Natural Product: NPC176381

Natural Product ID:  NPC176381
Common Name:   Neomycin
IUPAC Name:   (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Synonyms:   Neomycin
Molecular Formula:   C23H46N6O13
Standard InCHIKey:  PGBHMTALBVVCIT-VCIWKGPPSA-N
Standard InCHI:  InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
Canonical SMILES:  OC[C@H]1O[C@H]([C@@H]([C@@H]1O[C@H]1O[C@@H](CN)[C@H]([C@@H]([C@H]1N)O)O)O)O[C@@H]1[C@@H](O)[C@H](N)C[C@@H]([C@H]1O[C@H]1O[C@H](CN)[C@H]([C@@H]([C@H]1N)O)O)N
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   BGC0000709;BGC0000710;BGC0000711 ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO5029 Streptomyces marinensis Species Streptomycetaceae Bacteria StreptomeDB*
NPO24126.20 Streptomyces albus var. metamycinus Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO18220 Streptomyces lividus Species Streptomycetaceae Bacteria StreptomeDB*
NPO24176 Streptomyces fradiae Species Streptomycetaceae Bacteria StreptomeDB*
NPO24176.21 Streptomyces fradiae ncimb 8233 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.7 Streptomyces fradiae 75-078 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.6 Streptomyces fradiae 676 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO4890.9 Streptomyces rimosus forma paromomycinus Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.5 Streptomyces fradiae 3535 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.9 Streptomyces fradiae 918 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.17 Streptomyces fradiae isp 5063 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO21999 Streptomyces faradae Species Streptomycetaceae Bacteria StreptomeDB*
NPO4890 Streptomyces rimosus Species Streptomycetaceae Bacteria StreptomeDB*
NPO22810 Streptomyces Species Streptomycetaceae Bacteria StreptomeDB*
NPO27507.1 Streptomyces ribosidificus atcc 21294 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO22678 Streptomyces albogriseus Species Streptomycetaceae Bacteria StreptomeDB*
NPO24176.12 Streptomyces fradiae atcc 10745 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO24176.20 Streptomyces fradiae ncim 2418 Subspecies Streptomycetaceae Bacteria StreptomeDB*
NPO11943.6 Streptomyces albogriseolus nov. sp. Subspecies Streptomycetaceae Bacteria StreptomeDB*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT317 Uncleic Acid Nucleic Acid MIC = 1000 nM 9457241
NPT317 Uncleic Acid Nucleic Acid Kd = 410 nM 11814798
NPT317 Uncleic Acid Nucleic Acid Kd = 380 nM 11814798
NPT317 Uncleic Acid Nucleic Acid Kd = 4340 nM 11814798
NPT317 Uncleic Acid Nucleic Acid Kd = 470 nM 11814798
NPT317 Uncleic Acid Nucleic Acid Kd = 91 nM 11814798
NPT2 Others Unspecified Ki = 13500 nM 10021931
NPT4977 Individual Protein Human immunodeficiency virus type 1 REV Human immunodeficiency virus 1 Kd = 180 nM 11354359
NPT4978 Individual Protein Phosphatidylcholine-retinol O-acyltransferase Homo sapiens IC50 = 14900 nM 12617917
NPT317 Uncleic Acid Nucleic Acid IC50 = 920 nM 10.1016/0960-894X(95)00467-8
NPT317 Uncleic Acid Nucleic Acid Kd = 440 nM 10915059
NPT317 Uncleic Acid Nucleic Acid Kd = 380 nM 10915059
NPT2 Others Unspecified Kd = 140 nM 12127547
NPT2 Others Unspecified Kd = 120 nM 12127547
NPT2 Others Unspecified Kd = 160 nM 12127547
NPT2 Others Unspecified Kd = 3970 nM 12127547
NPT2 Others Unspecified Kd = 350 nM 11677142
NPT2 Others Unspecified IC50 = 50 nM 12643896
NPT2 Others Unspecified Inhibition = 76 % 12643896
NPT2 Others Unspecified IC50 = 9 nM 12643896
NPT2 Others Unspecified Inhibition = 100 % 12643896
NPT4383 Uncleic Acid Ribosomal RNA A-site Kd = 19 nM 11206440
NPT19 Organism Escherichia coli Escherichia coli MIC = 2000 nM 15357959
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 3000 nM 15357959
NPT4383 Uncleic Acid Ribosomal RNA A-site Activity = -474.3 15357959
NPT79 Organism Bacillus subtilis Bacillus subtilis Kd = 8500 nM 15808490
NPT2 Others Unspecified IC50 = 7000 nM 16153833
NPT2 Others Unspecified IC50 = 35000 nM 16153833
NPT150 Individual Protein Anthrax lethal factor Bacillus anthracis Ki = 500 nM 16870442
NPT4979 Uncleic Acid Rev responsive element (RRE) RNA Kd = 180 nM 16875816
NPT4979 Uncleic Acid Rev responsive element (RRE) RNA Kd = 370 nM 16875816
NPT4979 Uncleic Acid Rev responsive element (RRE) RNA Ratio = 2.1 16875816
NPT19 Organism Escherichia coli Escherichia coli IZ = 15 mm 17149863
NPT19 Organism Escherichia coli Escherichia coli IZ = 18 mm 17149863
NPT19 Organism Escherichia coli Escherichia coli IZ = 12 mm 17149863
NPT19 Organism Escherichia coli Escherichia coli MIC = 0.5 ug/ml 17088477
NPT19 Organism Escherichia coli Escherichia coli MIC = 64 ug/ml 17088477
NPT1521 Organism Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC = 512 ug/ml 17088477
NPT1521 Organism Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC = 64 ug/ml 17088477
NPT2 Others Unspecified MIC = 250 ug/ml 17060530
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC = 250 ug/ml 17060530
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC = 125 ug/ml 17060530
NPT2901 Organism Bifidobacterium thermophilum Bifidobacterium thermophilum MIC = 250 ug/ml 17060530
NPT2 Others Unspecified MIC = 125 ug/ml 17060530
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC = 500 ug/ml 17060530
NPT2 Others Unspecified MIC = 62.5 ug/ml 17060530
NPT2 Others Unspecified MIC = 500 ug/ml 17060530
