Prescription Description
| Prescription ID | TCMFx1752 |
| Pinyin Name | Gua Lou Qu Mai Wan |
| Chinese Name | 瓜蒌瞿麦丸 |
| English Name | Trichosanthis and Dianthi Pills |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH923 | Radix trichosanthis | 花粉 | TCMH923 | |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 | |
| TCMH623 | Aconitum carmichaeli | 附子 | TCMH623 | ITSAH2410-14 |
| TCMH1706 | Dianthus superbus | 瞿麦 | TCMH1706 | ITSAJ4556-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT38 | DRD2 | Dopamine D2 receptor | GPCR | P14416 |
| TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
| TCMT634 | SLC6A2 | Norepinephrine transporter | Transporter | P23975 |
| TCMT635 | SLC6A3 | Dopamine transporter | Transporter | Q01959 |
| TCMT648 | DRD4 | Dopamine D4 receptor | GPCR | P21917 |
| TCMT651 | DRD3 | Dopamine D3 receptor | GPCR | P35462 |
| TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
| TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
| TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
| TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
| TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
| TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
| TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1207 | Legionella pneumophila |
| TCMT1212 | Verticillium dahliae |
| TCMT1218 | Staphylococcus aureus |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1243 | Aspergillus flavus |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1454 | Bacillus subtilis |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples