Prescription ID | TCMF6133 |
Pinyin Name | Yao Shen Gao |
Chinese Name | 腰肾膏 |
English Name | Yao Shen Ointment |
Function Description | 腰痛, 遗精, 早泄, 阳痿 |
Indications | Premature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Lumbago disorder, Sexual dysfunction, Lumbago, Premature ejaculation |
Disease ICD-11 Category |
SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1)
]; SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ]; SB0B [Impotence disorder (TM1), 阳痿 (TM1) ]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍,未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛,未特指的 ]; HA03.0Z [Male early ejaculation, unspecified, 男性早泄,未特指的 ]; |
Human Tissues Associated with Indication | Kidney, Bladder |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1740 | Cistanche deserticola | 肉苁蓉 | TCMH1740 | ITSAM2511-14 |
TCMH33 | Illicium verum | 八角茴香 | TCMH33 | ITSAJ4138-14 |
TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH1866 | Cnidium monnieri | 蛇床子 | TCMH1866 | ITSAL2575-14 |
TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
TCMH2334 | Dipsacus japonicus | 续断 | TCMH2334 | ITSAC1509-14 |
TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
TCMH2295 | fructus foeniculi | 小茴香 | TCMH2295 | |
TCMH623 | Aconitum carmichaeli | 附子 | TCMH623 | ITSAH2410-14 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH1753 | Boswellia carterii | 乳香 | TCMH1753 | |
TCMH1508 | Commiphora myrrha | 没药 | TCMH1508 | MH522406 |
TCMH486 | Syzygium aromaticum | 丁香 | TCMH486 | GBVI185-11 |
TCMH2056 | Cynomorium songaricum | 锁阳 | TCMH2056 | ITSAO3649-14 |
TCMH2585 | Cinnamomum camphora | 樟脑 | TCMH2585 | SDH069-14 |
TCMH183 | Dryobalanops aromatica | 冰片 | TCMH183 | GBVK4926-11 |
TCMH191 | Mentha haplocalyx | 薄荷油 | TCMH191 | HM595443 |
TCMH1745 | NA | 肉桂油 | TCMH1745 | |
TCMH2009 | Methyl salicylatum | 水杨酸甲酯 | TCMH2009 | |
TCMH594 | Liquidambar formosana | 枫香脂稠膏 | TCMH594 | ITSAM899-14 |
TCMH2385 | NA | 盐酸苯海拉明 | TCMH2385 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
TCMT154 | PRKCD | Protein kinase C delta | Kinase | Q05655 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT209 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase 2 | Oxidoreductase | P80365 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT231 | GBA2 | Beta-glucosidase | Hydrolase | Q9HCG7 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT249 | CDK6 | Cyclin-dependent kinase 6 | Kinase | Q00534 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT337 | XPO1 | Exportin-1 | Unclassified | O14980 |
TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT506 | PTK2B | Protein tyrosine kinase 2 beta | Kinase | Q14289 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT619 | HSP90AA1 | Heat shock protein HSP 90-alpha | Unclassified | P07900 |
TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT651 | DRD3 | Dopamine D3 receptor | GPCR | P35462 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
TCMT683 | MIF | Macrophage migration inhibitory factor | Isomerase | P14174 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT783 | NR3C2 | Mineralocorticoid receptor | Nuclear receptor | P08235 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
TCMT904 | PGR | Progesterone receptor | Nuclear receptor | P06401 |
TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1186 | Plasmodium yoelii yoelii |
TCMT1187 | Enterococcus faecalis ATCC 29212 |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1219 | Enterococcus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1234 | Bacillus coagulans |
TCMT1235 | Clostridium sporogenes |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1238 | Mycobacterium xenopi |
TCMT1239 | Mycobacterium marinum |
TCMT1243 | Aspergillus flavus |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1319 | Corynebacterium xerosis |
TCMT1321 | Staphylococcus hominis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1354 | Streptococcus mutans UA159 |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1457 | Leishmania major |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, PPARA, PPARG, PRKCA, PRKCD, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH | 16.3049 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 13.714 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PPARG, PRKCD, RORC, SRC, TEK, TRPV1, TYR | 13.5496 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 11.8918 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TRPV1, TYR | 11.5085 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PPARA, PPARG, TRPV1 | 11.248 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 11.248 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 10.9683 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 10.8112 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 10.778 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 10.7438 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HSP90AB1, NR3C1, PPARG, RORC, SRC, TEK, TRPV1, TYR | 10.6731 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 10.4327 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, PRKCD, SMAD3, SRC, TEK, TRPV1 | 10.355 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PGR, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, XDH | 10.217 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, NR3C1, PPARA, PPARG, PRKCD, SRC, TEK, TRPV1 | 9.76142 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 | 9.68092 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 9.65703 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARG, PRKCD, RORC, SMAD3, SRC, TRPV1 | 9.12845 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 9.03395 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARG, PRKCD, RORC, SMAD3, SRC, TRPV1 | 9.02847 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 8.94332 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1 | 8.91774 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK | 8.91774 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 8.91774 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 8.91774 |
[BP] GO:0043401 | steroid hormone mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC | 8.82001 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 8.66338 |
[BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 | 8.55198 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 8.40531 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK | 8.39576 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK | 8.39576 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, GLO1, HSPA1A, MIF, PIM1, PPARA, PPARG, TYR, XDH | 8.38877 |
[BP] GO:0033993 | response to lipid | ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PPARG, RORC, SRC, TYR | 8.32123 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 8.25671 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 8.19134 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR | 8.19134 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 8.18768 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK | 8.08701 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PPARG, PRKCD, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 | 7.82293 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK | 7.80815 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 7.80123 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK | 7.80123 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 | 7.78756 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 7.74635 |
[BP] GO:0007215 | None | APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.74635 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 7.74635 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, MMP2, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 7.74246 |
[BP] GO:0009755 | hormone-mediated signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC | 7.74246 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR | 7.73549 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF | 7.67835 |
[BP] GO:0030522 | intracellular receptor signaling pathway | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, PPARG, RORC, SRC | 7.54474 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 7.54474 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MIF, PRKCA, PTPN1, SRC, TEK, XDH | 7.54474 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PPARG, PRKCA, SMAD3, SRC, TEK | 7.52977 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR | 7.50012 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC, TRPV1 | 7.48869 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF | 7.43659 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 7.34505 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARG, PRKCD, RORC, SRC, TRPV1 | 7.31958 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH | 7.1814 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.12084 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, RORC, SRC, TRPV1 | 7.11664 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 7.00113 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MIF, MMP9, PIM1, PPARG, PRKCA, PRKCD, SLC1A1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH | 6.90318 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA6, CA7, CA9 | 6.88727 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MIF, MMP2, MMP9, PIM1, PRKCA, TEK | 6.88575 |
[BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC | 6.86173 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARG, TYR, XDH | 6.79917 |
[BP] GO:0048513 | animal organ development | ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR | 6.67498 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 6.60977 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 6.60977 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 6.60977 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, SRC, TEK, TRPV1, TYR | 6.51296 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, SRC | 6.4774 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 6.3121 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, MET, MIF, PPARA, PPARG | 6.25638 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 6.25638 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 6.24956 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PPARG, PRKCD, SRC, TEK, TRPV1 | 6.24956 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK | 6.24341 |
[BP] GO:0080134 | regulation of response to stress | ADORA1, ALOX12, APP, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MIF, MMP2, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 6.23283 |
[BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.21687 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK | 6.18544 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PPARG | 6.15835 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 6.08828 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PGR, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TYR | 6.07082 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH | 6.06296 |
[BP] GO:0008283 | cell proliferation | ACHE, AR, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, PRKCD, SRC, TEK, TYR | 6.02134 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HSD11B2, HSP90AB1, KDR, NR3C1, PPARG, PRKCD, SRC, TRPV1 | 6.02134 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, SRC, TEK, TRPV1, TYR | 6.01833 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, GRM1, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR | 6.002 |
[BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 5.99693 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A | 5.98594 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF | 5.9317 |
[BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.91887 |
[BP] GO:0007188 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 | 5.91139 |
[BP] GO:0006352 | DNA-templated transcription, initiation | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC | 5.87185 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TNKS | 5.82361 |
[BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 5.80734 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PPARG, SMAD3, TRPV1 | 5.76578 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 5.75301 |
[BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.73494 |
[BP] GO:0007154 | None | ADORA1, AR, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PPARG, SLC1A1, TEK, TRPV1 | 5.65371 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 5.65281 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, SMAD3, TRPV1, XDH | 5.61527 |
[BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.59469 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH | 5.57173 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD3, EGFR, HCAR2, KDR, MIF, SRC, TNKS, TNKS2, TRPV1 | 5.55192 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, SMAD3, TRPV1, XDH | 5.54006 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PPARA, PPARG | 5.50955 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, PRKCD, SRC, TRPV1 | 5.49215 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, MIF, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 5.48747 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, PGR, PPARA, PPARG, RORC, SRC, TOP2A | 5.46682 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 5.44754 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 5.43625 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, MIF, MMP9, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 5.42934 |
[BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK | 5.42849 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 5.42849 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1, TRPV1 | 5.41311 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 5.40089 |
[BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, INSR, MIF, MMP9, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TRPV1 | 5.40089 |
[BP] GO:0044093 | positive regulation of molecular function | ADORA1, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MIF, MMP9, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 5.38911 |
[BP] GO:0007187 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 | 5.35038 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, MIF, MMP9, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 5.33163 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, INSR, MIF, PPARG, PRKCD, PTPN1, SRC, TEK, TNKS | 5.32047 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AR, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, KDR, MET, MIF, MMP9, PIM1, PPARG, PRKCA, SLC1A1, SMAD3, SRC, TEK, TRPV1 | 5.3196 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PPARG, PRKCD, RORC, SRC, TEK | 5.26991 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.24729 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 | 5.24729 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 | 5.24729 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA | 5.23447 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, APP, AR, EGFR, FLT3, GRM1, INSR, KDR, MIF, PRKCA, PTPN1, SRC, TEK, XDH | 5.21463 |
[BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 5.2081 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AB1, INSR, MIF, PRKCA, SRC | 5.17663 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 | 5.1381 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 | 5.1381 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.13753 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, APP, AR, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARG, PRKCD, SMAD3, SRC, TRPV1 | 5.11086 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 5.11086 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, PPARG, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 5.10811 |
[BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD3, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, SLC1A1, SMAD3, TRPV1 | 5.04253 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.0297 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 5.02187 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC | 5.02187 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ALOX12, ALOX15, AR, BCL2, CDK6, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP9, PPARA, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 5.01255 |
[BP] GO:0051726 | regulation of cell cycle | APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, PIM1, PRKCA, SMAD3, SRC, TNKS, TOP2A | 5.01255 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SRC, TNKS | 5.01255 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 5.00154 |
[BP] GO:0051130 | positive regulation of cellular component organization | ALOX15, APP, AR, AURKB, AXL, BCL2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PRKCD, SMAD3, SRC, TEK, TNKS, TNKS2 | 4.98464 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, PGR, PPARA, PPARG, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A | 4.97809 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SRC, TEK, TNKS, XDH | 4.97184 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 4.96281 |
[BP] GO:0007267 | None | ADORA1, AR, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1, TEK | 4.89439 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 4.88973 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH | 4.84906 |
[BP] GO:0051054 | positive regulation of DNA metabolic process | AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PRKCD, SRC, TNKS, TNKS2 | 4.81301 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, XDH | 4.78146 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 4.74976 |
[BP] GO:0051972 | regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS | 4.71376 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, NR3C1, PGR, PPARA, PPARG, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 4.70948 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, PRKCD, SMAD3, SRC, TNKS | 4.70408 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, GBA2, TYR | 4.69114 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 4.61386 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK | 4.58529 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SRC, TEK, TNKS, XDH | 4.57728 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 | 4.5706 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC | 4.5523 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 4.51991 |
[BP] GO:0007268 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.51558 |
[BP] GO:0098916 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.51558 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 4.50209 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TNKS | 4.50209 |
[BP] GO:0099536 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.42317 |
[BP] GO:0099537 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 | 4.42317 |
[BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD3, EGFR, HCAR2, HSP90AB1, INSR, MIF, PPARG, PRKCD, SMAD3, SRC, TRPV1 | 4.42237 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MIF, PRKCD, PTPN1, SRC, TEK, TNKS | 4.41811 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PGR, PPARG, SRC | 4.41811 |
[BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD3, EGFR, GPR35, GRM1, HCAR2, PRKCA, SLC1A1, SMAD3, TRPV1 | 4.40947 |
[BP] GO:0051172 | None | APEX1, APP, AR, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MIF, MMP9, NR3C1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 4.36779 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 | 4.35824 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, PPARA, PPARG, PRKCA, PRKCD, SMAD3, TEK | 4.358 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, PRKCD, SRC, TEK, TNKS, TOP2A | 4.35533 |
[BP] GO:0023052 | None | ADORA1, AR, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1, TEK | 4.32649 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.31487 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APEX1, APP, AR, AURKB, BCL2, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MET, MIF, MMP9, NR3C1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 4.28654 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 | 4.28654 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.24293 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC | 4.20525 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, KDR, MIF, MMP9, PRKCA, PRKCD, PTPN1, SRC, TEK, XDH | 4.20525 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | APP, AR, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A | 4.19835 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1, TRPV1 | 4.18737 |
[BP] GO:0010564 | regulation of cell cycle process | APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, TNKS | 4.17654 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA | 4.16951 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, SRC, TRPV1 | 4.12876 |
[BP] GO:2000573 | positive regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 | 4.09406 |
[BP] GO:0050678 | None | AR, CDK6, EGFR, F3, KDR, PGR, PPARG, PRKCA, SMAD3, TEK, XDH | 4.05394 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD3, HSP90AA1, KDR, PRKCD, SRC | 4.05394 |
[BP] GO:0051128 | regulation of cellular component organization | ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 4.03669 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PRKCD, SRC | 4.02709 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PGR, PPARG, SRC, TOP2A | 4.01497 |
[BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.01497 |
[BP] GO:2000278 | regulation of DNA biosynthetic process | AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 | 4.01472 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, F10, F3, INSR, MET, SRC, TEK | 4.01268 |
[BP] GO:1901653 | cellular response to peptide | AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PPARG, PRKCD, SRC | 3.98487 |
[BP] GO:0048608 | reproductive structure development | AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC | 3.9754 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC | 3.94659 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC | 3.94376 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC, TEK | 3.93819 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | ALOX15, APP, DUSP3, EGFR, KDR, MIF, PRKCA, PTPN1, SRC, TEK | 3.92771 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC | 3.91772 |
[BP] GO:0043434 | None | APEX1, FABP3, HSD11B2, INSR, PPARA, PPARG, PRKCD, SRC, TEK, TRPV1 | 3.87885 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARG, TYR | 3.87885 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PRKCA, PRKCD, RORC, SMAD3, SRC, TRPV1 | 3.87204 |
[BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, DRD3, MIF, PPARA, PPARG, PRKCD, SMAD3, TEK | 3.86832 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK | 3.86383 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, AR, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PPARG, PRKCD, PTPN1, SMAD3, SRC, XDH | 3.8446 |
[BP] GO:1903725 | regulation of phospholipid metabolic process | CHRM5, FABP3, FLT3, PRKCD, SRC, TEK | 3.83598 |
[BP] GO:0048545 | response to steroid hormone | ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1, SRC | 3.83195 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, AR, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP9, PPARG, PRKCD, PTPN1, SMAD3, SRC, XDH | 3.82942 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, APP, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, SRC, TRPV1 | 3.81958 |
[BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.81757 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1, RORC | 3.81757 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, PPARA, PPARG, PRKCD, SMAD3, TEK | 3.79364 |
[BP] GO:0050794 | regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 3.77783 |
[BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP2, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC | 3.77628 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH | 3.74593 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARG, SMAD3, SRC, TEK | 3.72773 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC | 3.7198 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.71233 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, PRKCD, SRC, TEK | 3.7067 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 3.69721 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 | 3.69272 |
