TCM Prescription: Xue Lian Yao Wine



Prescription Description
Prescription IDTCMF6416
Pinyin NameXue Lian Yao Jiu
Chinese Name雪莲药酒
English NameXue Lian Yao Wine
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2352 Saussurea involucrata 雪莲花 TCMH2352 ITSAJ4356-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH296 Radix aconiti 川乌 TCMH296
TCMH2314 Conioselinum vaginatum 新疆藁本 TCMH2314 ITSAI1329-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3253
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3372
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 8.4657
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.17602
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 7.27667
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.26852
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 7.26852
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.26852
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 6.8535
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, SMAD3, SRC, TEK, TYR 6.52144
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.40104
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.39277
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 6.23893
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TYR 6.17845
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.99456
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, XDH 5.97226
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.69318
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 5.53082
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 5.51944
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.51435
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.51276
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TYR 5.51101
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.476
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.47056
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.43806
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.31203
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.28056
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.14698
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 5.14698
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.14698
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 5.14698
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.08234
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 4.87542
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 4.85586
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.8406
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.82746
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.80898
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.80898
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.69727
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 4.64896
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CHRM1, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.63109
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.6161
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.58277
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 4.57843
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.57766
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 4.55626
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 4.52462
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.52462
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.42462
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.41464
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.37281
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.34663
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, CHRM5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.32792
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.30718
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.28563
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.23576
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.17519
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, SRC, TYR 4.17519
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.1586
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, SRC, TEK, TYR 4.15636
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.08667
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 4.08667
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.08667
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 4.01492
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.98375
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.97152
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.89806
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.88414
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.82105
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR 3.81944
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.81784
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.81784
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.7584
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75225
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.7114
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.70847
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.70847
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.69401
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.69401
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.59162
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.57308
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.53217
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC 3.51129
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.51004
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC, TEK 3.50902
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.50902
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.50902
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.50526
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.49771
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.47613
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.46234
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.41172
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.40273
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.35386
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.32198
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 3.32026
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.29139
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 3.27473
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27473
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 3.27155
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 3.2615
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.2615
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.23919
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.22441
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.16706
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.10275
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.10275
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.06244
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 3.02924
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.00796
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, XDH 3.00796
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.00796
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.00796
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.98076
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.96467
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.94297
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, SRC, TEK 2.94297
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.9238
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.92336
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.90496
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 2.89724
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.89721
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.89721
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.87413
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.8467
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.84051
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.82964
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CHRM3, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 2.80975
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.74162
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.73807
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.73754
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.73754
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73754
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.73754
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73754
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.73754
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.7144
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.69012
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 2.68236
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.68232
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.68232
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.66758
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.6578
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.64794
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.62118
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.5998
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.5908
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.5908
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 2.57493
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.52932
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.52932
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52127
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.52127
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.5182
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.51647
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.51626
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, SMAD3 2.51486
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.50968
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.49681
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.48976
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.48268
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.48198
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.46866
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, EGFR, HCAR2, MMP12, PTPN1, SMAD3, SRC 2.44615
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.44101
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.44044
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.42348
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.41021
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, SRC, TEK 2.39868
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.39868
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.38439
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.38439
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.37022
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.36247
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.35544
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34379
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3373
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.3373
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.32008
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.30957
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.30957
[BP] GO:0051894 None KDR, SMAD3, TEK 2.30391
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30391
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.30391
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, MMP9, SMAD3, SRC, TEK 2.29937
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29937
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29937
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.29722
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.27514
[BP] GO:1903393 None KDR, SMAD3, TEK 2.2141
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.20083
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.17306
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.1653
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR 2.14419
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC 2.11701
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.1165
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.1165
[BP] GO:0046541 None CHRM1, CHRM3 2.10576
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09969
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.09481
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.09476
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC 2.08588
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.07581
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, SRC 2.07449
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, SRC 2.07292
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.07292
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.07052
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.06247
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.06247
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.05787
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.05787
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.05787
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, HCAR2, MMP12, SMAD3, SRC 2.04703
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.04216
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.04216
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.04216
[BP] GO:1901890 None KDR, SMAD3, TEK 2.03479
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.03479
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.02999
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.02999
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.02999
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.50902
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 3.23919
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.00728
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, INSR, MET, SRC, TEK 2.97651
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.73596
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.67092
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK 2.51499
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TYR 2.32008
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK, TYR 2.2796
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.6107
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 13.8376
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TYR, XDH 13.5832
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3621
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0763
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 9.38788
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.50379
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 6.91094
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.84799
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.75779
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.58236
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.40104
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3 5.78037
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.51944
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.36857
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.0944
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 5.03281
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.85586
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.55723
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.37281
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 4.21246
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.19313
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.17666
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.17519
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR 4.17519
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.1586
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TYR, XDH 4.14096
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.93129
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 3.88031
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.82855
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.79448
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.73757
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 3.73757
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.49771
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.42945
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40273
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 3.35698
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 3.29448
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.2535
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 3.14546
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.07948
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90496
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.85375
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.71182
[MF] GO:0042578 None ADORA1, ALPL, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.71182
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 2.70836
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.68519
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.51626
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.37962
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.32008
[MF] GO:0051425 None APP, INSR 2.29937
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.25159
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.16907
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.1165
[MF] GO:0043559 insulin binding IGF1R, INSR 2.10576
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.0944
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03479


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.1567
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.8739
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.626
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1627
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.415
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.349
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3202
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 4.0169
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.349
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8972
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8972
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.7029
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.7286
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.1957
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1 3.7409
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 3.4607
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.372
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.372
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, EGFR 2.8784
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3838
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.8312
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.7525
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.8312
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.7397
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4791
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4947
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3563
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8389
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0781
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3273
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8941
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2815
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3225
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0102
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3513
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6325
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8351
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.585
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2371
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.5363
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.4073
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1577
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.155
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.353
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2723
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1077
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4252
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1264
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3965
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3491
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1563
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.0167
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1536
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2377
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9897
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.1169
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9897
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9129
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9834
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.971
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4073
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9237
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3211
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9083
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.971
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9041
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9041
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8996
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9083
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8752
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8579
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7111
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2662
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3325
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3756
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3688
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.359
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3684
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3688
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3756
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3915
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.399
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3587
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4418
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5849
Platelet activation_Homo sapiens_hsa04611 SRC 0.4653
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4653
Axon guidance_Homo sapiens_hsa04360 MET 0.4574
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4953
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4733
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5196
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5196
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5196
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5123
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5196
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.543
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5275
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.536
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5426
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5317
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5406
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5406
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5406
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5421
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5406
Peroxisome_Homo sapiens_hsa04146 XDH 0.543
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.58
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.581
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5635
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5834
Bile secretion_Homo sapiens_hsa04976 CA2 0.5822
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6021
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6123
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6036
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6087
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8844
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6036
Shigellosis_Homo sapiens_hsa05131 SRC 0.6036
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6351
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6087
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.655
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6373
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7615
Malaria_Homo sapiens_hsa05144 MET 0.6741
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8401
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6774
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7518
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0781
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7913
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7913
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8722
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8309
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8533
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8752
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8722
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0439


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)