NPASS Compound

Natural Product: NPC331654

Natural Product ID	NPC331654
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	FBOZXECLQNJBKD-ZDUSSCGKSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	126941
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000264] Organic acids and derivatives [CHEMONTID:0000265] Carboxylic acids and derivatives [CHEMONTID:0000013] Amino acids, peptides, and analogues [CHEMONTID:0000347] Amino acids and derivatives [CHEMONTID:0000060] Alpha amino acids and derivatives [CHEMONTID:0004323] Glutamic acid and derivatives

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 55 57 0 0 0 0 0 0 0 0999 V2000 1.8552 -1.9268 -2.4591 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8960 -0.5317 -2.0136 N 0 0 0 0 0 0 0 0 0 0 0 0 3.1130 0.1975 -2.2554 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2963 -0.3601 -1.5343 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1371 -1.2425 -2.1762 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2120 -1.7833 -1.5625 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4589 -1.4388 -0.2784 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6162 -0.5543 0.3635 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8532 -0.1834 1.6937 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9741 0.7295 2.3393 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9243 -0.7322 2.2809 N 0 0 0 0 0 0 0 0 0 0 0 0 7.7572 -1.5947 1.6752 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7911 -2.0956 2.3125 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5058 -1.9320 0.4010 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5464 -0.0162 -0.2469 N 0 0 0 0 0 0 0 0 0 0 0 0 0.7396 -0.0109 -1.3722 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.3699 -0.8266 -1.1824 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5310 -0.4051 -0.5733 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.6326 0.8747 -0.1197 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5600 1.7112 -0.2877 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6161 1.2742 -0.9079 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.8400 1.3468 0.5245 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.8963 2.5602 0.9383 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.0004 0.5843 0.7521 N 0 0 0 0 0 0 0 0 0 0 0 0 -5.1712 1.1491 1.4114 C 0 0 1 0 0 0 0 0 0 0 0 0 -6.3280 1.1030 0.4366 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.6356 -0.3225 0.0070 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.7852 -0.2509 -0.9455 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.3243 0.8220 -1.2664 O 0 0 0 0 0 0 0 0 0 0 0 0 -8.2693 -1.4297 -1.4930 O 0 0 0 0 0 0 0 0 0 0 0 0 -5.5165 0.3500 2.6272 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.5086 0.7117 3.3094 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.7820 -0.7541 3.0066 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6870 -2.1527 -3.1447 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7737 -2.6204 -1.6126 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9324 -2.0926 -3.0947 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9759 1.2423 -1.9935 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3140 0.1861 -3.3724 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9272 -1.5055 -3.2305 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1500 1.7459 2.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1801 0.4321 2.9426 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1066 -0.4603 3.2715 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9383 -1.7990 3.3005 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.3142 -1.8655 -1.5362 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3597 -1.0779 -0.4521 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.6058 2.7370 0.0614 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4488 1.9590 -1.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.0256 -0.4038 0.4448 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.0018 2.2084 1.6910 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.9692 1.6213 -0.4881 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.2004 1.5839 0.8768 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.7792 -0.7850 -0.5148 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.8906 -0.9419 0.8829 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.1535 -1.4207 -2.0233 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.2757 -1.5549 3.4240 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 2 0 6 7 1 0 7 8 1 0 8 9 2 0 9 10 1 0 9 11 1 0 11 12 1 0 12 13 2 3 12 14 1 0 8 15 1 0 2 16 1 0 16 17 2 0 17 18 1 0 18 19 2 0 19 20 1 0 20 21 2 0 19 22 1 0 22 23 2 0 22 24 1 0 24 25 1 0 25 26 1 0 26 27 1 0 27 28 1 0 28 29 2 0 28 30 1 0 25 31 1 0 31 32 2 0 31 33 1 0 15 4 2 0 21 16 1 0 14 7 2 0 1 34 1 0 1 35 1 0 1 36 1 0 3 37 1 0 3 38 1 0 5 39 1 0 10 40 1 0 10 41 1 0 11 42 1 0 13 43 1 0 17 44 1 0 18 45 1 0 20 46 1 0 21 47 1 0 24 48 1 0 25 49 1 1 26 50 1 0 26 51 1 0 27 52 1 0 27 53 1 0 30 54 1 0 33 55 1 0 M END

Standard InCHIKey	FBOZXECLQNJBKD-ZDUSSCGKSA-N
Standard InCHI	InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
SMILES	CN(Cc1cnc2c(c(N)[nH]c(=N)n2)n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Calculated Properties

Physi-Chem Properties

Molecular Weight:	454.17	Volume:	431.731 ? Van der Waals volume.
Dense:	1.052	LogP:	-1.62 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	0.752 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-4.439 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	10.0	Rigid Bonds:	21.0
TPSA:	211.27 ? Topological Polar Surface Area.	H-Bond Acceptor:	13.0
H-Bond Donor:	7.0	Rings:	3.0
Heavy Atoms:	13.0

MedChem Properties

QED Drug-Likeness Score:	0.256	GASA:	0.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.425	Fsp³:	0.25
MCE-18:	42.0 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Rejected	GSK Rule:	Accepted
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.059	Fluc inhibitor:	0.539 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.945 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.695 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.013	Promiscuous compounds:	0.185

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-5.958	MDCK Permeability:	-5.338
Pgp-inhibitor:	0.0	Pgp-substrate:	0.959
PAMPA:	1.0 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.0
20% Bioavailability (F20%):	0.0	30% Bioavailability (F30%):	0.001
50% Bioavailability (F50%):	0.001

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.0	MRP1:	0.993
Plasma Protein Binding (PPB):	73.533%	Volume Distribution (VD):	-0.47
Fu:	27.939% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.017
OATP1B3 inhibitor:	0.91	BCRP inhibitor:	0.0
BSEP inhibitor:	0.001

ADMET: Metabolism

CYP1A2-inhibitor:	0.0	CYP1A2-substrate:	0.0
CYP2C19-inhibitor:	0.0	CYP2C19-substrate:	0.0
CYP2C9-inhibitor:	0.005	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.0	CYP2D6-substrate:	0.0
CYP3A4-inhibitor:	0.0	CYP3A4-substrate:	0.0
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	0.0
HLM stability:	0.0 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

2.255

Half-life (T1/2):

2.139

ADMET: Toxicity

hERG Blockers:	0.168	hERG Blockers (10um):	0.106
Human Hepatotoxicity (H-HT):	0.997	Drug-induced Liver Injury (DILI):	0.993
AMES Toxicity:	0.107	Rat Oral Acute Toxicity:	0.85
Maximum Recommended Daily Dose:	0.987	Skin Sensitization:	0.96
Carcinogencity:	0.428	Eye Corrosion:	0.0
Eye Irritation:	0.002	Respiratory Toxicity:	0.91
Drug-induced Neurotoxicity:	0.462	Ototoxicity:	0.967
Hematotoxicity:	0.579	Drug-induced Nephrotoxicity:	0.998
Genotoxicity:	1.0	RPMI-8226 Immunitoxicity:	0.698
A549 Cytotoxicity:	0.052	Hek293 Cytotoxicity:	0.902
BCF:	-0.144 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	2.743 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	4.076 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	3.411 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[11087592]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[15730242]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	bark	n.a.	PMID[1593281]
NPO40501	Usnea longissima	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27186821]
NPO40313	Quambalaria cyanescens	Species	Quambalariaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27571379]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30028612]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[8676130]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8946743]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40501	Usnea longissima	Species	Parmeliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40313	Quambalaria cyanescens	Species	Quambalariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
ID50	37
IC50	1368
Ki	81
Kd	17
Inhibition	78
Ratio	54
Activity	137
IC80	1
FC	6
AC50	92
ED50	17
EC50	89
MIC50	3
GI50	27
Ratio IC50	29
IZ	9
TGI	14
MIC	14
Ratio Ki	2
Ratio ED50	1
MIC90	1
GI	1
Selectivity Index	1
IC50 relative	2
CC50	5
Survival	9

Activity Type	# Activity
Individual protein	368
Cell line	1149
Single protein	175
Organism	193
Tissue	2
Protein family	3
Unchecked	17
Others	125
Non-molecular	63

