TCM Prescription: Fu Fang Du Zhong Qiang Yao Wine



Prescription Description
Prescription IDTCMF6912
Pinyin NameFu Fang Du Zhong Qiang Yao Jiu
Chinese Name复方杜仲强腰酒
English NameFu Fang Du Zhong Qiang Yao Wine
Function Description滋补肝肾, 通经活血。用于肾阳虚所致的腰痛, 转侧不利, 腰膝酸软, 倦怠乏力的辅助治疗。
IndicationsLumbago disorder, Kidney yang deficiency pattern
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
SF97 [Kidney yang deficiency pattern (TM1), 肾阳虚证 (TM1) ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1344 Cornu cervi 鹿角 TCMH1344
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6614
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8628
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, PPARA, PPARG, SLC1A1, SRC, XDH 10.7281
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 9.63708
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.55993
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.55993
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 9.20332
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FDPS, HTR2B, PIM1, PPARA, PPARG, TYR, XDH 8.9768
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HTR5A, IGF1R, KDR, MMP2, PPARA, PPARG, RORC, SRC, TYR 8.95565
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PPARG, RORC, SRC, TYR 8.77785
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, SLC1A1 8.60596
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, FABP3, GRIK5, GRM5, HSD17B2, HSP90AB1, HTR5A, IGF1R, MMP2, MMP9, PPARA, PPARG, RORC, SRC, TYR 8.60596
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 8.34863
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 8.34863
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FDPS, HSD17B2, MET, PPARA, PPARG 7.55056
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 7.51508
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MET, PPARG, SRC 7.35401
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 7.2913
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, GRM1, HCAR2, HSP90AB1, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, PTPN1, SRC, XDH 7.23348
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, GRM1, HCAR2, HSP90AB1, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, PTPN1, SRC, XDH 7.20325
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, FDPS, HSD17B2 7.17583
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 7.17583
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, SLC1A1 7.14446
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, PPARG, SLC1A1 7.00393
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.91892
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91892
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91892
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, CA1, CA2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SIGMAR1, SRC 6.55157
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 6.51159
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PPARG, RORC, SRC 6.51159
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.51159
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.51159
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARG, SIGMAR1, SRC 6.43153
[BP] GO:0099536 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.42067
[BP] GO:0099537 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.42067
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, FLT3, HSP90AB1, HTR5A, PPARG, RORC, SRC, TYR 6.4188
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.4188
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, XDH 6.16303
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 6.0572
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.95436
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, FDPS, HTR1A, TYR 5.90732
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.83194
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.81151
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.77764
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.77764
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.75746
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, PPARG 5.61764
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.60785
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.58355
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, HSP90AB1, RORC 5.5712
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSP90AB1, HTR2A, HTR2B, KDR, PPARG, SRC 5.55143
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.52984
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.52054
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FDPS, MET, PPARA, PPARG 5.51045
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG 5.50065
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 5.43688
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CDC25B, CYP1B1, DRD2, DRD3, ESR1, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PPARG, SRC, XDH 5.41735
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HSP90AB1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SIGMAR1, SRC, XDH 5.39692
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PPARG, SLC1A1 5.39555
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.30295
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA6, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, TYR 5.30295
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HSP90AB1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SIGMAR1, SRC, XDH 5.29998
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, GRM1, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MMP2, PPARA, PPARG, SRC, TYR 5.28562
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.27544
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B 5.11125
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, GRIK5, HSP90AA1, HSP90AB1, HTR1A, SLC1A1 5.08543
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.07047
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HSD17B2, HTR1A, HTR2A 4.99019
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, HTR5A, PPARG, RORC, SRC, TYR 4.89426
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.84072
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARG, RORC, SRC 4.81063
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, PPARG, RORC, SRC 4.79416
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.72964
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HSP90AB1, HTR2B, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SIGMAR1, SRC, XDH 4.72569
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.72569
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.72569
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, CA2, CA9, CYP1A2, DRD1, ESR1, FABP3, FLT3, GRM5, HTR5A, IGF1R, MMP2, PPARA, PPARG, SRC 4.69405
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD3, F3, FLT3, GRM1, HSP90AB1, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, PTPN1, SRC, XDH 4.69405
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, DRD2, DRD3, ESR1, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.66407
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 4.66407
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.66407
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.66407
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, GRIK5, GRM5, HCAR2, HSP90AB1, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, SRC 4.66407
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.59923
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.59923
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS 4.57632
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.55184
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B2, PPARG, TYR, XDH 4.52441
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.52441
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2, HTR2A, HTR2B, KDR, SRC 4.48611
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.47727
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SIGMAR1, SLC1A1, SRC, TYR, XDH 4.31114
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HSP90AA1, KDR, SRC 4.31114
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.22237
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, PPARG, SRC 4.19413
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.17636
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.17636
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, FLT3, GRM1, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 4.1756
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FDPS 4.1587
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 4.15085
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.14553
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.14553
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.14249
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, MMP9, PPARG, PTPN1, SRC, XDH 4.11542
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.07665
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 4.0693
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3 4.0516
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.02448
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.01043
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.00794
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 4.00164
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD3, F3, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR6, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 3.98054
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, HSP90AB1, PPARG, RORC, SRC 3.97023
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, GRIK5, GRM5, HCAR2, HSP90AB1, HTR1A, HTR2A, HTR2B, MMP9, PPARA, PPARG, PTPN1, SRC 3.96725
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 3.94948
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.93534
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1 3.91911
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, PPARG, PTPN1, SRC 3.89189
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, HTR5A, PPARA, PPARG, SRC 3.87973
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.87304
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 3.86821
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.84432
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MET, MMP9, PPARG, PTPN1, SRC, XDH 3.82842
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 3.82842
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, FABP3, GRM1, GRM5, HTR2A, HTR2B 3.82731
[BP] GO:0048511 rhythmic process AXL, DRD2, DRD3, ESR1, HTR7, PPARA, PPARG, RORC, SRC 3.82372
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 3.81547
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, PTPN1, SRC 3.72081
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MMP9, PPARA, PPARG, SIGMAR1, SLC1A1, SRC, XDH 3.6962
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG 3.67686
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.66615
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, PPARG, PTPN1, RORC, SRC 3.66164
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PPARG, RORC 3.64792
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 3.61037
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MMP9, PPARA, PPARG, SIGMAR1, SLC1A1, SRC, XDH 3.55487
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.51712
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.51213
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 3.48851
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PPARG, PTPN1, SRC, XDH 3.48816
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.48816
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.48816
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, GRM5, HTR2B, HTR5A, KDR 3.48529
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, MMP9, PPARA, PPARG, SIGMAR1, SLC1A1, SRC, XDH 3.48502
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, PTPN1, SRC 3.41904
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, PPARG, PTPN1, SRC, XDH 3.34037
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.33174
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.33174
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 3.32631
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARG, RORC, SRC 3.32322
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, RORC, SRC, XDH 3.29302
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 3.29302
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 3.25075
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.25075
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA, PPARG 3.24776
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.24649
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.23997
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2, DRD3, HTR1A 3.23563
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B 3.23563
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 3.23563
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.23114
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.2178
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.21536
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21536
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, PTPN1, SRC 3.20463
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PPARG, PTPN1, SRC, XDH 3.19957
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.19712
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.19313
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.16094
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 3.1553
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.15342
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, PPARA, PPARG, SRC, TYR 3.15297
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 3.15297
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP4, FLT3, HSD17B2, HSP90AB1, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, RORC, SIGMAR1, SRC, TYR 3.14669
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.137
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 3.137
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.12536
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.11085
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 3.09744
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 3.08463
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.08463
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD17B2, HSP90AB1, HTR5A, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SIGMAR1, SRC, TYR 3.08029
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, CDC25B, DRD2, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.07868
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, KDR, SRC 3.06562
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 3.05737
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.04553
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.04553
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR7 3.04435
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.02426
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 3.0196
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.0157
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.0157
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.01131
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, HSP90AB1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.01131
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.00612
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.99198
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.95768
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.92651
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.92651
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 2.91482
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.88482
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 2.87639
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.87639
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.86892
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.85236
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, TYR 2.83934
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83904
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.83904
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.83904
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.83506
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.82927
[BP] GO:0042391 None ADORA1, ADRA1A, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.82102
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.81926
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.8042
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, HSP90AB1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 2.80071
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.79741
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.79741
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA, PPARG 2.78936
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.77928
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.76337
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.76337
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.76337
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.76178
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, HCAR2 2.76012
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.75145
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.743
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.69799
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.69799
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.69612
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.6921
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6921
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.6921
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, PPARA 2.67953
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SIGMAR1, SLC1A1, SRC, XDH 2.66865
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B, PPARG 2.66865
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 2.65833
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.63837
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, FDPS, TYR 2.61697
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.61109
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A, PPARA 2.61109
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.61109
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.61109
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.61109
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MET, PPARA, PPARG 2.61104
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AURKB, CA9, CDC25B, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.60741
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B 2.59768
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, HSP90AA1, MMP1, MMP2, MMP9, SRC, XDH 2.59453
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRM1, HSP90AB1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.59453
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HSP90AA1, PPARA, PPARG, SIGMAR1, SLC1A1 2.58802
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.58578
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.58362
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.56376
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.56169
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GRM1, HTR2A, HTR2B 2.55556
[BP] GO:0099566 None GRM1, GRM5 2.55556
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.55556
[BP] GO:0060160 None DRD2, DRD3 2.55556
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55556
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.55556
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC 2.53126
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, CA2, CYP1B1, DRD2, DRD3, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, PPARG, SLC1A1, SRC 2.52318
[BP] GO:0015909 None DRD2, DRD3, FABP3, PPARG 2.5083
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.5083
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, SRC 2.5083
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.5083
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.5031
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 2.49918
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, TYR 2.49109
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HSP90AB1, HTR2A, HTR2B, PTPN1, SRC 2.47618
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.45935
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.45935
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.45935
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.45381
