Prescription Description
| Prescription ID | TCMF1450 |
| Pinyin Name | Gou Pi Gao |
| Chinese Name | 狗皮膏 |
| English Name | Goupi Plaster |
| Function Description | 筋骨疼痛, 手足麻木, 跌打损伤, 小肠疝气, 腹胀腹痛 |
| Indications | Abdominal pain disorder, Lower abdominal colic disorder, Numbness disorder |
| Disease ICD-11 Category |
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1)
]; SB07 [Lower abdominal colic disorder (TM1), 疝气 (TM1) ]; SC62 [Numbness disorder (TM1), 麻木 (TM1) ]; |
| Human Tissues Associated with Indication | SkeletalMuscle |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH296 | Radix aconiti | 川乌 | TCMH296 | |
| TCMH222 | Aconitum carmichaelii | 草乌 | TCMH222 | ITSAH2410-14 |
| TCMH1665 | Notopterygium incisum | 羌活 | TCMH1665 | JF755946 |
| TCMH517 | Angelica pubescens | 独活 | TCMH517 | ITSAF170-14 |
| TCMH1680 | Sinomenium acutum | 青风藤 | TCMH1680 | ITSAJ4218-14 |
| TCMH2267 | Periploca sepium | 香加皮 | TCMH2267 | ITSAJ4400-14, GBVP4570-15 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH2112 | Radix smilacis | 铁丝威灵仙 | TCMH2112 | |
| TCMH211 | Atractylodes lancea | 苍术 | TCMH211 | ITSAN4439-14 |
| TCMH1866 | Cnidium monnieri | 蛇床子 | TCMH1866 | ITSAL2575-14 |
| TCMH1398 | Ephedra sinica | 麻黄 | TCMH1398 | ITSAM882-14 |
| TCMH672 | Alpinia officinarum | 高良姜 | TCMH672 | ITSAK2176-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
Showing 1 to 10 of 97 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 62 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, SRC | 2.04683 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGES, SRC | 2.47546 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3 | 3.90006 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2 | 2.20753 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, DRD2, PPARA, SMAD3, SRC, TEK | 2.95917 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 | 5.23902 |
| [BP] GO:0001819 | positive regulation of cytokine production | CYP1B1, DRD2, HSPA1A, MIF, MMP12, SMAD3, SRC | 2.04762 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH | 3.0341 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, DRD2, EGFR, FLT3, INSR, KDR, MIF, SRC, TEK, XDH | 2.21877 |
| [BP] GO:0001963 | None | DRD1, DRD2, DRD3, DRD5 | 4.68189 |
Showing 1 to 10 of 454 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCG2 | 0.7272 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4053 |
| Adherens junction_Homo sapiens_hsa04520 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.0609 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6077 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIM1, F3 | 1.8542 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.7986 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.762 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3975 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.6207 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9718 |
Showing 1 to 10 of 142 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples