Natural Product: NPC470838

Natural Product ID:  NPC470838
Common Name:   (1R,E)-5-(2-((3R,5Ar,6R,7S,9Ar)-3,7-Dihydroxy-2,2,5A,7-Tetramethyl-Decahydrobenzo[B]Oxepin-6-Yl)Ethyl)-1-Hydroxy-1,4,4-Trimethyl-1,2,3,3A,4,5,8,8A-Octahydroazulene-6-Carbaldehyde
IUPAC Name:   (3R)-7-[2-[(3R,5aR,6R,7S,9aR)-3,7-dihydroxy-2,2,5a,7-tetramethyl-4,5,6,8,9,9a-hexahydro-3H-benzo[b]oxepin-6-yl]ethyl]-3-hydroxy-3,8,8-trimethyl-1,2,3a,4,7,8a-hexahydroazulene-6-carbaldehyde
Synonyms:  
Molecular Formula:   C30H50O5
Standard InCHIKey:  BDNMFPOVAWCGRX-NXHAIPTASA-N
Standard InCHI:  InChI=1S/C30H50O5/c1-26(2)20(19(18-31)8-9-22-21(26)12-16-29(22,6)33)10-11-23-28(5)15-13-24(32)27(3,4)35-25(28)14-17-30(23,7)34/h8,18,20-25,32-34H,9-17H2,1-7H3/t20?,21?,22?,23-,24-,25-,28-,29-,30+/m1/s1
Canonical SMILES:  O=CC1=CCC2C(C(C1CC[C@H]1[C@@](C)(O)CC[C@@H]3[C@]1(C)CC[C@H](C(O3)(C)C)O)(C)C)CC[C@@]2(C)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO26982 Callyspongia siphonella Species Callyspongiidae Eukaryota PMID[17488128]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 > 50000 nM 18811205
NPT2 Others Unspecified IC50 = 2850 nM 9651160
NPT2 Others Unspecified IC50 > 50000 nM 12762819
NPT91 Cell Line KB Homo sapiens IC50 > 50000 nM 20516287
NPT2 Others Unspecified IC50 > 50000 nM 16038548
NPT2 Others Unspecified IC50 = 5 nM 17910513

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC470838 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.875 High Similarity NPC470832
0.8725 High Similarity NPC470839
0.8485 Intermediate Similarity NPC473258
0.8235 Intermediate Similarity NPC470834
0.8095 Intermediate Similarity NPC470840
0.8058 Intermediate Similarity NPC272451
0.8 Intermediate Similarity NPC237190
0.7961 Intermediate Similarity NPC91439
0.7941 Intermediate Similarity NPC111015
0.7925 Intermediate Similarity NPC22388
0.7876 Intermediate Similarity NPC298278
0.787 Intermediate Similarity NPC60315
0.7857 Intermediate Similarity NPC178981
0.7857 Intermediate Similarity NPC317210
0.785 Intermediate Similarity NPC473694
0.785 Intermediate Similarity NPC475623
0.785 Intermediate Similarity NPC475334
0.7788 Intermediate Similarity NPC472400
0.7788 Intermediate Similarity NPC477580
0.7788 Intermediate Similarity NPC326542
0.7778 Intermediate Similarity NPC121518
0.7778 Intermediate Similarity NPC181104
0.7778 Intermediate Similarity NPC103298
0.7778 Intermediate Similarity NPC474550
0.7778 Intermediate Similarity NPC473577
0.7778 Intermediate Similarity NPC288502
0.7778 Intermediate Similarity NPC475331
0.7778 Intermediate Similarity NPC475335
0.7778 Intermediate Similarity NPC201144
0.7778 Intermediate Similarity NPC80809
0.7778 Intermediate Similarity NPC475585
0.7768 Intermediate Similarity NPC234042
0.7768 Intermediate Similarity NPC207251
0.7768 Intermediate Similarity NPC152117
0.7748 Intermediate Similarity NPC6206
0.7748 Intermediate Similarity NPC76084
0.7745 Intermediate Similarity NPC210268
0.7736 Intermediate Similarity NPC154072
0.7727 Intermediate Similarity NPC217201
0.7719 Intermediate Similarity NPC196931
0.7706 Intermediate Similarity NPC260268
0.7706 Intermediate Similarity NPC85829
0.7706 Intermediate Similarity NPC171137
0.7706 Intermediate Similarity NPC150531
0.7706 Intermediate Similarity NPC152695
0.7706 Intermediate Similarity NPC214264
0.7706 Intermediate Similarity NPC296945
0.7706 Intermediate Similarity NPC48733
0.7706 Intermediate Similarity NPC97202
0.7706 Intermediate Similarity NPC49958
0.7706 Intermediate Similarity NPC202167
0.7706 Intermediate Similarity NPC475290
0.7706 Intermediate Similarity NPC476027
0.7706 Intermediate Similarity NPC302607
0.7706 Intermediate Similarity NPC319077
0.7706 Intermediate Similarity NPC50692
0.7699 Intermediate Similarity NPC260665
0.7699 Intermediate Similarity NPC472757
0.7699 Intermediate Similarity NPC962
0.7699 Intermediate Similarity NPC250109
0.7699 Intermediate Similarity NPC194100
0.7677 Intermediate Similarity NPC290731
0.7672 Intermediate Similarity NPC472667
0.7658 Intermediate Similarity NPC11710
0.7658 Intermediate Similarity NPC170221
0.7658 Intermediate Similarity NPC10064
0.7652 Intermediate Similarity NPC156252
0.7647 Intermediate Similarity NPC191684
0.7636 Intermediate Similarity NPC220229
0.7636 Intermediate Similarity NPC475060
0.7636 Intermediate Similarity NPC83744
0.7632 Intermediate Similarity NPC74727
0.7615 Intermediate Similarity NPC204833
0.7615 Intermediate Similarity NPC209502
0.7593 Intermediate Similarity NPC473424
0.7589 Intermediate Similarity NPC197428
0.7586 Intermediate Similarity NPC472758
0.7586 Intermediate Similarity NPC171905
0.7586 Intermediate Similarity NPC472397
0.7586 Intermediate Similarity NPC475372
0.7586 Intermediate Similarity NPC471125
0.7586 Intermediate Similarity NPC146280
0.7586 Intermediate Similarity NPC124676
0.7573 Intermediate Similarity NPC94127
0.757 Intermediate Similarity NPC112167
0.757 Intermediate Similarity NPC167974
0.7568 Intermediate Similarity NPC65941
0.7568 Intermediate Similarity NPC329417
0.7565 Intermediate Similarity NPC266728
0.7565 Intermediate Similarity NPC49492
0.7565 Intermediate Similarity NPC154363
0.7565 Intermediate Similarity NPC190286
0.7565 Intermediate Similarity NPC234858
0.7565 Intermediate Similarity NPC471127
0.7563 Intermediate Similarity NPC129992
0.7547 Intermediate Similarity NPC475032
0.7547 Intermediate Similarity NPC475033
0.7545 Intermediate Similarity NPC149047
0.7545 Intermediate Similarity NPC470980
0.7525 Intermediate Similarity NPC189777
0.7524 Intermediate Similarity NPC472824
0.7524 Intermediate Similarity NPC279974
0.7522 Intermediate Similarity NPC158523
0.7522 Intermediate Similarity NPC475937
0.7521 Intermediate Similarity NPC22628
0.7521 Intermediate Similarity NPC255081
0.7521 Intermediate Similarity NPC475041
0.7521 Intermediate Similarity NPC5991
0.7521 Intermediate Similarity NPC275696
0.7521 Intermediate Similarity NPC312536
0.7521 Intermediate Similarity NPC471108
0.7521 Intermediate Similarity NPC5989
0.75 Intermediate Similarity NPC163004
0.75 Intermediate Similarity NPC470257
0.75 Intermediate Similarity NPC10721
0.75 Intermediate Similarity NPC473656
0.7479 Intermediate Similarity NPC257017
0.7479 Intermediate Similarity NPC162009
0.7478 Intermediate Similarity NPC238667
0.7478 Intermediate Similarity NPC216665
0.7478 Intermediate Similarity NPC178289
0.7477 Intermediate Similarity NPC477916
0.7477 Intermediate Similarity NPC119036
0.7458 Intermediate Similarity NPC472004
0.7458 Intermediate Similarity NPC143755
0.7458 Intermediate Similarity NPC475885
0.7458 Intermediate Similarity NPC79579
0.7458 Intermediate Similarity NPC471128
0.7458 Intermediate Similarity NPC145182
0.7458 Intermediate Similarity NPC157252
0.7458 Intermediate Similarity NPC471126
0.7456 Intermediate Similarity NPC470063
0.7455 Intermediate Similarity NPC149124
0.7455 Intermediate Similarity NPC75531
0.7455 Intermediate Similarity NPC471293
0.7451 Intermediate Similarity NPC476704
0.7451 Intermediate Similarity NPC193360
0.7438 Intermediate Similarity NPC250556
0.7438 Intermediate Similarity NPC469750
0.7436 Intermediate Similarity NPC288679
0.7436 Intermediate Similarity NPC153440
0.7434 Intermediate Similarity NPC179642
0.7434 Intermediate Similarity NPC101450
0.7434 Intermediate Similarity NPC250956
0.7434 Intermediate Similarity NPC153036
0.7434 Intermediate Similarity NPC235077
0.7434 Intermediate Similarity NPC163314
0.7431 Intermediate Similarity NPC470972
0.7431 Intermediate Similarity NPC477915
0.7431 Intermediate Similarity NPC162973
0.7429 Intermediate Similarity NPC67831
0.7429 Intermediate Similarity NPC196485
0.7429 Intermediate Similarity NPC103527
0.7429 Intermediate Similarity NPC174051
0.7429 Intermediate Similarity NPC245972
0.7426 Intermediate Similarity NPC476217
0.7426 Intermediate Similarity NPC232156
0.7426 Intermediate Similarity NPC94755
0.7417 Intermediate Similarity NPC473979
0.7414 Intermediate Similarity NPC469794
0.7414 Intermediate Similarity NPC470793
0.7414 Intermediate Similarity NPC138372
0.7414 Intermediate Similarity NPC106228
0.7414 Intermediate Similarity NPC72772
0.7411 Intermediate Similarity NPC258323
0.7411 Intermediate Similarity NPC306265
0.7411 Intermediate Similarity NPC88701
0.7411 Intermediate Similarity NPC472217
0.7411 Intermediate Similarity NPC472219
0.7411 Intermediate Similarity NPC472825
0.7411 Intermediate Similarity NPC177064
0.7411 Intermediate Similarity NPC472218
0.7407 Intermediate Similarity NPC470074
0.7407 Intermediate Similarity NPC144956
0.7407 Intermediate Similarity NPC83709
0.7404 Intermediate Similarity NPC155304
0.7395 Intermediate Similarity NPC46570
0.7395 Intermediate Similarity NPC472401
0.7395 Intermediate Similarity NPC52839
0.7395 Intermediate Similarity NPC310511
0.7391 Intermediate Similarity NPC477944
0.7391 Intermediate Similarity NPC108721
0.7391 Intermediate Similarity NPC71889
0.7391 Intermediate Similarity NPC73300
0.7387 Intermediate Similarity NPC96377
0.7387 Intermediate Similarity NPC278628
0.7387 Intermediate Similarity NPC469874
0.7387 Intermediate Similarity NPC470309
0.7387 Intermediate Similarity NPC231530
0.7383 Intermediate Similarity NPC18509
0.7383 Intermediate Similarity NPC108078
0.7383 Intermediate Similarity NPC190554
0.7379 Intermediate Similarity NPC97103
0.7379 Intermediate Similarity NPC472983
0.7379 Intermediate Similarity NPC115607
0.7379 Intermediate Similarity NPC32830
0.7377 Intermediate Similarity NPC179412
0.7377 Intermediate Similarity NPC471356
0.7373 Intermediate Similarity NPC5292
0.7373 Intermediate Similarity NPC473203

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC470838 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7699 Intermediate Similarity NPD4632 Approved
0.75 Intermediate Similarity NPD4202 Approved
0.7477 Intermediate Similarity NPD6412 Phase 2
0.7458 Intermediate Similarity NPD6054 Approved
0.7458 Intermediate Similarity NPD6319 Approved
0.7456 Intermediate Similarity NPD8297 Approved
0.7438 Intermediate Similarity NPD7507 Approved
0.7434 Intermediate Similarity NPD4634 Approved
0.7411 Intermediate Similarity NPD6881 Approved
0.7411 Intermediate Similarity NPD6899 Approved
0.7407 Intermediate Similarity NPD5286 Approved
0.7407 Intermediate Similarity NPD4696 Approved
0.7407 Intermediate Similarity NPD5285 Approved
0.7387 Intermediate Similarity NPD7128 Approved
0.7387 Intermediate Similarity NPD6675 Approved
0.7387 Intermediate Similarity NPD6402 Approved
0.7387 Intermediate Similarity NPD5739 Approved
0.7383 Intermediate Similarity NPD4755 Approved
0.735 Intermediate Similarity NPD6009 Approved
0.7339 Intermediate Similarity NPD5223 Approved
0.7333 Intermediate Similarity NPD6370 Approved
0.7321 Intermediate Similarity NPD5697 Approved
0.7315 Intermediate Similarity NPD7638 Approved
0.7311 Intermediate Similarity NPD6059 Approved
0.7281 Intermediate Similarity NPD7102 Approved
0.7281 Intermediate Similarity NPD6371 Approved
0.7281 Intermediate Similarity NPD6883 Approved
0.7281 Intermediate Similarity NPD7290 Approved
0.7273 Intermediate Similarity NPD4633 Approved
0.7273 Intermediate Similarity NPD5225 Approved
0.7273 Intermediate Similarity NPD5226 Approved
0.7273 Intermediate Similarity NPD5224 Approved
0.7273 Intermediate Similarity NPD5211 Phase 2
0.7273 Intermediate Similarity NPD7604 Phase 2
0.7258 Intermediate Similarity NPD7319 Approved
0.7257 Intermediate Similarity NPD7320 Approved
0.7257 Intermediate Similarity NPD6011 Approved
0.725 Intermediate Similarity NPD6015 Approved
0.725 Intermediate Similarity NPD5983 Phase 2
0.725 Intermediate Similarity NPD6016 Approved
0.7248 Intermediate Similarity NPD7639 Approved
0.7248 Intermediate Similarity NPD4700 Approved
0.7248 Intermediate Similarity NPD7640 Approved
0.7238 Intermediate Similarity NPD6079 Approved
0.7217 Intermediate Similarity NPD8130 Phase 1
0.7217 Intermediate Similarity NPD6617 Approved
0.7217 Intermediate Similarity NPD6869 Approved
0.7217 Intermediate Similarity NPD6650 Approved
0.7217 Intermediate Similarity NPD6847 Approved
0.7217 Intermediate Similarity NPD6649 Approved
0.7213 Intermediate Similarity NPD7492 Approved
0.7212 Intermediate Similarity NPD5328 Approved
0.7207 Intermediate Similarity NPD5174 Approved
0.7207 Intermediate Similarity NPD5175 Approved
0.7193 Intermediate Similarity NPD6372 Approved
0.7193 Intermediate Similarity NPD6014 Approved
0.7193 Intermediate Similarity NPD6012 Approved
0.7193 Intermediate Similarity NPD6013 Approved
0.7193 Intermediate Similarity NPD6373 Approved
0.719 Intermediate Similarity NPD5988 Approved
0.7168 Intermediate Similarity NPD5701 Approved
0.7155 Intermediate Similarity NPD6882 Approved
0.7154 Intermediate Similarity NPD6336 Discontinued
0.7154 Intermediate Similarity NPD6616 Approved
0.7143 Intermediate Similarity NPD5141 Approved
0.713 Intermediate Similarity NPD4697 Phase 3
0.7097 Intermediate Similarity NPD7078 Approved
0.7087 Intermediate Similarity NPD3618 Phase 1
0.708 Intermediate Similarity NPD6008 Approved
0.7069 Intermediate Similarity NPD6401 Clinical (unspecified phase)
0.7064 Intermediate Similarity NPD6084 Phase 2
0.7064 Intermediate Similarity NPD6083 Phase 2
0.7059 Intermediate Similarity NPD3665 Phase 1
0.7059 Intermediate Similarity NPD3666 Approved
0.7059 Intermediate Similarity NPD3133 Approved
0.7054 Intermediate Similarity NPD4754 Approved
0.7048 Intermediate Similarity NPD4753 Phase 2
0.704 Intermediate Similarity NPD7736 Approved
0.7 Intermediate Similarity NPD7328 Approved
0.7 Intermediate Similarity NPD7327 Approved
0.6972 Remote Similarity NPD5222 Approved
0.6972 Remote Similarity NPD5221 Approved
0.6972 Remote Similarity NPD5220 Clinical (unspecified phase)
0.696 Remote Similarity NPD8293 Discontinued
0.6957 Remote Similarity NPD5128 Approved
0.6957 Remote Similarity NPD6686 Approved
0.6957 Remote Similarity NPD4730 Approved
0.6957 Remote Similarity NPD4729 Approved
0.6942 Remote Similarity NPD7516 Approved
0.693 Remote Similarity NPD4768 Approved
0.693 Remote Similarity NPD4767 Approved
0.6917 Remote Similarity NPD7115 Discovery
0.6909 Remote Similarity NPD5173 Approved
0.6905 Remote Similarity NPD6033 Approved
0.6897 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6893 Remote Similarity NPD4786 Approved
0.6881 Remote Similarity NPD5695 Phase 3
0.6881 Remote Similarity NPD4629 Approved
0.6881 Remote Similarity NPD5210 Approved
0.6864 Remote Similarity NPD6053 Discontinued
0.6863 Remote Similarity NPD4221 Approved
0.6863 Remote Similarity NPD4223 Phase 3
0.686 Remote Similarity NPD6335 Approved
0.6855 Remote Similarity NPD6067 Discontinued
0.6852 Remote Similarity NPD6399 Phase 3
0.6838 Remote Similarity NPD5250 Approved
0.6838 Remote Similarity NPD5249 Phase 3
0.6838 Remote Similarity NPD5134 Clinical (unspecified phase)
0.6838 Remote Similarity NPD5251 Approved
0.6838 Remote Similarity NPD5247 Approved
0.6838 Remote Similarity NPD5135 Approved
0.6838 Remote Similarity NPD5169 Approved
0.6838 Remote Similarity NPD5248 Approved
0.6833 Remote Similarity NPD6274 Approved
0.6832 Remote Similarity NPD7525 Registered
0.6827 Remote Similarity NPD5329 Approved
0.6803 Remote Similarity NPD7101 Approved
0.6803 Remote Similarity NPD7100 Approved
0.6796 Remote Similarity NPD4788 Approved
0.678 Remote Similarity NPD5215 Approved
0.678 Remote Similarity NPD5216 Approved
0.678 Remote Similarity NPD5217 Approved
0.678 Remote Similarity NPD5127 Approved
0.6777 Remote Similarity NPD6317 Approved
0.6762 Remote Similarity NPD5279 Phase 3
0.6762 Remote Similarity NPD6684 Approved
0.6762 Remote Similarity NPD7334 Approved
0.6762 Remote Similarity NPD3574 Clinical (unspecified phase)
0.6762 Remote Similarity NPD7146 Approved
0.6762 Remote Similarity NPD6409 Approved
0.6762 Remote Similarity NPD5330 Approved
0.6762 Remote Similarity NPD7521 Approved
0.6762 Remote Similarity NPD5690 Phase 2
0.6748 Remote Similarity NPD8377 Approved
0.6748 Remote Similarity NPD8294 Approved
0.6731 Remote Similarity NPD4197 Approved