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC = 62.5 ug/ml 17060530
NPT2901 Organism Bifidobacterium thermophilum Bifidobacterium thermophilum MIC = 125 ug/ml 17060530
NPT2901 Organism Bifidobacterium thermophilum Bifidobacterium thermophilum MIC = 500 ug/ml 17060530
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 128 ug/ml 17088479
NPT19 Organism Escherichia coli Escherichia coli MIC = 12 ug/ml 17088479
NPT19 Organism Escherichia coli Escherichia coli MIC = 96 ug/ml 17088479
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 17158944
NPT19 Organism Escherichia coli Escherichia coli MIC = 0.12 ug/ml 17158944
NPT938 Organism Cavia porcellus Cavia porcellus Activity = 0 % 17416529
NPT938 Organism Cavia porcellus Cavia porcellus Activity = 100 % 17416529
NPT938 Organism Cavia porcellus Cavia porcellus Activity = 50 % 17416529
NPT2 Others Unspecified Kd = 308 nM 17869523
NPT2 Others Unspecified Kd = 313 nM 17869523
NPT2 Others Unspecified Kd = 320 nM 17869523
NPT2 Others Unspecified Kd = 6300 nM 17869523
NPT2 Others Unspecified Kd = 2300 nM 17869523
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 17870543
NPT19 Organism Escherichia coli Escherichia coli MIC >= 32 ug/ml 17870543
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC >= 32 ug/ml 17870543
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 16 ug/ml 17870543
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 8 ug/ml 17870543
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 0.5 ug/ml 17870543
NPT16 Organism Staphylococcus aureus Staphylococcus aureus IZ = 9 mm 11520215
NPT2 Others Unspecified Kd = 8000 nM 18329274
NPT19 Organism Escherichia coli Escherichia coli MIC = 384 ug/ml 19301822
NPT19 Organism Escherichia coli Escherichia coli MIC = 96 ug/ml 19301822
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 1.5 ug/ml 19301822
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 384 ug/ml 19301822
NPT19 Organism Escherichia coli Escherichia coli MIC = 6 ug/ml 19301822
NPT19 Organism Escherichia coli Escherichia coli MIC > 384 ug/ml 19301822
NPT19 Organism Escherichia coli Escherichia coli Ratio > 64 19301822
NPT19 Organism Escherichia coli Escherichia coli Ratio = 16 19301822
NPT19 Organism Escherichia coli Escherichia coli MIC = 48 ug/ml 19301822
NPT19 Organism Escherichia coli Escherichia coli Ratio = 8 19301822
NPT19 Organism Escherichia coli Escherichia coli IC50 = 10500 nM 19301822
NPT19 Organism Escherichia coli Escherichia coli MIC = 24 ug/ml 19301822
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 2 ug/ml 18778047
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 256 ug/ml 18778047
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC = 1 ug/ml 18778047
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC = 0.5 ug/ml 18778047
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 64 ug/ml 18778047
NPT19 Organism Escherichia coli Escherichia coli MIC = 8 ug/ml 18778047
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 18778047
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 512 ug/ml 18778047
NPT20 Organism Candida albicans Candida albicans MIC >= 512 ug/ml 18778047
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 19012394
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 19012394
NPT19 Organism Escherichia coli Escherichia coli MIC >= 2000 ug/ml 19012394
NPT19 Organism Escherichia coli Escherichia coli MIC = 64 ug/ml 19012394
NPT19 Organism Escherichia coli Escherichia coli MIC = 8 ug/ml 19012394
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 4 ug/ml 19012394
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 16 ug/ml 19012394
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 125 ug/ml 19012394
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 19012394
NPT175 Organism Enterococcus faecalis Enterococcus faecalis MIC = 64 ug/ml 19012394
NPT175 Organism Enterococcus faecalis Enterococcus faecalis MIC >= 250 ug/ml 19012394
NPT2 Others Unspecified IC50 = 11000 nM 18588282
NPT317 Uncleic Acid Nucleic Acid Kd = 60 nM 19445516
NPT19 Organism Escherichia coli Escherichia coli MIC > 256 ug/ml 17875999
NPT19 Organism Escherichia coli Escherichia coli MIC = 64 ug/ml 17875999
NPT19 Organism Escherichia coli Escherichia coli MIC = 0.13 ug/ml 17875999
NPT19 Organism Escherichia coli Escherichia coli MIC = 0.25 ug/ml 17875999
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae IC50 = 0.6 ug/ml 19655779
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 2 ug/ml 20000576
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 20000576
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 128 ug/ml 20000576
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 32 ug/ml 20000576
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 128 ug/ml 20000576
NPT2898 Organism Acinetobacter lwoffii Acinetobacter lwoffii MIC = 0.5 ug/ml 20000576
NPT2898 Organism Acinetobacter lwoffii Acinetobacter lwoffii MIC > 128 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 128 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 32 ug/ml 20000576
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 16 ug/ml 20000576
NPT19 Organism Escherichia coli Escherichia coli MIC = 2 ug/ml 20000576
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 20000576
NPT19 Organism Escherichia coli Escherichia coli MIC = 32 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition = 40 % 20000576
NPT317 Uncleic Acid Nucleic Acid Kd = 1550 nM 20000576
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 MIC = 4 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 8 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 4 ug/ml 20000576
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 2 ug/ml 20000576
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 20133139
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 20133139
NPT605 Organism Homo sapiens Homo sapiens Activity = 0 % 20022146
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 1 ug/ml 20373816
NPT747 Organism Acinetobacter baumannii Acinetobacter baumannii MIC = 64 ug/ml 20373816
NPT1521 Organism Stenotrophomonas maltophilia Stenotrophomonas maltophilia MIC > 512 ug/ml 20373816
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 512 ug/ml 20373816
NPT19 Organism Escherichia coli Escherichia coli MIC = 8 ug/ml 20373816
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 20373816
NPT1118 Organism Streptococcus pneumoniae Streptococcus pneumoniae MIC = 32 ug/ml 20373816
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC = 0.5 ug/ml 20373816
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC = 0.25 ug/ml 20373816
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 256 ug/ml 20373816
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 20373816
NPT35 Others n.a. Kd = 2600 nM 20672840
NPT317 Uncleic Acid Nucleic Acid Activity = 10 % 19946275
NPT317 Uncleic Acid Nucleic Acid Activity = 6 % 19946275
NPT317 Uncleic Acid Nucleic Acid FC = 1.5 19946275
NPT317 Uncleic Acid Nucleic Acid FC = 3 19946275
NPT317 Uncleic Acid Nucleic Acid Activity = 70.3 % 19946275
NPT317 Uncleic Acid Nucleic Acid Activity = 52 % 19946275
NPT317 Uncleic Acid Nucleic Acid Activity = 0.31 /s 19946275
NPT317 Uncleic Acid Nucleic Acid Activity = 0.06 /s 19946275
NPT2905 Organism Nocardia farcinica Nocardia farcinica MIC > 1024 ug/ml 20308368
NPT2905 Organism Nocardia farcinica Nocardia farcinica MIC = 16 ug/ml 20308368
NPT4981 Organism Clostridium sordellii Clostridium sordellii MIC90 = 1024 ug/ml 18955526
NPT2 Others Unspecified MIC90 = 1024 ug/ml 18955526
NPT1824 Organism Clostridium sporogenes Clostridium sporogenes MIC90 = 1024 ug/ml 18955526
NPT4835 Organism Clostridium tertium Clostridium tertium MIC90 = 1024 ug/ml 18955526
NPT4831 Organism Actinomyces meyeri Actinomyces meyeri MIC90 = 1024 ug/ml 18955526
NPT1129 Organism Actinomyces viscosus Actinomyces viscosus MIC90 = 1024 ug/ml 18955526
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC90 = 1024 ug/ml 18955526
NPT4982 Organism Collinsella aerofaciens Collinsella aerofaciens MIC90 = 1024 ug/ml 18955526
NPT4836 Organism Eggerthella lenta Eggerthella lenta MIC90 = 1024 ug/ml 18955526
NPT4983 Organism Eubacterium limosum Eubacterium limosum MIC90 = 1024 ug/ml 18955526
NPT4128 Organism Lactobacillus fermentum Lactobacillus fermentum MIC90 = 1024 ug/ml 18955526
NPT1825 Organism Lactobacillus plantarum Lactobacillus plantarum MIC90 = 1024 ug/ml 18955526
NPT3593 Organism Lactobacillus sp. Lactobacillus sp. MIC90 = 1024 ug/ml 18955526
NPT167 Organism Propionibacterium acnes Propionibacterium acnes MIC90 = 1024 ug/ml 18955526
NPT4819 Organism Anaerococcus prevotii Anaerococcus prevotii MIC90 = 512 ug/ml 18955526
NPT4984 Organism Anaerococcus tetradius Anaerococcus tetradius MIC90 = 512 ug/ml 18955526
NPT4817 Organism Finegoldia magna Finegoldia magna MIC90 = 512 ug/ml 18955526
NPT4818 Organism Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC90 = 512 ug/ml 18955526
NPT2 Others Unspecified MIC90 = 512 ug/ml 18955526
NPT4821 Organism Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC90 = 512 ug/ml 18955526
NPT4820 Organism Peptostreptococcus micros Parvimonas micra MIC90 = 512 ug/ml 18955526
NPT2 Others Unspecified MIC = 4 ug/ml 18955526
NPT2 Others Unspecified MIC = 128 ug/ml 18955526
NPT4985 Organism Clostridium acetobutylicum Clostridium acetobutylicum MIC = 1 ug/ml 18955526
NPT2 Others Unspecified MIC = 1 ug/ml 18955526
NPT4986 Organism Clostridium bifermentans Clostridium bifermentans MIC = 1 ug/ml 18955526
NPT4987 Organism Clostridium butyricum Clostridium butyricum MIC = 1 ug/ml 18955526
NPT4988 Organism Clostridium cadaveris Clostridium cadaveris MIC = 1 ug/ml 18955526
NPT4833 Organism Clostridium paraputrificum Clostridium paraputrificum MIC = 1 ug/ml 18955526
NPT4989 Organism Clostridium ramosum Clostridium ramosum MIC = 1 ug/ml 18955526
NPT4834 Organism Clostridium septicum Clostridium septicum MIC = 1 ug/ml 18955526
NPT4981 Organism Clostridium sordellii Clostridium sordellii MIC = 1 ug/ml 18955526
NPT1824 Organism Clostridium sporogenes Clostridium sporogenes MIC = 1 ug/ml 18955526
NPT4835 Organism Clostridium tertium Clostridium tertium MIC = 1 ug/ml 18955526
NPT4831 Organism Actinomyces meyeri Actinomyces meyeri MIC = 2 ug/ml 18955526
NPT2 Others Unspecified MIC = 2 ug/ml 18955526
NPT1129 Organism Actinomyces viscosus Actinomyces viscosus MIC = 2 ug/ml 18955526
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC = 2 ug/ml 18955526
NPT4982 Organism Collinsella aerofaciens Collinsella aerofaciens MIC = 2 ug/ml 18955526
NPT4836 Organism Eggerthella lenta Eggerthella lenta MIC = 2 ug/ml 18955526
NPT4983 Organism Eubacterium limosum Eubacterium limosum MIC = 2 ug/ml 18955526
NPT4128 Organism Lactobacillus fermentum Lactobacillus fermentum MIC = 2 ug/ml 18955526
