Prescription Description
| Prescription ID | TCMF6208 |
| Pinyin Name | Zhi Er Ling Gao Zi |
| Chinese Name | 稚儿灵膏滋 |
| English Name | Zhi Er Ling Gao Zi |
| Function Description | 疳病, 厌食 |
| Indications | Infantile malnutrition disorder, Anorexia |
| Disease ICD-11 Category |
SE37 [Infantile malnutrition disorder (TM1), 疳病 (TM1)
]; MG43.7 [Anorexia, 纳差 ]; |
| Human Tissues Associated with Indication | Spleen, Stomach |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH2059 | Radix pseudostellariae | 太子参 | TCMH2059 | |
| TCMH1542 | Radix adenophorae | 南沙参 | TCMH1542 | |
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH833 | Glycine max | 黑大豆 | TCMH833 | ITSAJ4675-14 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH45 | Lablab purpureus | 白扁豆 | TCMH45 | ITSAM881-14 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH2252 | Agrimonia pilosa var. japonica | 仙鹤草 | TCMH2252 | |
| TCMH687 | Mahonia bealei | 功劳叶 | TCMH687 | MG730545 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
| TCMH1920 | Acorus tatarinowii | 石菖蒲 | TCMH1920 | ITSAI4409-14 |
| TCMH621 | Fructus tritici levis | 浮小麦 | TCMH621 | |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1525 | Crassostrea gigas | 牡蛎 | TCMH1525 | BCMOL364-12 |
| TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 | |
| TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
| TCMH388 | Ziziphus jujuba | 大枣 | TCMH388 | ITSAM869-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 149 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
Showing 1 to 10 of 81 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.58023 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGS2, SRC | 2.62814 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.7513 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3, TRPV1 | 5.8483 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, TRPV1 | 2.94576 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 4.8882 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 | 7.53076 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PTAFR, RORC, SMAD3, SRC, TRPV1 | 2.71678 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.38273 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, BCL2, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.62059 |
Showing 1 to 10 of 613 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.1412 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.0367 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4694 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.2034 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 5.0863 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.5685 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, INSR, PIK3CB | 3.7022 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.8959 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, DRD1, GRIA4 | 1.9927 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, HMGCR, IGF1R | 2.8911 |
Showing 1 to 10 of 176 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples