NPASS Compound

Natural Product: NPC259182

Natural Product ID	NPC259182
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Phlorizin
IUPAC Name	1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
Synonyms	Phloridzin
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL245067
PubChem CID	6072
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000261] Phenylpropanoids and polyketides [CHEMONTID:0000334] Flavonoids [CHEMONTID:0001111] Flavonoid glycosides [CHEMONTID:0001583] Flavonoid O-glycosides

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 55 57 0 0 0 0 0 0 0 0999 V2000 3.4862 1.7285 -3.0654 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9740 1.4811 -4.3416 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3848 0.5045 -5.1187 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3067 -0.2450 -4.6545 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8562 0.0321 -3.3872 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4152 0.9943 -2.5850 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9252 1.2936 -1.2096 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6744 0.4187 -0.2228 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2294 0.6735 1.1511 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7724 0.0260 2.0904 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1929 1.6299 1.5273 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5294 2.9438 1.8178 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5489 3.8718 2.1805 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7577 3.4392 2.2396 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0587 2.1198 1.9431 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.1188 1.1974 1.5871 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4087 -0.0884 1.2978 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.5956 -0.7901 1.2733 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.9726 -1.3187 -0.0840 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.9453 -2.8181 -0.1838 C 0 0 2 0 0 0 0 0 0 0 0 0 -2.7047 -3.4773 0.9489 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.8588 -2.4640 2.0682 C 0 0 1 0 0 0 0 0 0 0 0 0 -3.4381 -3.0744 3.3034 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.7116 -2.1260 4.2799 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.6596 -1.7881 2.2722 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.9379 -3.9463 0.5132 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.6897 -3.3625 -0.2710 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.2717 -0.9195 -0.4765 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.7252 4.3617 2.5992 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8310 3.4056 1.7670 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8598 0.2415 -6.4019 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9582 2.4975 -2.4664 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8124 2.0428 -4.7398 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8464 -1.0123 -5.2695 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0176 -0.5204 -2.9706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8411 1.0348 -1.1468 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0081 2.3642 -0.9571 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4714 -0.6527 -0.4418 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7748 0.5606 -0.3584 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8189 4.9024 2.4073 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.0796 1.8440 2.0059 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.4252 -0.0900 1.5606 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.3067 -0.9364 -0.8885 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.4998 -3.0718 -1.1336 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1349 -4.3466 1.3252 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5998 -1.7130 1.6949 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.4189 -3.5186 3.0111 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.8318 -3.9115 3.7029 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0377 -2.0932 5.0049 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.4827 -3.1353 0.3088 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0836 -2.8179 -0.8581 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.4166 -0.0326 -0.0310 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7095 5.3357 2.4177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0655 3.9669 0.9342 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2805 -0.6413 -6.6317 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 2 3 1 0 3 4 2 0 4 5 1 0 5 6 2 0 6 7 1 0 7 8 1 0 8 9 1 0 9 10 2 0 9 11 1 0 11 12 2 0 12 13 1 0 13 14 2 0 14 15 1 0 15 16 2 0 16 17 1 0 17 18 1 0 18 19 1 0 19 20 1 0 20 21 1 0 21 22 1 0 22 23 1 0 23 24 1 0 22 25 1 0 21 26 1 0 20 27 1 0 19 28 1 0 14 29 1 0 12 30 1 0 3 31 1 0 6 1 1 0 16 11 1 0 25 18 1 0 1 32 1 0 2 33 1 0 4 34 1 0 5 35 1 0 7 36 1 0 7 37 1 0 8 38 1 0 8 39 1 0 13 40 1 0 15 41 1 0 18 42 1 1 19 43 1 6 20 44 1 6 21 45 1 1 22 46 1 6 23 47 1 0 23 48 1 0 24 49 1 0 26 50 1 0 27 51 1 0 28 52 1 0 29 53 1 0 30 54 1 0 31 55 1 0 M END

Standard InCHIKey	IOUVKUPGCMBWBT-QNDFHXLGSA-N
Standard InCHI	InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
SMILES	c1cc(ccc1CCC(=O)c1c(cc(cc1O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)O)O)O

Calculated Properties

Physi-Chem Properties

Molecular Weight:	436.14	Volume:	415.55 ? Van der Waals volume.
Dense:	1.05	LogP:	0.745 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	1.247 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-2.553 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	7.0	Rigid Bonds:	19.0
TPSA:	177.14 ? Topological Polar Surface Area.	H-Bond Acceptor:	10.0
H-Bond Donor:	7.0	Rings:	3.0
Heavy Atoms:	10.0

MedChem Properties

QED Drug-Likeness Score:	0.288	GASA:	0.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	3.785	Fsp³:	0.381
MCE-18:	70.241 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Accepted
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.465	Fluc inhibitor:	0.427 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.141 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.372 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.174	Promiscuous compounds:	0.318

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-6.024	MDCK Permeability:	-4.967
Pgp-inhibitor:	0.004	Pgp-substrate:	0.1
PAMPA:	0.922 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.013
20% Bioavailability (F20%):	0.045	30% Bioavailability (F30%):	0.989
50% Bioavailability (F50%):	1.0

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.0	MRP1:	0.1
Plasma Protein Binding (PPB):	85.679%	Volume Distribution (VD):	-0.218
Fu:	14.108% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	1.0
OATP1B3 inhibitor:	1.0	BCRP inhibitor:	0.075
BSEP inhibitor:	0.167

ADMET: Metabolism

CYP1A2-inhibitor:	0.776	CYP1A2-substrate:	0.0
CYP2C19-inhibitor:	0.0	CYP2C19-substrate:	0.006
CYP2C9-inhibitor:	0.005	CYP2C9-substrate:	0.001
CYP2D6-inhibitor:	0.002	CYP2D6-substrate:	0.817
CYP3A4-inhibitor:	0.0	CYP3A4-substrate:	0.0
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	1.0
HLM stability:	0.474 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

3.505

Half-life (T1/2):

3.166

ADMET: Toxicity

hERG Blockers:	0.046	hERG Blockers (10um):	0.21
Human Hepatotoxicity (H-HT):	0.7	Drug-induced Liver Injury (DILI):	0.355
AMES Toxicity:	0.823	Rat Oral Acute Toxicity:	0.026
Maximum Recommended Daily Dose:	0.08	Skin Sensitization:	0.994
Carcinogencity:	0.2	Eye Corrosion:	0.0
Eye Irritation:	0.546	Respiratory Toxicity:	0.041
Drug-induced Neurotoxicity:	0.024	Ototoxicity:	0.86
Hematotoxicity:	0.149	Drug-induced Nephrotoxicity:	0.528
Genotoxicity:	0.893	RPMI-8226 Immunitoxicity:	0.058
A549 Cytotoxicity:	0.442	Hek293 Cytotoxicity:	0.663
BCF:	0.473 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	3.064 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	4.555 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	3.723 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[ 10835233]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Seeds	n.a.		DOI[10.1002/(SICI)1097-0010(199909)79:12<1620::AID-JSFA410>3.0.CO;2-G]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	Nigeria(latitude 80Ã‚Â°N and longitude 4Ã‚Â°E)	2005; 2006	DOI[10.1002/ejlt.201000080]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1002/ejlt.201100207]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1007/s00217-002-0656-1]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	fruit	n.a.	DOI[10.1007/s00217-007-0799-1]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1007/s00217-015-2561-4]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	Flowers	Tantempango, Hidalgo, Mexico	2019-May	DOI[10.1007/s11130-020-00822-2]
NPO24421	Agave salmiana	Species	Asparagaceae	Eukaryota	Flowers	Tantempango, Hidalgo, Mexico	2019-May	DOI[10.1007/s11130-020-00822-2]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	Flowers	Tantempango, Hidalgo, Mexico	2019-May	DOI[10.1007/s11130-020-00822-2]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s11240-015-0761-z]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s11306-010-0259-y]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s11306-014-0638-x]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1007/s11746-010-1670-2]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s11746-997-0093-1]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1007/s12010-013-0354-4]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.		DOI[10.1016/j.foodchem.2007.07.014]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.		DOI[10.1016/j.foodchem.2010.05.061]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1016/j.foodchem.2010.05.061]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	flower	n.a.	DOI[10.1016/j.foodchem.2011.01.077]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.foodcont.2016.09.002]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1016/j.indcrop.2013.08.051]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.jarmap.2018.11.004]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.jfca.2010.08.006]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/j.phytol.2008.07.007]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.		DOI[10.1016/j.ssnmr.2006.05.001]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.supflu.2010.06.003]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.supflu.2010.12.007]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.supflu.2016.02.010]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.1016/j.supflu.2018.06.017]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1016/j.yclnex.2017.01.002; 10.31989/ffhd.v6i3.245]DOI[10.1016/j.yclnex.2017.01.002; 10.31989/ffhd.v6i3.245]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Fruit	n.a.	n.a.	DOI[10.1016/S0963-9969(99)00095-2]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	DOI[10.1021/jf970571j]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Seeds	Plovdiv, Plovdiv region in South Bulgaria		DOI[10.1051/CTV/20163101031]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1055/S-2006-958077]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1080/09064710.2011.598543]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1111/j.1365-2621.1989.tb04709.x]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.1111/j.1745-4530.2009.00507.x]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1186/s40064-015-0831-z]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.12691/jfnr-2-5-9]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1501/Tarimbil_0000001065]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.15835/NBHA4017181]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.17221/540/2012-CJFS]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.2137/145960607781635822]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.2478/aoas-2014-0072]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.3136/NSKKK.48.606]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		DOI[10.3390/agriculture2030244]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		DOI[10.5219/332]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[10336650]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	kernel	n.a.	PMID[10670815]
NPO9305	Iotrochota purpurea	Species	Iotrochotidae	Eukaryota	n.a.	n.a.	n.a.	PMID[10924179]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11170689]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	leaf	n.a.	PMID[11312782]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	fruit	n.a.	PMID[11312782]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11408943]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11520216]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11908994]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	fruit	n.a.	PMID[12105962]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	kernel	n.a.	PMID[12232058]
NPO8035	Tylophora tanakae	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12350151]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[13160012]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[15217296]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[15563205]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Seeds	n.a.	n.a.	PMID[15620261]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15679315]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	leaves	n.a.	n.a.	PMID[15787442]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	n.a.	leaf	n.a.	PMID[15787442]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16252923]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16297615]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[16499319]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	leaf	n.a.	PMID[16926516]
NPO10900	Cinnamomum subavenium	Species	Lauraceae	Eukaryota	stems	Wulai Hsiang, Taipei County, Taiwan	2005-MAY	PMID[17253858]