[BP] GO:0050730 | None | ADORA1, APP, EGFR, FLT3, GRM5, MIF, PRKCD, PTPN1, SRC | 3.66892 |
[BP] GO:0030518 | intracellular steroid hormone receptor signaling pathway | AR, ESR1, ESR2, NR3C1, PGR, SRC | 3.66357 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD3, EGFR, HSPA1A | 3.66357 |
[BP] GO:0010638 | positive regulation of organelle organization | ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 | 3.6551 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PPARG, PRKCD, SRC, TEK | 3.62365 |
[BP] GO:1901655 | None | AKR1B1, AR, EGFR, NR3C1, PPARG, SRC | 3.57372 |
[BP] GO:1901654 | None | AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC | 3.57235 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PTPN1, SMAD3 | 3.56161 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.56117 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 | 3.55859 |
[BP] GO:0044070 | regulation of anion transport | ADORA1, CA2, CA7, GRM5, MIF, PRKCD | 3.55105 |
[BP] GO:1903426 | None | EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 | 3.55105 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.53595 |
[BP] GO:0050793 | regulation of developmental process | ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HSP90AB1, INSR, KDR, MIF, NUAK1, PIM1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH | 3.50983 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, MIF, PRKCD, PTPN1, SRC, TEK | 3.50768 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.50544 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.50544 |
[BP] GO:0051052 | regulation of DNA metabolic process | AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PRKCD, SRC, TNKS, TNKS2 | 3.47626 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF | 3.47048 |
[BP] GO:0050789 | regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH | 3.46966 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MIF, MMP2, MMP9, PGR, PPARG, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A | 3.45347 |
[BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.44149 |
[BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.44149 |
[BP] GO:0046903 | None | ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PRKCD, SLC1A1, TRPV1, XDH | 3.43744 |
[BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 | 3.42174 |
[BP] GO:0080135 | regulation of cellular response to stress | APP, CDK6, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PTPN1, XDH | 3.42174 |
[BP] GO:0040008 | regulation of growth | ALOX12, APP, AR, BCL2, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SMAD3, TNKS2 | 3.39267 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARG, TYR | 3.38207 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.37206 |
[BP] GO:0042391 | None | ADORA1, APP, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 | 3.36969 |
[BP] GO:0050878 | regulation of body fluid levels | ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, F10, F3, MET, PRKCA, PRKCD, XDH | 3.36969 |
[BP] GO:0010605 | negative regulation of macromolecule metabolic process | APEX1, APP, AR, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSP90AB1, HSPA1A, IGF1R, KDR, MIF, MMP9, NR3C1, PGR, PPARA, PPARG, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH | 3.32698 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 3.31652 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PPARG, TYR | 3.29139 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ALOX15, APP, EGFR, KDR, MIF, PRKCA, SRC, TEK | 3.29139 |
[BP] GO:0050801 | ion homeostasis | APP, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 3.2904 |
[BP] GO:0030155 | regulation of cell adhesion | ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, PRKCD, SMAD3, SRC, TEK | 3.2904 |
[BP] GO:0035235 | None | APP, GRIA2, GRIA4, GRIK5 | 3.24286 |
[BP] GO:0032845 | None | ADORA1, BCL2, MIF, SRC, TNKS, TNKS2, TRPV1 | 3.22561 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC | 3.22372 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK | 3.22196 |
[BP] GO:0045934 | None | APEX1, AR, AURKB, DRD3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, NR3C1, PPARA, PPARG, PRKCA, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 | 3.20715 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, DUSP3, EGFR, FLT3, GRM1, HSP90AB1, IGF1R, INSR, MIF, PRKCD, PTPN1, SRC | 3.19431 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 | 3.18689 |
[BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.18506 |
[BP] GO:0032870 | cellular response to hormone stimulus | APEX1, AR, EGFR, ESR1, FLT3, INSR, NR3C1, PPARG, PRKCD, SRC | 3.18211 |
[BP] GO:0042752 | None | ADORA1, DRD3, PPARA, PPARG, RORC, TOP2A | 3.15844 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK | 3.15443 |
[BP] GO:0008217 | None | ADORA1, AR, DRD3, HSD11B2, PPARA, PPARG, SMAD3 | 3.14499 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC, TRPV1 | 3.14324 |
[BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, MIF, PRKCD, PTPN1, SRC | 3.1141 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PPARG, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH | 3.08162 |
[BP] GO:0072593 | reactive oxygen species metabolic process | ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR | 3.06722 |
[BP] GO:0071396 | cellular response to lipid | AR, AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PPARG, RORC, SRC | 3.05693 |
[BP] GO:0002009 | morphogenesis of an epithelium | AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 3.056 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, SMAD3, SRC, TEK | 3.0481 |
[BP] GO:0009889 | regulation of biosynthetic process | ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 3.0481 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, SRC | 3.0476 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PPARG, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH | 3.0476 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH | 3.0476 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1, PRKCD | 3.04664 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.04529 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.04529 |
