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.51811
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.51811
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP12, SRC, TEK 2.51613
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGES, SRC 2.47546
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.47546
[BP] GO:0051894 None KDR, SMAD3, TEK 2.4693
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.4693
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF 2.46617
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.44863
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.44863
[BP] GO:0050927 None F3, KDR, SMAD3 2.42413
[BP] GO:0050678 None EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.4226
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.41536
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, MIF, MMP12, SRC 2.41522
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC 2.40788
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, PPARA 2.38492
[BP] GO:0050926 None F3, KDR, SMAD3 2.38104
[BP] GO:1903393 None KDR, SMAD3, TEK 2.38104
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CSNK2A1, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MIF, SMAD3, SRC, TEK, XDH 2.3798
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NUAK1, SMAD3, SRC, TEK, XDH 2.37905
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.37905
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5 2.37905
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, MIF, SRC 2.37137
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA 2.34167
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CYP1A1, DRD3, DUSP3, INSR 2.33849
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.33653
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, DRD3, DRD5, EGFR, KDR 2.33653
[BP] GO:0050714 None ACHE, DRD2, EGFR, MIF, MMP12, SRC 2.33653
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, DRD5, EGFR, IGF1R, INSR, SRC 2.3252
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR 2.31644
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, GPR35, MIF 2.31027
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MIF, MMP12, SRC, TEK 2.30754
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.30471
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3 2.30471
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.30471
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA 2.2874
[BP] GO:0042060 None DRD5, EGFR, PPARA, SMAD3 2.28498
[BP] GO:0010638 positive regulation of organelle organization AURKB, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.28227
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.28118
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, XDH 2.27594
[BP] GO:0021853 None DRD1, DRD2 2.27578
[BP] GO:0010641 None F3, SRC 2.27578
[BP] GO:0090325 None DRD2, DRD3 2.27578
[BP] GO:1904936 None DRD1, DRD2 2.27578
[BP] GO:0042321 None ADORA1, DRD2 2.27578
[BP] GO:0019098 None APP, DRD1, DRD5 2.27468
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, MIF, MMP12, SMAD3, SRC 2.27184
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, MIF, MMP12, SRC 2.26619
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.26619
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 2.25044
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, DRD5 2.23929
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.23929
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.23929
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, DRD2, EGFR, FLT3, INSR, KDR, MIF, SRC, TEK, XDH 2.21877
[BP] GO:0007188 None ADORA1, DRD1, DRD2, DRD3, DRD5 2.21559
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.20753
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.20753
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.20753
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, XDH 2.20753
[BP] GO:0042220 None DRD2, DRD3, DRD5 2.20753
[BP] GO:1901890 None KDR, SMAD3, TEK 2.20753
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.20753
[BP] GO:0045744 None DRD2, DRD3, MET 2.20753
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.1691
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.1691
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CYP1B1, DRD2, EGFR, INSR, MET, POLB, SMAD3, SRC, TEK 2.16906
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, SRC 2.16293
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC 2.1472
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, XDH 2.1472
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.14388
[BP] GO:0010907 None INSR, PPARA, SRC 2.14388
[BP] GO:0106027 None APP, IGF1R, INSR 2.14388
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.14388
[BP] GO:0021843 None DRD1, DRD2 2.14388
[BP] GO:1990535 None APP, INSR 2.14388
[BP] GO:0021830 None DRD1, DRD2 2.14388
[BP] GO:0021826 None DRD1, DRD2 2.14388
[BP] GO:0046958 None DRD1, DRD5 2.14388
[BP] GO:0040008 regulation of growth APP, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.13918
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MIF, SMAD3, SRC, TEK, XDH 2.12937
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, MIF, SRC 2.1293
[BP] GO:0006874 cellular calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 2.12516
[BP] GO:0030336 None ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, MIF 2.1225
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD5 2.12006
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, DRD2, EGFR, MIF, MMP12, SMAD3, SRC 2.11657
[BP] GO:0071868 None APP, DRD1, DRD5 2.11657
[BP] GO:0071870 None APP, DRD1, DRD5 2.11657
[BP] GO:0048534 hematopoietic or lymphoid organ development FLT3, KDR, POLB, TEK, TYR 2.11657
[BP] GO:2001023 None DRD1, DRD2, DRD3, MET 2.10637
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, XDH 2.0945
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, DRD2, EGFR, FLT3, INSR, KDR, MIF, SRC, TEK, XDH 2.09311
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.09076
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.08809
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, XDH 2.07656
[BP] GO:0019933 None DRD1, DRD2, DRD3, DRD5 2.07638
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CYP1A1, DRD2, DRD3, INSR 2.0591
[BP] GO:0055074 calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 2.0591
[BP] GO:0045124 None CA2, EGFR, SRC 2.05341
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, DRD2, HSPA1A, MIF, MMP12, SMAD3, SRC 2.04762
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.04683
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, MMP12, SMAD3, SRC, XDH 2.04194
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, SRC 2.03919
[BP] GO:0050679 None EGFR, F3, KDR, MMP12, TEK 2.03919
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, XDH 2.03919
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD5, GPR35, SMAD3 2.0358
[BP] GO:0007435 salivary gland morphogenesis EGFR, POLB 2.0358
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC 2.0358
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, MIF, MMP12, SRC 2.0358
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC 2.0358
[BP] GO:0007190 None ADORA3, DRD1, DRD5 2.0358
[BP] GO:0032467 None AURKB, DRD2, DRD3 2.0358
[BP] GO:0071867 None APP, DRD1, DRD5 2.0358
[BP] GO:0071869 None APP, DRD1, DRD5 2.0358
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGES 2.0358
[BP] GO:2000146 None ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, MIF 2.02872
[BP] GO:0032989 cellular component morphogenesis APP, AXL, DRD2, EGFR, MET, SRC, TEK 2.02747
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, XDH 2.02747
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, FLT3, INSR, MIF, SRC, TEK 2.0268
[BP] GO:0051704 multi-organism process APP, AXL, CYP1A1, DRD3, EGFR, HSPA1A, INSR, KDR, MET, MMP12, POLA1, SMAD3, SRC 2.02289
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, SRC 2.02289
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, SRC, TEK, TYR 2.02102
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, F3, INSR, KDR, MIF, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, XDH 2.01983
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, MET, SMAD3, SRC 2.01983
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PPARA 2.01648
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.01558
[BP] GO:0002686 None ADORA1, CYP19A1, MIF 2.01272
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CYP19A1, DRD2, DUSP3, MIF, MMP12 2.00533
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, TEK 2.00533
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR 2.00533
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.90514
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK 3.84227
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.73658
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, PTGES, SRC, TBXAS1, TEK, TYR 3.5717
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, PIM1, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR 3.46059
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 3.32329
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, DRD1, DRD2, DRD5, EGFR, INSR, MET, SRC, TEK 3.2558
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PIM1, SMAD3, SRC, TEK 3.23082
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.95917
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.79049
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, EGFR, F3, MET, MIF, TEK 2.63099
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, HSD17B2, PTGES, TBXAS1 2.30471
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, FLT3, HSD17B2, PTGES, TBXAS1 2.24996
[CC] GO:0097730 None DRD1, DRD2, DRD5 2.1691
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, HSPA1A, PTGES, SRC, TYR 2.16014
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 11.5297
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, NUAK1, PIM1, POLA1, POLB, PTGES, SRC, TBXAS1, TEK, TYR, XDH 10.7205
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4601
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 8.98952
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP12, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 8.62974
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.90205
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.29855
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.1777
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.07574
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.80315
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.67582
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.30106
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.87939
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.78906
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.63447
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.57333
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 5.2867
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.23902
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.17696
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TYR, XDH 5.09226
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 5.03518
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.90641
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.8972
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.78852
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.43062
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.39384
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 4.25039
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.25039
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.16495
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 4.08499
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 4.08499
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.79662
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 3.71381
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 3.63223
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.58638
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, DRD5 3.51156
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 3.4728
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.44389
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 3.3831
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.23072
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, SMAD3, SRC 3.22326
[MF] GO:0043168 anion binding ABCG2, APP, AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGES, SRC, TEK, XDH 3.20805
[MF] GO:0008389 None CYP2A13, CYP2A6 3.06866
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, XDH 2.95917
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TYR, XDH 2.8355
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC 2.77274
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.76349
[MF] GO:0000166 nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.69311
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.69251
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.6735
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.64588
[MF] GO:0097367 carbohydrate derivative binding ABCG2, ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK 2.54408
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.51613
[MF] GO:0001588 None DRD1, DRD5 2.44863
[MF] GO:0051425 None APP, INSR 2.44863
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.43689
[MF] GO:0043559 insulin binding IGF1R, INSR 2.27578
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.27468
[MF] GO:0004064 arylesterase activity CA1, CA2 2.14388
[MF] GO:0019899 enzyme binding APP, AURKB, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, F3, HSPA1A, MET, MIF, POLA1, POLB, PPARA, SMAD3, SRC, TEK 2.07656
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.0358
[MF] GO:0001609 None ADORA1, ADORA3 2.0358


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.9788
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4947
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0609
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2343
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.3324
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.2348
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.4041
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8636
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD1, DRD2, DRD3, DRD5 3.7158
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.2046
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2324
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.8687
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA, DRD5 2.6207
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.6207
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.6207
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.4722
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6672
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6678
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3, DRD5 2.4201
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4116
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4116
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2983
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 2.32
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2751
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2727
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2493
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2964
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1, F3 1.8542
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.8649
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MET, EGFR, IGF1R 1.6513
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2701
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5754
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MET, EGFR 1.4381
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2632
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3964
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR, DRD5 1.3504
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3504
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0408
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3504
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4053
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3784
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1479
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1583
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1456
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1273
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 1.0318
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1456
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3496
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3964
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.0176
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9838
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2384
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.978
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.978
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9136
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9245
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3217
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9718
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9052
Bile secretion_Homo sapiens_hsa04976 CA2, ABCG2 1.3067
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5107
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9052
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9052
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9052
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC 0.8959
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9007
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.628
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8765
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8645
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.806
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7986
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7314
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5532
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7272
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7049
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6243
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.7268
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8333
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3766
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3975
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3864
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3889
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3975
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4141
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3762
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4219
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4621
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4522
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4833
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4833
Axon guidance_Homo sapiens_hsa04360 MET 0.4779
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4946
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5137
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5393
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5385
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5393
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5311
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5385
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7149
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5385
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5402
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5399
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5309
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5445
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5533
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5544
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5544
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5646
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7908
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5538
Peroxisome_Homo sapiens_hsa04146 XDH 0.5653
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5993
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6007
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5981
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5805
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5865
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6077
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6225
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6207
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6243
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6345
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6258
Shigellosis_Homo sapiens_hsa05131 SRC 0.6243
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6243
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0215
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6576
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6603
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6782
Malaria_Homo sapiens_hsa05144 MET 0.6977
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7014
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.762
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7272
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7967
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8677
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8262
DNA replication_Homo sapiens_hsa03030 POLA1 0.7899
Base excision repair_Homo sapiens_hsa03410 POLB 0.806
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8486
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8722
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8677
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.978
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0318


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)