NPO13478	Scorzonera pseudodivaricata	Species	Asteraceae	Eukaryota	n.a.	Mongolian	n.a.	PMID[17542634]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[17624889]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Fruits	Malatya Fruit Research Institute	between the first and third weeks of 2005-Jul.	PMID[18038980]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	root	n.a.	PMID[1823989]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	sand-covered bottom at -10 to -15 m at Hurghada, on the Egyptian Red Sea coast	2003-JUN	PMID[18298079]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[18543151]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18611049]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18768384]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	PMID[18942825]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	Esuela Tecnica Superior de Ingenieros AgrÃƒÂ³nomos de Albacete	2007	PMID[19256538]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19476340]
NPO2298	Streptomyces platensis	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[19581087]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[19628108]
NPO2298	Streptomyces platensis	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[20299229]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	bark	n.a.	n.a.	PMID[20363129]
NPO12855	Alkanna cappadocica	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20405844]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[20826702]
NPO2298	Streptomyces platensis	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[21214253]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	seed	n.a.	PMID[21287989]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[21381697]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	fruit	n.a.	PMID[21648406]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	fruit	n.a.	PMID[21648406]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21912858]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[21954959]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	roots	Whitessence Srl, Viterbo, Italy	2005-OCT	PMID[21954959]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	cone	n.a.	PMID[22111577]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	flower	n.a.	PMID[22166201]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22537213]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[22538527]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	flower buds	n.a.	n.a.	PMID[22834923]
NPO10900	Cinnamomum subavenium	Species	Lauraceae	Eukaryota	Leaves	n.a.	n.a.	PMID[23025417]
NPO9305	Iotrochota purpurea	Species	Iotrochotidae	Eukaryota	n.a.	n.a.	n.a.	PMID[23131412]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[23497864]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23759170]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23790907]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	n.a.	fruit	n.a.	PMID[240326]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24358188]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Stalks	n.a.	n.a.	PMID[24521157]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[24811150]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[24948953]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[25026919]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25564559]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[25977015]
NPO10900	Cinnamomum subavenium	Species	Lauraceae	Eukaryota	stem bark	Laifeng, Hubei Province, China	2012-JUL	PMID[26087384]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[26351516]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[27556441]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[28274428]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29154541]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Seeds	Benedictine Pannonhalma Archabbey, Hungary		PMID[29803478]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[30236698]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30384263]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	Roots	n.a.	n.a.	PMID[30395460]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	Guangzhou, China		PMID[30563201]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[30583361]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[30599958]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[31159190]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	Schirgiswalde, Germany	2008-Aug	PMID[31206724]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	Cracow, Poland	2008-Sep	PMID[31206724]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	Schirgiswalde, Germany	2008-Sep	PMID[31206724]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	Schirgiswalde, Germany	2008-Oct	PMID[31206724]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31433178]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[31619015]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31747281]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[31809052]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	Seeds	n.a.		PMID[31861466]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	DingXi, GanSu, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	LanZhou, GanSu, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32569471]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	10 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	20 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	30 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	40 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	50 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	60 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	70 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	80 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	90 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Fruits	Yangling, Shaanxi, China	Maturation	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	10 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	20 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	30 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	40 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	50 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	60 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	70 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	80 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	90 days after pollination	PMID[33131958]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	Seeds	Yangling, Shaanxi, China	Maturation	PMID[33131958]
NPO11699	Ecballium elaterium	Species	Cucurbitaceae	Eukaryota	Fruit juice	n.a.	n.a.	PMID[3404148]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36560643]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36613240]
NPO19632	Terminalia ivorensis	Species	Combretaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[36964494]
NPO53555	Vitis riparia	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446586]
NPO42254	Vitis californica	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446586]
NPO3690	Vitis amurensis	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446586]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37446586]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[37570937]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37570937]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37631012]
NPO54044	Aristolochia olivieri	Genus	Aristolochiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37958986]
NPO53268	Cistus laurifolius	Species	Cistaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38129637]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38279238]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38354824]
NPO48832	Paeonia tenuifolia	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38675478]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38791403]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[38893452]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39065796]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39138188]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39181940]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39199155]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39527985]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[39716808]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[521818]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8594148]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8778246]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Flowers	n.a.		PMID[9301422]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		PMID[9301422]
NPO3204	Centaurea malacitana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[9358646]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12855	Alkanna cappadocica	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13030	Artemisia dentata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1834	Atalantia racemosa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21830	Buddleja cordata	Species	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12196	Buphane fischeri	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5930	Crambe tatarica	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12700	Diospyros eriantha	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9313	Fritillaria ningguoensis	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO252	Hoffmannia strigillosa	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO24390.1	Juniperus rigida var. conferta	Varieties	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11848	Lemaireocereus griseus	Species	Cactaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2398	Millettia erythrocalyx	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9934	Mycobacterium leprae	Species	Mycobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13671	Ononis vaginalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14578	Prorocentrum micans	Species	Prorocentraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8928	Pteris semipinnata	Species	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13585	Rapanea lancifolia	Species	Primulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13478	Scorzonera pseudodivaricata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10783	Syncarpia hillii	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6360	Xenoacremonium recifei	Species	Nectriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3628	Solanum aethiopicum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2298	Streptomyces platensis	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3199	Balanophora involucrata	Species	Balanophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2922	Botryosphaeria berengeriana	Species	Botryosphaeriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11699	Ecballium elaterium	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3378	Alstonia undulifolia	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10737	Asteriscus aquaticus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11811	Capparis ovata	Species	Capparaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12669	Cassine papillosa	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9509	Charpentiera obovata	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10900	Cinnamomum subavenium	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO15252	Clathria prolifera	Species	Microcionidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6253	Conus pulicarius	Species	Conidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1182	Croton montevidensis	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12188	Datisca glomerata	Species	Datiscaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12544	Dioscorea olfersiana	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12888	Echinus microtuberculatus	Species	Echinidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO761	Fagus fusca	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5823	Helichrysum auriceps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5008	Hubertia tomentosa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9305	Iotrochota purpurea	Species	Iotrochotidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5384	Ligustrum obtusifolium	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9672	Lotus ucrainicus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12308	Metridium senile	Species	Metridiidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9922	Myelobia smerintha	Species	Crambidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8477	Myristica cagayanensis	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10393	Ophidiaster ophidianus	Species	Ophidiasteridae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11553	Phebalium dentatum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO20291	Phyllanthus oligospermus	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4493	Polygonum flaccidum	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11256	Pseudowintera colorata	Species	Winteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12436	Quercus imbricaria	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3736	Scrophularia koelzii	Species	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2608	Solanum andigena	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7709	Spiracantha cornifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8035	Tylophora tanakae	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7045	Viviparus japonicus	Species	Viviparidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3204	Centaurea malacitana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8870	Boehmeria tricuspis	Species	Urticaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3690	Vitis amurensis	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO53268	Cistus laurifolius	Species	Cistaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO48832	Paeonia tenuifolia	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO794	Lippia graveolens	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO53555	Vitis riparia	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Bark	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Fruit	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Fruit	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Leaf	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Leaf	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Leaf Essent. Oil	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Pericarp	n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Plant	n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Pollen Or Spore	n.a.	n.a.	Database[FooDB]
NPO794	Lippia graveolens	Species	Verbenaceae	Eukaryota	Root	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Root Bark	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Seed	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO794	Lippia graveolens	Species	Verbenaceae	Eukaryota	Shoot	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Stem	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Stem Bark	n.a.	n.a.	Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Twig	n.a.	n.a.	Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO19774	Rubus idaeus	Species	n.a.	n.a.		n.a.	n.a.	Database[FooDB]
NPO794	Lippia graveolens	Species	Verbenaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Fruits	n.a.		Database[FooDB]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[FooDB]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3690	Vitis amurensis	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11699	Ecballium elaterium	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[HerDing]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO2398	Millettia erythrocalyx	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[MetaboLights]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	Fruits	n.a.		Database[Phenol-Explorer]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.		Database[Phenol-Explorer]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	Fruits	n.a.		Database[Phenol-Explorer]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.		Database[Phenol-Explorer]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3199	Balanophora involucrata	Species	Balanophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO2398	Millettia erythrocalyx	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[TCMID]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO3690	Vitis amurensis	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11699	Ecballium elaterium	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9313	Fritillaria ningguoensis	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO24390.1	Juniperus rigida var. conferta	Varieties	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO1834	Atalantia racemosa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9313	Fritillaria ningguoensis	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Title]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8928	Pteris semipinnata	Species	Pteridaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9934	Mycobacterium leprae	Species	Mycobacteriaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO10783	Syncarpia hillii	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13585	Rapanea lancifolia	Species	Primulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3199	Balanophora involucrata	Species	Balanophoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13030	Artemisia dentata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21830	Buddleja cordata	Species	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12855	Alkanna cappadocica	Species	Boraginaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13408	Cordeauxia edulis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12700	Diospyros eriantha	Species	Ebenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17024	Vitis vinifera	Species	Vitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5008	Hubertia tomentosa	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13879	Humulus lupulus	Species	Cannabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6360	Xenoacremonium recifei	Species	Nectriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11848	Lemaireocereus griseus	Species	Cactaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26351	Agastache rugosa	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3492	Negombata magnifica	Species	Latrunculiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO590	Malus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24390.1	Juniperus rigida var. conferta	Varieties	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3628	Solanum aethiopicum	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8477	Myristica cagayanensis	Species	Myristicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9313	Fritillaria ningguoensis	Species	Liliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO761	Fagus fusca	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12436	Quercus imbricaria	Species	Fagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13478	Scorzonera pseudodivaricata	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11699	Ecballium elaterium	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4795	Prunus armeniaca	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4138	Betula platyphylla	Species	Betulaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12544	Dioscorea olfersiana	Species	Dioscoreaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO252	Hoffmannia strigillosa	Species	Rubiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9305	Iotrochota purpurea	Species	Iotrochotidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14578	Prorocentrum micans	Species	Prorocentraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5823	Helichrysum auriceps	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13281	Salvia hispanica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3286	Erythrina americana	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21349	Punica granatum	Species	Lythraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9922	Myelobia smerintha	Species	Crambidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5731	Euphorbia humifusa	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5930	Crambe tatarica	Species	Brassicaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7709	Spiracantha cornifolia	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9672	Lotus ucrainicus	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2608	Solanum andigena	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12196	Buphane fischeri	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO1834	Atalantia racemosa	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2398	Millettia erythrocalyx	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10393	Ophidiaster ophidianus	Species	Ophidiasteridae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4493	Polygonum flaccidum	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11811	Capparis ovata	Species	Capparaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1182	Croton montevidensis	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12308	Metridium senile	Species	Metridiidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6253	Conus pulicarius	Species	Conidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15265	Paeonia rockii	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5384	Ligustrum obtusifolium	Species	Oleaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11256	Pseudowintera colorata	Species	Winteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13671	Ononis vaginalis	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10737	Asteriscus aquaticus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2922	Botryosphaeria berengeriana	Species	Botryosphaeriaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10900	Cinnamomum subavenium	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11553	Phebalium dentatum	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3736	Scrophularia koelzii	Species	Scrophulariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12188	Datisca glomerata	Species	Datiscaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7045	Viviparus japonicus	Species	Viviparidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23380	Camellia japonica	Species	Theaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8035	Tylophora tanakae	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9509	Charpentiera obovata	Species	Amaranthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO15252	Clathria prolifera	Species	Microcionidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3378	Alstonia undulifolia	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12888	Echinus microtuberculatus	Species	Echinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12669	Cassine papillosa	Species	Celastraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2298	Streptomyces platensis	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO20291	Phyllanthus oligospermus	Species	Phyllanthaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11578	Aloe vera	Species	Xanthorrhoeaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29209	Litchi chinensis	Species	Sapindaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7269	Aronia melanocarpa	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3204	Centaurea malacitana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19632	Terminalia ivorensis	Species	Combretaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3519	Gracilaria corticata	Species	Gracilariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14617	Aloe hijazensis	Species	Asphodelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO794	Lippia graveolens	Species	Verbenaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17962	Tagetes erecta	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19198	Kalmia latifolia	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19774	Rubus idaeus	Species	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO4916	Toxicodendron vernicifluum	Species	Anacardiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8870	Boehmeria tricuspis	Species	Urticaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7546	Prunus domestica	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO13961	Pieris japonica	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6180	Ocotea puberula	Species	Lauraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO24421	Agave salmiana	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO16230	Malus pumila	Species	Rosaceae	Eukaryota	Fruit	n.a.	n.a.	Database[USDA]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference
NPO11578	Aloe vera	n.a.	Flowers	0.864	n.a.	n.a.	mg/g of DW	DOI[10.1007/s11130-020-00822-2]
NPO15265	Paeonia rockii	n.a.	Seeds	2.02 Â± 0.15	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.31 Â± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.46 Â± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.62 Â± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.79 Â± 0.06	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.25 Â± 0.06	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.42 Â± 0.02	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.32 Â± 0.04	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Fruits	0.87 Â± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	3.45 Â± 0.03	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	7.08 Â± 0.05a	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	6.75 Â± 0.03	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	6.72 Â± 0.11	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	4.55 Â± 0.15	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	3.77 Â± 0.23	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	3.59 Â± 0.14	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	0.43 Â± 0.14	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO15265	Paeonia rockii	n.a.	Seeds	0.14 Â± 0.01	n.a.	n.a.	mg/100g of DW	PMID[33131958]
NPO16230	Malus pumila	Beverage (juice)	n.a.	1.375333319	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	0.231999993	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	0.602499992	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	2.37308696	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	5.553999901	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	2.75443853	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	0.100000001	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	Beverage (juice)	n.a.	2.496956488	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	Beverage (juice)	n.a.	1.531568482	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	0.916000009	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO16230	Malus pumila	n.a.	n.a.	1.543626098	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO17024	Vitis vinifera	n.a.	n.a.	0.198 Â± 0.025	n.a.	n.a.	mg/100g	PMID[37446586]
NPO17962	Tagetes erecta	Ultrasound-assisted extraction	n.a.	6.62Â±4.15	n.a.	n.a.	mg/kg	PMID[39716808]
NPO17962	Tagetes erecta	Ultrasound-assisted extraction	n.a.	6.25Â±2.31	n.a.	n.a.	mg/kg	PMID[39716808]
NPO17962	Tagetes erecta	Ultrasound-assisted extraction	n.a.	10.28Â±3.11	n.a.	n.a.	mg/kg	PMID[39716808]
NPO17962	Tagetes erecta	Ultrasound-assisted extraction	n.a.	7.64Â±1.29	n.a.	n.a.	mg/kg	PMID[39716808]
NPO19632	Terminalia ivorensis	Hot water extraction	n.a.	91.2Â±22.8	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Organic solvents extraction	n.a.	0.04	n.a.	n.a.	%	PMID[36964494]
NPO19632	Terminalia ivorensis	Organic solvents extraction	n.a.	14.6Â±5.1	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Hot water extraction	n.a.	0.16	n.a.	n.a.	%	PMID[36964494]
NPO19632	Terminalia ivorensis	Aqueous extraction	n.a.	0.16	n.a.	n.a.	%	PMID[36964494]
NPO19632	Terminalia ivorensis	Aqueous extraction	n.a.	116.4Â±35.6	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Cold water extraction	n.a.	0.16	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Cold water extraction	n.a.	141.6Â±35.4	n.a.	n.a.	%	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethanol extract	n.a.	19.7Â±4.9	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Petroleum ether extract	n.a.	1.7Â±0.4	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethyl acetate extract	n.a.	8.1Â±1.2	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethyl acetate extract	n.a.	75.2Â±12.5	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethanol extract	n.a.	34.0Â±4.5	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethyl acetate extract	n.a.	158.8Â±24.2	n.a.	n.a.	ng/mg	PMID[36964494]
NPO19632	Terminalia ivorensis	Ethanol extract	n.a.	58.4Â±6.2	n.a.	n.a.	ng/mg	PMID[36964494]
NPO21349	Punica granatum	Beverage (juice)	n.a.	0.098846155	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO21349	Punica granatum	n.a.	n.a.	0.09585	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO21349	Punica granatum	n.a.	n.a.	44.88	n.a.	n.a.	mg/kg	PMID[36560643]
NPO21349	Punica granatum	n.a.	n.a.	123.67	n.a.	n.a.	mg/kg	PMID[36560643]
NPO23380	Camellia japonica	n.a.	Flowers	0.410	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.367	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	1.163	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.414	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.335	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.363	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.411	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO23380	Camellia japonica	n.a.	Flowers	0.352	n.a.	n.a.	Î¼g/100g	PMID[39065796]
NPO24421	Agave salmiana	n.a.	Flowers	1.167	n.a.	n.a.	mg/g of DW	DOI[10.1007/s11130-020-00822-2]
NPO3286	Erythrina americana	n.a.	Flowers	3.204	n.a.	n.a.	mg/g of DW	DOI[10.1007/s11130-020-00822-2]
NPO3690	Vitis amurensis	n.a.	n.a.	2.77 Â± 0.16	n.a.	n.a.	mg/100g	PMID[37446586]
NPO42254	Vitis californica	n.a.	n.a.	2.425 Â± 0.062	n.a.	n.a.	mg/100g	PMID[37446586]
NPO4795	Prunus armeniaca	n.a.	n.a.	0.027499999	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO48832	Paeonia tenuifolia	n.a.	n.a.	0.26	n.a.	n.a.	%	PMID[38675478]
NPO48832	Paeonia tenuifolia	n.a.	n.a.	0.33	n.a.	n.a.	%	PMID[38675478]
NPO53268	Cistus laurifolius	Aqueous extract	n.a.	17.589Â±0.270	n.a.	n.a.	mg/kg	PMID[38129637]
NPO53555	Vitis riparia	n.a.	n.a.	2.72 Â± 0.17	n.a.	n.a.	mg/100g	PMID[37446586]
NPO54044	Aristolochia olivieri	n.a.	n.a.	2.64	n.a.	n.a.	mg/kg	PMID[37958986]
NPO590	Malus domestica	n.a.	n.a.	2.68122	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	n.a.	1.52841	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	n.a.	1.37167	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	n.a.	0.6025	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	2.68982	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	2.49696	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	1.54339	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	0.91	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	0.23	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO590	Malus domestica	n.a.	Fruits	0.1	n.a.	n.a.	mg/100g of FW	Database [Phenol-Explorer]
NPO7269	Aronia melanocarpa	Ultrasonic extraction	Fruits	1.69 Â± 0.07	n.a.	n.a.	%	PMID[38893452]
NPO7546	Prunus domestica	Beverage (juice)	n.a.	5.850000064	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]
NPO7546	Prunus domestica	n.a.	n.a.	5.85	n.a.	n.a.	mg/100mL	Database [Phenol-Explorer]
NPO794	Lippia graveolens	Dried Or Powder	n.a.	135.9999975	n.a.	n.a.	mg/100g	Database [PHENOL EXPLORER]

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Ki	4
IC50	47
EC50	13
Inhibition	28
Potency	2
Ratio EC50	4
Ratio	1
Activity	11
ED50	1
Ratio IC50	9

Activity Type	# Activity
Individual protein	74
Cell line	6
Tissue	1
Others	22
Organism	3
Unchecked	2
Single protein	1
Non-molecular	11

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT2875	Individual protein	Solute carrier family 28 member 3	Homo sapiens	Ki	=	16000.0	nM	PMID[19097778]
NPT2877	Individual protein	Sodium/nucleoside cotransporter 1	Homo sapiens	IC50	=	250000.0	nM	PMID[19097778]
NPT2876	Individual protein	Sodium/nucleoside cotransporter 2	Homo sapiens	IC50	=	100000.0	nM	PMID[19097778]
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	Ki	>	1000000.0	nM	PMID[19097778]
NPT151	Individual protein	15-hydroxyprostaglandin dehydrogenase [NAD+]	Homo sapiens	Potency	=	35481.3	nM	PubChem BioAssay data set
NPT2876	Individual protein	Sodium/nucleoside cotransporter 2	Homo sapiens	IC50	>	1000000.0	nM	PMID[25815140]
NPT2876	Individual protein	Sodium/nucleoside cotransporter 2	Homo sapiens	Inhibition	<	50.0	%	PMID[25815140]
NPT2876	Individual protein	Sodium/nucleoside cotransporter 2	Homo sapiens	Inhibition	=	14.0	%	PMID[25815140]
NPT1120	Individual protein	Pancreatic triacylglycerol lipase	Sus scrofa	IC50	=	29.8	ug.mL-1	PMID[28958622]
NPT1120	Individual protein	Pancreatic triacylglycerol lipase	Sus scrofa	IC50	>	300000.0	nM	PMID[28958622]
NPT5493	Individual protein	Low affinity sodium-glucose cotransporter	Homo sapiens	IC50	=	16.0	nM	PMID[21873071]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	106.28	%	PMID[23571415]
NPT862	Individual protein	Epoxide hydratase	Homo sapiens	Inhibition	>	40.0	%	PMID[24679441]
NPT862	Individual protein	Epoxide hydratase	Homo sapiens	IC50	=	41720.0	nM	PMID[24679441]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	100.0	nM	PMID[17374486]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	35.6	nM	PMID[18260618]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	752.0	nM	PMID[18755586]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	35.0	nM	PMID[18707880]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	Ki	=	18.6	nM	PMID[19243175]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	160.0	nM	PMID[18707880]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	Inhibition	=	80.0	%	PMID[20036535]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	100000.0	nM	PMID[20189404]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	27.8	nM	PMID[20302302]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	108.0	nM	PMID[21128592]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	36.0	nM	PMID[21398124]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	16.0	nM	PMID[22652255]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	38.0	nM	PMID[23062824]
NPT67	Individual protein	Cholinesterase	Equus caballus	Inhibition	=	5.38	%	PMID[23062825]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	16.4	nM	PMID[22889351]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	77.0	nM	PMID[24071445]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	50.32	%	PMID[23571415]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	58.6	nM	PMID[24556379]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	123.0	nM	PMID[27075813]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	67.3	nM	PMID[28098449]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	EC50	=	79.0	nM	PMID[29216560]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	34.6	nM	PMID[32738984]
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	160.0	nM	PMID[31774679]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	3.03	%	DOI[10.6019/CHEMBL4495564]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	0.98	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT641	Individual protein	Sodium/glucose cotransporter 2	Homo sapiens	IC50	=	21.0	nM	PMID[37608596]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-0.7	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT5495	Individual protein	Sodium/glucose cotransporter 1	Rattus norvegicus	IC50	=	350.0	nM	PMID[23062824]
NPT66	Individual protein	Acetylcholinesterase	Electrophorus electricus	Inhibition	=	-6.94	%	PMID[23062825]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	Ki	=	180.0	nM	PMID[10794686]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	200.0	nM	PMID[17374486]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	EC50	=	330.0	nM	PMID[18260618]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	Inhibition	=	30.0	%	PMID[17686765]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	210.0	nM	PMID[19785435]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	Inhibition	=	50.0	%	PMID[20036535]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	200000.0	nM	PMID[20189404]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	246.0	nM	PMID[20302302]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	EC50	=	197.4	nM	PMID[21128592]
NPT443	Individual protein	Histone acetyltransferase GCN5	Homo sapiens	Potency	n.a.	316.2	nM	PubChem BioAssay data set
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	330.0	nM	PMID[21398124]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	190.0	nM	PMID[22652255]
NPT5494	Individual protein	Sodium/glucose cotransporter 2	Rattus norvegicus	IC50	=	96.0	nM	PMID[23062824]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	536.0	nM	PMID[23062824]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	185.0	nM	PMID[22889351]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	EC50	=	120.0	nM	PMID[24071445]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	60.7	nM	PMID[24556379]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	47.73	%	PMID[25913862]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	31.39	%	PMID[25913862]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	45.26	%	PMID[25913862]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	52.7	%	PMID[25913862]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	34.02	%	PMID[25913862]
NPT43	Individual protein	Tyrosinase	Agaricus bisporus	Inhibition	=	9.0	%	PMID[25913862]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	EC50	=	153.0	nM	PMID[27075813]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	499.0	nM	PMID[28098449]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	EC50	=	240.0	nM	PMID[29216560]
NPT640	Individual protein	Sodium/glucose cotransporter 1	Homo sapiens	IC50	=	190.0	nM	PMID[37608596]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	14400.0	nM	PMID[24679441]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	21.5	%	PMID[24679441]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	14600.0	nM	PMID[31747281]
NPT407	Cell line	COLO 205	Homo sapiens	IC50	>	100000.0	nM	PMID[37413981]
NPT393	Cell line	HCT-116	Homo sapiens	IC50	>	100000.0	nM	PMID[37413981]
NPT139	Cell line	HT-29	Homo sapiens	IC50	>	100000.0	nM	PMID[37413981]
NPT1765	Tissue	Intestine	Rattus norvegicus	Inhibition	=	100.0	%	PMID[22209731]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	-0.07	%	DOI[10.6019/CHEMBL4495565]
NPT28438	Unchecked	Unchecked	n.a.	Ratio IC50	=	14.0	n.a.	PMID[37608596]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	n.a.	n.a.	%	PMID[33819035]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	47.0	%	PMID[521818]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	100.0	%	PMID[521818]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	100.0	ug ml-1	PMID[521818]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	30.48	10'-3cpm	PMID[15787442]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	32.42	10'-3cpm	PMID[15787442]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	33.02	10'-3cpm	PMID[15787442]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	35.51	10'-3cpm	PMID[15787442]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	36.14	10'-3cpm	PMID[15787442]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	120.2	umol/L	PMID[23266182]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	166.3	umol/L	PMID[23266182]
NPT1	Others	Radical scavenging activity	n.a.	IC50	=	1488900.0	nM	PMID[23266182]
NPT2	Others	Unspecified	n.a.	Inhibition	=	11.9	%	DOI[10.1016/S0960-894X(97)00102-9]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	10.0	n.a.	PMID[18260618]
NPT2	Others	Unspecified	n.a.	Ratio	=	10.0	n.a.	PMID[19243175]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	5.6	n.a.	PMID[19785435]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	8.8	n.a.	PMID[20302302]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	1.8	n.a.	PMID[21128592]
NPT2	Others	Unspecified	n.a.	IC50	=	17000.0	nM	PMID[18443109]
NPT2	Others	Unspecified	n.a.	IC50	=	340000.0	nM	PMID[18443109]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	12.0	n.a.	PMID[22652255]
NPT2	Others	Unspecified	n.a.	IC50	=	60500.0	nM	PMID[23025417]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.27	n.a.	PMID[23062824]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	0.071	n.a.	PMID[23062824]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	11.0	n.a.	PMID[22889351]
NPT2	Others	Unspecified	n.a.	Inhibition	=	16.56	%	PMID[23266182]
NPT2	Others	Unspecified	n.a.	Inhibition	=	0.0	%	PMID[23266182]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	1.6	n.a.	PMID[24071445]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	1.04	n.a.	PMID[24556379]
NPT2	Others	Unspecified	n.a.	IC50	=	160.0	nM	DOI[10.1039/C2MD20008B]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	1.0	n.a.	PMID[27075813]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	80.0	mg	PMID[19243175]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC259182 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	16850
0.1-0.2	26877
0.2-0.3	4892
0.3-0.4	962
0.4-0.5	229
0.5-0.6	25
0.6-0.7	9
0.7-0.8	0
0.8-0.85	0
0.85-0.9	1
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.8769	High Similarity	NPC257963
0.7941	Intermediate Similarity	NPC106625
0.7424	Intermediate Similarity	NPC121001
0.7286	Intermediate Similarity	NPC127782
0.7231	Intermediate Similarity	NPC199335
0.7121	Intermediate Similarity	NPC190217
0.6986	Remote Similarity	NPC300537
0.6857	Remote Similarity	NPC148273
0.6716	Remote Similarity	NPC477240
0.6667	Remote Similarity	NPC88484
0.6667	Remote Similarity	NPC106025
0.6286	Remote Similarity	NPC479374
0.6145	Remote Similarity	NPC479369
0.6133	Remote Similarity	NPC26195
0.6053	Remote Similarity	NPC6985
0.5946	Remote Similarity	NPC601828
0.5811	Remote Similarity	NPC177742
0.5714	Remote Similarity	NPC39351
0.5658	Remote Similarity	NPC169248
0.5658	Remote Similarity	NPC72649
0.5568	Remote Similarity	NPC168789
0.5556	Remote Similarity	NPC127406
0.5395	Remote Similarity	NPC99233
0.5375	Remote Similarity	NPC181014
0.5316	Remote Similarity	NPC471457
0.5309	Remote Similarity	NPC287294
0.5275	Remote Similarity	NPC479370
0.5205	Remote Similarity	NPC97326
0.519	Remote Similarity	NPC308265
0.519	Remote Similarity	NPC170475
0.5156	Remote Similarity	NPC142319
0.5122	Remote Similarity	NPC472320
0.5119	Remote Similarity	NPC259834
0.5075	Remote Similarity	NPC20560
0.507	Remote Similarity	NPC23084
0.5067	Remote Similarity	NPC610303
0.5063	Remote Similarity	NPC160156
0.5063	Remote Similarity	NPC92565
0.5062	Remote Similarity	NPC206378
0.5052	Remote Similarity	NPC483821

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC259182 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	4141
0.1-0.2	4843
0.2-0.3	146
0.3-0.4	18
0.4-0.5	2
0.5-0.6	0
0.6-0.7	0
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
		NPD

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data