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	0.82	nM	PMID[8691451]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.2	nM	PMID[6403710]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	66.0	nM	PMID[11384244]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	3600.0	nM	PMID[11384244]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	26.0	nM	PMID[7365749]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.00519	nM	PMID[9857098]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	100000.0	nM	PMID[3091834]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[2918496]
NPT2819	Individual protein	Dihydrofolate reductase	Leishmania major	Ki	=	0.1288	nM	PMID[3599028]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.0012	nM	PMID[7877140]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.11	nM	PMID[7877140]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	3.9	nM	PMID[1992121]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	24.0	nM	PMID[1992122]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	190000.0	nM	PMID[4009615]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[12408727]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[12570380]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	4.3	nM	PMID[2738891]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.18	nM	PMID[8568827]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.4	nM	PMID[8568827]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	0.72	nM	PMID[8568827]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	0.6	nM	PMID[8568827]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	30.0	nM	PMID[2296020]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	0.0012	ug.mL-1	PMID[2423690]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	25.0	nM	PMID[1992118]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	24.0	nM	PMID[1995880]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[11960504]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	2.0	nM	PMID[11052790]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	75000.0	nM	PMID[7108907]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	120000.0	nM	PMID[3184124]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	2.7	nM	PMID[1578484]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	3.8	nM	PMID[3339615]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	2.7	nM	PMID[3091832]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	120000.0	nM	PMID[3091832]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	170000.0	nM	PMID[3091832]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[10956221]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	4.3	nM	PMID[2704031]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	600000.0	nM	PMID[3100797]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.038	nM	PMID[10360757]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.179	nM	PMID[10360757]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	720.0	nM	PMID[8568828]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Inhibition	=	0.0000000012	%	PMID[6699882]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	Inhibition	=	0.00015	%	PMID[6699882]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	Inhibition	=	0.00008	%	PMID[6699882]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	86000.0	nM	PMID[3121855]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	11.2	nM	PMID[8035423]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	4.0	nM	PMID[8164259]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	170000.0	nM	PMID[8164259]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	38.0	nM	PMID[8691474]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	14.5	nM	PMID[11052789]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	40000.0	nM	PMID[6772788]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	7.9	nM	PMID[6772788]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	40.0	nM	PMID[7562910]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	0.7	nM	PMID[7562910]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	170000.0	nM	PMID[7562910]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[16078850]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[16451071]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	9.0	nM	PMID[15615522]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[15615538]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[16279780]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	29000.0	nM	PMID[16279780]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[17552508]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[17569517]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	35.0	nM	PMID[17127067]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	9.0	nM	PMID[17127067]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[18072727]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.0	nM	PMID[18205293]
NPT2755	Individual protein	Protein-arginine deiminase type-4	Homo sapiens	IC50	>	10000000.0	nM	PMID[17964793]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	4420.0	nM	PMID[17532099]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[18800768]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	32.94	nM	PMID[18555562]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	29000.0	nM	PMID[18605720]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[18605720]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[19719239]
NPT2621	Individual protein	Pteridine reductase 1	Leishmania major	Ki	=	39.0	nM	PMID[19916554]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.077	nM	PMID[19748785]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[20056546]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	=	29000.0	nM	PMID[20056546]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	80.0	nM	PMID[20350811]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[20092323]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	IC50	>	18000.0	nM	PMID[21550809]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[21550809]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[22739090]
NPT1739	Individual protein	Canalicular multispecific organic anion transporter 2	Rattus norvegicus	Ki	=	90000.0	nM	PMID[11837698]
NPT1594	Individual protein	Multidrug resistance-associated protein 1	Homo sapiens	Activity	=	82.0	%	PMID[9188796]
NPT2850	Individual protein	Multidrug resistance associated protein	Homo sapiens	Activity	<	10.0	%	PMID[12388190]
NPT1739	Individual protein	Canalicular multispecific organic anion transporter 2	Rattus norvegicus	Activity	=	10.7	%	PMID[10329726]
NPT1739	Individual protein	Canalicular multispecific organic anion transporter 2	Rattus norvegicus	Activity	=	18.5	%	PMID[10329726]
NPT1028	Individual protein	Multidrug resistance-associated protein 4	Homo sapiens	Activity	=	39.0	%	PMID[12883481]
NPT1028	Individual protein	Multidrug resistance-associated protein 4	Homo sapiens	Activity	=	40.3	%	PMID[11447229]
NPT1028	Individual protein	Multidrug resistance-associated protein 4	Homo sapiens	Activity	=	53.0	%	PMID[14643890]
NPT2850	Individual protein	Multidrug resistance associated protein	Homo sapiens	Ki	=	1200000.0	nM	PMID[11837698]
NPT304	Individual protein	Canalicular multispecific organic anion transporter 1	Rattus norvegicus	Ki	=	236000.0	nM	PMID[9270020]
NPT304	Individual protein	Canalicular multispecific organic anion transporter 1	Rattus norvegicus	Ki	=	326000.0	nM	PMID[9270020]
NPT304	Individual protein	Canalicular multispecific organic anion transporter 1	Rattus norvegicus	Ki	=	462000.0	nM	PMID[11465411]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC80	=	1.44	uM	PMID[22734697]
NPT2621	Individual protein	Pteridine reductase 1	Leishmania major	Ki	=	180.0	nM	PMID[22946585]
NPT2926	Individual protein	Thymidylate synthase	Homo sapiens	Ki	=	600.0	nM	PMID[22946585]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.00034	nM	PMID[22946585]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.7	nM	PMID[23627352]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Inhibition	=	86.0	%	PMID[23665106]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	2.1	nM	PMID[23665106]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	<=	0.004	nM	PMID[24428639]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	3.0	nM	DOI[10.1039/C3MD00013C]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.5	nM	PMID[110934]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	=	100000.0	nM	PMID[109616]
NPT2924	Individual protein	Thymidylate synthase	Lactobacillus casei	IC50	>	100000.0	nM	PMID[409842]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[26670841]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.6	nM	PMID[26617968]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	7.9	nM	PMID[26994844]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1500.0	nM	PMID[26979156]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.0034	nM	PMID[27437079]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	4.6	nM	PMID[27994750]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Inhibition	=	89.7	%	PMID[27886545]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Inhibition	=	86.4	%	PMID[27886545]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	6.67	nM	PMID[27886545]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	30.9	nM	PMID[28152430]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	22.0	nM	PMID[28258797]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	7.9	nM	PMID[28177228]
NPT1249	Individual protein	Canalicular multispecific organic anion transporter 2	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1028	Individual protein	Multidrug resistance-associated protein 4	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Ki	=	0.01	nM	PMID[28477572]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	7.1	nM	PMID[29274493]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	35.0	nM	PMID[29691154]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	24.99	nM	PMID[31200235]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1000.0	nM	PMID[31447082]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	4.74	nM	PMID[30624926]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	FC	=	1.0	n.a.	PMID[27397500]
NPT110	Individual protein	Cytochrome P450 2D6	Homo sapiens	FC	=	1.0	n.a.	PMID[27397500]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	1.97	nM	PMID[30827867]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	6.0	nM	PMID[32503687]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	20.0	nM	PMID[32503687]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	83.0	nM	PMID[32676149]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	Inhibition	=	91.0	%	PMID[32676149]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	5.0	nM	PMID[33187806]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	3.0	nM	PMID[33187806]
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT248	Individual protein	Estrogen receptor beta	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT1464	Individual protein	Phosphodiesterase 4D	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT259	Individual protein	Melanocortin receptor 4	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT227	Individual protein	Beta-3 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1163	Individual protein	Glutamate (NMDA) receptor subunit zeta 1	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1647	Individual protein	Vasopressin V2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT2769	Individual protein	Thromboxane A2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	61.0	nM	PMID[35964425]
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2719	Individual protein	Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT2818	Individual protein	Dihydrofolate reductase	Homo sapiens	IC50	=	88.0	nM	PMID[37054758]
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1814	Individual protein	Glucagon receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	ID50	=	6.2	nM	PMID[6811744]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	ID50	=	16.0	nM	PMID[6811744]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.3	nM	PMID[7490723]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	Ki	=	0.008	nM	PMID[7490723]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	ID50	=	11.0	nM	PMID[6139480]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	8.0	nM	PMID[6403710]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	4400.0	nM	PMID[11384244]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	880.0	nM	PMID[7490723]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	16.0	nM	PMID[2447278]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	26.0	nM	PMID[2447278]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	15.0	nM	PMID[2447278]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	Ki	=	0.004	nM	PMID[6438320]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	10.0	nM	PMID[3091834]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	1.3	nM	PMID[8201595]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Ki	=	0.021	nM	PMID[3973902]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.0	nM	PMID[12408727]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.1	nM	PMID[12408727]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	22.0	nM	PMID[12570380]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	7.0	nM	PMID[12570380]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	ID50	=	0.021	uM	PMID[6787199]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	0.0016	ug.mL-1	PMID[2423690]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	9.0	nM	PMID[11960504]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	10.0	nM	PMID[3712374]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	12.0	nM	PMID[7108907]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	16.0	nM	PMID[3184124]
NPT19413	Single protein	GAR transformylase	Mus musculus	IC50	>	20000.0	nM	PMID[3184124]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	<	1.0	nM	PMID[15081026]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.0	nM	PMID[9089339]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	0.023	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	2.3	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	3.2	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	0.096	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	140.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	84.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	31.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	1700.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Kd	=	1100.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Ki	=	330.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Ki	=	2400.0	nM	PMID[3275776]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Ki	=	170000.0	nM	PMID[3275776]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	8.5	nM	PMID[3091832]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	11.0	nM	PMID[10956221]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	9.0	nM	PMID[10956221]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	8.0	nM	PMID[3100797]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	Inhibition	=	0.00000001	%	PMID[6699882]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.3	nM	PMID[9301666]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	16.0	nM	PMID[3121855]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	6.0	nM	PMID[8164259]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.0	nM	PMID[8164259]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.3	nM	PMID[8691474]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	2.2	nM	PMID[8691474]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	2.2	nM	PMID[8691474]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	55.0	nM	PMID[8691474]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	0.0000000000033	ug.mL-1	PMID[6793726]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.0	nM	PMID[7783147]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.0	nM	PMID[9554874]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	44.0	nM	PMID[11052789]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.0	nM	PMID[11052789]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	13.8	nM	PMID[11052789]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	9.6	nM	PMID[6772788]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	6.0	nM	PMID[7562910]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	7.0	nM	PMID[16078850]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	22.0	nM	PMID[16078850]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	3.0	nM	PMID[17125251]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	32.0	nM	PMID[15615522]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	7.0	nM	PMID[15615538]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	22.0	nM	PMID[15615538]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.6	nM	PMID[16279780]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	6.0	nM	PMID[17569517]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	Inhibition	=	26.3	%	PMID[18788725]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	8.8	nM	PMID[18800768]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.6	nM	PMID[18605720]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	8.8	nM	PMID[19719239]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.6	nM	PMID[20056546]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	6.6	nM	PMID[20092323]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	5.0	nM	PMID[20580561]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	4.4	nM	PMID[21550809]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	IC50	=	8.8	nM	PMID[22739090]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	17.2	%	PMID[22541068]
NPT17144	Single protein	Dihydrofolate reductase	Pneumocystis carinii	IC50	=	1.3	nM	PMID[23627352]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	3.0	nM	PMID[109616]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	4.5	nM	PMID[820858]
NPT27920	Single protein	Dihydrofolate reductase	Lactobacillus casei	IC50	=	3.0	nM	PMID[409842]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Activity	=	12.0	%	PMID[25618019]
NPT944	Individual protein	Glucose transporter	Leishmania mexicana	Inhibition	=	-0.37	%	DOI[10.6019/CHEMBL3433997]
NPT944	Individual protein	Glucose transporter	Leishmania mexicana	Inhibition	=	1.34	%	DOI[10.6019/CHEMBL3433997]
NPT944	Individual protein	Glucose transporter	Leishmania mexicana	Inhibition	=	3.42	%	DOI[10.6019/CHEMBL3433997]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	1000000.0	nM	PMID[21965623]
NPT24902	Single protein	Dihydrofolate reductase	Escherichia coli	Ki	=	0.001	nM	PMID[27437079]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	1000000.0	nM	PMID[22961681]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT30134	Single protein	Gastric inhibitory polypeptide receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5301	Individual protein	Motilin receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT5318	Individual protein	Corticotropin releasing factor receptor 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT28473	Single protein	Serine hydroxymethyltransferase, cytosolic	Homo sapiens	Ki	>	200000.0	nM	PMID[37582241]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	2.7	nM	PMID[6811744]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	2.0	nM	PMID[6139480]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	9.0	nM	PMID[6139480]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	32.0	nM	PMID[6139480]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	35.0	nM	PMID[2428979]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	6.6	nM	PMID[8201595]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.006	nM	PMID[2299633]
NPT3791	Individual protein	Thymidylate synthase	Mus musculus	Ki	=	45000.0	nM	PMID[7086836]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	25.0	nM	PMID[2898531]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	35.0	nM	PMID[2871191]
NPT24900	Single protein	Folylpoly-gamma-glutamate synthetase	Mus musculus	Ki	=	166000.0	nM	PMID[2871191]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.006	nM	PMID[4020824]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00581	nM	PMID[4020824]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	0.0068	uM	PMID[6787199]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.0056	nM	PMID[2296020]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	3900.0	nM	PMID[2296020]
NPT4519	Individual protein	Folate transporter 1	Homo sapiens	Ki	=	3500.0	nM	PMID[10821704]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.0043	nM	PMID[7057425]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00548	nM	PMID[2423690]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00000000562	nM	PMID[3373490]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	25.0	nM	PMID[1995880]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.0032	nM	PMID[7143361]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	2.0	nM	PMID[11052790]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	2.5	nM	PMID[12877583]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	ID50	=	0.05	uM	PMID[6546949]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00442	nM	PMID[3712374]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.006	nM	PMID[7108907]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00545	nM	PMID[3184124]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00575	nM	PMID[8340923]
NPT3791	Individual protein	Thymidylate synthase	Mus musculus	IC50	=	20000.0	nM	PMID[3339615]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00482	nM	PMID[8277497]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	73.0	nM	PMID[8863812]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.006	nM	PMID[1732549]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	3.0	nM	PMID[9089339]
NPT3791	Individual protein	Thymidylate synthase	Mus musculus	IC50	=	20000.0	nM	PMID[2704031]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	25.0	nM	PMID[3385730]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	50.0	nM	PMID[6737432]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	20.0	nM	PMID[3462394]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	2.5	nM	PMID[9301666]
NPT476	Individual protein	AICAR transformylase	Homo sapiens	IC50	>	20000.0	nM	PMID[3121855]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	3.0	nM	PMID[8164259]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	2.5	nM	PMID[8691474]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	4.6	nM	PMID[3968685]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	45.0	nM	PMID[3968685]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00482	nM	PMID[1501226]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	3.0	nM	PMID[7783147]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.00528	nM	PMID[1732551]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	3.0	nM	PMID[9554874]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	IC50	=	25.0	nM	PMID[3112397]
NPT4519	Individual protein	Folate transporter 1	Homo sapiens	Inhibition	=	60.0	%	PMID[18680275]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	Activity	=	130.0	%	PMID[18457386]
NPT25183	Single protein	Dihydrofolate reductase	Mus musculus	Ki	=	0.003	nM	PMID[19748785]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	Ki	=	0.073	nM	PMID[19748785]
NPT957	Individual protein	Multidrug resistance-associated protein 7	Homo sapiens	Activity	=	74.0	%	PMID[12527806]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	27.4	%	PMID[22541068]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	=	2.5	nM	PMID[23627352]
NPT27633	Single protein	Dihydrofolate reductase	Rattus norvegicus	IC50	<	1.0	nM	PMID[850245]
NPT4519	Individual protein	Folate transporter 1	Homo sapiens	IC50	=	12.0	nM	PMID[25234128]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	FC	=	-0.2	n.a.	PMID[21051535]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT5133	Individual protein	High mobility group protein B1	Homo sapiens	Kd	=	24.0	nM	PMID[29268019]
NPT5133	Individual protein	High mobility group protein B1	Homo sapiens	Kd	=	500.0	nM	PMID[29268019]
NPT4519	Individual protein	Folate transporter 1	Homo sapiens	IC50	=	12.0	nM	PMID[29425443]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	16.96	%	DOI[10.6019/CHEMBL4495564]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-4.284	%	DOI[10.6019/CHEMBL4495564]
NPT476	Individual protein	AICAR transformylase	Homo sapiens	Ki	=	880.0	nM	PMID[33773393]
NPT19433	Single protein	Methionine synthase	Homo sapiens	IC50	=	0.0	nM	PMID[32058237]
NPT29430	Single protein	Neuronal acetylcholine receptor protein alpha-4 subunit	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT98	Individual protein	HERG	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT476	Individual protein	AICAR transformylase	Homo sapiens	Ki	>	200000.0	nM	PMID[37582241]
NPT4729	Individual protein	Cholecystokinin B receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT3735	Individual protein	Neurotensin receptor 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT3952	Individual protein	Endothelin receptor ET-B	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT26536	Single protein	Thymidylate synthase	Escherichia coli	IC50	=	1800.0	nM	PMID[11384244]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	7943282.35	nM	PMID[2404122]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	1.7	nM	PMID[4009615]
NPT6232	Individual protein	Dihydrofolate reductase	Gallus gallus	IC50	=	90.0	nM	PMID[7069726]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	3.3	nM	PMID[6585550]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	ID50	=	0.0000000048	M	PMID[6948961]
NPT6232	Individual protein	Dihydrofolate reductase	Gallus gallus	IC50	=	19.0	nM	PMID[3712374]
NPT19416	Single protein	GAR transformylase	Homo sapiens	IC50	>	20000.0	nM	PMID[3121855]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	10.8	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	12.1	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	9.9	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	69.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	58.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	63.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	57.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	42.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	36.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	46.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	40.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	72.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	66.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	59.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	50.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	62.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	61.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	49.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	45.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	60.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	52.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	53.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	43.0	ug.mL-1	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	100.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	18.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	19.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	17.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	29.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	26.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	28.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	25.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	16.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	21.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	20.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	27.0	n.a.	PMID[2810330]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	Ratio	=	23.0	n.a.	PMID[2810330]
NPT26536	Single protein	Thymidylate synthase	Escherichia coli	IC50	=	90000.0	nM	PMID[16279780]
NPT26536	Single protein	Thymidylate synthase	Escherichia coli	IC50	=	90000.0	nM	PMID[18605720]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	80.0	nM	PMID[20350811]
NPT6065	Individual protein	Dihydrofolate reductase	Bacillus anthracis	IC50	=	15.0	nM	PMID[19364848]
NPT6065	Individual protein	Dihydrofolate reductase	Bacillus anthracis	IC50	=	12.2	nM	PMID[19364848]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	3.4	nM	PMID[20036565]
NPT622	Individual protein	Solute carrier organic anion transporter family member 2B1	Homo sapiens	Inhibition	=	-13.4	%	PMID[22541068]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	80.0	nM	PMID[23454532]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	80.0	nM	PMID[23792351]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	80.0	nM	PMID[24469112]
NPT17155	Single protein	Dihydrofolate reductase	Staphylococcus aureus	Ki	<=	0.004	nM	PMID[24428639]
NPT19428	Single protein	Dihydrofolate reductase	Enterococcus faecium	IC50	=	1.4	nM	PMID[850245]
NPT19430	Single protein	Proton-coupled folate transporter	Homo sapiens	IC50	=	120.5	nM	PMID[25234128]
NPT28272	Single protein	Folate receptor alpha	Homo sapiens	IC50	=	461.0	nM	PMID[25234128]
NPT28272	Single protein	Folate receptor alpha	Homo sapiens	IC50	=	114.0	nM	PMID[25234128]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	8.0	nM	PMID[25139568]
NPT943	Individual protein	Hexose transporter 1	Plasmodium falciparum	Inhibition	=	2.33	%	DOI[10.6019/CHEMBL3433997]
NPT943	Individual protein	Hexose transporter 1	Plasmodium falciparum	Inhibition	=	2.91	%	DOI[10.6019/CHEMBL3433997]
NPT943	Individual protein	Hexose transporter 1	Plasmodium falciparum	Inhibition	=	0.06	%	DOI[10.6019/CHEMBL3433997]
NPT712	Individual protein	Bile salt export pump	Rattus norvegicus	IC50	>	1000000.0	nM	PMID[21965623]
NPT6551	Individual protein	Dihydrofolate reductase	Mycobacterium tuberculosis	IC50	=	8.25	nM	PMID[26617968]
NPT17155	Single protein	Dihydrofolate reductase	Staphylococcus aureus	Ki	=	1.0	nM	PMID[27437079]
NPT6236	Individual protein	Dihydrofolate reductase	Bos taurus	IC50	=	8.0	nM	PMID[27554444]
NPT6551	Individual protein	Dihydrofolate reductase	Mycobacterium tuberculosis	IC50	=	35.0	nM	PMID[29274493]
NPT26779	Single protein	Dihydrofolate reductase	Plasmodium falciparum K1	IC50	=	84.0	nM	PMID[29111368]
NPT28272	Single protein	Folate receptor alpha	Homo sapiens	IC50	=	114.0	nM	PMID[29425443]
NPT28272	Single protein	Folate receptor alpha	Homo sapiens	IC50	=	216.0	nM	PMID[29425443]
NPT19430	Single protein	Proton-coupled folate transporter	Homo sapiens	IC50	=	121.0	nM	PMID[29425443]
NPT6551	Individual protein	Dihydrofolate reductase	Mycobacterium tuberculosis	IC50	=	8.8	nM	PMID[30827867]
NPT92	Individual protein	Serotonin 1a (5-HT1a) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT29454	Single protein	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Homo sapiens	Inhibition	=	-7.834	%	PMID[38318365]
NPT17155	Single protein	Dihydrofolate reductase	Staphylococcus aureus	IC50	=	360.0	nM	PMID[37360390]
NPT6127	Individual protein	Bradykinin B1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT25297	Single protein	Toll-like receptor 4	Homo sapiens	IC50	=	1040.0	nM	PMID[34390826]
NPT19416	Single protein	GAR transformylase	Homo sapiens	Ki	>	150000.0	nM	PMID[37582241]
NPT17155	Single protein	Dihydrofolate reductase	Staphylococcus aureus	IC50	=	190.0	nM	PMID[38107183]
NPT28814	Single protein	Ghrelin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT28448	Single protein	Corticotropin releasing factor receptor 2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT25297	Single protein	Toll-like receptor 4	Homo sapiens	IC50	=	1040.0	nM	PMID[38070351]
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT28787	Single protein	Voltage-gated N-type calcium channel alpha-1B subunit	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT5975	Individual protein	Cyclooxygenase-1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT20859	Single protein	Neuropeptide Y receptor type 2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	1100.0	nM	PMID[11384244]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	22.0	nM	PMID[12408727]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	11.0	nM	PMID[11960504]
NPT24901	Single protein	Folylpoly-gamma-glutamate synthetase	Homo sapiens	IC50	=	3200.0	nM	PMID[8863812]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14.0	nM	PMID[9089339]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	22.0	nM	PMID[10956221]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	1.4	nM	PMID[9301666]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14.0	nM	PMID[8164259]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14.0	nM	PMID[8691474]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	22.0	nM	PMID[8691474]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14.0	nM	PMID[7783147]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14.0	nM	PMID[9554874]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	22.0	nM	PMID[11052789]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	Activity	=	0.33	n.a.	PMID[17269758]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	14000.0	nM	PMID[17269758]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	11.0	nM	PMID[16279780]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	18000.0	nM	PMID[16279780]
NPT661	Individual protein	Solute carrier family 22 member 6	Mus musculus	Ki	=	891250.94	nM	PMID[17553798]
NPT661	Individual protein	Solute carrier family 22 member 6	Mus musculus	Ki	=	901000.0	nM	PMID[17553798]
NPT662	Individual protein	Solute carrier family 22 member 20	Mus musculus	Ki	=	602559.59	nM	PMID[17553798]
NPT662	Individual protein	Solute carrier family 22 member 20	Mus musculus	Ki	=	597000.0	nM	PMID[17553798]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	33.0	nM	PMID[18800768]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	18000.0	nM	PMID[18605720]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	11.0	nM	PMID[18605720]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	33.0	nM	PMID[19719239]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	11.0	nM	PMID[20056546]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	18000.0	nM	PMID[20056546]
NPT19423	Single protein	Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)	Escherichia coli	IC50	>	18000.0	nM	PMID[21550809]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	>	18000.0	nM	PMID[21550809]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	22.0	nM	PMID[21550809]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	33.0	nM	PMID[22739090]
NPT877	Individual protein	Solute carrier family 22 member 8	Mus musculus	Activity	=	48.4	%	PMID[14762099]
NPT19427	Single protein	Dihydrofolate reductase	Oryctolagus cuniculus	ID50	=	9.0	10'-9mol/L	PMID[565818]
NPT28271	Single protein	Folate receptor beta	Homo sapiens	IC50	=	211.0	nM	PMID[25234128]
NPT28271	Single protein	Folate receptor beta	Homo sapiens	IC50	=	106.0	nM	PMID[25234128]
NPT942	Individual protein	Glucose transporter	Homo sapiens	Inhibition	=	3.29	%	DOI[10.6019/CHEMBL3433997]
NPT942	Individual protein	Glucose transporter	Homo sapiens	Inhibition	=	4.83	%	DOI[10.6019/CHEMBL3433997]
NPT942	Individual protein	Glucose transporter	Homo sapiens	Inhibition	=	0.58	%	DOI[10.6019/CHEMBL3433997]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	71.0	nM	PMID[27994750]
NPT28271	Single protein	Folate receptor beta	Homo sapiens	IC50	=	106.0	nM	PMID[29425443]
NPT28271	Single protein	Folate receptor beta	Homo sapiens	IC50	=	211.0	nM	PMID[29425443]
NPT5829	Individual protein	Dihydrofolate reductase	Toxoplasma gondii	IC50	=	78.3	nM	PMID[30624926]
NPT425	Individual protein	Serotonin 3a (5-HT3a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT29024	Single protein	Bifunctional dihydrofolate reductase-thymidylate synthase	Trypanosoma cruzi	IC50	=	110.0	nM	PMID[35189560]
NPT25143	Single protein	Serine hydroxymethyltransferase, mitochondrial	Homo sapiens	Ki	=	98000.0	nM	PMID[37582241]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT2246	Cell line	T-cells	n.a.	IC50	=	0.0061	ug.mL-1	PMID[9379448]
NPT4590	Cell line	EL4	Mus musculus	IC50	=	1570.0	nM	PMID[9379448]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ED50	=	14.5	nM	PMID[8691451]
NPT137	Cell line	L1210	Mus musculus	IC50	=	0.84	nM	PMID[6403710]
NPT1317	Cell line	CCRF S-180	Mus musculus	IC50	=	5.4	nM	PMID[6403710]
NPT1490	Cell line	Ehrlich	Mus musculus	IC50	=	12.6	nM	PMID[6403710]
NPT1948	Cell line	A253 cell line	n.a.	EC50	=	19.0	nM	PMID[11384244]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	17.0	nM	PMID[11384244]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.0	nM	PMID[11384244]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	600.0	nM	PMID[11384244]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	1900.0	nM	PMID[11384244]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	15.0	nM	PMID[11384244]
NPT1171	Cell line	HEp-2	Homo sapiens	ED50	=	2.4	nM	PMID[7365749]
NPT137	Cell line	L1210	Mus musculus	IC50	=	200.0	nM	PMID[2428979]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	29.0	nM	PMID[9857098]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	39.0	nM	PMID[9857098]
NPT111	Cell line	K562	Homo sapiens	IC50	=	26.0	nM	PMID[9857098]
NPT112	Cell line	MOLT-4	Homo sapiens	IC50	=	28.0	nM	PMID[9857098]
NPT389	Cell line	RPMI-8226	Homo sapiens	IC50	=	33.0	nM	PMID[9857098]
NPT385	Cell line	SR	Homo sapiens	IC50	=	33.0	nM	PMID[9857098]
NPT81	Cell line	A549	Homo sapiens	IC50	=	33.0	nM	PMID[9857098]
NPT394	Cell line	EKVX	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT372	Cell line	HOP-92	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT405	Cell line	NCI-H226	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT370	Cell line	NCI-H23	Homo sapiens	IC50	=	43.0	nM	PMID[9857098]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	28.0	nM	PMID[9857098]
NPT455	Cell line	NCI-H522	Homo sapiens	IC50	=	450.0	nM	PMID[9857098]
NPT390	Cell line	LOX IMVI	Homo sapiens	IC50	=	26.0	nM	PMID[9857098]
NPT375	Cell line	Malme-3M	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT387	Cell line	M14	Homo sapiens	IC50	=	32.0	nM	PMID[9857098]
NPT147	Cell line	SK-MEL-2	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT170	Cell line	SK-MEL-28	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT373	Cell line	SK-MEL-5	Homo sapiens	IC50	=	87.0	nM	PMID[9857098]
NPT403	Cell line	UACC-257	Homo sapiens	IC50	=	790.0	nM	PMID[9857098]
NPT398	Cell line	UACC-62	Homo sapiens	IC50	=	28.0	nM	PMID[9857098]
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	65.0	nM	PMID[9857098]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	=	400.0	nM	PMID[9857098]
NPT456	Cell line	OVCAR-4	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT382	Cell line	OVCAR-5	Homo sapiens	IC50	=	980.0	nM	PMID[9857098]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	31.0	nM	PMID[9857098]
NPT407	Cell line	COLO 205	Homo sapiens	IC50	=	870.0	nM	PMID[9857098]
NPT391	Cell line	HCC 2998	Homo sapiens	IC50	=	110.0	nM	PMID[9857098]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	30.0	nM	PMID[9857098]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	30.0	nM	PMID[9857098]
NPT386	Cell line	KM12	Homo sapiens	IC50	=	33.0	nM	PMID[9857098]
NPT395	Cell line	SF-268	Homo sapiens	IC50	=	52.0	nM	PMID[9857098]
NPT399	Cell line	SF-295	Homo sapiens	IC50	=	36.0	nM	PMID[9857098]
NPT374	Cell line	SF-539	Homo sapiens	IC50	=	35.0	nM	PMID[9857098]
NPT380	Cell line	U-251	Homo sapiens	IC50	=	63.0	nM	PMID[9857098]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	27.0	nM	PMID[9857098]
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	45.0	nM	PMID[9857098]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	33.0	nM	PMID[9857098]
NPT376	Cell line	A498	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT369	Cell line	ACHN	Homo sapiens	IC50	=	40.0	nM	PMID[9857098]
NPT406	Cell line	RXF 393	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT384	Cell line	TK-10	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	36.0	nM	PMID[9857098]
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	IC50	=	78.0	nM	PMID[9857098]
NPT402	Cell line	Hs-578T	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT400	Cell line	MDA-MB-435	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT457	Cell line	BT-549	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT396	Cell line	T47D	Homo sapiens	IC50	>	1000.0	nM	PMID[9857098]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	12.0	nM	DOI[10.1016/S0960-894X(96)00486-6]
NPT112	Cell line	MOLT-4	Homo sapiens	IC50	=	48.0	nM	DOI[10.1016/S0960-894X(96)00486-6]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.5	nM	PMID[3091834]
NPT137	Cell line	L1210	Mus musculus	Ki	=	0.0032	nM	PMID[3091834]
NPT137	Cell line	L1210	Mus musculus	IC50	=	9.0	nM	PMID[2918496]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	18.0	nM	PMID[6694171]
NPT660	Cell line	SW480	Homo sapiens	IC50	=	15.0	nM	PMID[6694171]
NPT1183	Cell line	WiDr	Homo sapiens	IC50	=	25.0	nM	PMID[6694171]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	0.1	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	1.6	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	0.4	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	0.3	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	0.6	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	0.8	pM (10e6*cells)-1	PMID[1375963]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	4.1	pM (10e6*cells)-1	PMID[1375963]
NPT1842	Cell line	W256	Rattus norvegicus	ED50	=	0.02	uM	PMID[6928967]
NPT1317	Cell line	CCRF S-180	Mus musculus	ED50	=	0.016	uM	PMID[6928967]
NPT137	Cell line	L1210	Mus musculus	ED50	=	0.016	uM	PMID[6928967]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	12.0	nM	DOI[10.1016/S0960-894X(97)00071-1]
NPT137	Cell line	L1210	Mus musculus	IC50	=	9.0	nM	PMID[1992122]
NPT168	Cell line	P388	Mus musculus	IC50	=	23.0	nM	PMID[8201595]
NPT168	Cell line	P388	Mus musculus	IC50	=	223.0	nM	PMID[8201595]
NPT730	Cell line	MC-38	Mus musculus	IC50	=	66.0	nM	PMID[8201595]
NPT91	Cell line	KB	Homo sapiens	IC50	=	19.0	nM	PMID[8201595]
NPT2980	Cell line	Colon 26	Mus musculus	IC50	>	40000.0	nM	PMID[8201595]
NPT137	Cell line	L1210	Mus musculus	IC50	=	10.0	nM	PMID[4009615]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.92	nM	PMID[2299633]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	12.0	nM	PMID[12408727]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	32.0	nM	PMID[2898531]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	6600.0	nM	PMID[2898531]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.6	nM	PMID[2898531]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	13.7	nM	PMID[12570380]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.0	nM	PMID[2871191]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.28	nM	PMID[4020824]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.7	nM	PMID[4020824]
NPT137	Cell line	L1210	Mus musculus	IC50	=	5.0	nM	PMID[2296020]