NPT1825 Organism Lactobacillus plantarum Lactobacillus plantarum MIC = 2 ug/ml 18955526
NPT3593 Organism Lactobacillus sp. Lactobacillus sp. MIC = 2 ug/ml 18955526
NPT167 Organism Propionibacterium acnes Propionibacterium acnes MIC = 2 ug/ml 18955526
NPT4819 Organism Anaerococcus prevotii Anaerococcus prevotii MIC = 2 ug/ml 18955526
NPT4984 Organism Anaerococcus tetradius Anaerococcus tetradius MIC = 2 ug/ml 18955526
NPT4817 Organism Finegoldia magna Finegoldia magna MIC = 2 ug/ml 18955526
NPT4818 Organism Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC = 2 ug/ml 18955526
NPT4821 Organism Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC = 2 ug/ml 18955526
NPT4820 Organism Peptostreptococcus micros Parvimonas micra MIC = 2 ug/ml 18955526
NPT1092 Organism Bacteroides fragilis Bacteroides fragilis MIC50 > 1024 ug/ml 18955526
NPT4810 Organism Bacteroides distasonis Parabacteroides distasonis MIC50 = 1024 ug/ml 18955526
NPT4812 Organism Parabacteroides merdae Parabacteroides merdae MIC50 = 1024 ug/ml 18955526
NPT2 Others Unspecified MIC50 = 1024 ug/ml 18955526
NPT4811 Organism Bacteroides ovatus Bacteroides ovatus MIC50 > 1024 ug/ml 18955526
NPT3572 Organism Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC50 > 1024 ug/ml 18955526
NPT1092 Organism Bacteroides fragilis Bacteroides fragilis MIC90 > 1024 ug/ml 18955526
NPT4810 Organism Bacteroides distasonis Parabacteroides distasonis MIC90 > 1024 ug/ml 18955526
NPT4810 Organism Bacteroides distasonis Parabacteroides distasonis MIC = 512 ug/ml 18955526
NPT4812 Organism Parabacteroides merdae Parabacteroides merdae MIC90 > 1024 ug/ml 18955526
NPT4812 Organism Parabacteroides merdae Parabacteroides merdae MIC = 512 ug/ml 18955526
NPT2 Others Unspecified MIC90 > 1024 ug/ml 18955526
NPT2 Others Unspecified MIC = 512 ug/ml 18955526
NPT4811 Organism Bacteroides ovatus Bacteroides ovatus MIC90 > 1024 ug/ml 18955526
NPT3572 Organism Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron MIC90 > 1024 ug/ml 18955526
NPT4809 Organism Bacteroides caccae Bacteroides caccae MIC50 > 1024 ug/ml 18955526
NPT2 Others Unspecified MIC50 > 1024 ug/ml 18955526
NPT4813 Organism Bacteroides stercoris Bacteroides stercoris MIC50 > 1024 ug/ml 18955526
NPT4807 Organism Bacteroides uniformis Bacteroides uniformis MIC50 > 1024 ug/ml 18955526
NPT4809 Organism Bacteroides caccae Bacteroides caccae MIC90 > 1024 ug/ml 18955526
NPT4813 Organism Bacteroides stercoris Bacteroides stercoris MIC90 > 1024 ug/ml 18955526
NPT4807 Organism Bacteroides uniformis Bacteroides uniformis MIC90 > 1024 ug/ml 18955526
NPT2 Others Unspecified MIC > 1024 ug/ml 18955526
NPT2 Others Unspecified MIC50 = 256 ug/ml 18955526
NPT1484 Organism Fusobacterium nucleatum Fusobacterium nucleatum MIC50 = 1024 ug/ml 18955526
NPT4825 Organism Fusobacterium mortiferum Fusobacterium mortiferum MIC50 = 512 ug/ml 18955526
NPT4828 Organism Fusobacterium necrophorum Fusobacterium necrophorum MIC50 = 512 ug/ml 18955526
NPT4826 Organism Fusobacterium varium Fusobacterium varium MIC50 = 512 ug/ml 18955526
NPT4990 Organism Fusobacterium sp. Fusobacterium sp. MIC50 = 512 ug/ml 18955526
NPT2 Others Unspecified MIC50 = 512 ug/ml 18955526
NPT4827 Organism Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC50 = 512 ug/ml 18955526
NPT4991 Organism Porphyromonas somerae Porphyromonas somerae MIC50 = 512 ug/ml 18955526
NPT4824 Organism Prevotella bivia Prevotella bivia MIC50 = 512 ug/ml 18955526
NPT4992 Organism Prevotella corporis Prevotella corporis MIC50 = 512 ug/ml 18955526
NPT4993 Organism Prevotella disiens Prevotella disiens MIC50 = 512 ug/ml 18955526
NPT1128 Organism Prevotella intermedia Prevotella intermedia MIC50 = 512 ug/ml 18955526
NPT4429 Organism Prevotella loescheii Prevotella loescheii MIC50 = 512 ug/ml 18955526
NPT4829 Organism Prevotella melaninogenica Prevotella melaninogenica MIC50 = 512 ug/ml 18955526
NPT4994 Organism Clostridium clostridioforme Clostridium clostridioforme MIC50 = 128 ug/ml 18955526
NPT2940 Organism Clostridium difficile Clostridium difficile MIC50 = 256 ug/ml 18955526
NPT1484 Organism Fusobacterium nucleatum Fusobacterium nucleatum MIC90 = 1024 ug/ml 18955526
NPT4825 Organism Fusobacterium mortiferum Fusobacterium mortiferum MIC90 > 1024 ug/ml 18955526
NPT4828 Organism Fusobacterium necrophorum Fusobacterium necrophorum MIC90 > 1024 ug/ml 18955526
NPT4826 Organism Fusobacterium varium Fusobacterium varium MIC90 > 1024 ug/ml 18955526
NPT4990 Organism Fusobacterium sp. Fusobacterium sp. MIC90 > 1024 ug/ml 18955526
NPT4827 Organism Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC90 > 1024 ug/ml 18955526
NPT4991 Organism Porphyromonas somerae Porphyromonas somerae MIC90 > 1024 ug/ml 18955526
NPT4824 Organism Prevotella bivia Prevotella bivia MIC90 = 1024 ug/ml 18955526
NPT4992 Organism Prevotella corporis Prevotella corporis MIC90 = 1024 ug/ml 18955526
NPT4993 Organism Prevotella disiens Prevotella disiens MIC90 = 1024 ug/ml 18955526
NPT1128 Organism Prevotella intermedia Prevotella intermedia MIC90 = 1024 ug/ml 18955526
NPT4429 Organism Prevotella loescheii Prevotella loescheii MIC90 = 1024 ug/ml 18955526
NPT4829 Organism Prevotella melaninogenica Prevotella melaninogenica MIC90 = 1024 ug/ml 18955526
NPT4994 Organism Clostridium clostridioforme Clostridium clostridioforme MIC90 = 128 ug/ml 18955526
NPT2940 Organism Clostridium difficile Clostridium difficile MIC90 = 512 ug/ml 18955526
NPT2 Others Unspecified MIC = 32 ug/ml 18955526
NPT1484 Organism Fusobacterium nucleatum Fusobacterium nucleatum MIC = 128 ug/ml 18955526
NPT4825 Organism Fusobacterium mortiferum Fusobacterium mortiferum MIC = 2 ug/ml 18955526
NPT4828 Organism Fusobacterium necrophorum Fusobacterium necrophorum MIC = 2 ug/ml 18955526
NPT4826 Organism Fusobacterium varium Fusobacterium varium MIC = 2 ug/ml 18955526
NPT4990 Organism Fusobacterium sp. Fusobacterium sp. MIC = 2 ug/ml 18955526
NPT2 Others Unspecified MIC = 256 ug/ml 18955526
NPT4827 Organism Porphyromonas asaccharolytica Porphyromonas asaccharolytica MIC = 256 ug/ml 18955526
NPT4991 Organism Porphyromonas somerae Porphyromonas somerae MIC = 256 ug/ml 18955526
NPT4824 Organism Prevotella bivia Prevotella bivia MIC = 8 ug/ml 18955526
NPT4992 Organism Prevotella corporis Prevotella corporis MIC = 8 ug/ml 18955526
NPT4993 Organism Prevotella disiens Prevotella disiens MIC = 8 ug/ml 18955526
NPT1128 Organism Prevotella intermedia Prevotella intermedia MIC = 8 ug/ml 18955526
NPT4429 Organism Prevotella loescheii Prevotella loescheii MIC = 8 ug/ml 18955526
NPT4829 Organism Prevotella melaninogenica Prevotella melaninogenica MIC = 8 ug/ml 18955526
NPT4994 Organism Clostridium clostridioforme Clostridium clostridioforme MIC = 32 ug/ml 18955526
NPT2940 Organism Clostridium difficile Clostridium difficile MIC = 128 ug/ml 18955526
NPT2 Others Unspecified MIC50 = 64 ug/ml 18955526
NPT4995 Organism Clostridium innocuum Clostridium innocuum MIC50 > 1024 ug/ml 18955526
NPT1359 Organism Clostridium perfringens Clostridium perfringens MIC50 = 1024 ug/ml 18955526
NPT4985 Organism Clostridium acetobutylicum Clostridium acetobutylicum MIC50 = 256 ug/ml 18955526
NPT4986 Organism Clostridium bifermentans Clostridium bifermentans MIC50 = 256 ug/ml 18955526
NPT4987 Organism Clostridium butyricum Clostridium butyricum MIC50 = 256 ug/ml 18955526
NPT4988 Organism Clostridium cadaveris Clostridium cadaveris MIC50 = 256 ug/ml 18955526
NPT4833 Organism Clostridium paraputrificum Clostridium paraputrificum MIC50 = 256 ug/ml 18955526
NPT4989 Organism Clostridium ramosum Clostridium ramosum MIC50 = 256 ug/ml 18955526
NPT4834 Organism Clostridium septicum Clostridium septicum MIC50 = 256 ug/ml 18955526
NPT4981 Organism Clostridium sordellii Clostridium sordellii MIC50 = 256 ug/ml 18955526
NPT1824 Organism Clostridium sporogenes Clostridium sporogenes MIC50 = 256 ug/ml 18955526
NPT4835 Organism Clostridium tertium Clostridium tertium MIC50 = 256 ug/ml 18955526
NPT4831 Organism Actinomyces meyeri Actinomyces meyeri MIC50 = 128 ug/ml 18955526
NPT2 Others Unspecified MIC50 = 128 ug/ml 18955526
NPT1129 Organism Actinomyces viscosus Actinomyces viscosus MIC50 = 128 ug/ml 18955526
NPT2900 Organism Bifidobacterium longum Bifidobacterium longum MIC50 = 128 ug/ml 18955526
NPT4982 Organism Collinsella aerofaciens Collinsella aerofaciens MIC50 = 128 ug/ml 18955526
NPT4836 Organism Eggerthella lenta Eggerthella lenta MIC50 = 128 ug/ml 18955526
NPT4983 Organism Eubacterium limosum Eubacterium limosum MIC50 = 128 ug/ml 18955526
NPT4128 Organism Lactobacillus fermentum Lactobacillus fermentum MIC50 = 128 ug/ml 18955526
NPT1825 Organism Lactobacillus plantarum Lactobacillus plantarum MIC50 = 128 ug/ml 18955526
NPT3593 Organism Lactobacillus sp. Lactobacillus sp. MIC50 = 128 ug/ml 18955526
NPT167 Organism Propionibacterium acnes Propionibacterium acnes MIC50 = 128 ug/ml 18955526
NPT4819 Organism Anaerococcus prevotii Anaerococcus prevotii MIC50 = 128 ug/ml 18955526
NPT4984 Organism Anaerococcus tetradius Anaerococcus tetradius MIC50 = 128 ug/ml 18955526
NPT4817 Organism Finegoldia magna Finegoldia magna MIC50 = 128 ug/ml 18955526
NPT4818 Organism Peptoniphilus asaccharolyticus Peptoniphilus asaccharolyticus MIC50 = 128 ug/ml 18955526
NPT4821 Organism Peptostreptococcus anaerobius Peptostreptococcus anaerobius MIC50 = 128 ug/ml 18955526
NPT4820 Organism Peptostreptococcus micros Parvimonas micra MIC50 = 128 ug/ml 18955526
NPT4995 Organism Clostridium innocuum Clostridium innocuum MIC90 > 1024 ug/ml 18955526
NPT1359 Organism Clostridium perfringens Clostridium perfringens MIC90 > 1024 ug/ml 18955526
NPT4985 Organism Clostridium acetobutylicum Clostridium acetobutylicum MIC90 = 1024 ug/ml 18955526
NPT4986 Organism Clostridium bifermentans Clostridium bifermentans MIC90 = 1024 ug/ml 18955526
NPT4987 Organism Clostridium butyricum Clostridium butyricum MIC90 = 1024 ug/ml 18955526
NPT4988 Organism Clostridium cadaveris Clostridium cadaveris MIC90 = 1024 ug/ml 18955526
NPT4833 Organism Clostridium paraputrificum Clostridium paraputrificum MIC90 = 1024 ug/ml 18955526
NPT4989 Organism Clostridium ramosum Clostridium ramosum MIC90 = 1024 ug/ml 18955526
NPT4834 Organism Clostridium septicum Clostridium septicum MIC90 = 1024 ug/ml 18955526
NPT1101 Organism Staphylococcus aureus subsp. aureus RN4220 Staphylococcus aureus subsp. aureus RN4220 MIC = 2 ug/ml 18519725
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 4 ug/ml 18519725
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 2 ug/ml 18519725
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 20970332
NPT19 Organism Escherichia coli Escherichia coli MIC = 3 ug/ml 20970332
NPT2908 Organism Streptomyces coelicolor Streptomyces coelicolor MIC = 0.3 ug/ml 19104019
NPT2908 Organism Streptomyces coelicolor Streptomyces coelicolor MIC = 0.8 ug/ml 19104019
NPT2908 Organism Streptomyces coelicolor Streptomyces coelicolor MIC = 0.5 ug/ml 19104019
NPT2908 Organism Streptomyces coelicolor Streptomyces coelicolor MIC = 0.2 ug/ml 19104019
NPT2 Others Unspecified Activity = 8 ug/ml 19064898
NPT2909 Organism Shigella flexneri Shigella flexneri Activity = 8 ug/ml 19064898
NPT2911 Organism Pseudomonas putida Pseudomonas putida Activity = 8 ug/ml 19064898
NPT2898 Organism Acinetobacter lwoffii Acinetobacter lwoffii Activity = 8 ug/ml 19064898
NPT317 Uncleic Acid Nucleic Acid EC50 = 7 nM 21041083
NPT2 Others Unspecified IC50 = 32 nM 21041083
NPT2 Others Unspecified IC50 = 252000 nM 21041083
NPT175 Organism Enterococcus faecalis Enterococcus faecalis MIC = 125 ug/ml 21111625
NPT175 Organism Enterococcus faecalis Enterococcus faecalis MIC = 16 ug/ml 21111625
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 21111625
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 125 ug/ml 21111625
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 2 ug/ml 21111625
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 21111625
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 21111625
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 8 ug/ml 19349516
NPT19 Organism Escherichia coli Escherichia coli MIC = 2 ug/ml 19349516
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 19349516
NPT2 Others Unspecified IC50 = 7.9 nM 20875743
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC50 = 2 ug/ml 19770287
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC90 = 32 ug/ml 19770287
NPT1101 Organism Staphylococcus aureus subsp. aureus RN4220 Staphylococcus aureus subsp. aureus RN4220 MIC <= 1 ug/ml 19470508
NPT1101 Organism Staphylococcus aureus subsp. aureus RN4220 Staphylococcus aureus subsp. aureus RN4220 MIC = 64 ug/ml 19470508
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 128 ug/ml 20876371
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC <= 1 ug/ml 20876371
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 32 ug/ml 20876371
NPT317 Uncleic Acid Nucleic Acid Kd = 1500 nM 21764581
NPT317 Uncleic Acid Nucleic Acid Kd = 1100 nM 21764581
NPT317 Uncleic Acid Nucleic Acid Kd < 1000 nM 21757341
NPT317 Uncleic Acid Nucleic Acid IC50 = 417 nM 21757341
NPT317 Uncleic Acid Nucleic Acid Kd = 6000 nM 22257890
NPT317 Uncleic Acid Nucleic Acid Inhibition = 10 % 22257890
NPT317 Uncleic Acid Nucleic Acid Kd = 11000 nM 22257890
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 0.5 ug/ml 24900282
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 64 ug/ml 24900282
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens IC50 = 8000000 nM 22536944
NPT4996 Organism Chryseobacterium meningosepticum Elizabethkingia meningoseptica MIC = 12.5 ug/ml 10.1007/s00044-010-9490-3
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 6.25 ug/ml 10.1007/s00044-010-9490-3
NPT4997 Organism Klebsiella oxytoca Klebsiella oxytoca MIC = 6.25 ug/ml 10.1007/s00044-010-9490-3
NPT19 Organism Escherichia coli Escherichia coli MIC = 3.13 ug/ml 10.1007/s00044-010-9490-3
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 25 ug/ml 10.1007/s00044-010-9490-3
NPT4998 Organism Staphylococcus xylosus Staphylococcus xylosus MIC = 0.2 ug/ml 10.1007/s00044-010-9490-3
NPT4805 Organism Rhodococcus equi Rhodococcus equi MIC = 1.56 ug/ml 10.1007/s00044-010-9490-3
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 0.78 ug/ml 10.1007/s00044-010-9490-3
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 18.75 ug/ml 10.1007/s00044-012-0450-y
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 18.75 ug/ml 10.1007/s00044-012-0450-y
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 18.75 ug/ml 10.1007/s00044-012-0450-y
NPT2 Others Unspecified Kd = 1270 nM 23414844
NPT2 Others Unspecified Kd = 1148 nM 23414844
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1100 nM 23414844
NPT19 Organism Escherichia coli Escherichia coli MIC = 4400 nM 23414844
NPT19 Organism Escherichia coli Escherichia coli IZ = 26.12 mm 10.1007/s00044-013-0755-5
NPT79 Organism Bacillus subtilis Bacillus subtilis IZ = 26.12 mm 10.1007/s00044-013-0755-5
NPT2 Others Unspecified IZ = 25.78 mm 10.1007/s00044-013-0755-5
NPT766 Organism Proteus vulgaris Proteus vulgaris IZ = 25.29 mm 10.1007/s00044-013-0755-5
NPT19 Organism Escherichia coli Escherichia coli MIC = 1 ug/ml 24083676
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 24083676
NPT317 Uncleic Acid Nucleic Acid IC50 = 1474 nM 24012122
NPT19 Organism Escherichia coli Escherichia coli MIC = 2 ug/ml 24083676
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 16 ug/ml 24083676
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 32 ug/ml 24083676
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 128 ug/ml 24083676
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 24083676
NPT2898 Organism Acinetobacter lwoffii Acinetobacter lwoffii MIC > 128 ug/ml 24083676
NPT2898 Organism Acinetobacter lwoffii Acinetobacter lwoffii MIC = 0.5 ug/ml 24083676
NPT2 Others Unspecified MIC = 128 ug/ml 24083676
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 128 ug/ml 24083676
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 32 ug/ml 24083676
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 24083676
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 2 ug/ml 24083676
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC95 = 15.62 nM 24388809
NPT17 Organism Staphylococcus epidermidis Staphylococcus epidermidis MIC95 = 7.81 nM 24388809
NPT472 Individual Protein Vanilloid receptor Homo sapiens IC50 = 400 nM 10.1039/C0MD00207K
NPT2 Others Unspecified Ki = 18800 nM 24709560
NPT4999 Individual Protein Menin Homo sapiens Kd = 15600 nM 24709560
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 12.5 ug/ml 25241926
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 12.5 ug/ml 25241926
NPT729 Organism Micrococcus luteus Micrococcus luteus MIC = 12.5 ug/ml 25241926
NPT4619 Organism Raoultella planticola Raoultella planticola MIC = 12.5 ug/ml 25241926
NPT19 Organism Escherichia coli Escherichia coli MIC = 12.5 ug/ml 25241926
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 12.5 ug/ml 25241926
NPT1276 Organism Gibberella zeae Gibberella zeae MIC = 62.5 ug/ml 25110571
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 64 ug/ml 25110571
NPT175 Organism Enterococcus faecalis Enterococcus faecalis MIC >= 250 ug/ml 25110571
NPT19 Organism Escherichia coli Escherichia coli MIC = 4 ug/ml 25110571
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 125 ug/ml 25110571
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1 ug/ml 25110571
NPT317 Uncleic Acid Nucleic Acid IC50 = 192000 nM 27076899
NPT317 Uncleic Acid Nucleic Acid IC50 = 684000 nM 27076899
NPT317 Uncleic Acid Nucleic Acid IC50 = 150000 nM 27076899
NPT317 Uncleic Acid Nucleic Acid IC50 = 378000 nM 27076899
NPT2 Others Unspecified Inhibition = 60 % 26264847
NPT2 Others Unspecified IC50 = 88200 nM 26264847
NPT2 Others Unspecified IC50 = 93700 nM 26264847
NPT2 Others Unspecified IC50 = 143000 nM 26264847
NPT2 Others Unspecified IC50 = 76700 nM 26264847
NPT2 Others Unspecified Kd = 11600 nM 26264847
NPT2 Others Unspecified Kd = 1880 nM 26264847
NPT2 Others Unspecified Kd = 15200 nM 26264847
NPT2 Others Unspecified Kd = 11700 nM 26264847
NPT2 Others Unspecified Ratio = 1 26264847
NPT2 Others Unspecified Kd = 11300 nM 26264847
NPT2 Others Unspecified Activity = 70 % 26264847
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 240000 nM 26160112
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 1000 nM 26160112
NPT16 Organism Staphylococcus aureus Staphylococcus aureus Ratio = 240 26160112

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC176381 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC195969
0.9759 High Similarity NPC214376
0.9759 High Similarity NPC314408
0.9759 High Similarity NPC477060
0.9759 High Similarity NPC123746
0.9759 High Similarity NPC43850
0.9759 High Similarity NPC314007
0.9651 High Similarity NPC315334
0.9639 High Similarity NPC313552
0.9157 High Similarity NPC263058
0.9036 High Similarity NPC315969
0.9 High Similarity NPC330590
0.8617 High Similarity NPC315036
0.8571 High Similarity NPC318258
0.8421 Intermediate Similarity NPC471628
0.8421 Intermediate Similarity NPC56298
0.7864 Intermediate Similarity NPC57436
0.7864 Intermediate Similarity NPC121479
0.7717 Intermediate Similarity NPC306838
0.7624 Intermediate Similarity NPC221148
0.7447 Intermediate Similarity NPC470282
0.7416 Intermediate Similarity NPC316807
0.7349 Intermediate Similarity NPC322801
0.7349 Intermediate Similarity NPC129100
0.7349 Intermediate Similarity NPC291650
0.7333 Intermediate Similarity NPC70574
0.7333 Intermediate Similarity NPC100204
0.7333 Intermediate Similarity NPC83248
0.7315 Intermediate Similarity NPC241597
0.7283 Intermediate Similarity NPC165119
0.7222 Intermediate Similarity NPC98750
0.7174 Intermediate Similarity NPC36927
0.7174 Intermediate Similarity NPC271772
0.7105 Intermediate Similarity NPC94319
0.697 Remote Similarity NPC328646
0.6882 Remote Similarity NPC471420
0.6771 Remote Similarity NPC192025
0.6771 Remote Similarity NPC125253
0.6771 Remote Similarity NPC253975
0.6701 Remote Similarity NPC83839
0.6667 Remote Similarity NPC150557
0.6667 Remote Similarity NPC470284
0.6606 Remote Similarity NPC317534
0.6517 Remote Similarity NPC327486
0.6517 Remote Similarity NPC223174
0.6517 Remote Similarity NPC327753
0.6346 Remote Similarity NPC470283
0.6311 Remote Similarity NPC208537
0.6311 Remote Similarity NPC270005
0.631 Remote Similarity NPC34877
0.631 Remote Similarity NPC290179
0.6293 Remote Similarity NPC313813
0.625 Remote Similarity NPC20035
0.6211 Remote Similarity NPC314772
0.6211 Remote Similarity NPC314968
0.6161 Remote Similarity NPC59589
0.6147 Remote Similarity NPC188453
0.6147 Remote Similarity NPC42320
0.6118 Remote Similarity NPC317023
0.61 Remote Similarity NPC476523
0.6092 Remote Similarity NPC17455
0.6036 Remote Similarity NPC314413
0.6036 Remote Similarity NPC239705
0.6036 Remote Similarity NPC314398
0.6022 Remote Similarity NPC474468
0.6 Remote Similarity NPC244539
0.6 Remote Similarity NPC472025
0.5982 Remote Similarity NPC62845
0.5982 Remote Similarity NPC166242
0.5982 Remote Similarity NPC322449
0.5982 Remote Similarity NPC189854
0.5982 Remote Similarity NPC92874
0.5938 Remote Similarity NPC313762
0.5929 Remote Similarity NPC10897
0.5929 Remote Similarity NPC325900
0.5904 Remote Similarity NPC67660
0.5904 Remote Similarity NPC130683
0.5904 Remote Similarity NPC145112
0.5904 Remote Similarity NPC157514
0.5904 Remote Similarity NPC323361
0.5904 Remote Similarity NPC269166
0.5904 Remote Similarity NPC242073
0.5904 Remote Similarity NPC246558
0.5904 Remote Similarity NPC107914
0.5904 Remote Similarity NPC58629
0.5904 Remote Similarity NPC165198
0.5904 Remote Similarity NPC89145
0.5897 Remote Similarity NPC314306
0.5887 Remote Similarity NPC68327
0.5833 Remote Similarity NPC303727
0.5795 Remote Similarity NPC477757
0.5795 Remote Similarity NPC472026
0.5795 Remote Similarity NPC477755
0.5795 Remote Similarity NPC477750
0.5795 Remote Similarity NPC477762
0.5795 Remote Similarity NPC477753
0.5795 Remote Similarity NPC477763
0.5778 Remote Similarity NPC6848
0.5745 Remote Similarity NPC476694
0.5745 Remote Similarity NPC28959
0.5745 Remote Similarity NPC476695
0.5745 Remote Similarity NPC137554
0.5745 Remote Similarity NPC255535
0.5745 Remote Similarity NPC299603
0.5745 Remote Similarity NPC476696
0.5745 Remote Similarity NPC285014
0.5726 Remote Similarity NPC139857
0.5714 Remote Similarity NPC315980
0.5701 Remote Similarity NPC61894
0.5701 Remote Similarity NPC475603
0.5663 Remote Similarity NPC326533
0.5652 Remote Similarity NPC475918
0.5638 Remote Similarity NPC475694
0.5638 Remote Similarity NPC473710
0.5635 Remote Similarity NPC75839
0.5632 Remote Similarity NPC219040

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC176381 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD5795 Approved
1.0 High Similarity NPD5797 Approved
1.0 High Similarity NPD5794 Approved
1.0 High Similarity NPD5796 Clinical (unspecified phase)
1.0 High Similarity NPD5798 Approved
0.9759 High Similarity NPD3203 Approved
0.9759 High Similarity NPD3207 Approved
0.9759 High Similarity NPD3209 Approved
0.9759 High Similarity NPD2698 Approved
0.9759 High Similarity NPD3201 Approved
0.9759 High Similarity NPD3202 Approved
0.9759 High Similarity NPD3208 Approved
0.9639 High Similarity NPD3200 Clinical (unspecified phase)
0.9 High Similarity NPD5377 Approved
0.9 High Similarity NPD5381 Approved
0.9 High Similarity NPD5378 Approved
0.8602 High Similarity NPD4282 Approved
0.8421 Intermediate Similarity NPD4835 Approved
0.8421 Intermediate Similarity NPD4837 Approved
0.8421 Intermediate Similarity NPD4838 Approved
0.8421 Intermediate Similarity NPD4836 Approved
0.8182 Intermediate Similarity NPD5376 Approved
0.7864 Intermediate Similarity NPD35 Approved
0.7864 Intermediate Similarity NPD4833 Approved
0.7624 Intermediate Similarity NPD1450 Approved
0.7624 Intermediate Similarity NPD1449 Approved
0.7349 Intermediate Similarity NPD9033 Approved
0.7349 Intermediate Similarity NPD9030 Approved
0.7349 Intermediate Similarity NPD9031 Approved
0.7349 Intermediate Similarity NPD9032 Approved
0.7315 Intermediate Similarity NPD3731 Phase 3
0.729 Intermediate Similarity NPD2690 Discontinued
0.7212 Intermediate Similarity NPD2700 Approved
0.72 Intermediate Similarity NPD6428 Approved
0.7182 Intermediate Similarity NPD4832 Approved
0.7182 Intermediate Similarity NPD4831 Approved
0.7182 Intermediate Similarity NPD4830 Approved
0.7105 Intermediate Similarity NPD4826 Approved
0.7105 Intermediate Similarity NPD4828 Approved
0.7105 Intermediate Similarity NPD4827 Approved
0.7045 Intermediate Similarity NPD67 Phase 2
0.7045 Intermediate Similarity NPD9034 Approved
0.6957 Remote Similarity NPD6436 Phase 3
0.6792 Remote Similarity NPD8045 Clinical (unspecified phase)
0.6637 Remote Similarity NPD3204 Clinical (unspecified phase)
0.66 Remote Similarity NPD3716 Discontinued
0.6517 Remote Similarity NPD9445 Approved
0.6486 Remote Similarity NPD6941 Approved
0.6476 Remote Similarity NPD881 Approved
0.6239 Remote Similarity NPD7141 Clinical (unspecified phase)
0.6239 Remote Similarity NPD7140 Approved
0.6239 Remote Similarity NPD7139 Approved
0.6211 Remote Similarity NPD9435 Approved
0.6211 Remote Similarity NPD9434 Approved
0.614 Remote Similarity NPD8087 Discontinued
0.6095 Remote Similarity NPD1447 Phase 3
0.6095 Remote Similarity NPD1446 Phase 3
0.6078 Remote Similarity NPD4759 Clinical (unspecified phase)
0.5977 Remote Similarity NPD6123 Approved
0.5963 Remote Similarity NPD2255 Approved
0.595 Remote Similarity NPD8346 Approved
0.595 Remote Similarity NPD8347 Approved
0.595 Remote Similarity NPD8345 Approved
0.5904 Remote Similarity NPD895 Approved
0.5904 Remote Similarity NPD892 Phase 3
0.5904 Remote Similarity NPD893 Approved
0.5904 Remote Similarity NPD887 Approved
0.5904 Remote Similarity NPD890 Clinical (unspecified phase)
0.5904 Remote Similarity NPD891 Phase 3
0.5904 Remote Similarity NPD889 Approved
0.5904 Remote Similarity NPD894 Approved
0.5904 Remote Similarity NPD888 Phase 3
0.5897 Remote Similarity NPD6430 Approved
0.5897 Remote Similarity NPD6429 Approved
0.5826 Remote Similarity NPD8174 Phase 2
0.5783 Remote Similarity NPD2269 Approved
0.5778 Remote Similarity NPD1457 Discontinued
0.5773 Remote Similarity NPD372 Clinical (unspecified phase)
0.576 Remote Similarity NPD591 Approved
0.576 Remote Similarity NPD577 Phase 3
0.5739 Remote Similarity NPD8307 Discontinued
0.5728 Remote Similarity NPD394 Phase 3
0.5663 Remote Similarity NPD905 Approved
0.5663 Remote Similarity NPD904 Phase 3
0.5631 Remote Similarity NPD361 Discontinued
0.5625 Remote Similarity NPD389 Phase 3
0.5603 Remote Similarity NPD8140 Approved

Structure

External Identifiers

PubChem CID   8378
ChEMBL   CHEMBL184618
ZINC  

Physicochemical Properties

Molecular Weight:  614.31
ALogP:  -9.3091
MLogP:  1.9
XLogP:  -6.914
# Rotatable Bonds:  22
Polar Surface Area:  353.11
# H-Bond Aceptor:  19
# H-Bond Donor:  13
# Rings:  4
# Heavy Atoms:  42

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