Prescription ID | TCMF6689 |
Pinyin Name | Yi Shou Da Bu Jiu |
Chinese Name | 益寿大补酒 |
English Name | Yi Shou Da Bu Wine |
Function Description | 虚劳, 眩晕, 头痛, 不寐, 健忘 |
Indications | Vertigo disorder, Forgetfulness disorder, Consumptive disorder, Insomnia disorder, Insomnia, Headache, Dizziness |
Disease ICD-11 Category |
SD22 [Vertigo disorder (TM1), 眩晕 (TM1)
]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD72 [Consumptive disorder (TM1), 虚劳 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Brain, Heart |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
TCMH2334 | Dipsacus japonicus | 续断 | TCMH2334 | ITSAC1509-14 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH1768 | Panax notoginseng | 三七 | TCMH1768 | ITSAO2360-14 |
TCMH526 | Eucommia ulmoides | 杜仲叶 | TCMH526 | ITSAM1588-14 |
TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
TCMH865 | Carthamus tinctorius | 红花 | TCMH865 | ITSAI2447-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT759 | SAE1 | SUMO-activating enzyme subunit 1 | Unclassified | Q9UBE0 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1282 | Colletotrichum orbiculare |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1354 | Streptococcus mutans UA159 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.3309 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.4785 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 10.0616 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 9.792 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH | 9.792 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR | 9.17406 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 8.97957 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 8.97957 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH | 8.81124 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR | 8.81124 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH | 8.81124 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.81124 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 8.78871 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 8.29984 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH | 8.17247 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 8.08913 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 7.81266 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 7.66373 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 7.51378 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 7.26069 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 7.24617 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 7.19963 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 6.95652 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC | 6.95159 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.80413 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 6.80413 |
[BP] GO:0007215 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 6.73121 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 6.63425 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 6.63425 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK | 6.48239 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 6.44194 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC | 6.43015 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH | 6.43015 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.40478 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A | 6.40478 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 6.35735 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 6.35022 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 6.34271 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH | 6.26117 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 6.20744 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 6.18366 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR | 6.03866 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC | 6.00199 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.97156 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD17B1, HSD17B2 | 5.96371 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK | 5.8811 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK | 5.8348 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 5.83034 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.82239 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC | 5.66121 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 5.6462 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 5.6462 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 5.645 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK | 5.6243 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 | 5.62368 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH | 5.56154 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 5.39163 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1, RORC | 5.38003 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.37223 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR | 5.36519 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR | 5.32847 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK | 5.25648 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.21077 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.20415 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 | 5.20415 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.1775 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 5.13455 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.08087 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.08087 |
[BP] GO:0032787 | None | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 | 5.02139 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 5.01273 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK | 4.98129 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.98129 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 4.92578 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH | 4.90351 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 4.67455 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR | 4.63353 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3 | 4.62898 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 4.62802 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.62378 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH | 4.55535 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 | 4.44688 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH | 4.39787 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.39787 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.39134 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 4.39134 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.38738 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.35577 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR | 4.28281 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 4.27961 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 4.26427 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.26427 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.18457 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.11471 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 3.96429 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 3.94816 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 3.94428 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.93198 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.9307 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 3.92381 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC | 3.87423 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC | 3.84289 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.84289 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.8401 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.79283 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK | 3.79283 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.78307 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC | 3.77632 |
[BP] GO:0030335 | positive regulation of cell migration | EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 3.76055 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.73095 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH | 3.71581 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 3.70583 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.69644 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK | 3.66764 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK | 3.66527 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 3.6637 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC | 3.6412 |
[BP] GO:2000147 | positive regulation of cell motility | EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 3.6412 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.6359 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.5979 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK | 3.55711 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 3.55711 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 3.54817 |
[BP] GO:0051272 | positive regulation of cellular component movement | EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 3.54201 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.54201 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.49773 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 3.45823 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.45823 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.43456 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 3.42468 |
[BP] GO:0040017 | positive regulation of locomotion | EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK | 3.41177 |
[BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK | 3.41003 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.381 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 3.37822 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 3.3558 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.35242 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR | 3.31721 |
[BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.26597 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 | 3.25873 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 3.22446 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 3.22446 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.19372 |
[BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK | 3.17644 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 | 3.11748 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 3.11128 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.10962 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.10962 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 | 3.0935 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR | 3.09158 |
[BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.05079 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, AURKB, CDC25B, EGFR, ESR1, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 3.03466 |
[BP] GO:0016310 | phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 3.01839 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR | 3.01514 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 3.01514 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC, TEK | 3.01514 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC | 3.0033 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 2.99856 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR | 2.98345 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC, TEK | 2.98345 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 2.98208 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 2.97817 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 | 2.91144 |
[BP] GO:0007193 | None | ADORA1, GRM1, GRM3, GRM5, GRM8 | 2.90191 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PTGS2 | 2.90191 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5 | 2.87611 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX15, ALOX5, PTGS1, PTGS2 | 2.8725 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 2.87072 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC | 2.86073 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ALOX15, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.85119 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A | 2.83335 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC | 2.8306 |
[BP] GO:0048511 | rhythmic process | AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC, TOP2A | 2.81435 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.80082 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC | 2.79848 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 2.76903 |
[BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, EGFR, PTGS2, TYR | 2.76818 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 2.74787 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, PTGS2, SMAD3 | 2.72132 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.72132 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.71068 |
[BP] GO:0050727 | regulation of inflammatory response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK | 2.70351 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC | 2.64553 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.64553 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 2.64213 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK | 2.62738 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC | 2.60815 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, PTGS2, SMAD3, XDH | 2.59233 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.57868 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 | 2.56346 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, AURKB, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH | 2.56346 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.54907 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX15, ALOX5, PTGS2 | 2.54907 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, ALOX15, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.54907 |
[BP] GO:0032147 | activation of protein kinase activity | ADORA1, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 2.54305 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.53412 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APEX1, AURKB, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH | 2.53381 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.52666 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, AURKB, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH | 2.52629 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.52476 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 2.515 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A | 2.515 |
[BP] GO:0010038 | response to metal ion | ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 2.51002 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | HSPA1A, MMP9, PTGS2, PTPN1, SRC | 2.5089 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.48633 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 | 2.4777 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, EGFR, HSPA1A | 2.46828 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC | 2.42357 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.42357 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.42357 |
[BP] GO:0048732 | gland development | CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR | 2.41724 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.40589 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.40589 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.40589 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.40589 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A | 2.38133 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.38133 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK | 2.37424 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | KDR, PIK3CB, SMAD3, SRC, TEK | 2.37149 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH | 2.37048 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK | 2.34469 |
[BP] GO:0050801 | ion homeostasis | CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PIK3CB, SMAD3 | 2.33571 |
[BP] GO:0030155 | regulation of cell adhesion | ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK | 2.33571 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.33209 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.33209 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 2.31645 |
[BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.29477 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1, SRC | 2.29331 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 2.27874 |
[BP] GO:0071902 | positive regulation of protein serine/threonine kinase activity | ADORA1, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC | 2.27704 |
[BP] GO:0009888 | tissue development | ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 | 2.26786 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.2598 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.25897 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.25897 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 | 2.23774 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP2D6 | 2.20296 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, SMAD3, TEK | 2.18206 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.18206 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.18206 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.18206 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.17805 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.16239 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.16239 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | ALOX15, KDR, PIK3CB, SMAD3, SRC, TEK | 2.16239 |
[BP] GO:0016477 | cell migration | AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK | 2.16239 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.16239 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | ALOX15, DUSP3, EGFR, KDR, PTPN1, SRC, TEK | 2.14816 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC | 2.14013 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.11535 |
[BP] GO:0043434 | None | APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK | 2.11532 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.11532 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.11532 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, CA2, CA7, EGFR, PTGS2 | 2.10385 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC | 2.09752 |
[BP] GO:0044089 | positive regulation of cellular component biogenesis | ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK | 2.08981 |
[BP] GO:0002009 | morphogenesis of an epithelium | CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.08566 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, XDH | 2.07827 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.07735 |
[BP] GO:0043065 | positive regulation of apoptotic process | CYP1B1, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH | 2.0624 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, ALOX15, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.04631 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTGS2, SRC | 2.04631 |
[BP] GO:0043068 | positive regulation of programmed cell death | CYP1B1, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH | 2.03816 |
[BP] GO:0035235 | None | GRIA2, GRIA4, GRIK5 | 2.03816 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.03816 |
[BP] GO:0010638 | positive regulation of organelle organization | ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 2.03173 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, MMP2, MMP9, PTGS2 | 2.01932 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH | 2.00634 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1 | 2.00355 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5 | 2.00355 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK | 5.10534 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK | 4.91992 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SMAD3, SRC, TEK, TYR | 3.87716 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TEK, TYR | 3.71608 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTGS2, SLC1A1, SRC, TEK | 3.65126 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.27061 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, AXL, CA4, F10, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK | 2.91092 |
[CC] GO:0043235 | receptor complex | EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 | 2.48633 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, EGFR, TEK | 2.18004 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK | 2.16239 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH | 2.09752 |
[CC] GO:0014069 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.06421 |
[CC] GO:0099572 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.06421 |
[CC] GO:0044432 | endoplasmic reticulum part | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, F10, FLT3, GRIA2, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.05835 |
[CC] GO:0097060 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 2.05303 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 16.5099 |
[MF] GO:0046914 | transition metal ion binding | ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH | 15.9458 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP2A, TYR, XDH | 12.536 |
[MF] GO:0043167 | ion binding | ACHE, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 11.8747 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.6209 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.4785 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 | 8.17247 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 | 8.17247 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.08913 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 | 7.65602 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 7.55072 |
[MF] GO:0043169 | cation binding | ACHE, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH | 7.50237 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC | 7.28978 |
[MF] GO:0046872 | metal ion binding | ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TYR, XDH | 7.21092 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.18047 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC | 7.03965 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 | 6.81185 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR | 6.63425 |
[MF] GO:0005506 | iron ion binding | ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH | 6.50818 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.447 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A | 6.44194 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR | 5.9276 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 5.62072 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 | 5.25648 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.06111 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 4.98814 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, INSR, PIK3CA, PIK3CB | 4.82474 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 4.80089 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK | 4.7155 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK | 4.58691 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 | 4.40052 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK | 4.39134 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK | 4.33482 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK | 4.33482 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.24017 |
[MF] GO:0042562 | hormone binding | ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 | 3.80138 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 3.80119 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.76055 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC | 3.53037 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.24491 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 3.05251 |
[MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH | 2.90606 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.82433 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.82433 |
[MF] GO:0043168 | anion binding | ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH | 2.51597 |
[MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.42357 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.42357 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.40919 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.37048 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.37048 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.31027 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.29331 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.2807 |
[MF] GO:0030594 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 2.27874 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.18206 |
[MF] GO:0005518 | collagen binding | ACHE, MMP12, MMP9, SMAD3 | 2.11535 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK | 2.07877 |
[MF] GO:0000166 | nucleotide binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH | 2.05939 |
[MF] GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.05918 |
[MF] GO:1901265 | nucleoside phosphate binding | AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH | 2.05918 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX15, ALOX5, PTGS2 | 2.03816 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.01534 |
[MF] GO:0052813 | phosphatidylinositol bisphosphate kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.00355 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 17.9698 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.731 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, HSPA1A | 8.1319 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.8173 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 | 7.2425 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R | 6.863 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 6.5505 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR | 5.813 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 5.7981 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R | 5.3881 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 | 5.8055 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5.8055 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 | 5.359 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 4.6615 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R | 5.1456 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.2568 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 5.1477 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R | 4.6386 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.5376 |
Metabolic pathways_Homo sapiens_hsa01100 | ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH | 4.0639 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A | 4.4549 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 | 4.1336 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R | 4.1091 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, EGFR, IGF1R | 4.271 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET, EGFR | 4.3763 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B | 3.983 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 3.6014 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, PIM1, PIK3CB | 3.626 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.5114 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, PTGS2, GRM1, GRIA4 | 3.626 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, INSR, PIK3CB, PPARA | 3.5102 |
Serotonergic synapse_Homo sapiens_hsa04726 | CYP2D6, ALOX5, ALOX15, PTGS2, PTGS1 | 3.4803 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, PIK3CA, SRC, PIK3CB, MMP9 | 3.0202 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, EGFR, IGF1R | 3.2974 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2, EGFR | 2.8824 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.4836 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, PIK3CA, PIK3CB, EGFR | 3.2834 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.1591 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, INSR, ADORA1, PIK3CB | 2.8108 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB, EGFR | 2.8824 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, PTGS2, PTGS1 | 3.3655 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, PIK3CB, EGFR, IGF1R | 2.8671 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.0357 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.754 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, INSR, PIK3CB, IGF1R | 2.8049 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, GRM1, EGFR | 2.8761 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.2197 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.5822 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.5007 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.4623 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB, HSPA1A | 2.5007 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.5007 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.4814 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, IGF1R | 2.451 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA, EGFR | 2.3532 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 2.3315 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, INSR, PIK3CB | 2.3102 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, PIK3CA, PIK3CB, IGF1R | 2.2958 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, INSR, PIK3CB, PPARA | 2.2175 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.969 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 1.8374 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB, EGFR | 1.7665 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.5346 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.4843 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5 | 0.2822 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2922 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.302 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSPA1A | 0.3118 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PIK3CB | 1.8911 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.3012 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB, EGFR | 2.5007 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.9638 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.3406 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, PIK3CB | 1.7739 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB, EGFR | 1.8658 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.413 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3812 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3, PIK3CA, PIK3CB | 1.8374 |
Calcium signaling pathway_Homo sapiens_hsa04020 | GRM5, GRM1, EGFR | 1.2946 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.1651 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB, HSPA1A | 1.3165 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3965 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4047 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.3764 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.021 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3, PIK3CA, PIK3CB | 0.9646 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3, PIK3CA, PIK3CB | 2.2103 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.2605 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB, EGFR | 2.451 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.3045 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, PIK3CA, PIK3CB | 2.3494 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.8887 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.4708 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.4716 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 0.8801 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.8817 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 0.9017 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 0.8502 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4844 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.8732 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.3045 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4835 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 0.9614 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, GRIA4 | 0.9151 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.9404 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, INSR, PIK3CB | 2.5822 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.4972 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.3102 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5009 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.0474 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5009 |
Taste transduction_Homo sapiens_hsa04742 | GRM1 | 0.5136 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.5122 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4996 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.0582 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.4984 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.1246 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5136 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.0844 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.1122 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.2799 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.096 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.8108 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.142 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.1246 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10 | 0.5259 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP2D6, CYP1A2 | 2.268 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5325 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5465 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5444 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5563 |
Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5539 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5842 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5814 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.2946 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.3343 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.3084 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.3418 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.7972 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.4175 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.6398 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.3618 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4265 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6661 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6788 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6921 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.5648 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.6256 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.6123 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.8041 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.7533 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.719 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.8817 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8435 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.8041 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.8213 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9151 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8881 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.871 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2 | 1.9385 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8502 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7924 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8817 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.1146 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.2363 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.1059 |