TCM Prescription: Bolus as Kidney-Yin-Tonic; Kidney-yin-Tonifying Bolus



Prescription Description
Prescription IDTCMF2062
Pinyin Namezuo gui wan
Chinese Name左归丸
English NameBolus as Kidney-Yin-Tonic; Kidney-yin-Tonifying Bolus
Function Description腰痛, 遗精, 盗汗
IndicationsInvoluntary ejaculation disorder, Lumbago disorder
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
Human Tissues Associated with IndicationKidney, Bladder
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH289 Cyathula officinalis 川牛膝 TCMH289 ITSAF2788-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1351 Colla cornus cervi 鹿茸胶 TCMH1351
TCMH744 Colla carapacis et plastri testudinis 龟板胶 TCMH744
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 12.2993
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 10.4985
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 9.2105
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA 8.84653
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 8.55673
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A3, SRC, TYR 8.46745
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.46745
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 8.46745
[BP] GO:0010033 response to organic substance AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A3, SRC, TYR 7.74703
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.74612
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.74612
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.67815
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 7.67815
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.67815
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.67815
[BP] GO:0042221 response to chemical AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A3, SRC, TYR 7.20724
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A3, SRC, TYR 7.07692
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.02009
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.43795
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FDPS, HMGCR, SLC6A3, TYR 6.16694
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 6.12735
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, XDH 6.07547
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.01699
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FLT3, RORC, SLC6A3, SRC, TYR 5.98762
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 5.96806
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.96381
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.96381
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 5.96115
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 5.83786
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 5.70084
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FDPS, FUT7, HMGCR, PIM1, PPARA, TYR, XDH 5.68953
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.54124
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.54124
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.42824
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.42824
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.32197
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 5.28993
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.28628
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.2652
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, ESR1, GRM5 5.19484
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.17103
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.06345
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 4.99637
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.99453
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.94398
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 4.90767
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.84417
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 4.77179
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.67601
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC 4.66644
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.64232
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 4.64232
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 4.55392
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 4.54113
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.50775
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 4.4782
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, KDR, SLC6A2, SLC6A3, SRC 4.43015
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.43015
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.40317
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 4.35656
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 4.35213
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 4.33738
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 4.33645
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.3077
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 4.29915
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.27665
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 4.26879
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3, TYR 4.2395
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.17449
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.1381
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.1381
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A3, SRC, TYR 4.12861
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.10724
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 4.05714
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.03477
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.02497
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TYR 4.02497
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, ESR1, PPARA, RORC, SRC 4.02114
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 4.00935
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 3.97534
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.95943
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.92095
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.92095
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.87985
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.8453
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC 3.75556
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.75556
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.75556
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 3.71991
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.68796
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 3.68796
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 3.65121
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.62616
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, F10, IGF1R, KDR, MET, MMP9, SRC 3.62616
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 3.60898
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 3.60381
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.57285
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, SLC1A1, SLC6A3, XDH 3.56159
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 3.53917
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.53855
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.51925
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.51925
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.5172
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.5172
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 3.4977
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.47628
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 3.44968
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SLC6A3, SRC, TYR 3.44968
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TYR, XDH 3.38278
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.38278
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.36717
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.36717
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD2, DRD4 3.34
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.34
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.34
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.27855
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.27855
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR 3.26605
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.25486
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.25486
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25486
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD2, DRD3, HCAR2, HMGCR, KDR, SRC 3.2546
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.24304
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC 3.23452
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.23341
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 3.22885
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TYR, XDH 3.22467
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, DRD4, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 3.22467
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 3.22467
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.2185
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.20429
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD2, DRD3, GRM1, HMGCR, MMP2, PPARA, SRC, TYR 3.15325
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.14627
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.12705
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1 3.12637
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 3.12566
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.11645
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC 3.11024
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 3.11024
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.09163
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.07916
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, MET, SRC, XDH 3.07916
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 3.04935
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 3.04935
[BP] GO:0042391 None ADORA1, APP, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.04785
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, MET, SLC6A3, XDH 3.04785
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.04027
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, SLC6A3, TYR 3.03732
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.0353
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HMGCR, MMP9, PPARA, PTPN1, SRC 3.01463
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.00411
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 2.99159
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.96373
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96373
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.96373
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.95167
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 2.92843
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TYR, XDH 2.92235
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.9182
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.90772
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 2.90772
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, HMGCR, SLC6A3, SRC, TYR 2.89858
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88579
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.88579
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5 2.83517
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PTPN1, SRC, XDH 2.83113
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.81079
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.8088
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.80565
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A3 2.80319
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HMGCR, HSD11B1, HSD17B1, HSD17B2 2.80012
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, DRD3, DRD4, HCAR2, HMGCR, PTPN1, SRC 2.79012
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, SLC6A3, TYR 2.75951
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.74019
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.74019
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.73901
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.73233
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.73233
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.72278
[BP] GO:0008542 None APP, DRD2, DRD3, HMGCR 2.71674
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.6913
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.65966
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.60851
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.59815
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.59689
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 2.59375
[BP] GO:0007632 None APP, DRD2, DRD3, HMGCR 2.56387
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.56387
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.56097
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.55012
[BP] GO:0099566 None GRM1, GRM5 2.55012
[BP] GO:0051944 None DRD2, DRD4 2.55012
[BP] GO:0060160 None DRD2, DRD3 2.55012
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55012
[BP] GO:0051586 None DRD2, DRD4 2.55012
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.54983
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.54456
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC 2.53311
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.53097
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.53097
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CHRM1, DRD2, DRD3, DRD4, GRM5, MMP9 2.51464
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD2, DRD3, GRM5, HMGCR 2.51403
[BP] GO:0043086 negative regulation of catalytic activity APP, CSNK2A1, DRD2, DRD3, DRD4, FABP4, GRM3, HMGCR, IGF1R, MMP9, PTPN1, SRC 2.49663
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.49098
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.49096
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.49096
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, SRC 2.46026
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, HCAR2, HMGCR, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC 2.4599
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.4599
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, HMGCR, PPARA, SLC6A3 2.45643
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.44057
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.44057
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A3 2.43998
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.43998
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.43998
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.43998
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, SLC1A1 2.41004
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.39805
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.38488
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.38488
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.3585
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.35838
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.35127
[BP] GO:0098657 import into cell ACHE, ADORA1, APP, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3 2.34832
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.337
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.337
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.337
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.337
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, ESR1, FABP4, HMGCR, KDR, MET, PPARA, SLC6A3 2.33452
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.32535
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, ESR1, GRM1, HCAR2, HMGCR, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC, XDH 2.32465
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31932
[BP] GO:0051582 None DRD2, DRD4 2.31932
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31932
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5 2.30975
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.3075
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.30466
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.30466
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.29962
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.29962
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, SRC 2.28552
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, FDPS, HMGCR 2.28552
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.27219
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.27219
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.26581
[BP] GO:0040014 regulation of multicellular organism growth APP, DRD2, DRD3, SLC6A3 2.2652
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.26164
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.26164
[BP] GO:0048169 None APP, DRD2, GRM5 2.25861
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.24629
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DRD2, DRD4, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.24629
[BP] GO:0007610 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, HMGCR, PPARA, SLC6A3 2.23993
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.23684
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.22832
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.22832
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, DRD2, DRD3, DRD4, HCAR2, SRC 2.22275
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.21947
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.21947
[BP] GO:0007589 None CHRM1, CHRM3, SLC6A3, XDH 2.21031
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.20427
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SLC6A3, SRC, XDH 2.19754
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, HMGCR, SRC 2.19352
[BP] GO:0008306 None APP, DRD2, DRD3, HMGCR 2.19226
[BP] GO:0007612 None APP, DRD2, DRD3, GRM5, HMGCR 2.19226
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.18328
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.18328
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.17574
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, XDH 2.17574
[BP] GO:0032412 None APP, DRD2, DRD3, DRD4, GRM5, MMP9 2.16791
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, XDH 2.16231
[BP] GO:0046541 None CHRM1, CHRM3 2.15816
[BP] GO:0090325 None DRD2, DRD3 2.15816
[BP] GO:0042321 None ADORA1, DRD2 2.15816
[BP] GO:0030534 None APP, DRD2, DRD3, DRD4, PPARA 2.15143
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD2, DRD3, ESR1, ESR2, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, SLC6A3, SRC, XDH 2.14506
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.14457
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, DRD4, MMP9 2.14168
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2 2.13998
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.13252
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.13082
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.12782
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.1265
[BP] GO:0022898 None APP, DRD2, DRD3, DRD4, GRM5, MMP9 2.12499
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, XDH 2.12211
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.11881
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.11881
[BP] GO:0051952 None ADORA1, DRD2, DRD3, DRD4 2.11566
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.11566
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, XDH 2.11566
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, PTPN1, SRC 2.1033
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.08216
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.08216
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.07734
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, HCAR2, HMGCR, SRC 2.07544
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.07446
[BP] GO:0015893 None CA2, CHRM5, SLC1A1, SLC6A2, SLC6A3 2.06732
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 2.06638
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.04916
[BP] GO:0045744 None DRD2, DRD3, MET 2.04916
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.04916
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, DRD2, DRD4, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.035
[BP] GO:0032415 None DRD3, DRD4 2.03121
[BP] GO:0051934 None SLC6A2, SLC6A3 2.03121
[BP] GO:0021984 None DRD2, SLC6A3 2.03121
[BP] GO:0090494 None SLC6A2, SLC6A3 2.03121
[BP] GO:0090493 None SLC6A2, SLC6A3 2.03121
[BP] GO:0051583 None SLC6A2, SLC6A3 2.03121
[BP] GO:0006140 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.02888
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.02129
[BP] GO:0032409 None APP, DRD2, DRD3, DRD4, GRM5, MMP9 2.02129
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, XDH 2.01914
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.01914
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, HMGCR, SRC 2.00656
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, SRC 2.00535
[BP] GO:0032410 None DRD2, DRD3, DRD4, MMP9 2.00307
[BP] GO:1904063 None DRD2, DRD3, DRD4, MMP9 2.00307
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.00302
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, HMGCR, SRC 2.00302
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 8.2152
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 7.83403
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 7.13554
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 6.8001
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 6.60683
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 6.50828
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.82731
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 5.54124
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 5.02379
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TYR 4.94825
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 4.60054
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 4.12861
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 4.12861
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.97534
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.96882
[CC] GO:0098794 None ADORA1, APP, DRD2, DRD4, GRIA2, GRIA4, GRM3 3.82853
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.67642
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, F10, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TYR 3.50277
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.50277
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.38278
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC 3.36717
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.35355
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.95977
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.95977
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.59774
[CC] GO:0016021 None ADORA1, ADORA3, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TYR 2.55012
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.53097
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.21031
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1 2.0917
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03121
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 10.6331
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.87195
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 9.27139
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 8.95072
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 8.46745
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.29009
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 8.21618
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 7.71146
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 7.23119
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 7.23119
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TYR, XDH 6.71277
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.43795
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3974
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.56649
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 5.45611
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.17103
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F10, FDPS, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TYR, XDH 5.04812
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC 5.02995
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.63183
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 4.47467
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.4053
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 4.37183
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.12861
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC 4.02497
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.97534
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75556
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 3.71991
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.63532
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57285
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.5172
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.50277
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38278
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.37097
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.08499
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.04935
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.04702
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93786
[MF] GO:0046872 metal ion binding ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FDPS, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TYR, XDH 2.90772
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.80565
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.78642
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.77567
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.68615
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.68615
[MF] GO:0005330 None SLC6A2, SLC6A3 2.55012
[MF] GO:0099583 None GRM1, GRM5 2.55012
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.54456
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.54456
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.54456
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.43617
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.31932
[MF] GO:0004971 None GRIA2, GRIA4 2.31932
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.28552
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, DRD2, DRD4, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, TYR, XDH 2.22832
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.18328
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.18328
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.17109
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15816
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SRC 2.15143
[MF] GO:0051721 None HMGCR, PTPN1, SLC6A3 2.14981
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.11881
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.04916
[MF] GO:0005329 None SLC6A2, SLC6A3 2.03121
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03121
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.00302


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 13.1321
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.4059
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9083
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.9897
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.5638
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 5.1818
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.7595
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2394
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.2394
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, AKR1B1, HMGCR, TYR, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 4.0162
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2394
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2394
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.5839
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.6207
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.0725
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0162
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.7342
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2242
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6714
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.8595
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4114
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.4022
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1694
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0541
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2561
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6994
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.1663
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0915
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.927
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1694
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.927
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 1.7215
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.776
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4582
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0306
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3248
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2843
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3204
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0491
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0049
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9194
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1142
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2357
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0212
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.19
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0306
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.215
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9527
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.302
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2326
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2513
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9389
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1558
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0299
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.215
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.2806
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9194
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.848
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9194
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8033
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9129
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8116
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8945
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8213
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.734
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6953
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2395
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2395
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.301
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2998
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3275
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3118
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3184
Influenza A_Homo sapiens_hsa05164 FDPS 0.3275
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3273
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3524
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3357
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3604
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3184
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3815
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3524
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3777
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3778
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3777
Platelet activation_Homo sapiens_hsa04611 SRC 0.4026
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3856
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4026
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5844
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4671
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4299
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4026
Axon guidance_Homo sapiens_hsa04360 MET 0.3979
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4087
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4671
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4499
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4531
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4671
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4671
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4531
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4562
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4671
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4636
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4671
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4671
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4671
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4671
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4636
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4636
Peroxisome_Homo sapiens_hsa04146 XDH 0.4671
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4713
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4671
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5272
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.776
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.513
Glioma_Homo sapiens_hsa05214 IGF1R 0.5272
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5262
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5272
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5137
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5272
Shigellosis_Homo sapiens_hsa05131 SRC 0.5272
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6623
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7397
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5976
Malaria_Homo sapiens_hsa05144 MET 0.6082
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6196
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6229
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9606
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7231
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7617
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7775
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.9855
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8049
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7696
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8013
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1208


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)