TCM Prescription: Ru He San Jie Tablet



Prescription Description
Prescription IDTCMF654
Pinyin NameRu He San Jie Pian 
Chinese Name乳核散结片
English NameRu He San Jie Tablet
Function Description乳癖, 乳核
IndicationsBreast lump disorder
Disease ICD-11 Category SC24 [Breast lump disorder (TM1), 乳癖 (TM1) ];
Human Tissues Associated with IndicationBreast
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH720 Tulipa edulis 光慈菇 TCMH720 GBVT2777-13, GBVP2304-14
TCMH1331 Rhaponticum uniflorum 漏芦 TCMH1331 ITSAJ4341-14
TCMH1226 Laminaria japonica 昆布 TCMH1226 AB022790
TCMH797 Sargassum 海藻 TCMH797
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1359 Pyrola calliantha 鹿衔草 TCMH1359 FJ378582
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1384 Fusarium tricinctum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6946
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6988
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSD17B3, PIM1, PPARA, PTGES, XDH 8.83506
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HSD17B1, HSD17B3, MET, PPARA, PTGES 7.17418
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 6.61208
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 6.60878
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, RELA, SRC 6.33061
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, RELA, RORC, SRC, TOP1, XDH 6.23256
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.75886
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.47363
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, RELA, RORC, SRC, TOP1, XDH 5.40125
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, IGF1R, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC 5.27419
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, RELA, SRC, XDH 5.27419
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.27419
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP2, MMP9, PIM1, PTGES, RELA, SRC, XDH 5.25678
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, RELA, SRC, XDH 5.25112
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B3, KDR, MAOA, MET, PPARA, SRC, XDH 5.20658
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 5.18734
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 5.14934
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, RELA, SRC, XDH 5.04261
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 4.9935
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B3 4.78768
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.78633
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, PPARA, PTGES, RELA, RORC, SRC 4.69745
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 4.6455
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TOP1 4.49282
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, PTGES, RELA, RORC, SRC 4.45403
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIM1, RELA, SRC, XDH 4.45403
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGES, RELA, RORC, SRC 4.43488
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 4.43488
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC 4.36791
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES 4.26437
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 4.02693
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, RELA, SRC 4.00356
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 4.00356
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, PPARA, PTGES 3.96062
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, RELA, SRC, XDH 3.96062
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, XDH 3.92738
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 3.88201
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SRC 3.88155
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.71283
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B3 3.71283
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.71283
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, RELA, SRC 3.69842
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.6325
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.6325
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, RELA, SRC, XDH 3.63083
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.61294
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B3 3.61294
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PPARA, SRC 3.61294
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.61294
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.57211
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.48939
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.48332
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, XDH 3.46854
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B3 3.46854
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.4651
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.45117
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, F10, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TOP1 3.36433
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, RELA, SRC 3.35789
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RELA, RORC, SRC 3.33748
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.25332
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22329
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, RELA, SRC 3.10196
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, RELA, RORC, SRC 3.08378
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TOP1 3.00243
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, RELA, RORC, SRC 2.99575
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.95072
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B3, MAOA, XDH 2.93035
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, F10, F3, FABP4, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TOP1 2.8956
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, IGF1R, MMP2, MMP9, RELA, RORC, SRC 2.87859
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B3, KDR, MAP2K1, MMP9, PIM1, PPARA, RELA, RORC, SRC 2.87859
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES 2.86669
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.83512
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HSD17B3, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC 2.74884
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.74871
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.69634
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, SRC, XDH 2.66573
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.60496
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.59398
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC 2.58368
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.51002
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.51002
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.40961
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.38654
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38363
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.36181
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.35247
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B3 2.35247
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, SRC, XDH 2.34331
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, SRC, XDH 2.34083
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, RELA 2.31716
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES 2.3136
[BP] GO:0030335 positive regulation of cell migration APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.30757
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, KDR, MMP2, PTGES, RELA, SRC 2.29439
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, RELA, SRC, TOP1 2.27216
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23661
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, RELA, SRC, XDH 2.23279
[BP] GO:2000147 positive regulation of cell motility APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.21441
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.19245
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19245
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, RELA, SRC 2.14981
[BP] GO:0051272 positive regulation of cellular component movement APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.14981
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.14981
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14981
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, PPARA 2.13933
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, HCAR2, KDR, SRC 2.13083
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, RELA, SRC 2.11688
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, RORC, SRC 2.10422
[BP] GO:0040017 positive regulation of locomotion APP, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.05741
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.01329
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.48939
[CC] GO:0031233 None CA4, F10, F3 2.38396
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FLT3, FUT7, HCAR2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, SRC 1.79026
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, SRC 1.77494
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, RELA, SRC, TOP1, XDH 1.65784
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.1084
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, XDH 12.93
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.758
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, RELA, RORC, SRC, TOP1, XDH 11.6554
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5667
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FLT3, FUT7, HSD17B1, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTGES, SRC, TOP1, XDH 9.37791
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.83747
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.83747
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, RORC 5.38534
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.32398
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.01599
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, XDH 5.01599
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, XDH 4.6455
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.45403
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1 4.34626
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.29626
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.15216
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 4.07933
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.98356
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B3, MAOA, XDH 3.67694
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.63621
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PTGES, SRC, XDH 3.61294
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.61294
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.45117
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.23052
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.18151
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.09628
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 3.04292
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.99046
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGES, RELA, SRC, TOP1, XDH 2.88224
[MF] GO:0008389 None CYP2A13, CYP2A6 2.80249
[MF] GO:0008289 lipid binding AR, AXL, F10, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, SHBG 2.52785
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.47071
[MF] GO:0005497 None AR, SHBG 2.14981


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.5677
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4556
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 6.2328
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.465
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, MMP9, MET, RELA, IGF1R 4.5519
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 4.5519
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.514
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.514
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.338
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.7003
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.2154
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C 3.752
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.6992
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, MAOA, ALOX5, HSD17B1, CYP1A2, CYP1A1, HSD17B3, AKR1B1, CYP19A1, XDH, PTGES 3.0221
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, RELA, IGF1R 3.0202
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 3.0075
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.8989
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3995
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9 2.9115
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.9666
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, IGF1R 2.7967
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.7469
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.7959
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.6356
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.6876
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 2.4147
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2108
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.4336
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 2.294
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, MMP9, MET 2.2506
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, KDR, MET, RELA, IGF1R 2.0222
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.36
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.3281
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.3556
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.3234
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3837
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 2.3509
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.8871
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 1.9473
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.9333
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.9462
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA 1.7476
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 2.0514
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7333
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.8225
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.7817
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.7245
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.6975
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.5447
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.4489
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.4489
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.4001
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1438
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.4489
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5025
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4612
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.4489
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 1.2176
Insulin resistance_Homo sapiens_hsa04931 PPARA, RELA 1.1438
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 1.0889
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 1.0918
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 1.0036
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.2931
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0918
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.2455
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.4489
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 1.0684
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.4101
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.4489
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.4489
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 1.0336
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.9638
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.0889
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0044
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 1.0475
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.4101
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 1.0336
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 1.002
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4958
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 1.002
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.4489
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.4489
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.2972
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2931
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.4489
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.4257
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.4489
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.2931
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.9101
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.4101
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3679
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.8962
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.7849
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.8918
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.8918
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.8119
Purine metabolism_Homo sapiens_hsa00230 XDH 0.415
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6486
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.4101
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5977
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3634
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.4257
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4495
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4699
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4769
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1 0.4869
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4946
Axon guidance_Homo sapiens_hsa04360 MET 0.5141
Platelet activation_Homo sapiens_hsa04611 SRC 0.5261
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.5484
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6423
Melanogenesis_Homo sapiens_hsa04916 MAP2K1 0.5882
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5799
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5882
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.5882
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5935
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5882
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5882
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5913
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5902
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5913
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5988
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.6094
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5882
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.6
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.6052
Salmonella infection_Homo sapiens_hsa05132 RELA 0.6052
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.6094
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.6052
Peroxisome_Homo sapiens_hsa04146 XDH 0.6094
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.6094
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.6207
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6347
Pertussis_Homo sapiens_hsa05133 RELA 0.6326
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.6544
Bile secretion_Homo sapiens_hsa04976 CA2 0.6442
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6347
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6751
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6751
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.6807
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.697
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.7144
Legionellosis_Homo sapiens_hsa05134 RELA 0.7181
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.7371
Malaria_Homo sapiens_hsa05144 MET 0.754
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7493
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1061
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.7585
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.8693
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8219
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.9101
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9052
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.9278
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8962
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9101
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.8693
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8614
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9348
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9052
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9278
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9638
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0668


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)