TCM Prescription: Zhong Hua Gan Ling Capsules



Prescription Description
Prescription IDTCMF6245
Pinyin NameZhong Hua Gan Ling Jiao Nang
Chinese Name中华肝灵胶囊
English NameZhong Hua Gan Ling Capsules
Function Description症积
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5786
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 11.5426
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 10.8111
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8054
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, HSD17B3, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.6096
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 9.91436
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 9.60726
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.46132
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 9.4377
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.66255
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.64138
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 8.62964
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 8.44962
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD17B1, HSD17B2, HSD17B3 8.23125
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 8.23125
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 8.00274
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 7.94335
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.41297
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 7.3853
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 7.3372
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.28107
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PTGES, PTGS2, RELA, SRC, TYR 7.23026
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 7.00744
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.95108
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 6.86732
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.649
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.60633
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TYR 6.29888
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, PIK3CA, POLB, PPARA, RELA, SRC, TYR 6.26183
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.23902
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC 6.22717
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.11169
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 6.01255
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 5.82023
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TOP1, TYR 5.70216
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.62852
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.62852
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CNR1, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.62043
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.61765
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PTGES, PTGS2, RELA, SRC, TYR 5.54149
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.36326
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, CNR1, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.17542
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 5.13932
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.02382
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.94597
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.85605
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2, HSD17B3 4.85605
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC 4.75381
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.7482
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.5438
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 4.52916
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 4.46861
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.46551
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.3403
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TOP1, TYR 4.32054
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1 4.21268
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 4.13173
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, RELA, SRC, TNKS2, TYR 4.026
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 3.99723
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, KDR, POLB, PTGS2, RELA, SRC, TOP1 3.90898
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 3.89851
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.87895
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC 3.87895
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, CNR2, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, RELA 3.83415
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.74197
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MAP2K1, MET, PIK3CB, PIM1, POLA1, SRC, TYR 3.73669
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 3.7089
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, RELA, SRC 3.7089
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 3.70451
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 3.5985
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.59479
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, ESR1, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, XDH 3.59479
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 3.5414
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RELA, SRC 3.5414
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.5393
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 3.50479
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 3.50479
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 3.50069
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.49784
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RELA, SRC, TYR 3.48514
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.45656
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.45313
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.45313
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.36579
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.36579
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 3.36337
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, RELA, SRC 3.36209
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.36209
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.36209
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 3.2895
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 3.27184
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 3.27184
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.27184
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.26752
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 3.25915
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 3.25301
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 3.24602
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC 3.21645
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 3.19921
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, RELA, SRC 3.18201
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2, RELA 3.1687
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 3.1687
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 3.1568
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.12536
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.10475
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 3.10353
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 3.0989
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, PPARA, PTGS2, RELA 3.05068
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0473
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.04238
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MAP3K7, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 3.03596
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 3.03007
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.00594
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2 3.00594
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.00177
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.97782
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 2.97742
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.97126
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC 2.94539
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.94539
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, MAOA, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.94509
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RELA, SRC 2.9372
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.93398
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 2.88085
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.88085
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.87348
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, PTGES, PTGS1, PTGS2 2.8404
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.81104
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.80398
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 2.77585
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2, RELA 2.7579
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7579
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.7579
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.7579
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, ESR1, F10, F3, FLT3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.7579
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.75463
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, CDC25B, ESR1, F3, FLT3, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, XDH 2.73237
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.71024
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, PTGS2 2.7092
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, PTGS2 2.7092
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.6706
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, F10, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1 2.62822
[BP] GO:0008217 None ADORA1, AR, CNR1, PPARA, PTGS1, PTGS2 2.62822
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.62399
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 2.57083
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.57001
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, CNR1, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.56792
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 2.54803
[BP] GO:0007568 aging AURKB, CNR1, CYP1A1, MAP2K1, POLB, PTGS2, RELA 2.54803
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, TNKS2 2.50988
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50945
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CACNA1C, CHRM2, CNR1, CYP1B1, ESR1, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TNKS2, XDH 2.45337
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, PTGS2, SRC 2.44247
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43646
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 2.43646
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.43646
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.4363
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.38802
[BP] GO:0030335 positive regulation of cell migration APP, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.38404
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.38404
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CNR1, CYP1B1, F3, HCAR2, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SRC 2.38404
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.38404
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, CYP2D6, ESR1, FABP4, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.38279
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.37441
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC, TNKS 2.36348
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36306
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.35727
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.35727
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.33872
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.32857
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, PTGS2, RELA, SRC 2.32497
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.32008
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 2.31361
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.3009
[BP] GO:2000147 positive regulation of cell motility APP, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.3009
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.28691
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.27912
[BP] GO:0009895 negative regulation of catabolic process ADORA1, CNR1, HCAR2, MET, PIK3CA, PPARA, RELA 2.2642
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.25576
[BP] GO:0051272 positive regulation of cellular component movement APP, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.22304
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21532
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.20109
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, ESR1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.20109
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.20109
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.1992
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.19811
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.18576
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.17581
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.16798
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, PTGS2, SRC 2.16499
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.16447
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, MMP2, POLB, PPARA, PTGS2, RELA, SRC, TYR 2.14464
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.13992
[BP] GO:0040017 positive regulation of locomotion APP, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.13695
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.13695
[BP] GO:0070213 None TNKS, TNKS2 2.13695
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.13695
[BP] GO:0038171 None CNR1, CNR2 2.13695
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13695
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13203
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.12409
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.12409
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, RELA, SRC 2.12392
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.11142
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08647
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.08647
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08647
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.0857
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, MAP3K7, PIM1, RELA 2.0857
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 2.06506
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.0583
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.0583
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, PTGS2, SRC 2.05601
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2, HSD17B3 2.04532
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.01469
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.00478
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.00372
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00271
[BP] GO:0006693 None PTGES, PTGS1, PTGS2 2.00271
[BP] GO:0006692 None PTGES, PTGS1, PTGS2 2.00271
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.33509
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FLT3, HCAR2, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR 3.74473
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.29556
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, FLT3, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 3.18201
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, TBXAS1 2.44629
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 2.28474
[CC] GO:0031233 None CA4, F10, F3 2.27331
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.7599
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 15.6907
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 13.8365
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, F3, FLT3, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 13.7878
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.9602
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8054
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.7384
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 8.71626
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 8.44962
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.3603
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1, TYR 8.00274
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 7.83876
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 7.82226
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 7.49179
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 7.32869
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.31967
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.95108
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH 6.69856
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS 6.48303
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 6.24783
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.25726
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.33917
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.74197
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TOP1 3.74197
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TOP1 3.73945
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.64324
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.28286
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.23419
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.10475
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.94539
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.81588
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, HSD17B3, XDH 2.81104
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.7579
[MF] GO:0008389 None CYP2A13, CYP2A6 2.7579
[MF] GO:0004949 None CNR1, CNR2 2.36306
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, TOP1, XDH 2.32374
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.28691
[MF] GO:0005497 None AR, SHBG 2.13695
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD17B1, HSD17B2, HSD17B3 2.13695


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.2019
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.1091
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.9041
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, RELA, IGF1R 6.3185
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 7.0602
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, CYP2D6, ALOX5, CACNA1C, PTGS2, PTGS1 6.6366
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, MAP2K1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA, RELA 6.0103
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.9739
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.9739
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.9389
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.8811
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.702
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, POLA1, CYP2A6, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 5.5357
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.5357
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.5357
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.5357
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 5.1292
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, PIK3CB, RELA, IGF1R 5.1555
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB, F3, RELA 4.8729
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, PIK3CA, CACNA1C, PIK3CB 4.671
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.3447
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.4413
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 4.297
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.1712
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, ADORA1, PIK3CB, RELA 4.5092
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGES, PTGS1 4.671
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 4.0261
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET 4.5302
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, PIK3CB, MMP9, RELA 4.0965
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.4387
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 3.8312
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.9292
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB 3.8312
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.8542
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, PIK3CB, RELA, IGF1R 3.7865
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.7496
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.7781
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA, RELA 3.7025
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.5005
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, MAP3K7, RELA 3.5591
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.5591
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3954
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3432
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.4583
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.1322
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.4516
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 2.6467
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.7836
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.8517
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB, RELA 2.6347
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.4516
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.334
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.9974
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 3.0641
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.334
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.9586
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2 3.3954
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2, RELA 3.0755
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, PIK3CA, SRC, PIK3CB 2.5746
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2308
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2, MAP3K7, RELA 2.969
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3954
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, PIK3CB, RELA 2.6149
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6347
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.5746
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.4811
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, PIK3CB, RELA 2.423
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.4811
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.4286
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.316
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.4118
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 2.3311
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CNR2, CNR1, ADORA3, ADORA1 2.177
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 2.1269
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.622
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB, RELA 1.6234
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4394
Axon guidance_Homo sapiens_hsa04360 MET 0.4337
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9801
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.6554
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4662
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 2.0333
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.9582
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0143
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7833
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, CACNA1C, PIK3CB 1.5702
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.751
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, PIK3CB 1.5976
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.9606
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.5078
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.7817
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CACNA1C 0.7799
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4928
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7809
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9208
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5042
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.9147
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.813
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.9582
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.9322
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5213
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.52
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.3691
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5213
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5318
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5333
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.969
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5334
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5333
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.547
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5393
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.0165
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5409
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5333
Peroxisome_Homo sapiens_hsa04146 XDH 0.547
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5479
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.547
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5592
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.3817
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.1489
Pertussis_Homo sapiens_hsa05133 RELA 0.5712
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4286
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5735
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.161
Bile secretion_Homo sapiens_hsa04976 CA2 0.5835
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5735
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.3097
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, PIK3CB 2.4571
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.6347
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.5667
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2415
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.3817
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.2415
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6174
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4214
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.6144
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.7091
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3196
Legionellosis_Homo sapiens_hsa05134 RELA 0.6737
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.4054
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3976
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.4414
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.4054
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.4331
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.4587
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.45
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5072
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7084
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.5072
Malaria_Homo sapiens_hsa05144 MET 0.7133
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.727
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.5331
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5089
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.6368
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.821
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7817
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6944
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6805
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8918
DNA replication_Homo sapiens_hsa03030 POLA1 0.813
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.8052
Base excision repair_Homo sapiens_hsa03410 POLB 0.8419
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.9147
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8918
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9846
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.8874
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9147
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9539
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8681
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9504
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1926
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0809
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3689


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)