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, PPARA 2.4333
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HCAR2, HSP90AB1, HTR2B, PPARG, SRC 2.43156
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PPARG, TYR 2.42363
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, PTPN1, SRC 2.41771
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.41771
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.39544
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4 2.36007
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 2.36007
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.35375
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.35375
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, AURKB, CA9, CDC25B, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.34862
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.34263
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.34263
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34263
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.334
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, HSP90AB1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.3133
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B2 2.3105
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.3105
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3105
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3105
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.30299
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.3007
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3007
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.29808
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, PPARG 2.29808
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.29492
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, DRD1, DRD2, FDPS, FLT3, HSP90AA1, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.28309
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, SRC 2.27775
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, ESR1, F3, FABP4, HSP90AA1, HSP90AB1, IGF1R, MET, MMP2, PPARA, PPARG, PTPN1, SRC, XDH 2.27704
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A, MMP9 2.27704
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, HSP90AB1, KDR, SRC 2.27704
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, SRC 2.27197
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.26145
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.26079
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.26079
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.26079
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26079
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.25655
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.25655
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, PPARA, PPARG, RORC, SRC 2.23783
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SIGMAR1, SLC1A1, SRC, XDH 2.22854
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, CDC25B, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARG, PTPN1, SRC, XDH 2.21792
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HSP90AB1, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.20866
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PPARG, SRC 2.20655
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HSD17B2 2.20494
[BP] GO:0043393 regulation of protein binding AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.16884
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.16744
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.16744
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.16744
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.16562
[BP] GO:1900371 None DRD1, DRD2, DRD3, GRM3, GRM8 2.16328
[BP] GO:0030808 None DRD1, DRD2, DRD3, GRM3, GRM8 2.14858
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.14412
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, AXL, DRD2, DRD3, HSP90AA1, HTR2B, SLC1A1 2.13964
[BP] GO:0021853 None DRD1, DRD2 2.13964
[BP] GO:0010641 None F3, SRC 2.13964
[BP] GO:0090325 None DRD2, DRD3 2.13964
[BP] GO:1904936 None DRD1, DRD2 2.13964
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.13964
[BP] GO:0042321 None ADORA1, DRD2 2.13964
[BP] GO:0010513 None HTR2A, HTR2B 2.13964
[BP] GO:0010891 None PPARA, PPARG 2.13964
[BP] GO:0015718 None DRD2, DRD3, FABP3, PPARA, PPARG 2.1321
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, GRM1, HCAR2, HTR2A, SLC1A1 2.13155
[BP] GO:0001936 None F3, HTR2B, KDR, PPARG, XDH 2.11878
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PTPN1, SRC 2.09971
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.09603
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.09603
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.09603
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.09603
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.09603
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.09603
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.09603
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC 2.08354
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, DRD1, DRD2, FDPS, FLT3, HSP90AA1, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 2.07439
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.07144
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, HSP90AB1, MMP2, PPARA, PPARG, PTPN1, SRC 2.0633
[BP] GO:0030100 regulation of endocytosis ALOX15, AXL, DRD2, PPARG, PTPN1, SRC 2.04991
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.02971
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, DRD1, FLT3, HSP90AA1, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.02085
[BP] GO:0007610 None DRD1, DRD2, DRD3, GRM1, GRM5, HTR1A, HTR2A, HTR2B, PPARA 2.02085
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.01826
[BP] GO:0035265 organ growth ADRA1A, CYP19A1, ESR1 2.01755
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.01698
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.00787
[BP] GO:0030799 None DRD1, DRD2, DRD3, GRM3, GRM8 2.00787
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GRM1, GRM5, HTR2A, HTR2B 2.00318
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.00318
[BP] GO:0010887 None PPARA, PPARG 2.00318
[BP] GO:0010871 None PPARA, PPARG 2.00318
[BP] GO:0021843 None DRD1, DRD2 2.00318
[BP] GO:0021830 None DRD1, DRD2 2.00318
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.00318
[BP] GO:0021826 None DRD1, DRD2 2.00318
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00318
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 8.22607
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SRC 7.99947
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HTR2A, MET, SIGMAR1, SLC1A1, SRC 7.55056
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 7.14446
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 6.58303
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPN1, SIGMAR1, SLC1A1, SRC, TYR 6.43511
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SLC1A1, SRC, TYR 5.81151
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.96346
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.96346
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.3917
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 3.137
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, HTR2A, SIGMAR1, SRC 3.12669
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, HTR2A, SIGMAR1, SRC 3.12669
[CC] GO:0044456 None ACHE, ADORA1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 3.02447
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 2.9834
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 2.97507
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, HSP90AA1, HSP90AB1, SRC 2.73956
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 2.73924
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD1, DRD2, DRD3, ESR1, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, TYR 2.49109
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.3105
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.28395
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, GRIA2, HSD17B2, SIGMAR1 2.09173
[CC] GO:0097458 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SRC 2.00639
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00318
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.696
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, TYR, XDH 15.4739
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 13.6548
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARG, RORC, SIGMAR1 13.6548
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARG, RORC, SIGMAR1 12.2154
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARG, RORC, SIGMAR1 11.8988
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARG, RORC, SIGMAR1 11.2007
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARG, SIGMAR1 11.1785
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARG, SIGMAR1 11.1785
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HSP90AA1, HSP90AB1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 11.1452
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8628
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 10.2205
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.56298
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, FDPS, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 9.55993
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.77785
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.30326
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.2749
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 7.88461
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.6045
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 7.33128
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91892
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.91892
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.91892
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.91892
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, FLT3, HSP90AA1, HSP90AB1, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SIGMAR1, SRC 6.91365
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.89699
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, PPARG, SIGMAR1 6.86398
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC 6.51159
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC 6.4188
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.27505
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC 6.14676
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 6.07717
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.80828
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 5.7613
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.07299
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B2, TYR, XDH 4.83959
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 4.64137
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, F3, FDPS, FLT3, HSD17B2, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 4.36202
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.84432
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.84432
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.66615
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.48816
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3917
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33174
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.24649
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.0157
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.98518
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, XDH 2.95638
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.9315
[MF] GO:0008389 None CYP2A13, CYP2A6 2.9315
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.92651
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.56856
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55556
[MF] GO:0099583 None GRM1, GRM5 2.55556
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F3, FABP3, FABP4, PPARA, PPARG, RORC 2.53328
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.5083
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.5083
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.45381
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.33896
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3105
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3105
[MF] GO:0004971 None GRIA2, GRIA4 2.3105
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3105
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13964
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13964
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.13429
[MF] GO:0050543 None FABP3, PPARG 2.00318
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00318


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 16.848
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.2522
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 7.9041
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, GRM1, ESR2 7.0328
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7176
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1 6.4479
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.7176
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.3506
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA, GRIA4 6.226
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1 6.3218
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.0927
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.2582
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0861
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, IGF1R 3.9397
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.2994
Metabolic pathways_Homo sapiens_hsa01100 FDPS, ALOX15, AKR1B1, TYR, CYP3A4, CYP19A1, CYP2A6, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.0896
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, GRIA4 3.139
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9326
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.6463
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.1844
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, CYP3A4 3.1264
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.0543
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.6328
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6144
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.3337
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.6144
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1268
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.7926
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2291
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.1268
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1268
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0542
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, IGF1R 1.8179
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6527
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.716
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.7349
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, KDR, MET, IGF1R 1.6176
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7042
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.5682
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.5373
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3934
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, ADRA1A, IGF1R 1.5339
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.2584
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0543
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8771
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0487
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9352
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3267
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 1.03
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 1.1075
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0283
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0487
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8874
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7708
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2878
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3267
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8874
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7849
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8807
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8216
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2352
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2107
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1 0.6872
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.6068
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6523
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1498
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2308
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.153
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.2125
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2125
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2107
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3068
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2573
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2664
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.3267
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3022
Influenza A_Homo sapiens_hsa05164 FDPS 0.3022
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3022
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2905
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3295
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3402
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3371
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3538
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3295
Tight junction_Homo sapiens_hsa04530 SRC 0.3538
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3503
Platelet activation_Homo sapiens_hsa04611 SRC 0.3741
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15 1.2825
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3613
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3933
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3613
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3741
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3933
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3741
Axon guidance_Homo sapiens_hsa04360 MET 0.3696
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3741
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3758
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.412
Melanogenesis_Homo sapiens_hsa04916 TYR 0.415
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.415
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4403
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4252
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4252
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4403
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4403
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4403
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4403
Peroxisome_Homo sapiens_hsa04146 XDH 0.4442
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4403
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4783
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4582
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4949
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5139
Glioma_Homo sapiens_hsa05214 IGF1R 0.5139
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5127
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5139
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5139
Shigellosis_Homo sapiens_hsa05131 SRC 0.5139
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5682
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7387
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5844
Malaria_Homo sapiens_hsa05144 MET 0.5952
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6068
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6366
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.716
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9322
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7708
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7047
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7625
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7849
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.857
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2887
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0104


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)