NPASS Compound

Natural Product: NPC142319

Natural Product ID	NPC142319
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Arbutin
IUPAC Name	(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
Synonyms	Arbutin
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL232202
PubChem CID	440936
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0004603] Organic oxygen compounds [CHEMONTID:0000323] Organooxygen compounds [CHEMONTID:0000011] Carbohydrates and carbohydrate conjugates [CHEMONTID:0002105] Glycosyl compounds [CHEMONTID:0004165] Phenolic glycosides

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 35 36 0 0 0 0 0 0 0 0999 V2000 -1.5726 -2.8567 0.3589 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.0308 -1.8347 -0.4442 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4326 -0.6715 0.4511 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.3908 -0.1962 1.2072 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.4325 0.5152 0.5073 C 0 0 1 0 0 0 0 0 0 0 0 0 0.4181 -0.2749 -0.2442 O 0 0 0 0 0 0 0 0 0 0 0 0 1.7550 -0.4680 -0.1891 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5638 0.1613 0.7239 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9187 -0.0795 0.7267 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4896 -0.9582 -0.1884 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6671 -1.5929 -1.1107 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3071 -1.3636 -1.1281 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8592 -1.1920 -0.1744 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.0419 1.5990 -0.3637 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.5076 1.7145 0.0081 C 0 0 2 0 0 0 0 0 0 0 0 0 -3.1206 0.3664 -0.3832 C 0 0 2 0 0 0 0 0 0 0 0 0 -4.4834 0.4664 -0.0900 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.0918 2.7545 -0.6768 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.4676 2.8396 -0.1486 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.8176 -2.5205 0.8917 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.9859 -2.1813 -0.9338 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.3234 -1.5108 -1.2185 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.1928 -1.0775 1.1528 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1642 1.0551 1.2702 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1474 0.8425 1.4388 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5574 0.4149 1.4446 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1550 -2.2702 -1.8059 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6927 -1.8720 -1.8573 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4268 -0.7462 0.5119 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.0051 1.3037 -1.4330 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5595 1.8178 1.1133 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.9372 0.2237 -1.4671 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.8019 1.3178 -0.4810 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3747 3.4007 -0.9650 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4487 2.8735 -0.5032 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 1 0 6 7 1 0 7 8 2 0 8 9 1 0 9 10 2 0 10 11 1 0 11 12 2 0 10 13 1 0 5 14 1 0 14 15 1 0 15 16 1 0 16 17 1 0 15 18 1 0 14 19 1 0 16 3 1 0 12 7 1 0 1 20 1 0 2 21 1 0 2 22 1 0 3 23 1 1 5 24 1 1 8 25 1 0 9 26 1 0 11 27 1 0 12 28 1 0 13 29 1 0 14 30 1 6 15 31 1 1 16 32 1 6 17 33 1 0 18 34 1 0 19 35 1 0 M END

Standard InCHIKey	BJRNKVDFDLYUGJ-RMPHRYRLSA-N
Standard InCHI	InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
SMILES	OC[C@H]1O[C@@H](Oc2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O

Calculated Properties

Physi-Chem Properties

Molecular Weight:	272.09	Volume:	252.618 ? Van der Waals volume.
Dense:	1.077	LogP:	-0.996 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	-0.438 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-1.025 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	3.0	Rigid Bonds:	12.0
TPSA:	119.61 ? Topological Polar Surface Area.	H-Bond Acceptor:	7.0
H-Bond Donor:	5.0	Rings:	2.0
Heavy Atoms:	7.0

MedChem Properties

QED Drug-Likeness Score:	0.457	GASA:	0.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.331	Fsp³:	0.5
MCE-18:	46.222 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Rejected
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.474	Fluc inhibitor:	0.005 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.077 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.006 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.431	Promiscuous compounds:	0.33

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-6.446	MDCK Permeability:	-5.021
Pgp-inhibitor:	0.0	Pgp-substrate:	0.136
PAMPA:	0.994 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.69
20% Bioavailability (F20%):	0.548	30% Bioavailability (F30%):	0.928
50% Bioavailability (F50%):	0.885

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.411	MRP1:	0.121
Plasma Protein Binding (PPB):	54.223%	Volume Distribution (VD):	-0.332
Fu:	43.904% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.995
OATP1B3 inhibitor:	0.993	BCRP inhibitor:	0.023
BSEP inhibitor:	0.026

ADMET: Metabolism

CYP1A2-inhibitor:	0.0	CYP1A2-substrate:	0.001
CYP2C19-inhibitor:	0.0	CYP2C19-substrate:	0.001
CYP2C9-inhibitor:	0.002	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.066	CYP2D6-substrate:	0.019
CYP3A4-inhibitor:	0.183	CYP3A4-substrate:	0.557
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	0.446
HLM stability:	0.181 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

2.628

Half-life (T1/2):