0.6727 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6726 Remote Similarity NPD5344 Discontinued
0.6724 Remote Similarity NPD7899 Clinical (unspecified phase)
0.6721 Remote Similarity NPD6313 Approved
0.6721 Remote Similarity NPD6314 Approved
0.6699 Remote Similarity NPD3667 Approved
0.6698 Remote Similarity NPD7524 Approved
0.6696 Remote Similarity NPD5696 Approved
0.6696 Remote Similarity NPD4225 Approved
0.6694 Remote Similarity NPD8335 Approved
0.6694 Remote Similarity NPD7503 Approved
0.6694 Remote Similarity NPD8033 Approved
0.6694 Remote Similarity NPD8379 Approved
0.6694 Remote Similarity NPD8380 Approved
0.6694 Remote Similarity NPD8296 Approved
0.6694 Remote Similarity NPD8378 Approved
0.6667 Remote Similarity NPD7632 Discontinued
0.6636 Remote Similarity NPD6903 Approved
0.6636 Remote Similarity NPD7748 Approved
0.6636 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6612 Remote Similarity NPD5167 Approved
0.6607 Remote Similarity NPD7902 Approved
0.6606 Remote Similarity NPD8035 Phase 2
0.6606 Remote Similarity NPD8034 Phase 2
0.6606 Remote Similarity NPD5281 Approved
0.6606 Remote Similarity NPD7515 Phase 2
0.6606 Remote Similarity NPD5284 Approved
0.6604 Remote Similarity NPD4693 Phase 3
0.6604 Remote Similarity NPD4138 Approved
0.6604 Remote Similarity NPD4694 Approved
0.6604 Remote Similarity NPD4689 Approved
0.6604 Remote Similarity NPD4688 Approved
0.6604 Remote Similarity NPD5205 Approved
0.6604 Remote Similarity NPD5280 Approved
0.6604 Remote Similarity NPD4690 Approved
0.6574 Remote Similarity NPD6904 Approved
0.6574 Remote Similarity NPD6673 Approved
0.6574 Remote Similarity NPD6080 Approved
0.6571 Remote Similarity NPD7338 Clinical (unspecified phase)
0.656 Remote Similarity NPD6908 Approved
0.656 Remote Similarity NPD6909 Approved
0.656 Remote Similarity NPD6291 Clinical (unspecified phase)
0.6555 Remote Similarity NPD5955 Clinical (unspecified phase)
0.6532 Remote Similarity NPD4522 Approved
0.6529 Remote Similarity NPD8133 Approved
0.6514 Remote Similarity NPD6698 Approved
0.6514 Remote Similarity NPD46 Approved
0.6509 Remote Similarity NPD7520 Clinical (unspecified phase)
0.6486 Remote Similarity NPD5282 Discontinued
0.6481 Remote Similarity NPD6672 Approved
0.6481 Remote Similarity NPD5737 Approved
0.6476 Remote Similarity NPD6695 Phase 3
0.6455 Remote Similarity NPD6050 Approved
0.6436 Remote Similarity NPD6933 Approved
0.6423 Remote Similarity NPD6868 Approved
0.6412 Remote Similarity NPD5956 Approved
0.6408 Remote Similarity NPD4195 Approved
0.6387 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6387 Remote Similarity NPD5168 Approved
0.6381 Remote Similarity NPD6435 Approved
0.6364 Remote Similarity NPD5785 Approved
0.6364 Remote Similarity NPD5692 Phase 3
0.6364 Remote Similarity NPD4096 Approved
0.6348 Remote Similarity NPD6648 Approved

Structure

External Identifiers

PubChem CID   16736856
ChEMBL   CHEMBL226197
ZINC  

Physicochemical Properties

Molecular Weight:  490.37
ALogP:  0.8549
MLogP:  4.21
XLogP:  5.1
# Rotatable Bonds:  14
Polar Surface Area:  86.99
# H-Bond Aceptor:  5
# H-Bond Donor:  3
# Rings:  4
# Heavy Atoms:  35

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs