TCM Prescription: Xiao Er Bao An Pills



Prescription Description
Prescription IDTCMF6578
Pinyin NameXiao Er Bao An Wan
Chinese Name小儿保安丸
English NameXiao Er Bao An Pills
Function Description感冒, 积滞, 急惊风
IndicationsCommon cold disorder, Acute convulsion disorder, Common cold, Dyspepsia, Convulsions
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
SE33 [Acute convulsion disorder (TM1), 急惊风 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
MD92 [Dyspepsia, 消化不良 ];
8A68.Z [Type of seizure, unspecified, 癫痫发作类型，未特指的 ];
Human Tissues Associated with IndicationLung, Heart, Brain, Blood, Spleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH695 Uncaria rhynchophylla é’©è—¤ TCMH695 ITSAM939-14
TCMH1060 Bombyx batryticatus 僵蚕 TCMH1060
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH916 Succinus 琥珀 TCMH916
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH357 Pericarpium arecae 大腹皮 TCMH357
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH2605 Margarita 珍珠 TCMH2605
TCMH2682 Cinnabaris 朱砂 TCMH2682
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TYR 12.7089
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6454
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7976
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ERBB2, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS2 11.7976
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FDPS, FUT7, GBA2, GLO1, HMGCR, IDO1, MPO, PIM1, PPARA, PTGS2, TYR, XDH 11.7976
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 11.0227
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 10.8175
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, SRC, TERT, TOP1, TYR 10.8175
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PPARA, PTGS2, RORC, SRC, TYR 10.781
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.5642
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 9.26947
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, HSD11B2, KDR, PTGS2, SRC, TOP1 8.87439
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.84435
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.62788
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.59753
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, DRD1, DRD2, EGFR, HCAR2, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 8.48705
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 8.21505
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 8.18361
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.05868
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.05868
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.03072
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ERBB2, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, MET, PPARA, PTGS2 7.65278
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.56589
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TNKS2, TOP2A, TYR 7.56589
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 7.51436
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 7.50716
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 7.48949
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 7.43178
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CACNA1C, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 7.1601
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TOP2A, TYR 7.05923
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 6.90268
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.80478
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, SRC 6.78058
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 6.74322
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 6.56285
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.49499
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 6.30194
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT 6.20399
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.16514
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.15427
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC 6.0837
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, ERBB2, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.98149
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.81678
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.71264
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.71264
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, SRC 5.70872
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2 5.70872
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.70689
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, HCAR2, PTGS2, TNKS, TNKS2 5.70689
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT 5.61817
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 5.52104
[BP] GO:0007187 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, HTR6 5.49592
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.47941
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HMGCR, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 5.47797
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.42095
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F10, F3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 5.30035
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 5.22674
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.20238
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.07826
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.07008
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 5.04646
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, GBA2, HMGCR, TYR 4.9419
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 4.8874
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.84584
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, PPARA, RORC, SRC, TOP1, TOP2A 4.80332
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 4.75042
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.69958
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 4.69738
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC 4.69738
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, HMGCR, HSD11B2, MMP2, MPO, PPARA, PTGS2, SRC, TERT, TYR 4.66078
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS, HMGCR 4.66078
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, IDO1, MPO 4.63258
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRB1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 4.55692
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC, TERT 4.53851
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.53737
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.48324
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 4.48324
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FDPS, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 4.33505
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS2 4.30642
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.30194
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.28501
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.28501
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, PTGS2 4.28421
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.27961
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.26121
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.25448
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, ERBB2, ESR1, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.22114
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.18696
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.17604
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH 4.1644
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 4.12211
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, EGFR, MMP9, MPO, PTGS2, SRC 4.11754
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, KDR, SRC 4.11754
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, PTGS2 4.11373
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.11373
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, TNKS2, XDH 4.08807
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, ERBB2, F10, F3, MET, SRC, XDH 4.07865
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.07837
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 4.06688
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 4.06687
[BP] GO:0003018 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2, SRC 4.06687
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.05195
[BP] GO:0007188 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2 4.05195
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS 4.04427
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 4.03383
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.02296
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 4.02111
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.01118
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 3.97122
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.9502
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.94741
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.91782
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.91722
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.89329
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.88879
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 3.87063
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2 3.87063
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.87063
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.85601
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.84822
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.8405
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, MPO, PTGS2, TERT 3.83374
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.83033
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, PTGS2 3.8265
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, PTGS2 3.8265
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.77828
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.7759
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, DRD2, PPARA 3.77235
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 3.76777
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.76777
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.76746
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 3.73452
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 3.73452
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.73452
[BP] GO:0097746 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2 3.71346
[BP] GO:0035296 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2 3.71346
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, ERBB2, PPARA 3.70873
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.65736
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, TERT 3.63983
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.6331
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, ERBB2, F10, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP1, TOP2A 3.62583
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.62583
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.62583
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 3.60371
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.60371
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.60219
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.59031
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR 3.58615
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC, TOP2A 3.57082
[BP] GO:0050880 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2 3.56976
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 3.56976
[BP] GO:0035150 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2 3.55193
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 3.54844
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, ESR1 3.50302
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 3.47638
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.46175
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.46175
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CHRM1, CNR1, DRD2, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 3.39615
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.37778
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.37116
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.37116
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 3.36737
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.34855
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.34597
[BP] GO:0003013 None ADORA1, ADRB1, CHRM1, DRD1, EGFR, HMGCR, PTGS2, SRC 3.3404
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.29124
[BP] GO:0008217 None ADORA1, ADRB1, CNR1, DRD2, HSD11B2, PPARA, PTGS2 3.26097
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS2, TYR 3.2558
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, DRD2, EGFR, PTGS2 3.21044
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, MET, SRC 3.21004
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 3.19071
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, EGFR, ERBB2, HCAR2, MMP12, PTGS2, SRC, TERT 3.17998
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, CYP19A1, DRD1, DRD2, EGFR, ERBB2, HCAR2, HMGCR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 3.17478
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.16424
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.15378
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.15289
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.15005
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.14921
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS2, TYR 3.14886
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.13863
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.03429
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.03205
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2 3.01049
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01049
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.00566
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.00129
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.99568
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2 2.98756
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.98756
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 2.98607
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.9351
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, IDO1, MMP12, MPO, PTGS2, SRC, TYR 2.89047
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CACNA1C, CHRM1, CNR1, CSNK2A1, DRD2, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC, TERT 2.88468
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 2.86745
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, ERBB2, IDO1, MMP12 2.86145
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.84943
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, MET 2.84822
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 2.84387
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, HSD11B2, IDO1, MMP2, MMP9, MPO, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A 2.83339
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.77996
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.77864
[BP] GO:0009115 None AOX1, XDH 2.76815
[BP] GO:0070201 None ACHE, BCL2, CACNA1C, CHRM1, CNR1, DRD2, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.7646
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.74828
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, MET 2.73324
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.73255
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, AURKB, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.71733
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2 2.69116
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.68896
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HMGCR 2.67014
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SRC 2.67014
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.66705
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.66678
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, TYR 2.64911
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.64833
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.63552
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.62469
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, IDO1, MPO, PTGS2 2.62061
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.60615
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.60615
[BP] GO:0050890 None ADORA1, CHRM1, CNR1, DRD1, DRD2, EGFR, HMGCR, PTGS2 2.58394
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.55631
[BP] GO:0007154 None ADORA1, ADRB1, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, ESR2, HTR6, PTGS2 2.54621
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, ESRRB, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.53628
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.52869
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, DRD2, EGFR, HCAR2, HMGCR, MMP12, SRC 2.52869
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.52432
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2 2.51932
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.5097
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.50709
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, MMP9, PTGS2 2.47921
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.47921
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, EGFR, HMGCR, PTGS2, TYR 2.46289
[BP] GO:0050999 None CNR1, CNR2, EGFR, TERT 2.46247
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.45456
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.45456
[BP] GO:0070920 None EGFR, ESR1, TERT 2.45456
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.45456
[BP] GO:0051223 None ACHE, CACNA1C, CHRM1, CNR1, DRD2, EGFR, ERBB2, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.42237
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.4165
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.38056
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.38016
[BP] GO:0046110 None AOX1, XDH 2.37371
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.37371
[BP] GO:0033602 None CNR1, DRD2 2.37371
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.37236
[BP] GO:0050793 regulation of developmental process ADRB1, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HMGCR, IDO1, KDR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TNKS2, XDH 2.31755
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.31755
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.30487
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.30487
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.28629
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CDK6, CYP1B1, DRD2, ERBB2, FABP3, IDO1, PTGS2, TERT, XDH 2.26533
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.26186
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25372
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.24898
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.24173
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.2228
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.21875
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, EGFR, ERBB2, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.21313
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.2029
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 2.19958
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.19958
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, DRD1, DRD2, MMP9, PTGS2 2.19779
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.19779
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.1849
[BP] GO:0033555 multicellular organismal response to stress ADRB1, BCL2, DRD1, IDO1 2.16842
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, SRC, TNKS, TOP1 2.16596
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, EGFR, ERBB2, FLT3, HMGCR, KDR, PTPN1, SRC, XDH 2.16103
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.15788
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14714
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.14714
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.14714
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.14714
[BP] GO:0032768 None CNR1, CNR2, EGFR, TERT 2.14714
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, CHRM1, DRD2, EGFR, ERBB2, HCAR2, MMP12, PTGS2, SRC 2.14201
[BP] GO:0070213 None TNKS, TNKS2 2.12938
[BP] GO:0006145 None AOX1, XDH 2.12938
[BP] GO:0038171 None CNR1, CNR2 2.12938
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12938
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.12783
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.12783
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, DRD2, EGFR, HCAR2, PTGS2 2.12671
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA 2.10442
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.10442
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.10442
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.10442
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, DRD2, EGFR, HCAR2, HMGCR, MMP12, SRC 2.10001
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.09754
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.0659
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.06071
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.05686
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.05686
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.05686
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.05686
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.05686
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DRD2, ERBB2, ESR1, ESRRA, HCAR2, IDO1, MMP12, MMP2, PTPN1, SRC 2.03624
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, HMGCR, IGF1R, PTPN1, SRC 2.03407
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.03273
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC 2.02566
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.01146
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.00834
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.00834
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MPO 2.00834
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.00834
[BP] GO:0050729 positive regulation of inflammatory response CNR1, EGFR, FABP4, IDO1, PTGS2 2.00834
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.30194
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 3.83033
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2 3.40775
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, MET, MMP2, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 3.26861
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, DRD2, EGFR, ERBB2, MET, PTGS2, SRC 3.11912
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, ESR1, F10, F3, FLT3, GBA2, GLO1, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TERT 3.08246
[CC] GO:0009330 None TOP1, TOP2A 2.76815
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, F10, F3, FLT3, HTR6, IGF1R, KDR, MET 2.6546
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ADRB1, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, F10, F3, FLT3, HTR6, IGF1R, KDR, MET, PTGS2, SRC 2.54362
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CDK6, CES2, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR6, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.4165
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, TYR 2.35591
[CC] GO:0031233 None CA4, F10, F3 2.1989
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.5707
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 16.7701
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, F10, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 14.7448
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 13.966
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7813
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.733
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.60156
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 8.92742
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.92742
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.67441
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.18361
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC 8.01816
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.90162
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MPO, PTGS2, SRC 7.68602
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 6.94437
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, PTGS2, SRC, XDH 6.6576
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.52476
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 6.30194
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP1, TOP2A 6.29418
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 5.98149
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 5.962
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.74831
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.47797
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.47797
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.45155
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC 5.20238
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TYR 5.04592
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.891
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 4.78375
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.69958
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.69958
[MF] GO:0008227 None ADRB1, CHRM1, CHRM2, CHRM4, DRD2, HTR6 4.34429
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.28421
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.12028
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET 3.99267
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DRD2, EGFR, ERBB2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET 3.99267
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.88879
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.80579
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 3.675
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.60191
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.18261
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13967
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.13967
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP1 3.12048
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.08246
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.03429
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, TERT, TOP2A, TYR, XDH 3.03429
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1 3.03429
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, HTR6 3.01709
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.84822
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.76815
[MF] GO:0003845 None HSD11B1, HSD11B2 2.76815
[MF] GO:0008389 None CYP2A13, CYP2A6 2.76815
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 2.67226
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.54362
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRB1, AOX1, AXL, BCL2, DRD2, EGFR, ERBB2, FLT3, HMGCR, PTGS2, TERT, TOP2A, TYR, XDH 2.46772
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.46247
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP1 2.41533
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.37371
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.37371
[MF] GO:0004949 None CNR1, CNR2 2.37371
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.31755
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, ADRB1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TOP2A, XDH 2.29929
[MF] GO:1901338 None ADRB1, DRD1, DRD2 2.1989
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.1989
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12938
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.12938
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.12938
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP1 2.10327


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.9027
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5889
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.5239
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADORA1, ADRB1, CACNA1C, DRD1, DRD2, PPARA 6.2397
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.9412
Metabolic pathways_Homo sapiens_hsa01100 FDPS, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.9598
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.1759
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CHRM1, CNR2, CNR1, ADORA3, CHRM4, ADORA1, ADRB1, DRD1, DRD2 6.1715
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.1715
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.1715
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.3866
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.9991
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, ERBB2, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 4.8608
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, CHRM1, ERBB2, ADRB1, CACNA1C, DRD1, EGFR 4.8608
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2, CACNA1C 4.0672
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 4.3201
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 4.9957
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.5962
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, EGFR, IGF1R 3.4966
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0672
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, EGFR, IGF1R 3.0689
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, DRD1, DRD2, EGFR 3.4893
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1, PTGS2 3.1296
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 2.8608
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.3037
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8259
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 2.8438
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.466
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3002
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.4489
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.4435
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4, ABCG2 2.8259
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8438
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.2811
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.2607
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, CACNA1C, PTGS2 2.1706
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 1.9772
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.8483
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, PTGS2, EGFR 1.7542
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 1.6788
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.9821
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.0772
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9355
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8483
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 1.927
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 1.9442
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.6735
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.3136
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.6788
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.5358
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.618
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3572
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD1, DRD2 1.2887
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1506
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.1702
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1207
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.7118
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7703
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8389
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7688
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7328
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7328
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7118
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7328
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8897
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.6855
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.8918
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7118
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.8983
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6788
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6855
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6706
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6724
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2496
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2612
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.4909
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5471
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5471
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2676
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6706
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2493
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4853
Influenza A_Homo sapiens_hsa05164 FDPS 0.2612
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.2676
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9801
Phagosome_Homo sapiens_hsa04145 MPO 0.29
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2932
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3084
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3084
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.3051
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3067
HTLV-I infection_Homo sapiens_hsa05166 FDPS, TERT 0.4156
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9759
Platelet activation_Homo sapiens_hsa04611 SRC 0.3415
Axon guidance_Homo sapiens_hsa04360 MET 0.334
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3439
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3415
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3439
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3551
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C, DRD1 1.0935
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3934
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3934
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3934
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3949
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3997
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3997
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.399
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.3997
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.185
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4094
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4103
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4192
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4103
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4156
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4103
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4192
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.246
Peroxisome_Homo sapiens_hsa04146 XDH 0.4192
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4443
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4192
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4284
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1702
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4443
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4443
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4511
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.143
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4443
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.466
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.453
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.466
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.466
Shigellosis_Homo sapiens_hsa05131 SRC 0.466
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.48
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.466
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4713
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2877
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5311
Malaria_Homo sapiens_hsa05144 MET 0.5427
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5471
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5468
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5468
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5471
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.5569
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.5964
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6293
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5904
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6354
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5303
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6498
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.691
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5904
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5143
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6706
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6548
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6788
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.697
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8047
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6724
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.691
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.8339
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9957
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.803
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8918
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.185


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)