2.361

ADMET: Toxicity

hERG Blockers:	0.028	hERG Blockers (10um):	0.292
Human Hepatotoxicity (H-HT):	0.459	Drug-induced Liver Injury (DILI):	0.425
AMES Toxicity:	0.731	Rat Oral Acute Toxicity:	0.049
Maximum Recommended Daily Dose:	0.02	Skin Sensitization:	0.972
Carcinogencity:	0.142	Eye Corrosion:	0.004
Eye Irritation:	0.867	Respiratory Toxicity:	0.027
Drug-induced Neurotoxicity:	0.045	Ototoxicity:	0.7
Hematotoxicity:	0.106	Drug-induced Nephrotoxicity:	0.618
Genotoxicity:	0.078	RPMI-8226 Immunitoxicity:	0.094
A549 Cytotoxicity:	0.185	Hek293 Cytotoxicity:	0.14
BCF:	0.358 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	2.226 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	3.713 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	3.102 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1002/hlca.19270100148]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	whole plant	n.a.	DOI[10.1007/BF02329610]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[10.1016/0006-291X(79)91731-5]
NPO12418	Myroxylon peruiferum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/0031-9422(79)80020-5]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[10.1093/emboj/18.8.2021]
NPO12418	Myroxylon peruiferum	Species	Fabaceae	Eukaryota	n.a.	Brazilian	n.a.	PMID[10328294]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1091286]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[10977898]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1100617]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11032480]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11745165]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[11750815]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	bud covers	n.a.	n.a.	PMID[11975520]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12369847]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12467448]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	fruits	n.a.	n.a.	PMID[12467621]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	n.a.	root	n.a.	PMID[12662107]
NPO5415	Nanodea muscosa	Species	Nanodeaceae	Eukaryota	aerial parts	n.a.	n.a.	PMID[12762819]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[12805358]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	ChEBI[131529]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[13610867]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[13831814]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[14973046]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15031653]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	Petals	n.a.	n.a.	PMID[15043425]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15270561]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15292242]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15568764]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[15610037]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15678383]
NPO9553	Phyllodium pulchellum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15921433]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	pericarp	n.a.	n.a.	PMID[16038565]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16045947]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	root	n.a.	PMID[16212233]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[1644759]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	root	n.a.	PMID[16564530]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[16630633]
NPO5870	Xenia florida	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[16643051]
NPO2430	Detarium microcarpum	Species	Fabaceae	Eukaryota	fruits	n.a.	n.a.	PMID[16724838]
NPO12386	Russula japonica	Species	Russulaceae	Eukaryota	fruiting body	n.a.	n.a.	PMID[16989517]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[170247]
NPO12653	Diacarnus levii	Species	Podospongiidae	Eukaryota	n.a.	at a depth of -10 M off the coast of Papua New Guinea	1998-JUN	PMID[17253866]
NPO8764	Laurencia decumbens	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17711344]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[17765195]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[179975]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18166016]
NPO8653	Leuconostoc mesenteroides	Species	Leuconostocaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19025748]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19026742]
NPO11451	Lespedeza cyrtobotrya	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19102656]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19245240]
NPO397	Thymelaea hirsuta	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19284745]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19514719]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19561621]
NPO27763	Streptomyces actuosus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19678698]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19919095]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	stem	n.a.	PMID[20188156]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20232858]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20335035]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21437340]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21988831]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22289691]
NPO3123	Anthemis cretica	Species	Asteraceae	Eukaryota	n.a.	aerial part	n.a.	PMID[22351977]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[22855027]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	flower buds and leaves	Khon Kaen province, Thailand	2010	PMID[23270663]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	root bark	n.a.	n.a.	PMID[23282106]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[23537328]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[23642481]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[23676670]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[241475]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24206068]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24338885]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24783849]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24831709]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24939187]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24966042]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[24967680]
NPO27763	Streptomyces actuosus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25196319]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[2543976]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25559759]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[25867074]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26195826]
NPO33494	atriplex littoralis	Species	Chenopodiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26290401]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26337258]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	Flowers	n.a.	n.a.	PMID[26462418]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26670289]
NPO40378	Thalassotalea sp. PP2-459	Strain	Colwelliaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26824128]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[26826371]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	Root Bark	n.a.	n.a.	PMID[26982999]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29144743]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29359942]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[29897754]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[30302998]
NPO284	Albizia procera	Species	Fabaceae	Eukaryota	Bark	n.a.	n.a.	PMID[30520635]
NPO11695	Petasites hybridus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30600899]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31244143]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31397570]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[318639]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[31944695]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[3283102]
NPO21527	Vaccinium dunalianum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36587513]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37111302]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446592]
NPO20045	Burkholderia cepacia	Species	Burkholderiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[3839140]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38961030]
NPO53552	Verbascum gimgimense	Genus	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39632482]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[398096]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4877125]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4879561]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[4908789]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[5332408]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6102982]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6284709]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[6338507]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6821187]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[7042909]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	Malaysian	n.a.	PMID[7506311]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[7601837]
NPO20045	Burkholderia cepacia	Species	Burkholderiaceae	Bacteria	n.a.	n.a.	n.a.	PMID[7684040]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots; Tubers	n.a.	n.a.	PMID[7714535]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[8021657]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[8852895]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	fruits	n.a.	n.a.	PMID[9090870]
NPO17118	Toronia toru	Species	Proteaceae	Eukaryota	n.a.	New Zealand	n.a.	PMID[9214736]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	PMID[9470222]
NPO5870	Xenia florida	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[9868153]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	xylem	n.a.	Database[Article]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3959	Centroceras clavulatum	Species	Ceramiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9361	Aplophyllum villosum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12591	Archaster typicus	Species	Archasteridae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13555	Beaucarnea recurvata	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4746	Centaurea arenaria	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12819	Clitocybe subilludens	Species	Tricholomataceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9989	Cotylelobium scabriusculum	Species	Dipterocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1326	Cratystylis conocephala	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13042	Diospyros abyssinica	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12367	Diospyros elliptifolia	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12233	Diospyros peregrina	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6386	Gutenbergia cordifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9783	Mikania scandens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8601	Petrosia volcano	Species	Petrosiidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO22899	Phaeotremella fagi	Species	Phaeotremellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9553	Phyllodium pulchellum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11333	Trapa japonica	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7870	Zanthoxylum piperitum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO20045	Burkholderia cepacia	Species	Burkholderiaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12044	Dorstenia barteri	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11451	Lespedeza cyrtobotrya	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10637	Byssochlamys fulva	Species	Thermoascaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14075	Streptomyces viridogenes	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16267	Laurencia johnstonii	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9020	Eriostemon fitzgeraldii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19826	Helicoverpa armigera	Species	Noctuidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12606	Achillea spinulifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5668	Allium waldsteinii	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1965	Alnus incana	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11874	Ambrosia hispida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7387	Aster batangensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12491	Astragalus onobrychis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1545	Baeckea crenulata	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6008	Cacalia pilgeriana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12036	Fritillaria raddeana	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3661	Goniothalamus tamirensis	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8742	Hamamelistes betulae	Species	Hormaphididae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7743	Helicoverpa zea	Species	Noctuidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9256	Lecanora nipponica	Species	Lecanoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14802.1	Lonicera tatarica var. morrowii	Varieties	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12264	Mutisia orbignyana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10034	Penstemon mucronatus	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11695	Petasites hybridus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12388	Saccharopolyspora hirsuta	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6402	Sideritis kuegleriana	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10302	Sphagnum rubellum	Species	Sphagnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2544	Stemona saxorum	Species	Stemonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26103	Streptomyces bobili	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7705	Navanax inermis	Species	Aglajidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28741	Afrocarpus gracilior	Species	Podocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2495	Agave xylonacantha	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3123	Anthemis cretica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6766	Antiphiona pinnatisecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9567	Enicosanthum cupulare	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8764	Laurencia decumbens	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8653	Leuconostoc mesenteroides	Species	Leuconostocaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10991	Maackia tashiroi	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9136	Pseudocyclosorus subochthodes	Species	Thelypteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2012	Turnera diffusa	Species	Passifloraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5380	Eucalyptus australiana	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10594	Centaurea solstitialis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO397	Thymelaea hirsuta	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27817	Stephania hernandifolia	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1189	Aspergillus giganteus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5311	Isertia haenkeana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12653	Diacarnus levii	Species	Podospongiidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11674	Viburnum lantanoides	Species	Adoxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7648	Geigeria plumosa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14274	Rhododendron mucronatum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7731	Lactuca serriola	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7323	Lindera pipericarpa	Species	Tineidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10601	Lotus angustissimus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2289	Vicia hirsuta	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12726	Piptostigma fugax	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12418	Myroxylon peruiferum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5870	Xenia florida	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12526	Veronica turrilliana	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27763	Streptomyces actuosus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12762	Elattostachys apetala	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12386	Russula japonica	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO284	Albizia procera	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14379	Onobrychis viciifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2430	Detarium microcarpum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10444	Dendrophthoe falcata	Species	Loranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2384	Ircinia ramosa	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40378	Thalassotalea sp. PP2-459	Strain	Colwelliaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO22543	Cleome chrysantha	Species	Cleomaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO33494	atriplex littoralis	Species	Chenopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5415	Nanodea muscosa	Species	Nanodeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10892	Xanthorrhoea resinosa	Species	Asphodelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	Rhizome	n.a.	n.a.	Database[FooDB]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	Silk Stigma Style	n.a.	n.a.	Database[FooDB]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14379	Onobrychis viciifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO27817	Stephania hernandifolia	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11451	Lespedeza cyrtobotrya	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5131	Scorzonera hispanica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7731	Lactuca serriola	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14274	Rhododendron mucronatum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9783	Mikania scandens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO2469	Erythrophleum couminga	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11874	Ambrosia hispida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO2289	Vicia hirsuta	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3671	Rhodiola coccinea	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4572	Gossypium indicum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	DOI[https://doi.org/10.1016/j.jbiosc.2016.12.008]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14379	Onobrychis viciifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2469	Erythrophleum couminga	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14274	Rhododendron mucronatum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9783	Mikania scandens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14802.1	Lonicera tatarica var. morrowii	Varieties	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3671	Rhodiola coccinea	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7731	Lactuca serriola	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4572	Gossypium indicum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11451	Lespedeza cyrtobotrya	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO27817	Stephania hernandifolia	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28741	Afrocarpus gracilior	Species	Podocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3123	Anthemis cretica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO6671	Ulva conglobata	Species	Ulvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5131	Scorzonera hispanica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2289	Vicia hirsuta	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11874	Ambrosia hispida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO27817	Stephania hernandifolia	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14274	Rhododendron mucronatum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9783	Mikania scandens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO2469	Erythrophleum couminga	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO2012	Turnera diffusa	Species	Passifloraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2046	Cathormion altissimum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4746	Centaurea arenaria	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9553	Phyllodium pulchellum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2469	Erythrophleum couminga	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO730	Escherichia coli	Species	Enterobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO7925	Asparagus officinalis	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12418	Myroxylon peruiferum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7608	Phelline lucida	Species	Phellinaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8343	Centaurea corcubionensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO284	Albizia procera	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7731	Lactuca serriola	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11451	Lespedeza cyrtobotrya	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10034	Penstemon mucronatus	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13192	Chara ceratophylla	Species	Characeae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5311	Isertia haenkeana	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9361	Aplophyllum villosum	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO16013	Inga velutina	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12047	Solanum unguiculatum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24671	Lycopodium japonicum	Species	Lycopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12726	Piptostigma fugax	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1326	Cratystylis conocephala	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6008	Cacalia pilgeriana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15293	Lepidophorum grisleyi	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12035	Rhododendron ungerni	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9020	Eriostemon fitzgeraldii	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14274	Rhododendron mucronatum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6402	Sideritis kuegleriana	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20585	Urochloa decumbens	Species	Poaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16306	Curcuma caesia	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2544	Stemona saxorum	Species	Stemonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13683	Cosmos diversifolius	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12264	Mutisia orbignyana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3123	Anthemis cretica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO366	Pyrus communis	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19826	Helicoverpa armigera	Species	Noctuidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22899	Phaeotremella fagi	Species	Phaeotremellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3661	Goniothalamus tamirensis	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9342	Solenopsis punctaticeps	Species	Campanulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO206	Ormosia nobilis	Species	Limoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12606	Achillea spinulifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6938	Astragalus dissectus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4923	Ononis hircina	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26103	Streptomyces bobili	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO12386	Russula japonica	Species	Russulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9783	Mikania scandens	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2289	Vicia hirsuta	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11046	Ocimum pilosum	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7743	Helicoverpa zea	Species	Noctuidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1189	Aspergillus giganteus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10444	Dendrophthoe falcata	Species	Loranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5870	Xenia florida	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO6671	Ulva conglobata	Species	Ulvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10102	Pithecellobium albicans	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5131	Scorzonera hispanica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6766	Antiphiona pinnatisecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9567	Enicosanthum cupulare	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12367	Diospyros elliptifolia	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13555	Beaucarnea recurvata	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7870	Zanthoxylum piperitum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8653	Leuconostoc mesenteroides	Species	Leuconostocaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO9256	Lecanora nipponica	Species	Lecanoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10601	Lotus angustissimus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10892	Xanthorrhoea resinosa	Species	Asphodelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12819	Clitocybe subilludens	Species	Tricholomataceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1549	Amaroria soulameoides	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25145	Cydonia oblonga	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12491	Astragalus onobrychis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10594	Centaurea solstitialis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7648	Geigeria plumosa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5380	Eucalyptus australiana	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9989	Cotylelobium scabriusculum	Species	Dipterocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20045	Burkholderia cepacia	Species	Burkholderiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO2804	Calophyllum inophyllum	Species	Calophyllaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12653	Diacarnus levii	Species	Podospongiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12591	Archaster typicus	Species	Archasteridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6386	Gutenbergia cordifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12044	Dorstenia barteri	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8601	Petrosia volcano	Species	Petrosiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12207	Lagochilus leiacanthus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14075	Streptomyces viridogenes	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO8186	Ocotea minarum	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10302	Sphagnum rubellum	Species	Sphagnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14379	Onobrychis viciifolia	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8896	Anacardium occidentale	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10928	Xenia obscuronata	Species	Xeniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10991	Maackia tashiroi	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3059	Erythrina pallida	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9561	Preussia australis	Species	Sporormiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7613	Salvia bicolor	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO397	Thymelaea hirsuta	Species	Thymelaeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13042	Diospyros abyssinica	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12036	Fritillaria raddeana	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6843	Linaria maroccana	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2384	Ircinia ramosa	Species	Irciniidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11695	Petasites hybridus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13096	Lecidea kochiana	Species	Lecideaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10553	Heterophyllaea pustulata	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8764	Laurencia decumbens	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO875	Cryptocarya oblata	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12557	Strychnos tricalysioides	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9136	Pseudocyclosorus subochthodes	Species	Thelypteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5415	Nanodea muscosa	Species	Nanodeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9254	Scutellaria racemosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1965	Alnus incana	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5668	Allium waldsteinii	Species	Amaryllidaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO396	Ventilago goughii	Species	Rhamnaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21977	Psora corallina	Species	Psoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1398	Trichodesma incanum	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14158	Selaginella tamariscina	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14963	Umbraculum mediterraneum	Species	Umbraculidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO20026	Senecio callosus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12233	Diospyros peregrina	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7387	Aster batangensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11874	Ambrosia hispida	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26737	Solanum mauritianum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22543	Cleome chrysantha	Species	Cleomaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6749.1	Bergenia crassifolia var. cordifolia	Varieties	Saxifragaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7006	Garcinia subelliptica	Species	Clusiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17823	Lycium chinense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14802.1	Lonicera tatarica var. morrowii	Varieties	Caprifoliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23429	Lycium barbarum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11333	Trapa japonica	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1545	Baeckea crenulata	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21072	Rhododendron dauricum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10637	Byssochlamys fulva	Species	Thermoascaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18293	Pythium ultimum	Species	Pythiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8742	Hamamelistes betulae	Species	Hormaphididae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27116	Caccinia glauca	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15245	Paenibacillus macerans	Species	Paenibacillaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO3671	Rhodiola coccinea	Species	Crassulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16267	Laurencia johnstonii	Species	Rhodomelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18153	Crambe kotschyana	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8171	Artocarpus altilis	Species	Moraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12388	Saccharopolyspora hirsuta	Species	Pseudonocardiaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO21527	Vaccinium dunalianum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28741	Afrocarpus gracilior	Species	Podocarpaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11431	Jacobaea aquatica	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7705	Navanax inermis	Species	Aglajidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12762	Elattostachys apetala	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18431	Salvia rhyacophila	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5173	Antidesma pentandrum	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2495	Agave xylonacantha	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3959	Centroceras clavulatum	Species	Ceramiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10257	Rhododendron groenlandicum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3478	Nelumbo nucifera	Species	Nelumbonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4572	Gossypium indicum	Species	Malvaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8065	Solanum meridense	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1455	Aspergillus caelatus	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16919	Litsea lii	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11397	Cladophora rupestris	Species	Cladophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27763	Streptomyces actuosus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO10919	Salvia cyanescens	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12526	Veronica turrilliana	Species	Plantaginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9404	Lejeunea pallescens	Species	Lejeuneaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7323	Lindera pipericarpa	Species	Tineidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16628	Echinocereus triglochidiatus	Species	Cactaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2430	Detarium microcarpum	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11674	Viburnum lantanoides	Species	Adoxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2576	Eusideroxylon zwageri	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO853	Passiflora murucuja	Species	Passifloraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17118	Toronia toru	Species	Proteaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14776	Petrosia weinbergi	Species	Petrosiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3749	Streptomyces alboverticillatus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO3262	Quercus glauca	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28400	Selaginella pulvinata	Species	Selaginellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27476	Salvia paramiltiorrhiza	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9445	Crocus sativus	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27817	Stephania hernandifolia	Species	Menispermaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference
NPO21527	Vaccinium dunalianum	Dried	n.a.	160.37 Â± 2.54	n.a.	n.a.	Î¼g/g	PMID[36587513]
NPO25145	Cydonia oblonga	n.a.	Fruits	2.689	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO366	Pyrus communis	n.a.	Fruits	0.04667	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO366	Pyrus communis	n.a.	Fruits	1.398	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO53552	Verbascum gimgimense	n.a.	n.a.	0.046	n.a.	n.a.	mg/g	PMID[39632482]

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Potency	8
IC50	61
Inhibition	74
ID50	1
Ratio IC50	2
Activity	38
IZ	4
AC50	2
MIC	1
Ratio	2

Activity Type	# Activity
Individual protein	61
Cell line	53
Single protein	2
Organism	14
Others	50
Unchecked	1
Non-molecular	12

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT153	Individual protein	Androgen Receptor	Homo sapiens	Potency	n.a.	33491.5	nM	PubChem BioAssay data set
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	Inhibition	<	30.0	%	PMID[12444669]
NPT2739	Individual protein	Tyrosinase	Mus musculus	IC50	=	30260.0	nM	PMID[20022495]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	33.1	%	PMID[20973550]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	30.9	%	PMID[20973550]
NPT2739	Individual protein	Tyrosinase	Mus musculus	IC50	=	1550000.0	nM	PMID[21429753]
NPT154	Individual protein	Mothers against decapentaplegic homolog 3	Homo sapiens	Potency	n.a.	100.0	nM	PubChem BioAssay data set
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	146.5	%	PMID[25726329]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	51.67	%	PMID[30366788]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Activity	=	76.35	%	PMID[30011202]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	10.36	%	PMID[30011202]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	53.17	%	PMID[30347330]
NPT2739	Individual protein	Tyrosinase	Mus musculus	IC50	=	87500.0	nM	PMID[30446440]
NPT2739	Individual protein	Tyrosinase	Mus musculus	Inhibition	=	42.6	%	PMID[31027707]
NPT2739	Individual protein	Tyrosinase	Mus musculus	IC50	=	500000.0	nM	PMID[29763564]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	113.42	%	PMID[23571415]
NPT67	Individual protein	Cholinesterase	Equus caballus	Inhibition	=	6.63	%	PMID[23062825]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	103.74	%	PMID[23571415]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	1.824	%	DOI[10.6019/CHEMBL4495564]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-2.48	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-4.35	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	=	32000000.0	nM	PMID[12824045]
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	=	30260.0	nM	PMID[17693086]
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	=	230000.0	nM	PMID[16872137]
NPT741	Individual protein	Tyrosinase	Homo sapiens	Inhibition	=	-1.5	%	PMID[19036585]
NPT66	Individual protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	9.16	%	PMID[23062825]
NPT861	Individual protein	Isocitrate dehydrogenase [NADP] cytoplasmic	Homo sapiens	Potency	n.a.	2310.9	nM	PubChem BioAssay data set
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	>	1600.0	nM	PMID[30909021]
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	=	164000.0	nM	PMID[29763564]
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	=	6500000.0	nM	PMID[29763564]
NPT741	Individual protein	Tyrosinase	Homo sapiens	IC50	>	4000000.0	nM	PMID[35717871]
NPT29454	Single protein	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Homo sapiens	Inhibition	=	4.868	%	PMID[38318365]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	10400000.0	nM	PMID[21411319]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	30.0	%	PMID[21411319]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	24000000.0	nM	PMID[12398542]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	ID50	=	6.2	mM	PMID[8021657]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	7300000.0	nM	PMID[19800229]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	0.7	%	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	1.2	%	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	5.6	%	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	0.1	%	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	10.0	%	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	>	1000000.0	nM	PMID[19615910]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Ratio IC50	=	8.5	n.a.	PMID[20729091]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Ratio IC50	=	7.0	n.a.	PMID[20729091]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	210000.0	nM	PMID[20729091]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	2300.0	ppm	PMID[21050756]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	201200.0	nM	PMID[21377874]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	5300000.0	nM	PMID[21561780]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	146000.0	nM	PMID[21561780]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	194500.0	nM	PMID[24268551]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	100000.0	nM	PMID[26824128]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	32.65	%	PMID[29907470]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	366000.0	nM	PMID[31655335]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	560000.0	nM	PMID[30011202]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	IC50	=	10400.0	nM	PMID[30446440]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT319	Cell line	B16	Mus musculus	Inhibition	=	43.8	%	PMID[18501598]
NPT168	Cell line	P388	Mus musculus	IC50	>	25.0	ug.mL-1	PMID[9214736]
NPT319	Cell line	B16	Mus musculus	Inhibition	=	33.0	%	PMID[19284745]
NPT319	Cell line	B16	Mus musculus	IC50	=	116000.0	nM	PMID[19615910]
NPT319	Cell line	B16	Mus musculus	IC50	=	180000.0	nM	PMID[22217872]
NPT319	Cell line	B16	Mus musculus	Inhibition	>	100.0	%	PMID[20044259]
NPT169	Cell line	B16-F10	Mus musculus	Inhibition	=	41.0	%	PMID[20884093]
NPT319	Cell line	B16	Mus musculus	IC50	=	120000.0	nM	PMID[21388810]
NPT319	Cell line	B16	Mus musculus	IC50	=	99000.0	nM	PMID[21429753]
NPT319	Cell line	B16	Mus musculus	IC50	=	67.9	ug.mL-1	PMID[22450129]
NPT319	Cell line	B16	Mus musculus	IC50	=	140000.0	nM	PMID[23623417]
NPT885	Cell line	PBL	n.a.	Activity	=	15.8	%	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	15.0	%	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	15.1	%	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	1.6	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	1.8	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	1.7	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	1.2	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	1.3	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	191.2	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	189.3	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	197.2	n.a.	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	104.5	%	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	103.4	%	PMID[26290401]
NPT885	Cell line	PBL	n.a.	Activity	=	107.8	%	PMID[26290401]
NPT319	Cell line	B16	Mus musculus	IC50	=	400000.0	nM	PMID[28619537]
NPT319	Cell line	B16	Mus musculus	Activity	=	105.0	%	PMID[29887353]
NPT319	Cell line	B16	Mus musculus	Activity	=	89.0	%	PMID[29887353]
NPT319	Cell line	B16	Mus musculus	Activity	=	45.0	%	PMID[29887353]
NPT319	Cell line	B16	Mus musculus	IC50	=	247000.0	nM	PMID[29526485]
NPT319	Cell line	B16	Mus musculus	Activity	=	29.0	%	PMID[30011202]
NPT941	Cell line	HaCaT	Homo sapiens	Activity	=	31.0	%	PMID[30011202]
NPT169	Cell line	B16-F10	Mus musculus	Ratio	=	0.81	n.a.	PMID[30520635]
NPT169	Cell line	B16-F10	Mus musculus	Ratio	=	0.91	n.a.	PMID[30520635]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	101.0	%	PMID[30520635]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	102.3	%	PMID[30520635]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	81.5	%	PMID[30520635]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	92.7	%	PMID[30520635]
NPT319	Cell line	B16	Mus musculus	IC50	=	64000.0	nM	PMID[31387790]
NPT169	Cell line	B16-F10	Mus musculus	IC50	=	391200.0	nM	PMID[27720556]
NPT169	Cell line	B16-F10	Mus musculus	Inhibition	=	50.0	%	PMID[27720556]
NPT169	Cell line	B16-F10	Mus musculus	Inhibition	=	78.0	%	PMID[27720556]
NPT319	Cell line	B16	Mus musculus	Inhibition	=	55.4	%	PMID[34365131]
NPT24776	Cell line	B16-F1	Mus musculus	Inhibition	=	34.0	%	PMID[30030001]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-7.21	%	DOI[10.21203/rs.3.rs-23951/v1]
NPT24776	Cell line	B16-F1	Mus musculus	IC50	=	148300.0	nM	PMID[30446440]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.08	%	DOI[10.6019/CHEMBL4495565]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT24776	Cell line	B16-F1	Mus musculus	IC50	=	122000.0	nM	PMID[27720556]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	174000.0	nM	PMID[36273707]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	IZ	=	0.0	mm	PMID[9214736]
NPT330	Organism	Trichophyton mentagrophytes	Trichophyton mentagrophytes	IZ	=	0.0	mm	PMID[9214736]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	-27.6	%	PMID[12444684]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	-25.2	%	PMID[12444684]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	8.7	%	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	17.6	%	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	21.9	%	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	20.2	%	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	46.9	%	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	1000000.0	nM	PMID[19615910]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	20.4	%	PMID[27756508]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	38.1	%	PMID[27756508]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	61.5	%	PMID[27756508]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	83.7	%	PMID[27756508]
NPT19	Organism	Escherichia coli	Escherichia coli	IZ	=	0.0	mm	PMID[9214736]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	IZ	=	0.0	mm	PMID[9214736]
NPT1	Others	Radical scavenging activity	n.a.	Activity	=	1.9	%	PMID[12444684]
NPT1	Others	Radical scavenging activity	n.a.	Activity	=	18.3	%	PMID[12444684]
NPT1	Others	Radical scavenging activity	n.a.	Activity	=	23.5	%	PMID[12444684]
NPT1	Others	Radical scavenging activity	n.a.	Activity	=	52.6	%	PMID[12444684]
NPT1	Others	Radical scavenging activity	n.a.	Activity	=	78.6	%	PMID[12444684]
NPT20950	Cell line	Erythrocyte	n.a.	Activity	=	27.0	%	PMID[30011202]
NPT2	Others	Unspecified	n.a.	Potency	n.a.	61659.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Potency	n.a.	10590.1	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Potency	n.a.	16785.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Potency	n.a.	30637.9	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Potency	n.a.	3.5	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	IC50	=	118050.0	nM	PMID[17693086]
NPT2	Others	Unspecified	n.a.	Inhibition	=	5.5	%	PMID[19036585]
NPT2	Others	Unspecified	n.a.	IC50	=	103000.0	nM	PMID[19132934]
NPT2	Others	Unspecified	n.a.	IC50	=	2200.0	nM	PMID[19102656]
NPT2	Others	Unspecified	n.a.	Inhibition	=	6.7	%	PMID[19615910]
NPT2	Others	Unspecified	n.a.	Inhibition	=	17.8	%	PMID[19615910]
NPT2	Others	Unspecified	n.a.	Inhibition	=	46.9	%	PMID[19615910]
NPT2	Others	Unspecified	n.a.	Inhibition	=	71.0	%	PMID[19615910]
NPT2	Others	Unspecified	n.a.	Inhibition	=	88.7	%	PMID[19615910]
NPT22410	Cell line	Melan-a	Mus musculus	IC50	=	98050.0	nM	PMID[20022495]
NPT2	Others	Unspecified	n.a.	Inhibition	=	10.6	%	PMID[24601675]
NPT2	Others	Unspecified	n.a.	Inhibition	=	20.4	%	PMID[24601675]
NPT2	Others	Unspecified	n.a.	Inhibition	=	38.1	%	PMID[24601675]
NPT2	Others	Unspecified	n.a.	Inhibition	=	61.5	%	PMID[24601675]
NPT2	Others	Unspecified	n.a.	Inhibition	=	83.7	%	PMID[24601675]
NPT2	Others	Unspecified	n.a.	IC50	=	174000.0	nM	PMID[25987378]
NPT2	Others	Unspecified	n.a.	IC50	=	17000000.0	nM	PMID[20615711]
NPT2	Others	Unspecified	n.a.	Activity	=	-0.1	%	PMID[22834923]
NPT2	Others	Unspecified	n.a.	Activity	=	13.3	%	PMID[22834923]
NPT2	Others	Unspecified	n.a.	Activity	=	18.0	%	PMID[22834923]
NPT2	Others	Unspecified	n.a.	AC50	n.a.	3162.3	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	AC50	n.a.	2818.4	nM	PubChem BioAssay data set
NPT2	Others	Unspecified	n.a.	Inhibition	=	30.0	%	PMID[26395057]
NPT1019	Organism	Trichomonas vaginalis	Trichomonas vaginalis	MIC	=	500.0	ug.mL-1	PMID[29175675]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	82.4	%	PMID[27756508]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	78.1	%	PMID[27756508]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	79.8	%	PMID[27756508]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	53.1	%	PMID[27756508]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC142319 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	17296
0.1-0.2	27892
0.2-0.3	3313
0.3-0.4	759
0.4-0.5	438
0.5-0.6	106
0.6-0.7	31
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.72	Intermediate Similarity	NPC57751
0.7021	Intermediate Similarity	NPC221090
0.6818	Remote Similarity	NPC212729
0.6818	Remote Similarity	NPC604498
0.6739	Remote Similarity	NPC9248
0.6735	Remote Similarity	NPC40377
0.6667	Remote Similarity	NPC269242
0.6667	Remote Similarity	NPC484157
0.6667	Remote Similarity	NPC228907
0.6522	Remote Similarity	NPC153149
0.6522	Remote Similarity	NPC192810
0.6522	Remote Similarity	NPC294470
0.6471	Remote Similarity	NPC83975
0.6458	Remote Similarity	NPC12308
0.6444	Remote Similarity	NPC276195
0.6383	Remote Similarity	NPC25817
0.6383	Remote Similarity	NPC152722
0.6346	Remote Similarity	NPC214910
0.6346	Remote Similarity	NPC26080
0.6346	Remote Similarity	NPC165686
0.6327	Remote Similarity	NPC192229
0.6327	Remote Similarity	NPC145900
0.6304	Remote Similarity	NPC217854
0.625	Remote Similarity	NPC60589
0.625	Remote Similarity	NPC469708
0.625	Remote Similarity	NPC604439
0.625	Remote Similarity	NPC609376
0.62	Remote Similarity	NPC214454
0.6122	Remote Similarity	NPC200092
0.6	Remote Similarity	NPC85799
0.6	Remote Similarity	NPC303422
0.6	Remote Similarity	NPC97326
0.6	Remote Similarity	NPC80098
0.5882	Remote Similarity	NPC166168
0.5862	Remote Similarity	NPC121001
0.5849	Remote Similarity	NPC205054
0.5849	Remote Similarity	NPC23084
0.5818	Remote Similarity	NPC198487
0.5769	Remote Similarity	NPC310661
0.5667	Remote Similarity	NPC259767
0.5667	Remote Similarity	NPC99233
0.5667	Remote Similarity	NPC57587
0.5636	Remote Similarity	NPC473044
0.5614	Remote Similarity	NPC478871
0.5614	Remote Similarity	NPC478870
0.5614	Remote Similarity	NPC478872
0.5614	Remote Similarity	NPC233559
0.5614	Remote Similarity	NPC478873
0.5574	Remote Similarity	NPC92054
0.5574	Remote Similarity	NPC601828
0.5556	Remote Similarity	NPC251102
0.5556	Remote Similarity	NPC210298
0.5556	Remote Similarity	NPC19470
0.5556	Remote Similarity	NPC604356
0.5536	Remote Similarity	NPC222455
0.5536	Remote Similarity	NPC106025
0.5517	Remote Similarity	NPC242028
0.5517	Remote Similarity	NPC294166
0.5517	Remote Similarity	NPC203230
0.5517	Remote Similarity	NPC252169
0.5517	Remote Similarity	NPC115022
0.549	Remote Similarity	NPC226712
0.549	Remote Similarity	NPC608788
0.5484	Remote Similarity	NPC271479
0.5455	Remote Similarity	NPC210015
0.5455	Remote Similarity	NPC164599
0.5455	Remote Similarity	NPC481303
0.5439	Remote Similarity	NPC59324
0.5439	Remote Similarity	NPC473045
0.5439	Remote Similarity	NPC218003
0.5439	Remote Similarity	NPC65833
0.5424	Remote Similarity	NPC37074
0.5424	Remote Similarity	NPC8497
0.5424	Remote Similarity	NPC185778
0.541	Remote Similarity	NPC177742
0.5397	Remote Similarity	NPC308265
0.5397	Remote Similarity	NPC170475
0.5385	Remote Similarity	NPC97240
0.5385	Remote Similarity	NPC160882
0.537	Remote Similarity	NPC218685
0.5357	Remote Similarity	NPC105827
0.5345	Remote Similarity	NPC199335
0.5345	Remote Similarity	NPC475628
0.5345	Remote Similarity	NPC477240
0.5333	Remote Similarity	NPC260681
0.5333	Remote Similarity	NPC60756
0.5333	Remote Similarity	NPC287780
0.5333	Remote Similarity	NPC60982
0.5323	Remote Similarity	NPC165720
0.5323	Remote Similarity	NPC148273
0.5312	Remote Similarity	NPC39351
0.5294	Remote Similarity	NPC299144
0.5283	Remote Similarity	NPC166040
0.5283	Remote Similarity	NPC604209
0.5273	Remote Similarity	NPC479028
0.5273	Remote Similarity	NPC479031
0.5273	Remote Similarity	NPC606892
0.5263	Remote Similarity	NPC25292
0.5263	Remote Similarity	NPC599943
0.5254	Remote Similarity	NPC78809
0.5254	Remote Similarity	NPC190217
0.5254	Remote Similarity	NPC469661
0.5254	Remote Similarity	NPC65530
0.5254	Remote Similarity	NPC611586
0.5246	Remote Similarity	NPC98777
0.5246	Remote Similarity	NPC189115
0.5246	Remote Similarity	NPC212770
0.5238	Remote Similarity	NPC186406
0.5238	Remote Similarity	NPC299435
0.5238	Remote Similarity	NPC169248
0.5238	Remote Similarity	NPC72649
0.5231	Remote Similarity	NPC206378
0.5231	Remote Similarity	NPC106625
0.5185	Remote Similarity	NPC9912
0.5172	Remote Similarity	NPC287872
0.5172	Remote Similarity	NPC247146
0.5167	Remote Similarity	NPC111536
0.5167	Remote Similarity	NPC186418
0.5167	Remote Similarity	NPC479374
0.5167	Remote Similarity	NPC604095
0.5161	Remote Similarity	NPC78697
0.5156	Remote Similarity	NPC328093
0.5156	Remote Similarity	NPC259182
0.5156	Remote Similarity	NPC88484
0.5156	Remote Similarity	NPC185103
0.5152	Remote Similarity	NPC145319
0.5094	Remote Similarity	NPC69513
0.5088	Remote Similarity	NPC609351
0.5085	Remote Similarity	NPC100389
0.5085	Remote Similarity	NPC190714
0.5085	Remote Similarity	NPC99515
0.5085	Remote Similarity	NPC605646
0.5082	Remote Similarity	NPC604892
0.5079	Remote Similarity	NPC606353
0.5077	Remote Similarity	NPC471457
0.5077	Remote Similarity	NPC260604
0.5077	Remote Similarity	NPC26195
0.5075	Remote Similarity	NPC287294
0.5075	Remote Similarity	NPC143851

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC142319 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	5224
0.1-0.2	3734
0.2-0.3	157
0.3-0.4	28
0.4-0.5	5
0.5-0.6	1
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.549	Remote Similarity	NPD1091	Pre-clinical

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data