NPT1171	Cell line	HEp-2	Homo sapiens	ED50	=	0.0024	uM	PMID[7057425]
NPT137	Cell line	L1210	Mus musculus	Ki	=	3500.0	nM	PMID[7057425]
NPT168	Cell line	P388	Mus musculus	IC50	=	4.8	nM	PMID[8632413]
NPT3792	Cell line	143B	Homo sapiens	IC50	=	8.8	nM	PMID[8632413]
NPT1535	Cell line	U-87 MG	Homo sapiens	IC50	=	22.0	nM	PMID[8632413]
NPT81	Cell line	A549	Homo sapiens	IC50	=	31.0	nM	PMID[8632413]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	9.5	nM	PMID[8632413]
NPT933	Cell line	U373 MG	Homo sapiens	IC50	=	12.0	nM	PMID[8632413]
NPT189	Cell line	Vero	Chlorocebus aethiops	IC50	=	9.2	nM	PMID[8632413]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.55	nM	PMID[2423690]
NPT81	Cell line	A549	Homo sapiens	IC50	=	23.0	nM	PMID[9022795]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	27.0	nM	PMID[9022795]
NPT397	Cell line	NCI-H460	Homo sapiens	IC50	=	28.0	nM	PMID[9022795]
NPT370	Cell line	NCI-H23	Homo sapiens	IC50	=	43.0	nM	PMID[9022795]
NPT455	Cell line	NCI-H522	Homo sapiens	IC50	=	229.0	nM	PMID[9022795]
NPT394	Cell line	EKVX	Homo sapiens	IC50	>	1000.0	nM	PMID[9022795]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	30.0	nM	PMID[9022795]
NPT148	Cell line	HCT-15	Homo sapiens	IC50	=	30.0	nM	PMID[9022795]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	32.0	nM	PMID[9022795]
NPT323	Cell line	SW-620	Homo sapiens	IC50	=	33.0	nM	PMID[9022795]
NPT386	Cell line	KM12	Homo sapiens	IC50	=	42.0	nM	PMID[9022795]
NPT374	Cell line	SF-539	Homo sapiens	IC50	=	35.0	nM	PMID[9022795]
NPT395	Cell line	SF-268	Homo sapiens	IC50	=	52.0	nM	PMID[9022795]
NPT392	Cell line	SNB-75	Homo sapiens	IC50	>	1000.0	nM	PMID[9022795]
NPT390	Cell line	LOX IMVI	Homo sapiens	IC50	=	26.0	nM	PMID[9022795]
NPT398	Cell line	UACC-62	Homo sapiens	IC50	=	28.0	nM	PMID[9022795]
NPT373	Cell line	SK-MEL-5	Homo sapiens	IC50	=	87.0	nM	PMID[9022795]
NPT375	Cell line	Malme-3M	Homo sapiens	IC50	>	1000.0	nM	PMID[9022795]
NPT170	Cell line	SK-MEL-28	Homo sapiens	IC50	>	1000.0	nM	PMID[9022795]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	31.0	nM	PMID[9022795]
NPT382	Cell line	OVCAR-5	Homo sapiens	IC50	>	1000.0	nM	PMID[9022795]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	=	398.0	nM	PMID[9022795]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	33.0	nM	PMID[9022795]
NPT371	Cell line	UO-31	Homo sapiens	IC50	=	191.0	nM	PMID[9022795]
NPT369	Cell line	ACHN	Homo sapiens	IC50	=	40.0	nM	PMID[9022795]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	36.0	nM	PMID[9022795]
NPT378	Cell line	NCI/ADR-RES	Homo sapiens	IC50	=	78.0	nM	PMID[9022795]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	2.0	nM	PMID[9022795]
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	23.0	nM	PMID[9022795]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.6	nM	PMID[1992118]
NPT137	Cell line	L1210	Mus musculus	IC50	=	200000.0	nM	PMID[1992118]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.5	nM	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	ED50	=	609.0	uM	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	ED50	<	0.05	uM	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	ED50	<<	0.05	uM	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	Inhibition	=	34.2	%	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	Inhibition	=	64.0	%	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	Inhibition	=	87.7	%	PMID[3373490]
NPT116	Cell line	HL-60	Homo sapiens	ED50	=	0.1	uM	PMID[3373490]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.6	nM	PMID[1995880]
NPT137	Cell line	L1210	Mus musculus	MIC50	=	2.71	nM	PMID[7143361]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.5	nM	PMID[11960504]
NPT7275	Cell line	R1	Mus musculus	EC50	=	1050.0	nM	PMID[11960504]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	25.0	nM	PMID[6585550]
NPT4777	Cell line	Epidermoid carcinoma cell line	n.a.	ED50	=	0.001	uM	PMID[6948961]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	0.004	ug.mL-1	PMID[11428931]
NPT137	Cell line	L1210	Mus musculus	MIC50	=	2.48	nM	PMID[3712374]
NPT137	Cell line	L1210	Mus musculus	Ki	=	5610.0	nM	PMID[3712374]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.7	nM	PMID[7108907]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.1	nM	PMID[3184124]
NPT137	Cell line	L1210	Mus musculus	IC50	=	9.5	nM	PMID[8340923]
NPT137	Cell line	L1210	Mus musculus	Ki	=	3930.0	nM	PMID[8277497]
NPT137	Cell line	L1210	Mus musculus	IC50	=	9.0	nM	PMID[8277497]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	8.1	nM	PMID[8277497]
NPT1317	Cell line	CCRF S-180	Mus musculus	IC50	=	10.0	nM	PMID[8277497]
NPT137	Cell line	L1210	Mus musculus	IC50	=	7.0	nM	PMID[8863812]
NPT137	Cell line	L1210	Mus musculus	IC50	=	1300.0	nM	PMID[8863812]
NPT112	Cell line	MOLT-4	Homo sapiens	IC50	=	1400.0	nM	PMID[1895294]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.9	nM	PMID[1732549]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.0	nM	PMID[7473577]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	18.0	nM	PMID[7473577]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	17.0	nM	PMID[7473577]
NPT1948	Cell line	A253 cell line	n.a.	EC50	=	3000.0	nM	PMID[7473577]
NPT137	Cell line	L1210	Mus musculus	Inhibition	=	95.0	%	PMID[3091832]
NPT137	Cell line	L1210	Mus musculus	Inhibition	=	98.0	%	PMID[3091832]
NPT137	Cell line	L1210	Mus musculus	IC50	=	60000.0	nM	PMID[3091832]
NPT137	Cell line	L1210	Mus musculus	IC50	=	20.0	nM	PMID[9022805]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.4	nM	PMID[10956221]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	11.3	nM	PMID[10956221]
NPT1948	Cell line	A253 cell line	n.a.	EC50	=	14.5	nM	PMID[10956221]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.4	nM	PMID[2704031]
NPT137	Cell line	L1210	Mus musculus	IC50	=	186000.0	nM	PMID[2704031]
NPT137	Cell line	L1210	Mus musculus	IC50	=	5.0	nM	PMID[3351853]
NPT137	Cell line	L1210	Mus musculus	EC50	=	3.2	nM	PMID[6410066]
NPT2117	Cell line	HuTu80	Homo sapiens	EC50	=	4.5	nM	PMID[6410066]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	32.0	nM	PMID[3872941]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	6600.0	nM	PMID[3872941]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.0	nM	PMID[3872941]
NPT137	Cell line	L1210	Mus musculus	IC50	=	19000.0	nM	PMID[3872941]
NPT137	Cell line	L1210	Mus musculus	IC50	=	220000.0	nM	PMID[3872941]
NPT137	Cell line	L1210	Mus musculus	IC50	=	20.0	nM	PMID[9022804]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.6	nM	PMID[3385730]
NPT2062	Cell line	SCC-15	Homo sapiens	IC50	=	38.0	nM	PMID[3385730]
NPT2062	Cell line	SCC-15	Homo sapiens	IC50	=	580.0	nM	PMID[3385730]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	7.5	nM	PMID[3385730]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	150.0	nM	PMID[3385730]
NPT137	Cell line	L1210	Mus musculus	IC50	=	24.0	nM	PMID[6737432]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ED50	=	13.7	nM	PMID[8568828]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ED50	=	655.0	nM	PMID[8568828]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ED50	=	2550.0	nM	PMID[8568828]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ED50	=	15.5	nM	PMID[8568828]
NPT2117	Cell line	HuTu80	Homo sapiens	IC50	=	9.0	nM	PMID[3612694]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	18.0	nM	PMID[3612694]
NPT660	Cell line	SW480	Homo sapiens	IC50	=	15.0	nM	PMID[3612694]
NPT1183	Cell line	WiDr	Homo sapiens	IC50	=	25.0	nM	PMID[3612694]
NPT137	Cell line	L1210	Mus musculus	IC50	=	30.0	nM	PMID[3462394]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.0	nM	PMID[3462394]
NPT137	Cell line	L1210	Mus musculus	IC50	=	220000.0	nM	PMID[3462394]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.9	nM	PMID[3121855]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	7.5	nM	PMID[8035423]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	10.5	nM	PMID[8035423]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	2550.0	nM	PMID[8035423]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ki	=	4480.0	nM	PMID[8035423]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Ki	=	9740.0	nM	PMID[8035423]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	16.0	nM	PMID[8164259]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	2760.0	nM	PMID[8164259]
NPT7275	Cell line	R1	Mus musculus	EC50	=	720.0	nM	PMID[8164259]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	19.0	nM	PMID[8164259]
NPT137	Cell line	L1210	Mus musculus	IC50	=	2.7	nM	PMID[6793726]
NPT137	Cell line	L1210	Mus musculus	Ki	=	3650.0	nM	PMID[6793726]
NPT1490	Cell line	Ehrlich	Mus musculus	Ki	=	10100.0	nM	PMID[6793726]
NPT137	Cell line	L1210	Mus musculus	IC50	=	1000.0	nM	PMID[3968685]
NPT137	Cell line	L1210	Mus musculus	IC50	=	12.0	nM	PMID[3968685]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	25.0	ug.mL-1	PMID[2810330]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	4.5	ug.mL-1	PMID[2810330]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	3.3	ug.mL-1	PMID[2810330]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	3.4	ug.mL-1	PMID[2810330]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	3.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	109.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	117.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	119.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	115.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	118.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	112.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	108.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	120.0	ug.mL-1	PMID[2810330]
NPT2815	Cell line	M21	Homo sapiens	IC50	=	121.0	ug.mL-1	PMID[2810330]
NPT81	Cell line	A549	Homo sapiens	IC50	=	0.035	ug.mL-1	PMID[1847428]
NPT137	Cell line	L1210	Mus musculus	IC50	=	3.4	nM	PMID[1501226]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.5	nM	PMID[7783147]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	595.0	nM	PMID[7783147]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	3100.0	nM	PMID[7783147]
NPT1948	Cell line	A253 cell line	n.a.	EC50	=	17.0	nM	PMID[7783147]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	31.0	nM	PMID[7783147]
NPT137	Cell line	L1210	Mus musculus	IC50	=	4.51	nM	PMID[1732551]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.3	nM	PMID[9554874]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	8.0	nM	PMID[9554874]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	567.0	nM	PMID[9554874]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	13.8	nM	PMID[11052789]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	660.0	nM	PMID[11052789]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	2030.0	nM	PMID[11052789]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	15.5	nM	PMID[11052789]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.0	nM	PMID[7562910]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	18.0	nM	PMID[7562910]
NPT1216	Cell line	FaDu	Homo sapiens	EC50	=	17.0	nM	PMID[7562910]
NPT1948	Cell line	A253 cell line	n.a.	EC50	=	13.0	nM	PMID[7562910]
NPT137	Cell line	L1210	Mus musculus	IC50	=	0.005	nM	PMID[3112397]
NPT137	Cell line	L1210	Mus musculus	IC50	=	200.0	nM	PMID[3112397]
NPT111	Cell line	K562	Homo sapiens	IC50	=	419000.0	nM	PMID[15780632]
NPT393	Cell line	HCT-116	Homo sapiens	GI50	=	10.0	nM	PMID[15267250]
NPT393	Cell line	HCT-116	Homo sapiens	GI50	>	50000.0	nM	PMID[15267250]
NPT139	Cell line	HT-29	Homo sapiens	GI50	=	70.0	nM	PMID[15267250]
NPT139	Cell line	HT-29	Homo sapiens	GI50	>	50000.0	nM	PMID[15267250]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	1500.0	nM	PMID[16078850]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.5	nM	PMID[16078850]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	13.0	nM	PMID[16078850]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	620.0	nM	PMID[16078850]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.0	nM	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	17.0	nM	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	10.0	%	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	11.0	%	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	101.0	%	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	99.0	%	PMID[16451071]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	44.0	%	PMID[16451071]
NPT517	Cell line	Panel NCI-60 (60 carcinoma cell lines)	Homo sapiens	GI50	=	5.55	n.a.	PMID[16539384]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	17.5	nM	PMID[15615522]
NPT7275	Cell line	R1	Mus musculus	EC50	=	680.0	nM	PMID[15615522]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	16.5	nM	PMID[15615522]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Inhibition	=	10.0	%	PMID[15615522]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	8.2	nM	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	660.0	nM	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	1500.0	nM	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	7.9	nM	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	13.0	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	11.0	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	16.0	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	15.5	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	74.5	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	12.5	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	13.5	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	73.5	%	PMID[15615538]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	12.5	nM	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	615.0	nM	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	1500.0	nM	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	14.5	nM	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	12.0	%	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	5.0	%	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	90.0	%	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	96.0	%	PMID[16279780]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	95.0	%	PMID[16279780]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	6.92	nM	PMID[17497807]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	13.3	nM	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	410.0	nM	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	1950.0	nM	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	15.7	nM	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	11.0	%	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	13.0	%	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	14.0	%	PMID[17552508]
NPT404	Cell line	CCRF-CEM	Homo sapiens	Activity	=	74.0	%	PMID[17552508]
NPT579	Cell line	DLD-1	Homo sapiens	IC50	>	60.0	ug.mL-1	PMID[17569517]
NPT370	Cell line	NCI-H23	Homo sapiens	IC50	=	0.29	ug.mL-1	PMID[17569517]
NPT133	Cell line	ZR-75-1	Homo sapiens	IC50	>	60.0	ug.mL-1	PMID[17569517]
NPT390	Cell line	LOX IMVI	Homo sapiens	IC50	=	0.057	ug.mL-1	PMID[17569517]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	0.027	ug.mL-1	PMID[17569517]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	>	60.0	ug.mL-1	PMID[17569517]
NPT81	Cell line	A549	Homo sapiens	IC50	=	100.0	nM	PMID[17127067]
NPT5294	Cell line	PPC-1	Homo sapiens	IC50	=	100.0	nM	PMID[17127067]
NPT81	Cell line	A549	Homo sapiens	IC50	=	20.0	nM	PMID[17127067]
NPT5294	Cell line	PPC-1	Homo sapiens	IC50	=	10.0	nM	PMID[17127067]
NPT1893	Cell line	MEF	Mus musculus	IC50	=	120.0	nM	PMID[17383876]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	12.0	nM	PMID[11170674]
NPT456	Cell line	OVCAR-4	Homo sapiens	GI50	=	2.512	nM	PMID[17532099]
NPT404	Cell line	CCRF-CEM	Homo sapiens	GI50	=	39.81	nM	PMID[17532099]
NPT91	Cell line	KB	Homo sapiens	IC50	=	6.0	nM	PMID[18680275]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20.0	nM	PMID[18680275]
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	21.0	nM	PMID[18680275]
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	22.0	nM	PMID[18680275]
NPT2295	Cell line	5637	Homo sapiens	IC50	=	16.0	nM	PMID[19243173]
NPT4608	Cell line	RT-4	Homo sapiens	IC50	=	40.0	nM	PMID[19243173]
NPT2331	Cell line	A-427	Homo sapiens	IC50	=	5520.0	nM	PMID[19243173]
NPT3123	Cell line	DAN-G	Homo sapiens	IC50	=	77.0	nM	PMID[19243173]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	50.0	nM	PMID[19243173]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	210.0	nM	PMID[18555562]
NPT547	Cell line	BGC-823	Homo sapiens	IC50	=	110.0	nM	PMID[18555562]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	100.0	nM	PMID[18555562]
NPT181	Cell line	Bel-7402	Homo sapiens	IC50	=	82300.0	nM	PMID[18555562]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	4400.0	nM	PMID[2778449]
NPT168	Cell line	P388	Mus musculus	IC50	=	66.0	nM	PMID[2778449]
NPT168	Cell line	P388	Mus musculus	IZ	=	40.0	mm	PMID[2778449]
NPT168	Cell line	P388	Mus musculus	IZ	=	27.5	mm	PMID[2778449]
NPT80	Cell line	Raji	Homo sapiens	IC50	=	40.0	nM	PMID[18513976]
NPT168	Cell line	P388	Mus musculus	IC50	=	0.002	ug.mL-1	PMID[10579858]
NPT81	Cell line	A549	Homo sapiens	IC50	=	0.005	ug.mL-1	PMID[10579858]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	0.01	ug.mL-1	PMID[10579858]
NPT404	Cell line	CCRF-CEM	Homo sapiens	EC50	=	12.5	nM	PMID[18605720]
NPT65	Cell line	HepG2	Homo sapiens	Inhibition	=	65.0	%	PMID[20485427]
NPT65	Cell line	HepG2	Homo sapiens	Inhibition	=	0.0	%	PMID[20485427]
NPT492	Cell line	Caco-2	Homo sapiens	EC50	=	1100.0	nM	PMID[20674353]
NPT83	Cell line	MCF7	Homo sapiens	EC50	=	900.0	nM	PMID[20674353]
NPT82	Cell line	MDA-MB-231	Homo sapiens	EC50	=	80000.0	nM	PMID[20674353]
NPT81	Cell line	A549	Homo sapiens	IC50	=	5.0	nM	PMID[20580561]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	1.0	nM	PMID[20580561]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	0.16	ug.mL-1	PMID[20846760]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	0.23	ug.mL-1	PMID[20846760]
NPT492	Cell line	Caco-2	Homo sapiens	IC50	=	0.32	ug.mL-1	PMID[20846760]
NPT306	Cell line	PC-3	Homo sapiens	TGI	>	100000.0	nM	PMID[21115210]
NPT111	Cell line	K562	Homo sapiens	TGI	>	100000.0	nM	PMID[21115210]
NPT139	Cell line	HT-29	Homo sapiens	TGI	>	100000.0	nM	PMID[21115210]
NPT83	Cell line	MCF7	Homo sapiens	TGI	>	100000.0	nM	PMID[21115210]
NPT306	Cell line	PC-3	Homo sapiens	GI50	=	100.0	nM	PMID[21115210]
NPT111	Cell line	K562	Homo sapiens	GI50	=	30.0	nM	PMID[21115210]
NPT139	Cell line	HT-29	Homo sapiens	GI50	=	40.0	nM	PMID[21115210]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	60.0	nM	PMID[21115210]
NPT81	Cell line	A549	Homo sapiens	IC50	=	37.4	nM	PMID[20036565]
NPT81	Cell line	A549	Homo sapiens	Activity	=	16.0	%	PMID[20036565]
NPT81	Cell line	A549	Homo sapiens	Activity	=	77.3	%	PMID[20036565]
NPT81	Cell line	A549	Homo sapiens	Activity	=	96.6	%	PMID[20036565]
NPT81	Cell line	A549	Homo sapiens	Activity	=	14.3	%	PMID[20036565]
NPT405	Cell line	NCI-H226	Homo sapiens	GI50	=	10250.0	nM	PMID[21802949]
NPT15	Cell line	Jurkat	Homo sapiens	GI50	=	1250.0	nM	PMID[21802949]
NPT91	Cell line	KB	Homo sapiens	IC50	=	6.0	nM	PMID[21879757]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20.0	nM	PMID[21879757]
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	21.0	nM	PMID[21879757]
NPT458	Cell line	IGROV-1	Homo sapiens	IC50	=	22.0	nM	PMID[21879757]
NPT858	Cell line	LNCaP	Homo sapiens	IC50	=	300.0	nM	PMID[22480495]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	1400.0	nM	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	101.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	97.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	96.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	102.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	94.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	60.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	89.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	52.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	27.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	80.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Inhibition	=	29.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Ratio	=	0.98	n.a.	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Ratio	=	0.77	n.a.	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Ratio	=	0.76	n.a.	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Activity	=	140.0	%	PMID[22480495]
NPT2103	Cell line	MONO-MAC-6	Homo sapiens	Ratio	=	0.95	n.a.	PMID[22480495]
NPT146	Cell line	SK-OV-3	Homo sapiens	IC50	=	60.0	nM	PMID[23124219]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20900.0	nM	PMID[23124219]
NPT91	Cell line	KB	Homo sapiens	IC50	=	8.5	nM	PMID[22243528]
NPT71	Cell line	HEK293	Homo sapiens	IC50	=	1270.0	nM	DOI[10.1007/s00044-012-0260-2]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	2260.0	nM	DOI[10.1007/s00044-012-0260-2]
NPT1723	Cell line	HBL-100	Homo sapiens	IC50	=	40.0	nM	DOI[10.1007/s00044-012-0279-4]
NPT2268	Cell line	DOK	Homo sapiens	IC50	=	7582.05	nM	DOI[10.6019/CHEMBL1201861]
NPT1899	Cell line	DSH1	Homo sapiens	IC50	=	532.72	nM	DOI[10.6019/CHEMBL1201861]
NPT1184	Cell line	Daoy	Homo sapiens	IC50	=	12683.3	nM	DOI[10.6019/CHEMBL1201861]
NPT90	Cell line	DU-145	Homo sapiens	IC50	=	1010.74	nM	DOI[10.6019/CHEMBL1201861]
NPT394	Cell line	EKVX	Homo sapiens	IC50	=	9129.41	nM	DOI[10.6019/CHEMBL1201861]
NPT1901	Cell line	EM-2	Homo sapiens	IC50	=	57.13	nM	DOI[10.6019/CHEMBL1201861]
NPT2269	Cell line	EPLC-272H	Homo sapiens	IC50	=	5199.57	nM	DOI[10.6019/CHEMBL1201861]
NPT1905	Cell line	ES4	Homo sapiens	IC50	=	79.51	nM	DOI[10.6019/CHEMBL1201861]
NPT1903	Cell line	ES5	Homo sapiens	IC50	=	435.31	nM	DOI[10.6019/CHEMBL1201861]
NPT1902	Cell line	ES1	Homo sapiens	IC50	=	16.39	nM	DOI[10.6019/CHEMBL1201861]
NPT1904	Cell line	ES3	Homo sapiens	IC50	=	242.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2270	Cell line	Detroit562	Homo sapiens	IC50	=	6924.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2271	Cell line	DoTc2-4510	Homo sapiens	IC50	=	7058.21	nM	DOI[10.6019/CHEMBL1201861]
NPT1908	Cell line	EC-GI-10	Homo sapiens	IC50	=	10625.59	nM	DOI[10.6019/CHEMBL1201861]
NPT2272	Cell line	EFM-19	Homo sapiens	IC50	=	10592.33	nM	DOI[10.6019/CHEMBL1201861]
NPT2273	Cell line	EFO-21	Homo sapiens	IC50	=	3016.66	nM	DOI[10.6019/CHEMBL1201861]
NPT2274	Cell line	EFO-27	Homo sapiens	IC50	=	567.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2275	Cell line	EGI-1	Homo sapiens	IC50	=	19971.26	nM	DOI[10.6019/CHEMBL1201861]
NPT376	Cell line	A498	Homo sapiens	IC50	=	9373.67	nM	DOI[10.6019/CHEMBL1201861]
NPT81	Cell line	A549	Homo sapiens	IC50	=	11589.88	nM	DOI[10.6019/CHEMBL1201861]
NPT2276	Cell line	A673	Homo sapiens	IC50	=	1605.3	nM	DOI[10.6019/CHEMBL1201861]
NPT1081	Cell line	BXPC-3	Homo sapiens	IC50	=	4406.82	nM	DOI[10.6019/CHEMBL1201861]
NPT2277	Cell line	C-33-A	Homo sapiens	IC50	=	10685.38	nM	DOI[10.6019/CHEMBL1201861]
NPT2278	Cell line	COLO-741	Homo sapiens	IC50	=	162.12	nM	DOI[10.6019/CHEMBL1201861]
NPT2279	Cell line	COLO-792	Homo sapiens	IC50	=	16965.94	nM	DOI[10.6019/CHEMBL1201861]
NPT1913	Cell line	DJM-1	Homo sapiens	IC50	=	20249.98	nM	DOI[10.6019/CHEMBL1201861]
NPT2280	Cell line	A704	Homo sapiens	IC50	=	22814.47	nM	DOI[10.6019/CHEMBL1201861]
NPT2281	Cell line	ABC-1	Homo sapiens	IC50	=	21149.62	nM	DOI[10.6019/CHEMBL1201861]
NPT1911	Cell line	C2BBe1	Homo sapiens	IC50	=	996.16	nM	DOI[10.6019/CHEMBL1201861]
NPT2282	Cell line	C32	Homo sapiens	IC50	=	2924.7	nM	DOI[10.6019/CHEMBL1201861]
NPT1912	Cell line	COLO-800	Homo sapiens	IC50	=	123.72	nM	DOI[10.6019/CHEMBL1201861]
NPT1914	Cell line	COLO-824	Homo sapiens	IC50	=	14289.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2283	Cell line	DK-MG	Homo sapiens	IC50	=	17392.92	nM	DOI[10.6019/CHEMBL1201861]
NPT576	Cell line	DMS-114	Homo sapiens	IC50	=	9647.04	nM	DOI[10.6019/CHEMBL1201861]
NPT369	Cell line	ACHN	Homo sapiens	IC50	=	85.26	nM	DOI[10.6019/CHEMBL1201861]
NPT1916	Cell line	ACN	Homo sapiens	IC50	=	16378.87	nM	DOI[10.6019/CHEMBL1201861]
NPT2284	Cell line	C3A	Homo sapiens	IC50	=	2988.32	nM	DOI[10.6019/CHEMBL1201861]
NPT1452	Cell line	C8166	Homo sapiens	IC50	=	224.12	nM	DOI[10.6019/CHEMBL1201861]
NPT1915	Cell line	COLO-829	Homo sapiens	IC50	=	1429.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2285	Cell line	COR-L105	Homo sapiens	IC50	=	16863.49	nM	DOI[10.6019/CHEMBL1201861]
NPT1918	Cell line	DMS-79	Homo sapiens	IC50	=	628.13	nM	DOI[10.6019/CHEMBL1201861]
NPT1919	Cell line	DOHH-2	Homo sapiens	IC50	=	21.56	nM	DOI[10.6019/CHEMBL1201861]
NPT1920	Cell line	ALL-PO	Homo sapiens	IC50	=	5.858	nM	DOI[10.6019/CHEMBL1201861]
NPT308	Cell line	CAKI-1	Homo sapiens	IC50	=	671.49	nM	DOI[10.6019/CHEMBL1201861]
NPT2286	Cell line	CAL-120	Homo sapiens	IC50	=	10838.88	nM	DOI[10.6019/CHEMBL1201861]
NPT2287	Cell line	COR-L23	Homo sapiens	IC50	=	121.92	nM	DOI[10.6019/CHEMBL1201861]
NPT572	Cell line	DMS-273	Homo sapiens	IC50	=	3705.51	nM	DOI[10.6019/CHEMBL1201861]
NPT1924	Cell line	AM-38	Homo sapiens	IC50	=	603.87	nM	DOI[10.6019/CHEMBL1201861]
NPT2288	Cell line	AN3-CA	Homo sapiens	IC50	=	9489.0	nM	DOI[10.6019/CHEMBL1201861]
NPT2289	Cell line	CAL-12T	Homo sapiens	IC50	=	8430.14	nM	DOI[10.6019/CHEMBL1201861]
NPT2290	Cell line	CAL-27	Homo sapiens	IC50	=	9644.3	nM	DOI[10.6019/CHEMBL1201861]
NPT2291	Cell line	CP50-MEL-B	Homo sapiens	IC50	=	12292.46	nM	DOI[10.6019/CHEMBL1201861]
NPT1629	Cell line	CWR22R	Homo sapiens	IC50	=	536.88	nM	DOI[10.6019/CHEMBL1201861]
NPT1928	Cell line	ATN-1	Homo sapiens	IC50	=	3.924	nM	DOI[10.6019/CHEMBL1201861]
NPT2292	Cell line	CAL-33	Homo sapiens	IC50	=	7677.12	nM	DOI[10.6019/CHEMBL1201861]
NPT2293	Cell line	CAL-39	Homo sapiens	IC50	=	17407.18	nM	DOI[10.6019/CHEMBL1201861]
NPT1930	Cell line	CTB-1	Homo sapiens	IC50	=	16.23	nM	DOI[10.6019/CHEMBL1201861]
NPT2295	Cell line	5637	Homo sapiens	IC50	=	293.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2296	Cell line	AU565	Homo sapiens	IC50	=	61.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2297	Cell line	ASPC1	Homo sapiens	IC50	=	266.22	nM	DOI[10.6019/CHEMBL1201861]
NPT2298	Cell line	BALL-1	Homo sapiens	IC50	=	1186.96	nM	DOI[10.6019/CHEMBL1201861]
NPT2299	Cell line	CAL-51	Homo sapiens	IC50	=	4532.64	nM	DOI[10.6019/CHEMBL1201861]
NPT2300	Cell line	CAL-54	Homo sapiens	IC50	=	2791.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2301	Cell line	CAL-62	Homo sapiens	IC50	=	3175.41	nM	DOI[10.6019/CHEMBL1201861]
NPT1932	Cell line	CTV-1	Homo sapiens	IC50	=	77.1	nM	DOI[10.6019/CHEMBL1201861]
NPT1933	Cell line	CW-2	Homo sapiens	IC50	=	15777.17	nM	DOI[10.6019/CHEMBL1201861]
NPT2302	Cell line	639-V	Homo sapiens	IC50	=	6323.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2303	Cell line	647-V	Homo sapiens	IC50	=	9307.22	nM	DOI[10.6019/CHEMBL1201861]
NPT1931	Cell line	BB30-HNC	Homo sapiens	IC50	=	94.28	nM	DOI[10.6019/CHEMBL1201861]
NPT1934	Cell line	BB49-HNC	Homo sapiens	IC50	=	10186.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2304	Cell line	CAL-72	Homo sapiens	IC50	=	415.94	nM	DOI[10.6019/CHEMBL1201861]
NPT2305	Cell line	CAL-85-1	Homo sapiens	IC50	=	10940.48	nM	DOI[10.6019/CHEMBL1201861]
NPT2306	Cell line	Ca-Ski	Homo sapiens	IC50	=	373.19	nM	DOI[10.6019/CHEMBL1201861]
NPT1031	Cell line	Ca9-22	Homo sapiens	IC50	=	3404.94	nM	DOI[10.6019/CHEMBL1201861]
NPT1094	Cell line	697	Homo sapiens	IC50	=	12.57	nM	DOI[10.6019/CHEMBL1201861]
NPT2307	Cell line	769-P	Homo sapiens	IC50	=	45.26	nM	DOI[10.6019/CHEMBL1201861]
NPT401	Cell line	786-0	Homo sapiens	IC50	=	643.3	nM	DOI[10.6019/CHEMBL1201861]
NPT1935	Cell line	BB65-RCC	Homo sapiens	IC50	=	7085.95	nM	DOI[10.6019/CHEMBL1201861]
NPT2308	Cell line	CAMA-1	Homo sapiens	IC50	=	3937.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2309	Cell line	CAPAN-1	Homo sapiens	IC50	=	6096.15	nM	DOI[10.6019/CHEMBL1201861]
NPT2310	Cell line	CaR-1	Homo sapiens	IC50	=	13216.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2311	Cell line	Calu-3	Homo sapiens	IC50	=	15299.19	nM	DOI[10.6019/CHEMBL1201861]
NPT1939	Cell line	8-MG-BA	Homo sapiens	IC50	=	21805.65	nM	DOI[10.6019/CHEMBL1201861]
NPT2312	Cell line	8305C	Homo sapiens	IC50	=	196.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2313	Cell line	BCPAP	Homo sapiens	IC50	=	43.1	nM	DOI[10.6019/CHEMBL1201861]
NPT1937	Cell line	CAS-1	Homo sapiens	IC50	=	16566.67	nM	DOI[10.6019/CHEMBL1201861]
NPT404	Cell line	CCRF-CEM	Homo sapiens	IC50	=	695.81	nM	DOI[10.6019/CHEMBL1201861]
NPT1938	Cell line	Calu-6	Homo sapiens	IC50	=	552.72	nM	DOI[10.6019/CHEMBL1201861]
NPT1313	Cell line	Capan-2	Homo sapiens	IC50	=	2282.26	nM	DOI[10.6019/CHEMBL1201861]
NPT1215	Cell line	8505C	Homo sapiens	IC50	=	12212.13	nM	DOI[10.6019/CHEMBL1201861]
NPT1941	Cell line	A101D	Homo sapiens	IC50	=	14936.26	nM	DOI[10.6019/CHEMBL1201861]
NPT1940	Cell line	BE-13	Homo sapiens	IC50	=	38.75	nM	DOI[10.6019/CHEMBL1201861]
NPT2314	Cell line	BEN	Homo sapiens	IC50	=	9704.11	nM	DOI[10.6019/CHEMBL1201861]
NPT2315	Cell line	BFTC-905	Homo sapiens	IC50	=	9016.06	nM	DOI[10.6019/CHEMBL1201861]
NPT2316	Cell line	CFPAC-1	Homo sapiens	IC50	=	689.55	nM	DOI[10.6019/CHEMBL1201861]
NPT2317	Cell line	ChaGo-K-1	Homo sapiens	IC50	=	7738.26	nM	DOI[10.6019/CHEMBL1201861]
NPT1944	Cell line	D-247MG	Homo sapiens	IC50	=	15592.84	nM	DOI[10.6019/CHEMBL1201861]
NPT2318	Cell line	A172	Homo sapiens	IC50	=	1895.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2319	Cell line	A204	Homo sapiens	IC50	=	1084.08	nM	DOI[10.6019/CHEMBL1201861]
NPT2320	Cell line	BFTC-909	Homo sapiens	IC50	=	9208.64	nM	DOI[10.6019/CHEMBL1201861]
NPT2321	Cell line	BHT-101	Homo sapiens	IC50	=	26644.29	nM	DOI[10.6019/CHEMBL1201861]
NPT1943	Cell line	CGTH-W-1	Homo sapiens	IC50	=	31.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2322	Cell line	CHL-1	Homo sapiens	IC50	=	209.51	nM	DOI[10.6019/CHEMBL1201861]
NPT1946	Cell line	D-263MG	Homo sapiens	IC50	=	3983.99	nM	DOI[10.6019/CHEMBL1201861]
NPT1383	Cell line	A2058	Homo sapiens	IC50	=	1987.73	nM	DOI[10.6019/CHEMBL1201861]
NPT179	Cell line	A2780	Homo sapiens	IC50	=	54.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2323	Cell line	BHY	Homo sapiens	IC50	=	5725.8	nM	DOI[10.6019/CHEMBL1201861]
NPT2324	Cell line	CHP-212	Homo sapiens	IC50	=	7847.41	nM	DOI[10.6019/CHEMBL1201861]
NPT1947	Cell line	D283 Med	n.a.	IC50	=	7704.6	nM	DOI[10.6019/CHEMBL1201861]
NPT1953	Cell line	D-336MG	Homo sapiens	IC50	=	11889.84	nM	DOI[10.6019/CHEMBL1201861]
NPT1954	Cell line	D-392MG	Homo sapiens	IC50	=	158.09	nM	DOI[10.6019/CHEMBL1201861]
NPT1955	Cell line	A3-KAW	Homo sapiens	IC50	=	8.923	nM	DOI[10.6019/CHEMBL1201861]
NPT1083	Cell line	A-375	Homo sapiens	IC50	=	9816.46	nM	DOI[10.6019/CHEMBL1201861]
NPT2325	Cell line	BPH-1	Homo sapiens	IC50	=	772.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2326	Cell line	BT-20	Homo sapiens	IC50	=	1350.19	nM	DOI[10.6019/CHEMBL1201861]
NPT1952	Cell line	COLO-320-HSR	Homo sapiens	IC50	=	52.38	nM	DOI[10.6019/CHEMBL1201861]
NPT1956	Cell line	COLO-668	Homo sapiens	IC50	=	498.56	nM	DOI[10.6019/CHEMBL1201861]
NPT2327	Cell line	D-423MG	Homo sapiens	IC50	=	23828.49	nM	DOI[10.6019/CHEMBL1201861]
NPT1957	Cell line	D-502MG	Homo sapiens	IC50	=	22946.15	nM	DOI[10.6019/CHEMBL1201861]
NPT1958	Cell line	A388	Homo sapiens	IC50	=	1605.0	nM	DOI[10.6019/CHEMBL1201861]
NPT1959	Cell line	A4-Fuk	Homo sapiens	IC50	=	38.23	nM	DOI[10.6019/CHEMBL1201861]
NPT845	Cell line	BT-474	Homo sapiens	IC50	=	12541.84	nM	DOI[10.6019/CHEMBL1201861]
NPT2328	Cell line	COLO-678	Homo sapiens	IC50	=	11979.96	nM	DOI[10.6019/CHEMBL1201861]
NPT2329	Cell line	COLO-679	Homo sapiens	IC50	=	18583.67	nM	DOI[10.6019/CHEMBL1201861]
NPT2330	Cell line	D-566MG	Homo sapiens	IC50	=	21868.98	nM	DOI[10.6019/CHEMBL1201861]
NPT2331	Cell line	A-427	Homo sapiens	IC50	=	16184.22	nM	DOI[10.6019/CHEMBL1201861]
NPT762	Cell line	A-431	Homo sapiens	IC50	=	2197.1	nM	DOI[10.6019/CHEMBL1201861]
NPT1960	Cell line	BV-173	Homo sapiens	IC50	=	6.349	nM	DOI[10.6019/CHEMBL1201861]
NPT1963	Cell line	Becker	Homo sapiens	IC50	=	12792.55	nM	DOI[10.6019/CHEMBL1201861]
NPT2332	Cell line	COLO-680N	Homo sapiens	IC50	=	19598.22	nM	DOI[10.6019/CHEMBL1201861]
NPT1964	Cell line	COLO-684	Homo sapiens	IC50	=	37.55	nM	DOI[10.6019/CHEMBL1201861]
NPT1962	Cell line	DB	Homo sapiens	IC50	=	21.28	nM	DOI[10.6019/CHEMBL1201861]
NPT2333	Cell line	DBTRG-05MG	Homo sapiens	IC50	=	171.18	nM	DOI[10.6019/CHEMBL1201861]
NPT1965	Cell line	DEL	Homo sapiens	IC50	=	3.119	nM	DOI[10.6019/CHEMBL1201861]
NPT2334	Cell line	NCI-H1793	Homo sapiens	IC50	=	2340.4	nM	DOI[10.6019/CHEMBL1201861]
NPT1966	Cell line	NCI-H1838	Homo sapiens	IC50	=	2711.46	nM	DOI[10.6019/CHEMBL1201861]
NPT1967	Cell line	NCI-H526	Homo sapiens	IC50	=	0.6915	nM	DOI[10.6019/CHEMBL1201861]
NPT2335	Cell line	NCI-H596	n.a.	IC50	=	833.44	nM	DOI[10.6019/CHEMBL1201861]
NPT2336	Cell line	OE19	Homo sapiens	IC50	=	1544.6	nM	DOI[10.6019/CHEMBL1201861]
NPT2337	Cell line	OE33	Homo sapiens	IC50	=	281.67	nM	DOI[10.6019/CHEMBL1201861]
NPT1091	Cell line	RPMI-7951	Homo sapiens	IC50	=	1952.97	nM	DOI[10.6019/CHEMBL1201861]
NPT389	Cell line	RPMI-8226	Homo sapiens	IC50	=	101.2	nM	DOI[10.6019/CHEMBL1201861]
NPT311	Cell line	SK-LU-1	Homo sapiens	IC50	=	7598.39	nM	DOI[10.6019/CHEMBL1201861]
NPT926	Cell line	SK-MEL-1	Homo sapiens	IC50	=	500.44	nM	DOI[10.6019/CHEMBL1201861]
NPT1312	Cell line	SW1990	Homo sapiens	IC50	=	18063.1	nM	DOI[10.6019/CHEMBL1201861]
NPT2338	Cell line	SW48	Homo sapiens	IC50	=	12952.45	nM	DOI[10.6019/CHEMBL1201861]
NPT2339	Cell line	TGBC24TKB	Homo sapiens	IC50	=	4585.3	nM	DOI[10.6019/CHEMBL1201861]
NPT1971	Cell line	GI-1	Homo sapiens	IC50	=	19492.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2204	Cell line	HH	Homo sapiens	IC50	=	31.6	nM	DOI[10.6019/CHEMBL1201861]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	24.78	nM	DOI[10.6019/CHEMBL1201861]
NPT1973	Cell line	IST-SL1	Homo sapiens	IC50	=	390.1	nM	DOI[10.6019/CHEMBL1201861]
NPT1975	Cell line	KS-1	Homo sapiens	IC50	=	10768.71	nM	DOI[10.6019/CHEMBL1201861]
NPT2340	Cell line	KU-19-19	Homo sapiens	IC50	=	1077.52	nM	DOI[10.6019/CHEMBL1201861]
NPT1976	Cell line	LNCaP-Clone-FGC	Homo sapiens	IC50	=	9577.98	nM	DOI[10.6019/CHEMBL1201861]
NPT1978	Cell line	MFM-223	Homo sapiens	IC50	=	6060.13	nM	DOI[10.6019/CHEMBL1201861]
NPT2211	Cell line	NB12	Homo sapiens	IC50	=	19653.12	nM	DOI[10.6019/CHEMBL1201861]
NPT1979	Cell line	NB13	Homo sapiens	IC50	=	5260.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2342	Cell line	NCI-H630	Homo sapiens	IC50	=	6518.61	nM	DOI[10.6019/CHEMBL1201861]
NPT2343	Cell line	NCI-H650	Homo sapiens	IC50	=	807.79	nM	DOI[10.6019/CHEMBL1201861]
NPT1968	Cell line	OMC-1	Homo sapiens	IC50	=	24621.18	nM	DOI[10.6019/CHEMBL1201861]
NPT1984	Cell line	ONS-76	Homo sapiens	IC50	=	63.77	nM	DOI[10.6019/CHEMBL1201861]
NPT1987	Cell line	RPMI-8866	Homo sapiens	IC50	=	19.99	nM	DOI[10.6019/CHEMBL1201861]
NPT147	Cell line	SK-MEL-2	Homo sapiens	IC50	=	17057.62	nM	DOI[10.6019/CHEMBL1201861]
NPT2344	Cell line	SK-MEL-24	Homo sapiens	IC50	=	1056.05	nM	DOI[10.6019/CHEMBL1201861]
NPT323	Cell line	SW-620	Homo sapiens	IC50	=	541.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2345	Cell line	SW626	Homo sapiens	IC50	=	16469.27	nM	DOI[10.6019/CHEMBL1201861]
NPT2346	Cell line	TI-73	Homo sapiens	IC50	=	11605.08	nM	DOI[10.6019/CHEMBL1201861]
NPT384	Cell line	TK-10	Homo sapiens	IC50	=	26849.52	nM	DOI[10.6019/CHEMBL1201861]
NPT1972	Cell line	GI-ME-N	Homo sapiens	IC50	=	147.16	nM	DOI[10.6019/CHEMBL1201861]
NPT2347	Cell line	GMS-10	Homo sapiens	IC50	=	21842.66	nM	DOI[10.6019/CHEMBL1201861]
NPT2348	Cell line	HLE	Homo sapiens	IC50	=	7085.4	nM	DOI[10.6019/CHEMBL1201861]
NPT2349	Cell line	HMV-2 cell line	n.a.	IC50	=	1878.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2350	Cell line	HN	Homo sapiens	IC50	=	6884.48	nM	DOI[10.6019/CHEMBL1201861]
NPT1990	Cell line	J-RT3-T3-5	Homo sapiens	IC50	=	19.42	nM	DOI[10.6019/CHEMBL1201861]
NPT1505	Cell line	J82	Homo sapiens	IC50	=	4099.42	nM	DOI[10.6019/CHEMBL1201861]
NPT390	Cell line	LOX IMVI	Homo sapiens	IC50	=	201.86	nM	DOI[10.6019/CHEMBL1201861]
NPT2351	Cell line	MG-63	Homo sapiens	IC50	=	197.1	nM	DOI[10.6019/CHEMBL1201861]
NPT2352	Cell line	MHH-ES-1	Homo sapiens	IC50	=	107.01	nM	DOI[10.6019/CHEMBL1201861]
NPT1980	Cell line	NB14	Homo sapiens	IC50	=	75.01	nM	DOI[10.6019/CHEMBL1201861]
NPT1995	Cell line	NB17	Homo sapiens	IC50	=	16832.29	nM	DOI[10.6019/CHEMBL1201861]
NPT2353	Cell line	NCI-H1993	Homo sapiens	IC50	=	23188.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2355	Cell line	NCI-H2029	Homo sapiens	IC50	=	25796.66	nM	DOI[10.6019/CHEMBL1201861]
NPT2356	Cell line	NCI-H661	Homo sapiens	IC50	=	3562.87	nM	DOI[10.6019/CHEMBL1201861]
NPT1997	Cell line	OS-RC-2	Homo sapiens	IC50	=	5320.83	nM	DOI[10.6019/CHEMBL1201861]
NPT1998	Cell line	RS4-11	Homo sapiens	IC50	=	7.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2357	Cell line	RT-112	Homo sapiens	IC50	=	142.31	nM	DOI[10.6019/CHEMBL1201861]
NPT170	Cell line	SK-MEL-28	Homo sapiens	IC50	=	7394.01	nM	DOI[10.6019/CHEMBL1201861]
NPT2358	Cell line	SK-MEL3	Homo sapiens	IC50	=	1055.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2359	Cell line	SK-MEL-30	Homo sapiens	IC50	=	3851.21	nM	DOI[10.6019/CHEMBL1201861]
NPT1988	Cell line	SW684	Homo sapiens	IC50	=	9281.87	nM	DOI[10.6019/CHEMBL1201861]
NPT2360	Cell line	SW756	Homo sapiens	IC50	=	13860.85	nM	DOI[10.6019/CHEMBL1201861]
NPT2361	Cell line	SW780	Homo sapiens	IC50	=	116.29	nM	DOI[10.6019/CHEMBL1201861]
NPT2362	Cell line	TYK-nu	Homo sapiens	IC50	=	197.27	nM	DOI[10.6019/CHEMBL1201861]
NPT2363	Cell line	U-118-MG	Homo sapiens	IC50	=	4671.36	nM	DOI[10.6019/CHEMBL1201861]
NPT1989	Cell line	GOTO	Homo sapiens	IC50	=	2053.52	nM	DOI[10.6019/CHEMBL1201861]
NPT2364	Cell line	GP5d	Homo sapiens	IC50	=	9614.03	nM	DOI[10.6019/CHEMBL1201861]
NPT2365	Cell line	HO-1-N-1	Homo sapiens	IC50	=	6174.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2001	Cell line	JAR	Homo sapiens	IC50	=	188.36	nM	DOI[10.6019/CHEMBL1201861]
NPT2366	Cell line	JEG-3	Homo sapiens	IC50	=	7031.92	nM	DOI[10.6019/CHEMBL1201861]
NPT1992	Cell line	KURAMOCHI	Homo sapiens	IC50	=	1886.94	nM	DOI[10.6019/CHEMBL1201861]
NPT2367	Cell line	KYSE-140	Homo sapiens	IC50	=	1245.29	nM	DOI[10.6019/CHEMBL1201861]
NPT2003	Cell line	LS-1034	Homo sapiens	IC50	=	6867.75	nM	DOI[10.6019/CHEMBL1201861]
NPT2004	Cell line	LS-123	Homo sapiens	IC50	=	10289.17	nM	DOI[10.6019/CHEMBL1201861]
NPT2005	Cell line	MHH-NB-11	Homo sapiens	IC50	=	409.51	nM	DOI[10.6019/CHEMBL1201861]
NPT1996	Cell line	NB5	Homo sapiens	IC50	=	14227.49	nM	DOI[10.6019/CHEMBL1201861]
NPT2007	Cell line	NB6	Homo sapiens	IC50	=	25876.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2368	Cell line	NCI-H2030	Homo sapiens	IC50	=	9183.52	nM	DOI[10.6019/CHEMBL1201861]
NPT2369	Cell line	NCI-H2052	Homo sapiens	IC50	=	2509.68	nM	DOI[10.6019/CHEMBL1201861]
NPT377	Cell line	OVCAR-3	Homo sapiens	IC50	=	810.02	nM	DOI[10.6019/CHEMBL1201861]
NPT456	Cell line	OVCAR-4	Homo sapiens	IC50	=	4414.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2370	Cell line	RVH-421	Homo sapiens	IC50	=	23044.27	nM	DOI[10.6019/CHEMBL1201861]
NPT406	Cell line	RXF 393	Homo sapiens	IC50	=	13852.68	nM	DOI[10.6019/CHEMBL1201861]
NPT1506	Cell line	SK-MES-1	Homo sapiens	IC50	=	5069.11	nM	DOI[10.6019/CHEMBL1201861]
NPT2371	Cell line	SW837	Homo sapiens	IC50	=	4590.68	nM	DOI[10.6019/CHEMBL1201861]
NPT2014	Cell line	SW872	Homo sapiens	IC50	=	4600.2	nM	DOI[10.6019/CHEMBL1201861]
NPT1045	Cell line	U2OS	Homo sapiens	IC50	=	182.32	nM	DOI[10.6019/CHEMBL1201861]
NPT2015	Cell line	U-266	Homo sapiens	IC50	=	5528.57	nM	DOI[10.6019/CHEMBL1201861]
NPT2016	Cell line	ES6	Homo sapiens	IC50	=	428.37	nM	DOI[10.6019/CHEMBL1201861]
NPT2000	Cell line	GR-ST	Homo sapiens	IC50	=	36.28	nM	DOI[10.6019/CHEMBL1201861]
NPT2018	Cell line	GT3TKB	Homo sapiens	IC50	=	10714.66	nM	DOI[10.6019/CHEMBL1201861]
NPT2372	Cell line	H-EMC-SS	Homo sapiens	IC50	=	20774.97	nM	DOI[10.6019/CHEMBL1201861]
NPT372	Cell line	HOP-92	Homo sapiens	IC50	=	16653.88	nM	DOI[10.6019/CHEMBL1201861]
NPT307	Cell line	HOS	Homo sapiens	IC50	=	11007.14	nM	DOI[10.6019/CHEMBL1201861]
NPT2019	Cell line	JVM-2	Homo sapiens	IC50	=	2180.64	nM	DOI[10.6019/CHEMBL1201861]
NPT2020	Cell line	JVM-3	Homo sapiens	IC50	=	16.04	nM	DOI[10.6019/CHEMBL1201861]
NPT2373	Cell line	KYSE-150 cell line	n.a.	IC50	=	115.06	nM	DOI[10.6019/CHEMBL1201861]
NPT2374	Cell line	KYSE-180	Homo sapiens	IC50	=	1212.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2021	Cell line	LS-411N	Homo sapiens	IC50	=	117.59	nM	DOI[10.6019/CHEMBL1201861]
NPT2006	Cell line	MHH-PREB-1	Homo sapiens	IC50	=	13.23	nM	DOI[10.6019/CHEMBL1201861]
NPT783	Cell line	MIA PaCa-2	Homo sapiens	IC50	=	9125.28	nM	DOI[10.6019/CHEMBL1201861]
NPT2375	Cell line	MKN-1	Homo sapiens	IC50	=	2246.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2008	Cell line	NB69	Homo sapiens	IC50	=	14732.09	nM	DOI[10.6019/CHEMBL1201861]
NPT2023	Cell line	NB7	Homo sapiens	IC50	=	447.6	nM	DOI[10.6019/CHEMBL1201861]
NPT2376	Cell line	NBsusSR	Homo sapiens	IC50	=	29.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2377	Cell line	NCI-H2087	Homo sapiens	IC50	=	10166.71	nM	DOI[10.6019/CHEMBL1201861]
NPT2024	Cell line	NCI-H209	Homo sapiens	IC50	=	365.82	nM	DOI[10.6019/CHEMBL1201861]
NPT2378	Cell line	NCI-H727	Homo sapiens	IC50	=	1127.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2025	Cell line	NCI-H747	Homo sapiens	IC50	=	13077.3	nM	DOI[10.6019/CHEMBL1201861]
NPT382	Cell line	OVCAR-5	Homo sapiens	IC50	=	14668.74	nM	DOI[10.6019/CHEMBL1201861]
NPT381	Cell line	OVCAR-8	Homo sapiens	IC50	=	9990.71	nM	DOI[10.6019/CHEMBL1201861]
NPT2379	Cell line	P12-Ichikawa	Homo sapiens	IC50	=	41.3	nM	DOI[10.6019/CHEMBL1201861]
NPT2026	Cell line	Ramos-2G6-4C10	Homo sapiens	IC50	=	26.86	nM	DOI[10.6019/CHEMBL1201861]
NPT2380	Cell line	SK-N-AS	Homo sapiens	IC50	=	1417.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2027	Cell line	SK-N-DZ	Homo sapiens	IC50	=	743.08	nM	DOI[10.6019/CHEMBL1201861]
NPT2381	Cell line	SW900	Homo sapiens	IC50	=	11239.92	nM	DOI[10.6019/CHEMBL1201861]
NPT2382	Cell line	SW948	Homo sapiens	IC50	=	18626.92	nM	DOI[10.6019/CHEMBL1201861]
NPT1535	Cell line	U-87 MG	Homo sapiens	IC50	=	18560.6	nM	DOI[10.6019/CHEMBL1201861]
NPT2017	Cell line	ES7	Homo sapiens	IC50	=	148.36	nM	DOI[10.6019/CHEMBL1201861]
NPT2031	Cell line	ES8	Homo sapiens	IC50	=	521.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2891	Cell line	H4	Homo sapiens	IC50	=	11475.69	nM	DOI[10.6019/CHEMBL1201861]
NPT2384	Cell line	HPAF-II	Homo sapiens	IC50	=	6118.46	nM	DOI[10.6019/CHEMBL1201861]
NPT924	Cell line	HSC-2	Homo sapiens	IC50	=	398.7	nM	DOI[10.6019/CHEMBL1201861]
NPT2385	Cell line	HSC-3	Homo sapiens	IC50	=	10283.33	nM	DOI[10.6019/CHEMBL1201861]
NPT111	Cell line	K562	Homo sapiens	IC50	=	4875.06	nM	DOI[10.6019/CHEMBL1201861]
NPT2386	Cell line	KYSE-270	Homo sapiens	IC50	=	52.11	nM	DOI[10.6019/CHEMBL1201861]
NPT2387	Cell line	KYSE-410	Homo sapiens	IC50	=	3639.26	nM	DOI[10.6019/CHEMBL1201861]
NPT2022	Cell line	LS-513	Homo sapiens	IC50	=	4353.08	nM	DOI[10.6019/CHEMBL1201861]
NPT2034	Cell line	LU-134-A	Homo sapiens	IC50	=	88.65	nM	DOI[10.6019/CHEMBL1201861]
NPT2388	Cell line	LU-135	Homo sapiens	IC50	=	2230.07	nM	DOI[10.6019/CHEMBL1201861]
NPT1179	Cell line	MKN-28	Homo sapiens	IC50	=	1333.91	nM	DOI[10.6019/CHEMBL1201861]
NPT1097	Cell line	MKN-45	Homo sapiens	IC50	=	872.29	nM	DOI[10.6019/CHEMBL1201861]
NPT2389	Cell line	NCI-H1048	Homo sapiens	IC50	=	328.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2390	Cell line	NCI-H2122	Homo sapiens	IC50	=	151.43	nM	DOI[10.6019/CHEMBL1201861]
NPT1082	Cell line	NCI-H2126	Homo sapiens	IC50	=	13715.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2391	Cell line	NCI-H810	Homo sapiens	IC50	=	14315.86	nM	DOI[10.6019/CHEMBL1201861]
NPT2040	Cell line	P30-OHK	Homo sapiens	IC50	=	43.55	nM	DOI[10.6019/CHEMBL1201861]
NPT2392	Cell line	S-117	Homo sapiens	IC50	=	10816.64	nM	DOI[10.6019/CHEMBL1201861]
NPT2393	Cell line	SAS	Homo sapiens	IC50	=	3937.81	nM	DOI[10.6019/CHEMBL1201861]
NPT2028	Cell line	SK-N-FI	Homo sapiens	IC50	=	13184.17	nM	DOI[10.6019/CHEMBL1201861]
NPT2043	Cell line	SK-NEP-1	Homo sapiens	IC50	=	4.819	nM	DOI[10.6019/CHEMBL1201861]
NPT2029	Cell line	SW 954	Homo sapiens	IC50	=	213.15	nM	DOI[10.6019/CHEMBL1201861]
NPT2044	Cell line	SW 962	Homo sapiens	IC50	=	12996.33	nM	DOI[10.6019/CHEMBL1201861]
NPT371	Cell line	UO-31	Homo sapiens	IC50	=	3643.4	nM	DOI[10.6019/CHEMBL1201861]
NPT380	Cell line	U-251	Homo sapiens	IC50	=	12192.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2383	Cell line	ESS-1	Homo sapiens	IC50	=	1026.91	nM	DOI[10.6019/CHEMBL1201861]
NPT2045	Cell line	ETK-1	Homo sapiens	IC50	=	1395.88	nM	DOI[10.6019/CHEMBL1201861]
NPT2032	Cell line	HAL-01	Homo sapiens	IC50	=	22.27	nM	DOI[10.6019/CHEMBL1201861]
NPT2047	Cell line	HC-1	Homo sapiens	IC50	=	69.57	nM	DOI[10.6019/CHEMBL1201861]
NPT2394	Cell line	HSC-4	Homo sapiens	IC50	=	6472.78	nM	DOI[10.6019/CHEMBL1201861]
NPT2049	Cell line	HT	Homo sapiens	IC50	=	133.69	nM	DOI[10.6019/CHEMBL1201861]
NPT2051	Cell line	K5	Homo sapiens	IC50	=	59.8	nM	DOI[10.6019/CHEMBL1201861]
NPT2395	Cell line	KYSE-450	Homo sapiens	IC50	=	334.47	nM	DOI[10.6019/CHEMBL1201861]
NPT2396	Cell line	KYSE-510	Homo sapiens	IC50	=	91.72	nM	DOI[10.6019/CHEMBL1201861]
NPT2397	Cell line	KYSE-520 cell line	n.a.	IC50	=	4454.56	nM	DOI[10.6019/CHEMBL1201861]
NPT2053	Cell line	LU-139	Homo sapiens	IC50	=	235.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2398	Cell line	MKN-7	Homo sapiens	IC50	=	12063.92	nM	DOI[10.6019/CHEMBL1201861]
NPT2055	Cell line	ML-2	Homo sapiens	IC50	=	4.967	nM	DOI[10.6019/CHEMBL1201861]
NPT2036	Cell line	NCI-H1092	Homo sapiens	IC50	=	922.04	nM	DOI[10.6019/CHEMBL1201861]
NPT2057	Cell line	NCI-H1155	Homo sapiens	IC50	=	266.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2399	Cell line	NCI-H2170	Homo sapiens	IC50	=	7859.67	nM	DOI[10.6019/CHEMBL1201861]
NPT2039	Cell line	NCI-H82	Homo sapiens	IC50	=	789.92	nM	DOI[10.6019/CHEMBL1201861]
NPT2400	Cell line	PA-1	Homo sapiens	IC50	=	9897.78	nM	DOI[10.6019/CHEMBL1201861]
NPT2401	Cell line	PANC-03-27	Homo sapiens	IC50	=	7927.15	nM	DOI[10.6019/CHEMBL1201861]
NPT2402	Cell line	PANC-08-13	Homo sapiens	IC50	=	3886.13	nM	DOI[10.6019/CHEMBL1201861]
NPT2042	Cell line	SBC-1	Homo sapiens	IC50	=	563.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2403	Cell line	SBC-5	Homo sapiens	IC50	=	69.36	nM	DOI[10.6019/CHEMBL1201861]
NPT2063	Cell line	SK-PN-DW	Homo sapiens	IC50	=	8356.61	nM	DOI[10.6019/CHEMBL1201861]
NPT2404	Cell line	SW982	Homo sapiens	IC50	=	11016.95	nM	DOI[10.6019/CHEMBL1201861]
NPT2405	Cell line	SAOS-2	Homo sapiens	IC50	=	2963.6	nM	DOI[10.6019/CHEMBL1201861]
NPT403	Cell line	UACC-257	Homo sapiens	IC50	=	19229.51	nM	DOI[10.6019/CHEMBL1201861]
NPT398	Cell line	UACC-62	Homo sapiens	IC50	=	17915.82	nM	DOI[10.6019/CHEMBL1201861]
NPT2065	Cell line	EW-1	Homo sapiens	IC50	=	168.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2406	Cell line	HCC1395	Homo sapiens	IC50	=	23230.8	nM	DOI[10.6019/CHEMBL1201861]
NPT2407	Cell line	HCC1419	Homo sapiens	IC50	=	13812.21	nM	DOI[10.6019/CHEMBL1201861]
NPT453	Cell line	HT-1080	Homo sapiens	IC50	=	12992.21	nM	DOI[10.6019/CHEMBL1201861]
NPT658	Cell line	HT1197	Homo sapiens	IC50	=	2612.32	nM	DOI[10.6019/CHEMBL1201861]
NPT2052	Cell line	KALS-1	Homo sapiens	IC50	=	9083.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2067	Cell line	KARPAS-299	Homo sapiens	IC50	=	493.5	nM	DOI[10.6019/CHEMBL1201861]
NPT2408	Cell line	KYSE-70 cell line	n.a.	IC50	=	6165.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2068	Cell line	L-363	Homo sapiens	IC50	=	14.26	nM	DOI[10.6019/CHEMBL1201861]
NPT2069	Cell line	Lu-65	Homo sapiens	IC50	=	4077.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2409	Cell line	LU-99A	Homo sapiens	IC50	=	273.84	nM	DOI[10.6019/CHEMBL1201861]
NPT2056	Cell line	MLMA	Homo sapiens	IC50	=	96.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2071	Cell line	MMAC-SF	Homo sapiens	IC50	=	19553.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2410	Cell line	NCI-H1299	Homo sapiens	IC50	=	250.03	nM	DOI[10.6019/CHEMBL1201861]
NPT2073	Cell line	NCI-H1304	Homo sapiens	IC50	=	2408.94	nM	DOI[10.6019/CHEMBL1201861]
NPT465	Cell line	NCI-N87	Homo sapiens	IC50	=	6032.26	nM	DOI[10.6019/CHEMBL1201861]
NPT788	Cell line	SNU1	Homo sapiens	IC50	=	7.515	nM	DOI[10.6019/CHEMBL1201861]
NPT2412	Cell line	Panc1005	Homo sapiens	IC50	=	4317.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2413	Cell line	PC-14	Homo sapiens	IC50	=	572.86	nM	DOI[10.6019/CHEMBL1201861]
NPT2062	Cell line	SCC-15	Homo sapiens	IC50	=	805.09	nM	DOI[10.6019/CHEMBL1201861]
NPT2414	Cell line	SCC-25	Homo sapiens	IC50	=	6594.15	nM	DOI[10.6019/CHEMBL1201861]
NPT2078	Cell line	SK-UT-1	Homo sapiens	IC50	=	12169.67	nM	DOI[10.6019/CHEMBL1201861]
NPT2415	Cell line	SKG-IIIa	Homo sapiens	IC50	=	6786.83	nM	DOI[10.6019/CHEMBL1201861]
NPT2245	Cell line	SiHa	Homo sapiens	IC50	=	8502.33	nM	DOI[10.6019/CHEMBL1201861]
NPT550	Cell line	T-24	Homo sapiens	IC50	=	13954.82	nM	DOI[10.6019/CHEMBL1201861]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	24878.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2416	Cell line	UACC-893	Homo sapiens	IC50	=	1095.12	nM	DOI[10.6019/CHEMBL1201861]
NPT2417	Cell line	UMUC3	Homo sapiens	IC50	=	7035.19	nM	DOI[10.6019/CHEMBL1201861]
NPT2066	Cell line	EW-11	Homo sapiens	IC50	=	597.37	nM	DOI[10.6019/CHEMBL1201861]
NPT2080	Cell line	EW-13	Homo sapiens	IC50	=	72.3	nM	DOI[10.6019/CHEMBL1201861]
NPT2418	Cell line	HCC1569	Homo sapiens	IC50	=	6370.95	nM	DOI[10.6019/CHEMBL1201861]
NPT2419	Cell line	HT-1376	Homo sapiens	IC50	=	14994.27	nM	DOI[10.6019/CHEMBL1201861]
NPT2082	Cell line	HT-144	Homo sapiens	IC50	=	8206.87	nM	DOI[10.6019/CHEMBL1201861]
NPT2084	Cell line	KARPAS-45	Homo sapiens	IC50	=	123.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2086	Cell line	L-428	Homo sapiens	IC50	=	1256.7	nM	DOI[10.6019/CHEMBL1201861]
NPT2070	Cell line	LXF-289 cell line	n.a.	IC50	=	6562.65	nM	DOI[10.6019/CHEMBL1201861]
NPT114	Cell line	LoVo	Homo sapiens	IC50	=	13744.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2072	Cell line	MN-60	Homo sapiens	IC50	=	65.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2074	Cell line	NCI-H1355	Homo sapiens	IC50	=	10878.01	nM	DOI[10.6019/CHEMBL1201861]
NPT2089	Cell line	NCI-H1395	Homo sapiens	IC50	=	7279.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2411	Cell line	NCI-H2228	Homo sapiens	IC50	=	7687.12	nM	DOI[10.6019/CHEMBL1201861]
NPT405	Cell line	NCI-H226	Homo sapiens	IC50	=	5355.17	nM	DOI[10.6019/CHEMBL1201861]
NPT2420	Cell line	NCI-H2291	Homo sapiens	IC50	=	4340.85	nM	DOI[10.6019/CHEMBL1201861]
NPT2091	Cell line	SNU-5	Homo sapiens	IC50	=	1499.68	nM	DOI[10.6019/CHEMBL1201861]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	2637.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2421	Cell line	PFSK-1	Homo sapiens	IC50	=	1206.31	nM	DOI[10.6019/CHEMBL1201861]
NPT2422	Cell line	SCC-4	Homo sapiens	IC50	=	7609.07	nM	DOI[10.6019/CHEMBL1201861]
NPT2423	Cell line	SCC-9	Homo sapiens	IC50	=	7433.44	nM	DOI[10.6019/CHEMBL1201861]
NPT368	Cell line	SN12C	Homo sapiens	IC50	=	5554.32	nM	DOI[10.6019/CHEMBL1201861]
NPT392	Cell line	SNB-75	Homo sapiens	IC50	=	24775.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2424	Cell line	T84	Homo sapiens	IC50	=	17536.83	nM	DOI[10.6019/CHEMBL1201861]
NPT1125	Cell line	T98G	Homo sapiens	IC50	=	12845.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2425	Cell line	UMC-11	Homo sapiens	IC50	=	9583.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2096	Cell line	VA-ES-BJ	Homo sapiens	IC50	=	5058.84	nM	DOI[10.6019/CHEMBL1201861]
NPT2097	Cell line	EW-16	Homo sapiens	IC50	=	894.75	nM	DOI[10.6019/CHEMBL1201861]
NPT2426	Cell line	HCC1806	Homo sapiens	IC50	=	5254.67	nM	DOI[10.6019/CHEMBL1201861]
NPT1884	Cell line	HCC1937	Homo sapiens	IC50	=	8179.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2427	Cell line	HCC1954	Homo sapiens	IC50	=	11991.1	nM	DOI[10.6019/CHEMBL1201861]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	153.37	nM	DOI[10.6019/CHEMBL1201861]
NPT2428	Cell line	HT-3	Homo sapiens	IC50	=	69.37	nM	DOI[10.6019/CHEMBL1201861]
NPT2429	Cell line	HT55	Homo sapiens	IC50	=	2408.07	nM	DOI[10.6019/CHEMBL1201861]
NPT2099	Cell line	KE-37	Homo sapiens	IC50	=	15.53	nM	DOI[10.6019/CHEMBL1201861]
NPT1358	Cell line	LAMA-84	Homo sapiens	IC50	=	12.39	nM	DOI[10.6019/CHEMBL1201861]
NPT2101	Cell line	LAN-6	Homo sapiens	IC50	=	1745.62	nM	DOI[10.6019/CHEMBL1201861]
NPT2430	Cell line	M059J	Homo sapiens	IC50	=	15123.94	nM	DOI[10.6019/CHEMBL1201861]
NPT387	Cell line	M14	Homo sapiens	IC50	=	1942.98	nM	DOI[10.6019/CHEMBL1201861]
NPT2088	Cell line	MOLT-16	Homo sapiens	IC50	=	11.6	nM	DOI[10.6019/CHEMBL1201861]
NPT112	Cell line	MOLT-4	Homo sapiens	IC50	=	21.17	nM	DOI[10.6019/CHEMBL1201861]
NPT2431	Cell line	NCI-H1437	Homo sapiens	IC50	=	1677.36	nM	DOI[10.6019/CHEMBL1201861]
NPT370	Cell line	NCI-H23	Homo sapiens	IC50	=	293.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2432	Cell line	NCI-H2342	Homo sapiens	IC50	=	21618.45	nM	DOI[10.6019/CHEMBL1201861]
NPT2092	Cell line	NEC8	Homo sapiens	IC50	=	289.76	nM	DOI[10.6019/CHEMBL1201861]
NPT2106	Cell line	NH-12	Homo sapiens	IC50	=	3506.5	nM	DOI[10.6019/CHEMBL1201861]
NPT2107	Cell line	PSN1	Homo sapiens	IC50	=	1586.64	nM	DOI[10.6019/CHEMBL1201861]
NPT2109	Cell line	SCH	Homo sapiens	IC50	=	984.47	nM	DOI[10.6019/CHEMBL1201861]
NPT890	Cell line	SNU-387	Homo sapiens	IC50	=	12342.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2433	Cell line	SNU-423	Homo sapiens	IC50	=	16346.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2434	Cell line	TCC-SUP	Homo sapiens	IC50	=	8569.61	nM	DOI[10.6019/CHEMBL1201861]
NPT2435	Cell line	VM-CUB-1	Homo sapiens	IC50	=	374.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2436	Cell line	VMRC-RCZ	Homo sapiens	IC50	=	5079.77	nM	DOI[10.6019/CHEMBL1201861]
NPT1653	Cell line	WM-115	Homo sapiens	IC50	=	1827.33	nM	DOI[10.6019/CHEMBL1201861]
NPT2098	Cell line	EW-18	Homo sapiens	IC50	=	499.94	nM	DOI[10.6019/CHEMBL1201861]
NPT2437	Cell line	EW-22	Homo sapiens	IC50	=	217.95	nM	DOI[10.6019/CHEMBL1201861]
NPT2113	Cell line	EW-24	Homo sapiens	IC50	=	496.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2438	Cell line	HTC-C3	Homo sapiens	IC50	=	3442.45	nM	DOI[10.6019/CHEMBL1201861]
NPT2100	Cell line	KG-1	n.a.	IC50	=	508.53	nM	DOI[10.6019/CHEMBL1201861]
NPT2118	Cell line	KGN	Homo sapiens	IC50	=	150.12	nM	DOI[10.6019/CHEMBL1201861]
NPT2120	Cell line	LB1047-RCC	Homo sapiens	IC50	=	15223.85	nM	DOI[10.6019/CHEMBL1201861]
NPT2439	Cell line	MC-IXC	Homo sapiens	IC50	=	9512.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2122	Cell line	MC116	Homo sapiens	IC50	=	60.61	nM	DOI[10.6019/CHEMBL1201861]
NPT2123	Cell line	MPP-89	Homo sapiens	IC50	=	11256.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2440	Cell line	NCI-H1563	Homo sapiens	IC50	=	1433.68	nM	DOI[10.6019/CHEMBL1201861]
NPT2441	Cell line	NCI-H2347	Homo sapiens	IC50	=	9716.96	nM	DOI[10.6019/CHEMBL1201861]
NPT2442	Cell line	NCI-H2405	Homo sapiens	IC50	=	29089.52	nM	DOI[10.6019/CHEMBL1201861]
NPT2126	Cell line	NKM-1	Homo sapiens	IC50	=	7.702	nM	DOI[10.6019/CHEMBL1201861]
NPT2127	Cell line	NMC-G1	Homo sapiens	IC50	=	11348.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2108	Cell line	QIMR-WIL	Homo sapiens	IC50	=	139.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2128	Cell line	RCC10RGB	Homo sapiens	IC50	=	20210.19	nM	DOI[10.6019/CHEMBL1201861]
NPT2111	Cell line	SF-126	Homo sapiens	IC50	=	17962.51	nM	DOI[10.6019/CHEMBL1201861]
NPT395	Cell line	SF-268	Homo sapiens	IC50	=	427.97	nM	DOI[10.6019/CHEMBL1201861]
NPT2443	Cell line	SNU-449	Homo sapiens	IC50	=	827.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2112	Cell line	TE-1	Homo sapiens	IC50	=	388.24	nM	DOI[10.6019/CHEMBL1201861]
NPT2130	Cell line	TE-10	Homo sapiens	IC50	=	12658.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2444	Cell line	YAPC	Homo sapiens	IC50	=	665.75	nM	DOI[10.6019/CHEMBL1201861]
NPT2445	Cell line	YH-13	Homo sapiens	IC50	=	21406.55	nM	DOI[10.6019/CHEMBL1201861]
NPT391	Cell line	HCC 2998	Homo sapiens	IC50	=	211.57	nM	DOI[10.6019/CHEMBL1201861]
NPT2446	Cell line	HCC38	Homo sapiens	IC50	=	17567.12	nM	DOI[10.6019/CHEMBL1201861]
NPT402	Cell line	Hs-578T	Homo sapiens	IC50	=	24709.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2447	Cell line	HuCCT-1	Homo sapiens	IC50	=	16327.49	nM	DOI[10.6019/CHEMBL1201861]
NPT2119	Cell line	KINGS-1	Homo sapiens	IC50	=	614.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2448	Cell line	KLE	Homo sapiens	IC50	=	6159.07	nM	DOI[10.6019/CHEMBL1201861]
NPT2121	Cell line	LB2241-RCC	Homo sapiens	IC50	=	13798.38	nM	DOI[10.6019/CHEMBL1201861]
NPT2134	Cell line	LB2518-MEL	Homo sapiens	IC50	=	6822.67	nM	DOI[10.6019/CHEMBL1201861]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	16198.91	nM	DOI[10.6019/CHEMBL1201861]
NPT2137	Cell line	MS-1	Homo sapiens	IC50	=	45.26	nM	DOI[10.6019/CHEMBL1201861]
NPT2449	Cell line	NCI-H1573	Homo sapiens	IC50	=	13217.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2139	Cell line	NCI-H1581	Homo sapiens	IC50	=	8690.38	nM	DOI[10.6019/CHEMBL1201861]
NPT2450	Cell line	NCI-H2452	Homo sapiens	IC50	=	650.63	nM	DOI[10.6019/CHEMBL1201861]
NPT2451	Cell line	NCI-H28	Homo sapiens	IC50	=	299.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2452	Cell line	NCI-H292	n.a.	IC50	=	6477.48	nM	DOI[10.6019/CHEMBL1201861]
NPT2140	Cell line	NOMO-1	Homo sapiens	IC50	=	16.25	nM	DOI[10.6019/CHEMBL1201861]
NPT2453	Cell line	RCM-1	Homo sapiens	IC50	=	1461.39	nM	DOI[10.6019/CHEMBL1201861]
NPT2454	Cell line	RD	Homo sapiens	IC50	=	8437.19	nM	DOI[10.6019/CHEMBL1201861]
NPT399	Cell line	SF-295	Homo sapiens	IC50	=	12419.8	nM	DOI[10.6019/CHEMBL1201861]
NPT374	Cell line	SF-539	Homo sapiens	IC50	=	19090.24	nM	DOI[10.6019/CHEMBL1201861]
NPT2455	Cell line	SNU-C2B	Homo sapiens	IC50	=	144.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2456	Cell line	TE-11	Homo sapiens	IC50	=	773.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2144	Cell line	TE-12	Homo sapiens	IC50	=	510.68	nM	DOI[10.6019/CHEMBL1201861]
NPT2457	Cell line	YKG-1	Homo sapiens	IC50	=	23243.0	nM	DOI[10.6019/CHEMBL1201861]
NPT994	Cell line	ZR-75-30	Homo sapiens	IC50	=	2232.94	nM	DOI[10.6019/CHEMBL1201861]
NPT1216	Cell line	FaDu	Homo sapiens	IC50	=	6289.16	nM	DOI[10.6019/CHEMBL1201861]
NPT2458	Cell line	FTC-133	Homo sapiens	IC50	=	2513.95	nM	DOI[10.6019/CHEMBL1201861]
NPT2459	Cell line	HCC70	Homo sapiens	IC50	=	389.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2460	Cell line	HCE-4	Homo sapiens	IC50	=	778.72	nM	DOI[10.6019/CHEMBL1201861]
NPT1229	Cell line	Huh-7	Homo sapiens	IC50	=	3188.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2461	Cell line	HuO-3N1	Homo sapiens	IC50	=	89.09	nM	DOI[10.6019/CHEMBL1201861]
NPT2462	Cell line	HuO9	Homo sapiens	IC50	=	1327.94	nM	DOI[10.6019/CHEMBL1201861]
NPT2133	Cell line	KM-H2	Homo sapiens	IC50	=	369.4	nM	DOI[10.6019/CHEMBL1201861]
NPT386	Cell line	KM12	Homo sapiens	IC50	=	164.44	nM	DOI[10.6019/CHEMBL1201861]
NPT2463	Cell line	MDA-MB-157	Homo sapiens	IC50	=	3245.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2464	Cell line	MDA-MB-175-VII	Homo sapiens	IC50	=	17429.65	nM	DOI[10.6019/CHEMBL1201861]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	22897.96	nM	DOI[10.6019/CHEMBL1201861]
NPT2138	Cell line	MSTO-211H	Homo sapiens	IC50	=	518.65	nM	DOI[10.6019/CHEMBL1201861]
NPT1649	Cell line	MV4-11	Homo sapiens	IC50	=	19.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2465	Cell line	NCI-H1623	Homo sapiens	IC50	=	13117.5	nM	DOI[10.6019/CHEMBL1201861]
NPT2150	Cell line	NCI-H1648	Homo sapiens	IC50	=	14804.07	nM	DOI[10.6019/CHEMBL1201861]
NPT2141	Cell line	NOS-1	Homo sapiens	IC50	=	4555.51	nM	DOI[10.6019/CHEMBL1201861]
NPT2152	Cell line	NTERA-2-cl-D1	Homo sapiens	IC50	=	3148.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2467	Cell line	RERF-LC-MS	Homo sapiens	IC50	=	1110.7	nM	DOI[10.6019/CHEMBL1201861]
NPT2153	Cell line	RH-1	Homo sapiens	IC50	=	361.82	nM	DOI[10.6019/CHEMBL1201861]
NPT2154	Cell line	SH-4	Homo sapiens	IC50	=	6942.67	nM	DOI[10.6019/CHEMBL1201861]
NPT2159	Cell line	TE-5	Homo sapiens	IC50	=	11992.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2160	Cell line	no-10	Homo sapiens	IC50	=	7307.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2469	Cell line	G-401	Homo sapiens	IC50	=	639.01	nM	DOI[10.6019/CHEMBL1201861]
NPT2470	Cell line	G-402	Homo sapiens	IC50	=	21578.06	nM	DOI[10.6019/CHEMBL1201861]
NPT2162	Cell line	HCE-T	Homo sapiens	IC50	=	875.84	nM	DOI[10.6019/CHEMBL1201861]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	787.69	nM	DOI[10.6019/CHEMBL1201861]
NPT2471	Cell line	HuP-T3	Homo sapiens	IC50	=	4618.39	nM	DOI[10.6019/CHEMBL1201861]
NPT2472	Cell line	HuP-T4	Homo sapiens	IC50	=	8848.49	nM	DOI[10.6019/CHEMBL1201861]
NPT2163	Cell line	KMOE-2	Homo sapiens	IC50	=	97.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2148	Cell line	LB771-HNC	Homo sapiens	IC50	=	17719.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2166	Cell line	LB831-BLC	Homo sapiens	IC50	=	1711.51	nM	DOI[10.6019/CHEMBL1201861]
NPT2473	Cell line	MDA-MB-361	Homo sapiens	IC50	=	12293.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2474	Cell line	MDA-MB-415	Homo sapiens	IC50	=	8424.65	nM	DOI[10.6019/CHEMBL1201861]
NPT2149	Cell line	MZ1-PC	Homo sapiens	IC50	=	8833.46	nM	DOI[10.6019/CHEMBL1201861]
NPT2168	Cell line	MZ2-MEL	Homo sapiens	IC50	=	9826.77	nM	DOI[10.6019/CHEMBL1201861]
NPT1820	Cell line	NCI-H1650	Homo sapiens	IC50	=	1628.66	nM	DOI[10.6019/CHEMBL1201861]
NPT2475	Cell line	NCI-H1651	Homo sapiens	IC50	=	7802.43	nM	DOI[10.6019/CHEMBL1201861]
NPT2466	Cell line	NCI-H358	Homo sapiens	IC50	=	250.58	nM	DOI[10.6019/CHEMBL1201861]
NPT2476	Cell line	NCI-H441	Homo sapiens	IC50	=	672.92	nM	DOI[10.6019/CHEMBL1201861]
NPT937	Cell line	NCI-H446	Homo sapiens	IC50	=	11165.82	nM	DOI[10.6019/CHEMBL1201861]
NPT2477	Cell line	NUGC-3	Homo sapiens	IC50	=	6122.5	nM	DOI[10.6019/CHEMBL1201861]
NPT2478	Cell line	NY	Homo sapiens	IC50	=	722.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2479	Cell line	OAW-28	Homo sapiens	IC50	=	13852.46	nM	DOI[10.6019/CHEMBL1201861]
NPT2480	Cell line	RH-18	Homo sapiens	IC50	=	15800.38	nM	DOI[10.6019/CHEMBL1201861]
NPT2170	Cell line	RKO	Homo sapiens	IC50	=	4762.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2155	Cell line	SHP77	Homo sapiens	IC50	=	1914.59	nM	DOI[10.6019/CHEMBL1201861]
NPT2481	Cell line	SW1088	Homo sapiens	IC50	=	6443.97	nM	DOI[10.6019/CHEMBL1201861]
NPT2482	Cell line	SW 1116	Homo sapiens	IC50	=	12884.1	nM	DOI[10.6019/CHEMBL1201861]
NPT2483	Cell line	SW13	Homo sapiens	IC50	=	8043.7	nM	DOI[10.6019/CHEMBL1201861]
NPT2173	Cell line	TE-6	Homo sapiens	IC50	=	11032.73	nM	DOI[10.6019/CHEMBL1201861]
NPT2161	Cell line	no-11	Homo sapiens	IC50	=	11195.57	nM	DOI[10.6019/CHEMBL1201861]
NPT2175	Cell line	GAK	Homo sapiens	IC50	=	8806.09	nM	DOI[10.6019/CHEMBL1201861]
NPT2484	Cell line	GAMG	Homo sapiens	IC50	=	804.97	nM	DOI[10.6019/CHEMBL1201861]
NPT2176	Cell line	HD-MY-Z	Homo sapiens	IC50	=	309.51	nM	DOI[10.6019/CHEMBL1201861]
NPT2485	Cell line	IA-LM	Homo sapiens	IC50	=	13723.04	nM	DOI[10.6019/CHEMBL1201861]
NPT2486	Cell line	IGR-1	Homo sapiens	IC50	=	2738.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2165	Cell line	KNS-42	Homo sapiens	IC50	=	22979.1	nM	DOI[10.6019/CHEMBL1201861]
NPT2487	Cell line	KNS-62	Homo sapiens	IC50	=	5912.16	nM	DOI[10.6019/CHEMBL1201861]
NPT2180	Cell line	LC-2-ad	Homo sapiens	IC50	=	2162.7	nM	DOI[10.6019/CHEMBL1201861]
NPT2488	Cell line	MDA-MB-453	Homo sapiens	IC50	=	5897.94	nM	DOI[10.6019/CHEMBL1201861]
NPT1773	Cell line	ME-180	Homo sapiens	IC50	=	587.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2169	Cell line	MZ7-mel	Homo sapiens	IC50	=	11182.9	nM	DOI[10.6019/CHEMBL1201861]
NPT2489	Cell line	MeWo	Homo sapiens	IC50	=	3735.22	nM	DOI[10.6019/CHEMBL1201861]
NPT2490	Cell line	NCI-H1666	Homo sapiens	IC50	=	448.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2491	Cell line	NCI-H1693	Homo sapiens	IC50	=	6680.28	nM	DOI[10.6019/CHEMBL1201861]
NPT2184	Cell line	NCI-H510A	Homo sapiens	IC50	=	4791.54	nM	DOI[10.6019/CHEMBL1201861]
NPT2492	Cell line	OAW-42	Homo sapiens	IC50	=	8417.44	nM	DOI[10.6019/CHEMBL1201861]
NPT2493	Cell line	OC-314	Homo sapiens	IC50	=	686.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2494	Cell line	RMG-I	Homo sapiens	IC50	=	10692.98	nM	DOI[10.6019/CHEMBL1201861]
NPT2188	Cell line	SJSA-1	Homo sapiens	IC50	=	15658.5	nM	DOI[10.6019/CHEMBL1201861]
NPT2495	Cell line	SW1417	Homo sapiens	IC50	=	1913.34	nM	DOI[10.6019/CHEMBL1201861]
NPT2496	Cell line	SW1463	Homo sapiens	IC50	=	11376.93	nM	DOI[10.6019/CHEMBL1201861]
NPT1577	Cell line	SW1573	Homo sapiens	IC50	=	11519.79	nM	DOI[10.6019/CHEMBL1201861]
NPT2174	Cell line	TE-8	Homo sapiens	IC50	=	8756.99	nM	DOI[10.6019/CHEMBL1201861]
NPT2189	Cell line	TE-9	Homo sapiens	IC50	=	3470.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2190	Cell line	GB-1	Homo sapiens	IC50	=	15399.78	nM	DOI[10.6019/CHEMBL1201861]
NPT2177	Cell line	HDLM-2	Homo sapiens	IC50	=	10.04	nM	DOI[10.6019/CHEMBL1201861]
NPT2497	Cell line	HEC-1	Homo sapiens	IC50	=	8075.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2178	Cell line	KNS-81-FD	Homo sapiens	IC50	=	9632.43	nM	DOI[10.6019/CHEMBL1201861]
NPT2498	Cell line	KOSC-2	Homo sapiens	IC50	=	2342.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2499	Cell line	KP-4	Homo sapiens	IC50	=	3154.03	nM	DOI[10.6019/CHEMBL1201861]
NPT2500	Cell line	LCLC-103H cell line	n.a.	IC50	=	173.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2181	Cell line	MEG-01	Homo sapiens	IC50	=	99.44	nM	DOI[10.6019/CHEMBL1201861]
NPT2501	Cell line	MEL-HO	Homo sapiens	IC50	=	2928.93	nM	DOI[10.6019/CHEMBL1201861]
NPT2503	Cell line	NCI-H1703	Homo sapiens	IC50	=	20308.77	nM	DOI[10.6019/CHEMBL1201861]
NPT2504	Cell line	NCI-H1755	Homo sapiens	IC50	=	287.21	nM	DOI[10.6019/CHEMBL1201861]
NPT2505	Cell line	NCI-H520	n.a.	IC50	=	1389.32	nM	DOI[10.6019/CHEMBL1201861]
NPT2185	Cell line	OCI-AML2	Homo sapiens	IC50	=	265.63	nM	DOI[10.6019/CHEMBL1201861]
NPT2199	Cell line	OCUB-M	Homo sapiens	IC50	=	22246.22	nM	DOI[10.6019/CHEMBL1201861]
NPT2506	Cell line	RO82-W-1	Homo sapiens	IC50	=	7240.89	nM	DOI[10.6019/CHEMBL1201861]
NPT2507	Cell line	RPMI-2650	Homo sapiens	IC50	=	6187.82	nM	DOI[10.6019/CHEMBL1201861]
NPT1086	Cell line	SK-HEP1	Homo sapiens	IC50	=	1053.35	nM	DOI[10.6019/CHEMBL1201861]
NPT2508	Cell line	SW1710	Homo sapiens	IC50	=	5961.88	nM	DOI[10.6019/CHEMBL1201861]
NPT2509	Cell line	SW1783	Homo sapiens	IC50	=	15764.74	nM	DOI[10.6019/CHEMBL1201861]
NPT1354	Cell line	TGBC11TKB	Homo sapiens	IC50	=	18254.62	nM	DOI[10.6019/CHEMBL1201861]
NPT2202	Cell line	TGBC1TKB	Homo sapiens	IC50	=	7617.41	nM	DOI[10.6019/CHEMBL1201861]
NPT2191	Cell line	GCIY	Homo sapiens	IC50	=	12385.3	nM	DOI[10.6019/CHEMBL1201861]
NPT2510	Cell line	GCT	Homo sapiens	IC50	=	16594.23	nM	DOI[10.6019/CHEMBL1201861]
NPT2192	Cell line	HEL	Homo sapiens	IC50	=	11.45	nM	DOI[10.6019/CHEMBL1201861]
NPT2511	Cell line	HGC-27	Homo sapiens	IC50	=	3798.74	nM	DOI[10.6019/CHEMBL1201861]
NPT2205	Cell line	IST-MEL1	Homo sapiens	IC50	=	126.38	nM	DOI[10.6019/CHEMBL1201861]
NPT2206	Cell line	IST-MES1	Homo sapiens	IC50	=	20665.76	nM	DOI[10.6019/CHEMBL1201861]
NPT2207	Cell line	KP-N-YN	Homo sapiens	IC50	=	18849.42	nM	DOI[10.6019/CHEMBL1201861]
NPT2208	Cell line	KP-N-YS	Homo sapiens	IC50	=	3396.1	nM	DOI[10.6019/CHEMBL1201861]
NPT2512	Cell line	LCLC-97TM1	Homo sapiens	IC50	=	422.2	nM	DOI[10.6019/CHEMBL1201861]
NPT2513	Cell line	LK-2	Homo sapiens	IC50	=	317.51	nM	DOI[10.6019/CHEMBL1201861]
NPT2514	Cell line	LN-405	Homo sapiens	IC50	=	3363.25	nM	DOI[10.6019/CHEMBL1201861]
NPT2502	Cell line	MEL-JUSO	Homo sapiens	IC50	=	4744.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2515	Cell line	MFE-280	Homo sapiens	IC50	=	13761.05	nM	DOI[10.6019/CHEMBL1201861]
NPT2210	Cell line	NB10	Homo sapiens	IC50	=	5512.18	nM	DOI[10.6019/CHEMBL1201861]
NPT2197	Cell line	NCI-H1770	Homo sapiens	IC50	=	1.983	nM	DOI[10.6019/CHEMBL1201861]
NPT1669	Cell line	NCI-H1792	Homo sapiens	IC50	=	114.24	nM	DOI[10.6019/CHEMBL1201861]
NPT83	Cell line	MCF7	Homo sapiens	TGI	>	100000.0	nM	PMID[23831811]
NPT139	Cell line	HT-29	Homo sapiens	TGI	>	100000.0	nM	PMID[23831811]
NPT139	Cell line	HT-29	Homo sapiens	GI50	=	40.0	nM	PMID[23831811]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	60.0	nM	PMID[23831811]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	3450.0	nM	PMID[23968824]
NPT407	Cell line	COLO 205	Homo sapiens	IC50	=	3270.0	nM	PMID[23968824]
NPT886	Cell line	NIH3T3	Mus musculus	IC50	=	0.24	ug.mL-1	DOI[10.1007/s00044-013-0773-3]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	0.16	ug.mL-1	DOI[10.1007/s00044-013-0773-3]
NPT492	Cell line	Caco-2	Homo sapiens	IC50	=	0.32	ug.mL-1	DOI[10.1007/s00044-013-0773-3]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	0.23	ug.mL-1	DOI[10.1007/s00044-013-0773-3]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20.0	nM	PMID[24111942]
NPT91	Cell line	KB	Homo sapiens	IC50	=	6.0	nM	PMID[24111942]
NPT168	Cell line	P388	Mus musculus	Activity	=	56.0	mg kg-1	PMID[490545]
NPT168	Cell line	P388	Mus musculus	Activity	=	102.0	mg kg-1	PMID[490545]
NPT91	Cell line	KB	Homo sapiens	ED50	=	0.004	ug ml-1	PMID[448685]
NPT91	Cell line	KB	Homo sapiens	Ratio ED50	=	1.0	n.a.	PMID[448685]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20.0	nM	PMID[25234128]
NPT91	Cell line	KB	Homo sapiens	IC50	=	6.0	nM	PMID[25234128]
NPT91	Cell line	KB	Homo sapiens	IC50	=	10.0	nM	PMID[25668494]
NPT81	Cell line	A549	Homo sapiens	IC50	=	13.0	nM	PMID[25668494]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	990.0	nM	PMID[25668494]
NPT4590	Cell line	EL4	Mus musculus	IC50	=	5100.0	nM	PMID[25951057]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	24.0	nM	PMID[26994844]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	>	100000.0	nM	PMID[27031212]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	800.0	nM	PMID[27031212]
NPT91	Cell line	KB	Homo sapiens	IC50	=	10.0	nM	PMID[27017552]
NPT81	Cell line	A549	Homo sapiens	IC50	=	990.0	nM	PMID[27017552]
NPT376	Cell line	A498	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT81	Cell line	A549	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT71	Cell line	HEK293	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT1083	Cell line	A-375	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	22.0	nM	PMID[27217001]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	22.7	nM	PMID[28152430]
NPT165	Cell line	HeLa	Homo sapiens	IC50	>	100000.0	nM	PMID[28152430]
NPT81	Cell line	A549	Homo sapiens	IC50	=	13.5	nM	PMID[28152430]
NPT2410	Cell line	NCI-H1299	Homo sapiens	IC50	=	72.0	nM	PMID[28152430]
NPT393	Cell line	HCT-116	Homo sapiens	GI50	=	15.0	nM	PMID[28177228]
NPT83	Cell line	MCF7	Homo sapiens	GI50	=	24.0	nM	PMID[28177228]
NPT323	Cell line	SW-620	Homo sapiens	IC50	=	22.0	nM	PMID[28830032]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	97.0	nM	PMID[28830032]
NPT116	Cell line	HL-60	Homo sapiens	GI50	=	38.0	nM	PMID[28711701]
NPT81	Cell line	A549	Homo sapiens	GI50	=	14.0	nM	PMID[28711701]
NPT2410	Cell line	NCI-H1299	Homo sapiens	GI50	=	72.0	nM	PMID[28711701]
NPT165	Cell line	HeLa	Homo sapiens	GI50	>	100000.0	nM	PMID[28711701]
NPT393	Cell line	HCT-116	Homo sapiens	GI50	=	130.0	nM	PMID[28711701]
NPT139	Cell line	HT-29	Homo sapiens	GI50	>	100000.0	nM	PMID[28711701]
NPT81	Cell line	A549	Homo sapiens	Activity	=	62.0	%	PMID[28711701]
NPT81	Cell line	A549	Homo sapiens	Activity	=	38.0	%	PMID[28711701]
NPT81	Cell line	A549	Homo sapiens	Activity	=	0.0	%	PMID[28711701]
NPT91	Cell line	KB	Homo sapiens	IC50	=	6.0	nM	PMID[29425443]
NPT91	Cell line	KB	Homo sapiens	IC50	=	20.0	nM	PMID[29425443]
NPT165	Cell line	HeLa	Homo sapiens	IC50	>	100000.0	nM	PMID[29691154]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	130.0	nM	PMID[29691154]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	25.0	nM	PMID[29691154]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	32.7	nM	PMID[29468872]
NPT81	Cell line	A549	Homo sapiens	IC50	=	39.33	ug.mL-1	PMID[30554970]
NPT139	Cell line	HT-29	Homo sapiens	IC50	=	47.82	ug.mL-1	PMID[30554970]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	31.48	ug.mL-1	PMID[30554970]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	5020.0	nM	PMID[31260892]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	159200.0	nM	PMID[31260892]
NPT113	Cell line	RAW264.7	Mus musculus	Ratio IC50	=	31.9	n.a.	PMID[31260892]
NPT2482	Cell line	SW 1116	Homo sapiens	IC50	=	2490.0	nM	PMID[31260892]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	300.0	nM	PMID[31260892]
NPT91	Cell line	KB	Homo sapiens	IC50	=	10.0	nM	PMID[31200235]
NPT323	Cell line	SW-620	Homo sapiens	IC50	=	13.1	nM	PMID[31200235]
NPT81	Cell line	A549	Homo sapiens	IC50	=	990.0	nM	PMID[31200235]
NPT737	Cell line	HUVEC	Homo sapiens	IC50	=	6130.0	nM	PMID[31200235]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	27090.0	nM	PMID[31404864]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	9.8	nM	PMID[31843461]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	8.9	nM	PMID[31843461]
NPT71	Cell line	HEK293	Homo sapiens	IC50	=	35.0	nM	PMID[31843461]
NPT71	Cell line	HEK293	Homo sapiens	IC50	=	28.6	nM	PMID[31843461]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	59.3	nM	PMID[31843461]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	21.0	nM	PMID[31843461]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	17.0	%	PMID[31843461]
NPT116	Cell line	HL-60	Homo sapiens	Activity	=	14.0	%	PMID[31843461]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	1500.0	nM	PMID[32676149]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	820.0	nM	PMID[32676149]
NPT165	Cell line	HeLa	Homo sapiens	Ratio IC50	=	1.8	n.a.	PMID[32676149]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	50.0	%	PMID[33479665]
NPT83	Cell line	MCF7	Homo sapiens	IC50	>	22000.0	nM	PMID[33479665]
NPT83	Cell line	MCF7	Homo sapiens	TGI	=	55.0	%	PMID[33479665]
NPT83	Cell line	MCF7	Homo sapiens	TGI	=	79.92	%	PMID[33479665]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	15.0	nM	PMID[33479665]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	27940.0	nM	PMID[32503691]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	49220.0	nM	PMID[32503691]
NPT2410	Cell line	NCI-H1299	Homo sapiens	IC50	=	72.0	nM	PMID[32058237]
NPT81	Cell line	A549	Homo sapiens	IC50	=	14.0	nM	PMID[32058237]
NPT116	Cell line	HL-60	Homo sapiens	IC50	=	23.0	nM	PMID[32058237]
NPT165	Cell line	HeLa	Homo sapiens	IC50	>	100000.0	nM	PMID[32058237]
NPT139	Cell line	HT-29	Homo sapiens	IC50	>	100000.0	nM	PMID[32058237]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[38070351]
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	21900.0	nM	PMID[35964425]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	25320.0	nM	PMID[35964425]
NPT784	Cell line	MDA-MB-468	Homo sapiens	IC50	=	200.0	nM	PMID[26985967]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	500.0	nM	PMID[26985967]
NPT457	Cell line	BT-549	Homo sapiens	Inhibition	=	53.1	%	PMID[31877541]
NPT306	Cell line	PC-3	Homo sapiens	IC50	=	28780.0	nM	PMID[35964425]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	1230.0	nM	PMID[38070351]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	334.5	pg/L	PMID[38070351]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	235.3	pg/L	PMID[38070351]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	=	9250.0	nM	PMID[35964425]
NPT165	Cell line	HeLa	Homo sapiens	IC50	=	13690.0	nM	PMID[35964425]
NPT784	Cell line	MDA-MB-468	Homo sapiens	IC50	=	199.53	nM	PMID[26985967]
NPT83	Cell line	MCF7	Homo sapiens	Inhibition	=	82.8	%	PMID[31877541]
NPT396	Cell line	T47D	Homo sapiens	Inhibition	=	53.8	%	PMID[31877541]
NPT82	Cell line	MDA-MB-231	Homo sapiens	Inhibition	=	40.1	%	PMID[31877541]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	15000.0	nM	PMID[26985967]
NPT82	Cell line	MDA-MB-231	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[26985967]
NPT65	Cell line	HepG2	Homo sapiens	IC50 relative	<	100.0	nM	ECBD screening data for assay EOS300108
NPT396	Cell line	T47D	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[26985967]
NPT396	Cell line	T47D	Homo sapiens	IC50	=	15848.93	nM	PMID[26985967]
NPT71	Cell line	HEK293	Homo sapiens	Activity	=	65.0	%	PMID[26985967]
NPT784	Cell line	MDA-MB-468	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[26985967]
NPT82	Cell line	MDA-MB-231	Homo sapiens	IC50	=	501.19	nM	PMID[26985967]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	115.3	pg/L	PMID[38070351]
NPT137	Cell line	L1210	Mus musculus	ID50	=	20.0	nM	PMID[6139480]
NPT3577	Cell line	TA3	Mus musculus	ID50	=	0.008	M	PMID[7069721]
NPT137	Cell line	L1210	Mus musculus	ID50	=	0.01	uM	PMID[6796689]
NPT189	Cell line	Vero	Chlorocebus aethiops	ID50	=	0.02	uM	PMID[1548681]
NPT137	Cell line	L1210	Mus musculus	ID50	=	0.04	uM	PMID[1548681]
NPT80	Cell line	Raji	Homo sapiens	ID50	=	0.02	uM	PMID[1548681]
NPT759	Cell line	H9	Homo sapiens	ID50	=	0.03	uM	PMID[1548681]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.003	uM	PMID[6787199]
NPT137	Cell line	L1210	Mus musculus	ID50	=	0.01	uM	PMID[6787199]
NPT3527	Cell line	RBL-1	Rattus norvegicus	ID50	=	0.003	uM	PMID[6787199]
NPT137	Cell line	L1210	Mus musculus	ID50	=	0.012	uM	PMID[6546949]
NPT1868	Cell line	L1210 (1565)	n.a.	ID50	<	0.1	ug ml-1	PMID[8258836]
NPT319	Cell line	B16	Mus musculus	ID50	<	0.1	ug ml-1	PMID[8258836]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.02	ug ml-1	PMID[109617]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.003	ug ml-1	PMID[406398]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.006	10'-6 mol/L	PMID[565818]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.02	ug ml-1	PMID[109616]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.003	ug ml-1	PMID[271739]
NPT404	Cell line	CCRF-CEM	Homo sapiens	ID50	=	0.018	ug ml-1	PMID[409842]
NPT924	Cell line	HSC-2	Homo sapiens	CC50	>	400000.0	nM	PMID[33744685]
NPT19403	Cell line	SNB-	n.a.	IC50	>	1000.0	nM	PMID[9857098]
NPT19405	Cell line	H35R0.3	Rattus norvegicus	IC50	=	85.0	nM	PMID[1992121]
NPT19405	Cell line	H35R0.3	Rattus norvegicus	IC50	=	18000.0	nM	PMID[1992121]
NPT19407	Cell line	R1-CCRF-CEM	Homo sapiens	EC50	=	985.0	nM	PMID[12570380]
NPT19412	Cell line	R2	Homo sapiens	EC50	=	2600.0	nM	PMID[11960504]
NPT19405	Cell line	H35R0.3	Rattus norvegicus	IC50	=	1800.0	nM	PMID[6737432]
NPT19405	Cell line	H35R0.3	Rattus norvegicus	IC50	=	906.0	nM	PMID[2542557]
NPT17856	Cell line	carcinoma cell line	n.a.	EC50	=	13.8	nM	PMID[11052789]
NPT17856	Cell line	carcinoma cell line	n.a.	EC50	=	14.5	nM	PMID[11052789]
NPT19407	Cell line	R1-CCRF-CEM	Homo sapiens	EC50	=	565.0	nM	PMID[16451071]
NPT19412	Cell line	R2	Homo sapiens	EC50	=	2100.0	nM	PMID[15615522]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	216.0	nM	PMID[18680275]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	44.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	91.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	92.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	0.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	66.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	1.0	%	PMID[20485427]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.07	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.11	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.04	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.09	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	79.43	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	100.0	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	31.62	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	39.81	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	63.0	nM	PMID[19364853]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	40.0	nM	PMID[19528269]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	49.9	nM	PMID[19528269]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	83.6	nM	PMID[19528269]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	84.89	nM	PMID[19528269]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	83.59	nM	PMID[19528269]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	56.63	nM	PMID[19528269]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	216.0	nM	PMID[21879757]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	121.0	nM	PMID[21879757]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	121.0	nM	PMID[24111942]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	120.5	nM	PMID[24256410]
NPT19412	Cell line	R2	Homo sapiens	IC50	>	1000.0	nM	PMID[25234128]
NPT19412	Cell line	R2	Homo sapiens	IC50	=	216.0	nM	PMID[25234128]
NPT19431	Protein family	Thymidylate synthase/GAR transformylase/AICAR transformylase	Homo sapiens	IC50	=	10.0	nM	PMID[28830032]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-4.89	%	DOI[10.21203/rs.3.rs-23951/v1]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	45.35	%	DOI[10.6019/CHEMBL4495565]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	49.83	%	DOI[10.6019/CHEMBL4495565]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	=	50.0	nM	DOI[10.6019/CHEMBL4495565]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	n.a.	n.a.	%	PMID[34390826]
NPT28438	Unchecked	Unchecked	n.a.	Activity	n.a.	n.a.	n.a.	PMID[34390826]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	14.0	nM	PMID[34894691]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	0.038	nM	PMID[35189560]
NPT4276	Organism	Yersinia enterocolitica	Yersinia enterocolitica	MIC	>	35200.0	nM	PMID[36586133]
NPT28438	Unchecked	Unchecked	n.a.	Selectivity Index	=	1.0	n.a.	PMID[33744685]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	2330.0	nM	PMID[38070351]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>=	2200.0	nM	PMID[36586133]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50 relative	=	0.0551	uM	ECBD screening data for assay EOS300033
NPT28438	Unchecked	Unchecked	n.a.	CC50	>	400000.0	nM	PMID[33744685]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	595.0	nM	PMID[12408727]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	1700.0	nM	PMID[12408727]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	EC50	=	16.0	nM	PMID[12408727]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	8.3	nM	PMID[8632413]
NPT19411	Cell line	D54 cell line	Homo sapiens	IC50	=	16.0	nM	PMID[8632413]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	9.0	nM	PMID[8632413]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	13.0	nM	PMID[1992118]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	14.0	nM	PMID[9022805]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	14.0	nM	PMID[3872941]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	32.0	nM	PMID[3872941]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	13.0	nM	PMID[3872941]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	150.0	nM	PMID[3872941]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	250.0	nM	PMID[3872941]
NPT610	Others	Molecular identity unknown	n.a.	IC50	=	71.0	nM	PMID[3872941]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	14.0	nM	PMID[9022804]
NPT19415	Cell line	H35	Rattus norvegicus	IC50	=	10.0	nM	PMID[6737432]
NPT19418	Cell line	SCC-7	Mus musculus	IC50	=	5.8	nM	PMID[8035423]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	100.0	nM	PMID[17127067]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	8.0	nM	PMID[17127067]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	12.0	nM	PMID[18680275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	114.0	nM	PMID[18680275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	461.0	nM	PMID[18680275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	106.0	nM	PMID[18680275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	211.0	nM	PMID[18680275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	25.0	nM	PMID[19243173]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.01	ug.mL-1	PMID[10579858]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	1.0	mm	PMID[20739103]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	8.0	mm	PMID[20739103]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	100.0	nM	PMID[21802949]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	12.0	nM	PMID[21879757]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	114.0	nM	PMID[21879757]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	461.0	nM	PMID[21879757]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	106.0	nM	PMID[21879757]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	211.0	nM	PMID[21879757]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	340.0	nM	PMID[23031590]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	84.0	nM	PMID[23031590]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	534.0	nM	PMID[23031590]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	24.0	nM	PMID[23031590]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	78.66	%	DOI[10.1007/s00044-012-9979-z]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	54.08	%	DOI[10.1007/s00044-012-9979-z]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	64.6	%	DOI[10.1007/s00044-012-9979-z]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2200.0	nM	DOI[10.1007/s00044-012-0260-2]
NPT20	Organism	Candida albicans	Candida albicans	IZ	=	8.0	mm	PMID[23792351]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	IZ	=	8.0	mm	PMID[23792351]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	5250.0	nM	PMID[23968824]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	211.0	nM	PMID[24111942]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	106.0	nM	PMID[24111942]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	461.0	nM	PMID[24111942]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	114.0	nM	PMID[24111942]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	12.0	nM	PMID[24111942]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	1000.0	nM	PMID[24256410]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	400.0	nM	PMID[137981]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1500.0	nM	PMID[137981]
NPT4130	Organism	Lactobacillus rhamnosus	Lactobacillus rhamnosus	GI50	=	0.04	nM	PMID[409842]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	GI50	=	15.0	nM	PMID[26994844]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	13.0	nM	PMID[27017552]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2400.0	nM	PMID[27112448]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	15800.0	nM	PMID[27186821]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	750.0	nM	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	250.0	nM	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	1090.0	nM	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	410.0	nM	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	9490.0	nM	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	24.65	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	32.69	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	29.19	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	44.97	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	50.65	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TGI	=	50.84	%	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	115.14	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	153.09	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	189.83	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	223.6	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	271.71	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	335.97	mm3	PMID[27886545]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	440.75	mm3	PMID[27886545]
NPT88	Organism	Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	=	3380.0	nM	PMID[30827867]
NPT602	Organism	Mycobacterium smegmatis	Mycobacterium smegmatis	MIC	=	2200000.0	nM	PMID[31103404]
NPT334	Organism	Vaccinia virus	Vaccinia virus	EC50	=	6100.0	nM	PMID[36961984]
NPT334	Organism	Vaccinia virus	Vaccinia virus	EC50	=	2200.0	nM	PMID[36961984]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ID50	=	0.003	ug ml-1	PMID[406398]
NPT22224	Cell line	Vero C1008	Chlorocebus sabaeus	CC50	=	50.0	nM	DOI[10.6019/CHEMBL4495565]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.00007	ug.mL-1	PMID[6767031]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	500.0	ug.mL-1	PMID[6767031]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.000017	ug.mL-1	PMID[6403710]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	500.0	ug.mL-1	PMID[6403710]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.03	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.09	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.2	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.8	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	2.2	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	27.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.85	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	3.4	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	560.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	2600.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	1200.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	8000.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	100.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	6.0	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	1.1	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.18	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.28	nM	PMID[2447278]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.000009	ug.mL-1	PMID[3091834]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	500.0	ug.mL-1	PMID[3091834]
NPT19406	Cell line	L1210 ( R81)	Mus musculus	IC50	=	197000.0	nM	PMID[2898531]
NPT19406	Cell line	L1210 ( R81)	Mus musculus	IC50	=	220000.0	nM	PMID[2871191]
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	Activity	=	0.006	n.a.	PMID[8632413]
NPT419	Organism	Oryctolagus cuniculus	Oryctolagus cuniculus	Activity	=	0.05	n.a.	PMID[8632413]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.000012	ug.mL-1	PMID[2423690]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	500.0	ug.mL-1	PMID[2423690]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.000013	ug.mL-1	PMID[3712374]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	13.0	nM	PMID[7108907]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	10000000.0	nM	PMID[7108907]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.00002	nM	PMID[2498518]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.03	nM	PMID[3091832]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	1000000.0	nM	PMID[3091832]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.00002	ug.mL-1	PMID[3100797]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	500.0	ug.mL-1	PMID[3100797]
NPT19406	Cell line	L1210 ( R81)	Mus musculus	IC50	=	200000.0	nM	PMID[3385730]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	Inhibition	=	0.005	%	PMID[6699882]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	Inhibition	>	5.0	%	PMID[6699882]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.05	nM	PMID[3121855]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	>	0.00001	nM	PMID[3121855]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.00001	ug.mL-1	PMID[6793726]
NPT19406	Cell line	L1210 ( R81)	Mus musculus	IC50	=	205000.0	nM	PMID[3968685]
NPT19	Organism	Escherichia coli	Escherichia coli	Ratio	=	8.0	n.a.	PMID[22483632]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	640.0	ug.mL-1	PMID[22483632]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	IZ	=	8.0	mm	PMID[23792351]
NPT19	Organism	Escherichia coli	Escherichia coli	IZ	=	8.0	mm	PMID[23792351]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	IZ	=	8.0	mm	PMID[23792351]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	64.0	ug.mL-1	PMID[24428639]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.00001	ug.mL-1	PMID[109616]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.06	nM	PMID[137981]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	IC50	=	0.01	nM	PMID[137981]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	Ratio IC50	=	0.17	n.a.	PMID[137981]
NPT19	Organism	Escherichia coli	Escherichia coli	IC50	=	143000.0	nM	PMID[137981]
NPT631	Tissue	Brain	Mus musculus	Ratio	=	0.05	n.a.	PMID[23297298]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	40.0	ug.mL-1	PMID[27437079]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	40.0	ug.mL-1	PMID[27437079]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	40.0	ug.mL-1	PMID[27437079]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>=	40.0	ug.mL-1	PMID[27437079]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	64000.0	nM	PMID[27437079]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1000000.0	nM	PMID[27437079]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC50	=	20.0	ug.mL-1	PMID[27437079]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC90	=	100.0	ug.mL-1	PMID[27437079]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	Activity	=	24.25	%	PMID[29407968]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	3600.0	nM	PMID[29407968]
NPT1018	Organism	Trypanosoma brucei	Trypanosoma brucei	EC50	=	3500.0	nM	PMID[29407968]
NPT25088	Protein family	Janus Kinase (JAK)	Homo sapiens	Inhibition	n.a.	n.a.	%	WO-2022122668-A1
NPT3901	Tissue	Chorioallantoic membrane	Gallus gallus	IC50	=	3650.0	nM	PMID[35276362]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	13.4	nM	PMID[29656203]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	27.5	nM	PMID[29656203]
NPT4129	Organism	Lactobacillus casei	Lactobacillus casei	ID50	=	0.01	ug ml-1	PMID[109617]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.00005	ug.mL-1	PMID[6767031]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	3.5	ug.mL-1	PMID[6767031]
NPT2	Others	Unspecified	n.a.	IC50	=	0.0125	ug.mL-1	PMID[9379448]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.00012	ug.mL-1	PMID[6403710]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	2.9	ug.mL-1	PMID[6403710]
NPT2	Others	Unspecified	n.a.	IC50	=	150000.0	nM	PMID[6403710]
NPT2	Others	Unspecified	n.a.	IC50	=	60000.0	nM	PMID[6403710]
NPT2	Others	Unspecified	n.a.	IC50	=	15.0	nM	PMID[9857098]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.0002	ug.mL-1	PMID[3091834]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	3.3	ug.mL-1	PMID[3091834]
NPT2	Others	Unspecified	n.a.	IC50	=	13.0	nM	PMID[2918496]
NPT841	Organism	Leishmania major	Leishmania major	EC50	=	1000.0	nM	PMID[3599028]
NPT2	Others	Unspecified	n.a.	IC50	=	9.0	nM	PMID[6694171]
NPT2	Others	Unspecified	n.a.	Ratio	=	1.0	n.a.	PMID[1992121]
NPT2	Others	Unspecified	n.a.	IC50	=	61.0	nM	PMID[9016334]
NPT27	Others	Unspecified	n.a.	IC50	=	24.0	nM	PMID[9016334]
NPT2	Others	Unspecified	n.a.	IC50	=	13.0	nM	PMID[1992122]
NPT27	Others	Unspecified	n.a.	Ratio	=	0.024	n.a.	PMID[2308134]
NPT2	Others	Unspecified	n.a.	Ratio	=	3.7	n.a.	PMID[12408727]
NPT2	Others	Unspecified	n.a.	Ratio	=	20.0	n.a.	PMID[12408727]
NPT2	Others	Unspecified	n.a.	Ratio	=	1.0	n.a.	PMID[12408727]
NPT27	Others	Unspecified	n.a.	Ratio	=	0.9	n.a.	PMID[1992148]
NPT19408	Cell line	R2-CCRF-CEM	Homo sapiens	EC50	=	2630.0	nM	PMID[12570380]
NPT19409	Cell line	R30dm-CCRF-CEM	Homo sapiens	EC50	=	12.8	nM	PMID[12570380]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.00026	ug.mL-1	PMID[2423690]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	3.0	ug.mL-1	PMID[2423690]
NPT2	Others	Unspecified	n.a.	IC50	=	24.0	nM	PMID[1995880]
NPT2	Others	Unspecified	n.a.	EC50	=	15.0	nM	PMID[11960504]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.0004	ug.mL-1	PMID[3712374]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	90.0	nM	PMID[7108907]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	7200000.0	nM	PMID[7108907]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.9	nM	PMID[2498518]
NPT2	Others	Unspecified	n.a.	Ratio	=	4.3	n.a.	DOI[10.1016/0960-894X(96)00053-4]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.3	nM	PMID[3091832]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	3900.0	nM	PMID[3091832]
NPT2	Others	Unspecified	n.a.	Kd	=	10.0	n.a.	PMID[8627598]
NPT2	Others	Unspecified	n.a.	Ki	=	0.027	n.a.	PMID[8627598]
NPT2	Others	Unspecified	n.a.	Ki	=	4.4	n.a.	PMID[8627598]
NPT2	Others	Unspecified	n.a.	IC50	=	4.5	nM	PMID[8627598]
NPT2	Others	Unspecified	n.a.	IC50	=	20.0	nM	PMID[8627598]
NPT2	Others	Unspecified	n.a.	IC50	=	30.0	nM	PMID[8627598]
NPT2	Others	Unspecified	n.a.	EC50	=	675.0	nM	PMID[10956221]
NPT2	Others	Unspecified	n.a.	EC50	=	1600.0	nM	PMID[10956221]
NPT2	Others	Unspecified	n.a.	EC50	=	14.0	nM	PMID[10956221]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.00012	ug.mL-1	PMID[3100797]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	2.9	ug.mL-1	PMID[3100797]
NPT27	Others	Unspecified	n.a.	IC50	=	9200.0	nM	PMID[10360757]
NPT27	Others	Unspecified	n.a.	IC50	=	14500.0	nM	PMID[8568828]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	Inhibition	=	0.15	%	PMID[6699882]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	Inhibition	=	5000.0	%	PMID[6699882]
NPT2	Others	Unspecified	n.a.	Inhibition	=	190.0	%	PMID[6699882]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.8	nM	PMID[3121855]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	8000.0	nM	PMID[3121855]
NPT2	Others	Unspecified	n.a.	IC50	=	10.0	nM	PMID[2542557]
NPT2	Others	Unspecified	n.a.	Ratio	=	243.0	n.a.	PMID[8035423]
NPT2	Others	Unspecified	n.a.	Ratio	=	2.1	n.a.	PMID[8035423]
NPT19409	Cell line	R30dm-CCRF-CEM	Homo sapiens	EC50	=	18.0	nM	PMID[8164259]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	0.00015	ug.mL-1	PMID[6793726]
NPT2	Others	Unspecified	n.a.	IC50	=	9.0	nM	PMID[3968685]
NPT2	Others	Unspecified	n.a.	IC50	=	18.0	nM	PMID[3968685]
NPT2	Others	Unspecified	n.a.	IC50	=	15.0	nM	PMID[3968685]
NPT2	Others	Unspecified	n.a.	IC50	=	25.0	nM	PMID[3968685]
NPT27	Others	Unspecified	n.a.	IC50	=	0.00502	ug.mL-1	PMID[1847428]
NPT2	Others	Unspecified	n.a.	IC50	=	6.6	nM	PMID[16451071]
NPT19408	Cell line	R2-CCRF-CEM	Homo sapiens	EC50	=	1700.0	nM	PMID[16451071]
NPT2	Others	Unspecified	n.a.	Activity	=	0.32	n.a.	PMID[17269758]
NPT2	Others	Unspecified	n.a.	IC50	=	23000.0	nM	PMID[17269758]
NPT2	Others	Unspecified	n.a.	IC50	=	6.6	nM	PMID[17552508]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	3.33	n.a.	PMID[17552508]
NPT19419	Cell line	SNB-7	Homo sapiens	IC50	>	60.0	ug.mL-1	PMID[17569517]
NPT27	Others	Unspecified	n.a.	IC50	=	180.0	nM	PMID[17383876]
NPT2	Others	Unspecified	n.a.	IC50	=	33.0	nM	PMID[18072727]
NPT2	Others	Unspecified	n.a.	IC50	=	8.8	nM	PMID[18072727]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.6	n.a.	PMID[18072727]
NPT2	Others	Unspecified	n.a.	IC50	=	600.0	nM	PMID[18800768]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	3.3	n.a.	PMID[18605720]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	2.0	n.a.	PMID[18605720]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.6	n.a.	PMID[19719239]
NPT2	Others	Unspecified	n.a.	Ki	=	152.0	nM	PMID[19916554]
NPT2	Others	Unspecified	n.a.	Ratio	=	10.0	n.a.	PMID[19916554]
NPT2	Others	Unspecified	n.a.	Ratio	=	1000.0	n.a.	PMID[19916554]
NPT2	Others	Unspecified	n.a.	IC50	=	90000.0	nM	PMID[20056546]
NPT2	Others	Unspecified	n.a.	IC50	=	19.0	nM	PMID[20092323]
NPT2	Others	Unspecified	n.a.	IC50	=	68.6	nM	PMID[18794380]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	3.0	n.a.	PMID[21550809]
NPT27	Others	Unspecified	n.a.	IC50	>	1000.0	nM	PMID[21879757]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	4.0	n.a.	PMID[23031590]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	22.0	n.a.	PMID[23031590]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	3.0	n.a.	PMID[22946585]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	0.0	n.a.	PMID[22946585]
NPT27	Others	Unspecified	n.a.	Activity	=	53.85	%	DOI[10.1007/s00044-012-9979-z]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.9	n.a.	PMID[23627352]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	11.0	n.a.	PMID[23627352]
NPT2	Others	Unspecified	n.a.	IC50	=	0.22	nM	PMID[23627352]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.34	n.a.	PMID[23627352]
NPT2	Others	Unspecified	n.a.	IC50	=	5.1	nM	PMID[23627352]
NPT27	Others	Unspecified	n.a.	IC50	>	1000.0	nM	PMID[24111942]
NPT27	Others	Unspecified	n.a.	IC50	=	216.0	nM	PMID[24111942]
NPT2	Others	Unspecified	n.a.	IC50	=	26.0	nM	PMID[448685]
NPT2	Others	Unspecified	n.a.	Ratio	=	1.0	n.a.	PMID[448685]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	Ratio IC50	=	5.0	n.a.	PMID[137981]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	4.0	n.a.	PMID[137981]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	2.0	nM	PMID[137981]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	IC50	=	10.0	nM	PMID[137981]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	3660.0	nM	PMID[25007262]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	IC50	=	11.0	nM	PMID[25007262]
NPT27	Others	Unspecified	n.a.	Ratio	=	0.9	n.a.	PMID[21051535]
NPT27	Others	Unspecified	n.a.	Ratio	=	14.0	n.a.	PMID[21051535]
NPT27	Others	Unspecified	n.a.	Ratio	=	-11.0	n.a.	PMID[21051535]
NPT27	Others	Unspecified	n.a.	Ratio	=	30.0	n.a.	PMID[21051535]
NPT27	Others	Unspecified	n.a.	Ratio	=	0.8	n.a.	PMID[21051535]
NPT790	Organism	Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis H37Rv	MIC	=	968.0	nM	PMID[26617968]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.194	n.a.	PMID[26617968]
NPT2	Others	Unspecified	n.a.	IC50	>	100000.0	nM	PMID[26994844]
NPT27	Others	Unspecified	n.a.	Ratio IC50	=	1.0	n.a.	PMID[27217001]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.066	n.a.	PMID[27994750]
NPT2	Others	Unspecified	n.a.	IC50	=	6.6	nM	PMID[28258797]
NPT2	Others	Unspecified	n.a.	Activity	=	88.0	%	PMID[29072452]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.2	n.a.	PMID[29274493]
NPT2	Others	Unspecified	n.a.	IC50	=	114.0	nM	PMID[29425443]
NPT2	Others	Unspecified	n.a.	IC50	>	1000.0	nM	PMID[29425443]
NPT2	Others	Unspecified	n.a.	EC50	=	280.0	nM	PMID[31549836]
NPT2	Others	Unspecified	n.a.	IC50	=	149880.0	nM	PMID[31404864]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.061	n.a.	PMID[30624926]
NPT2	Others	Unspecified	n.a.	IC50	=	114.0	nM	PMID[27458733]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.194	n.a.	PMID[30827867]
NPT2	Others	Unspecified	n.a.	Ki	=	0.35	nM	PMID[31103404]
NPT2	Others	Unspecified	n.a.	Ratio	=	11714.0	n.a.	PMID[31103404]
NPT2	Others	Unspecified	n.a.	IC50	=	216.0	nM	PMID[32503687]
NPT2	Others	Unspecified	n.a.	IC50	=	12.0	nM	PMID[32503687]
NPT2	Others	Unspecified	n.a.	IC50	=	114.0	nM	PMID[32503687]
NPT2	Others	Unspecified	n.a.	IC50	=	106.0	nM	PMID[32503687]
NPT2	Others	Unspecified	n.a.	IC50	=	121.0	nM	PMID[32503687]
NPT2	Others	Unspecified	n.a.	IC50	=	2900.0	nM	PMID[32676149]
NPT2	Others	Unspecified	n.a.	IC50	=	1800.0	nM	PMID[32676149]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.6	n.a.	PMID[32676149]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.9	n.a.	PMID[32676149]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	2.2	n.a.	PMID[32676149]
NPT471	Organism	Trypanosoma brucei brucei	Trypanosoma brucei brucei	GI	=	19.0	%	PMID[31982652]
NPT2	Others	Unspecified	n.a.	Ki	=	5190.0	nM	PMID[33773393]
NPT2	Others	Unspecified	n.a.	IC50	=	5480.0	nM	PMID[33347967]
NPT2	Others	Unspecified	n.a.	Ki	=	500000.0	nM	PMID[33214838]
NPT2	Others	Unspecified	n.a.	Ki	=	10.0	nM	PMID[33214838]
NPT2	Others	Unspecified	n.a.	ID50	=	0.03	uM	PMID[1548681]
NPT2	Others	Unspecified	n.a.	CC50	>	10000.0	nM	PMID[31549836]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT137	Cell line	L1210	Mus musculus	Survival	=	17.2	day	PMID[2898531]
NPT5516	Cell line	EBV-positive nasopharyngealcell lines	n.a.	Survival	<	0.01	n.a.	PMID[6685770]
NPT5516	Cell line	EBV-positive nasopharyngealcell lines	n.a.	Survival	=	0.4	n.a.	PMID[6685770]
NPT137	Cell line	L1210	Mus musculus	Survival	=	68.0	%	PMID[915899]
NPT137	Cell line	L1210	Mus musculus	Survival	=	61.0	%	PMID[915899]
NPT137	Cell line	L1210	Mus musculus	Survival	=	48.0	%	PMID[915899]
NPT137	Cell line	L1210	Mus musculus	Survival	=	81.0	%	PMID[915899]
NPT82	Cell line	MDA-MB-231	Homo sapiens	Survival	>	60.0	%	PMID[33479665]
NPT82	Cell line	MDA-MB-231	Homo sapiens	Survival	=	35.0	%	PMID[33479665]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	31.0	nM	PMID[8201595]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	3.28	nM	PMID[4020824]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	78.0	%	PMID[6546949]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	100.0	%	PMID[6546949]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	133.0	%	PMID[6546949]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	4200.0	nM	PMID[8340923]
NPT32	Organism	Mus musculus	Mus musculus	Kd	=	220.0	n.a.	PMID[8627598]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	0.004	n.a.	PMID[8627598]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	0.13	n.a.	PMID[8627598]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	16.8	n.a.	PMID[16539384]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.17	mm	PMID[19010675]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.46	mm	PMID[19010675]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	15.0	mg kg-1	PMID[409842]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	49.0	%	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	38.0	%	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	2.1	n.a.	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	2.0	n.a.	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	2.8	n.a.	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	66.0	%	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	76.0	%	PMID[25863493]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	25.28	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	25.47	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	24.88	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	23.98	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	21.85	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	21.62	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	21.4	g	PMID[27886545]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	60.0	%	PMID[31368705]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	83.0	%	PMID[27476421]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	63.0	%	PMID[27476421]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	53.1	%	PMID[37167779]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37883692]
NPT605	Organism	Homo sapiens	Homo sapiens	Kd	=	0.0048	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	Kd	=	0.443	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	Kd	=	10.0	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	Ki	=	0.0034	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	Ki	=	0.289	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	Ki	=	3.5	n.a.	PMID[8627598]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	32.0	nM	PMID[3462394]
NPT605	Organism	Homo sapiens	Homo sapiens	IC50	=	6600.0	nM	PMID[3462394]
NPT605	Organism	Homo sapiens	Homo sapiens	EC50	=	17.2	nM	PMID[9554874]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	0.7	%	PMID[20022146]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.058	mg.kg-1	PMID[9379448]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	20.0	%	PMID[19010675]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	181.7	g	PMID[25516790]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.2795	inches	PMID[25516790]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	n.a.	n.a.	n.a.	PMID[33992926]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Mus musculus	n.a.	Cmax	=	200.0	nM	PMID[34843241]
Mus musculus	n.a.	Tmax	=	1.0	hr	PMID[34843241]
Mus musculus	n.a.	Cmax	=	100.0	nM	PMID[34843241]
Mus musculus	n.a.	AUC	=	272.67	ng.hr.mL-1	PMID[34843241]
Mus musculus	n.a.	AUC	=	181.78	ng.hr.mL-1	PMID[34843241]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC331654 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	30773
0.1-0.2	19044
0.2-0.3	33
0.3-0.4	0
0.4-0.5	8
0.5-0.6	0
0.6-0.7	0
0.7-0.8	1
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
		NPC

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC331654 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	3202
0.1-0.2	5866
0.2-0.3	47
0.3-0.4	15
0.4-0.5	14
0.5-0.6	1
0.6-0.7	3
0.7-0.8	1
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	1

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD3968	Phase 4
0.7738	Intermediate Similarity	NPD3967	Approved
0.6484	Remote Similarity	NPD3410	Approved
0.6484	Remote Similarity	NPD3411	Phase 2
0.6484	Remote Similarity	NPD5510	Phase 4
0.5283	Remote Similarity	NPD5046	Discontinued

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data