[BP] GO:0035265 | organ growth | AR, BCL2, CYP19A1, ESR1 | 3.02684 |
[BP] GO:0090087 | None | ACHE, ADORA1, APP, CA2, CHRM1, DRD3, EGFR, HCAR2, HSP90AB1, MIF, PRKCA, PRKCD, PTPN1, SMAD3, SRC | 3.02009 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.00679 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 2.97083 |
[BP] GO:0060736 | prostate gland growth | AR, CYP19A1, ESR1 | 2.92022 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, DRD3, EGFR, HCAR2, TNKS, TNKS2 | 2.91364 |
[BP] GO:0010907 | None | ESRRB, INSR, PPARA, SRC | 2.87051 |
[BP] GO:0006464 | cellular protein modification process | ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.86693 |
[BP] GO:0036211 | protein modification process | ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.86693 |
[BP] GO:0098771 | inorganic ion homeostasis | APP, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.8627 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.84901 |
[BP] GO:0043412 | macromolecule modification | ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.84901 |
[BP] GO:0009115 | None | AOX1, XDH | 2.84901 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.84901 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.84901 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.84901 |
[BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PPARG, SRC | 2.84229 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 | 2.82508 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP3A4 | 2.82464 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, PPARA, PPARG, PRKCD, SMAD3, TEK | 2.81767 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PPARG, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 | 2.79405 |
[BP] GO:0044267 | cellular protein metabolic process | ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.79284 |
[BP] GO:0009968 | negative regulation of signal transduction | AR, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP9, PPARG, PRKCD, PTPN1, SMAD3, SRC, XDH | 2.79284 |
[BP] GO:0050727 | regulation of inflammatory response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, PRKCD, SMAD3, TEK | 2.79244 |
[BP] GO:1900543 | None | DRD3, GRM3, GRM8, PPARA, PRKCA | 2.77218 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PPARG, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH | 2.75759 |
[BP] GO:0051973 | positive regulation of telomerase activity | AURKB, HSP90AA1, HSP90AB1, TNKS | 2.74911 |
[BP] GO:0045980 | None | DRD3, GRM3, GRM8, PPARA, PRKCA | 2.74584 |
[BP] GO:0048732 | gland development | AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR | 2.73971 |
[BP] GO:0032409 | None | APP, BCL2, DRD3, GPR35, GRM5, MMP9, PPARG, PRKCD | 2.73971 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD | 2.73226 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.72711 |
[BP] GO:0031326 | regulation of cellular biosynthetic process | ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 2.71545 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, MIF | 2.70948 |
[BP] GO:0071363 | cellular response to growth factor stimulus | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 2.70796 |
[BP] GO:0010038 | response to metal ion | ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.70292 |
[BP] GO:0071383 | None | AR, EGFR, FLT3, NR3C1, SRC | 2.69855 |
[BP] GO:0019219 | regulation of nucleobase-containing compound metabolic process | ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 2.66802 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH | 2.66245 |
[BP] GO:0031100 | animal organ regeneration | AXL, CSNK2A1, EGFR, FLT3, PPARG | 2.64764 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR | 2.64592 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PRKCA, SRC, TEK | 2.64592 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.63729 |
[BP] GO:0038128 | None | EGFR, HSP90AA1, PRKCA, SRC | 2.62982 |
[BP] GO:0018107 | peptidyl-threonine phosphorylation | BCL2, CSNK2A1, PRKCA, PRKCD, TNKS | 2.59827 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK | 2.58533 |
[BP] GO:0051254 | None | APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TOP2A | 2.56048 |
[BP] GO:1900182 | positive regulation of protein localization to nucleus | APP, EGFR, HSP90AB1, PRKCD, SMAD3, SRC | 2.55958 |
[BP] GO:0072507 | divalent inorganic cation homeostasis | APP, BCL2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.55191 |
[BP] GO:0008150 | biological_process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 2.53867 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PPARG, RORC | 2.53627 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, BCL2, EGFR, HCAR2, HSP90AB1, MET, PPARA, SMAD3 | 2.51498 |
[BP] GO:0001936 | None | F3, KDR, PPARG, PRKCA, TEK, XDH | 2.5112 |
[BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, EGFR, PPARG, TYR | 2.50769 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, EGFR, FLT3, GRM1, INSR, MIF, PTPN1, SRC | 2.50635 |
[BP] GO:0043269 | regulation of ion transport | ADORA1, APP, BCL2, CA2, CA7, CHRM1, DRD3, GPR35, GRM5, MIF, MMP9, PRKCD | 2.49718 |
[BP] GO:0030336 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF, PPARG | 2.49679 |
[BP] GO:1904951 | positive regulation of establishment of protein localization | ACHE, APP, BCL2, CHRM1, EGFR, HCAR2, HSP90AB1, MIF, PRKCD, SMAD3, SRC | 2.49629 |
[BP] GO:0032880 | regulation of protein localization | ACHE, APP, AR, BCL2, CHRM1, CSNK2A1, DRD3, EGFR, HCAR2, HSP90AB1, MIF, PRKCA, PRKCD, PTPN1, SMAD3, SRC | 2.49191 |
[BP] GO:0051094 | positive regulation of developmental process | ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HSP90AB1, INSR, KDR, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK | 2.47983 |
[BP] GO:0032075 | None | HSPA1A, PRKCD, PTPN1 | 2.47983 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.47983 |
[BP] GO:0051131 | None | HSP90AA1, HSP90AB1, HSPA1A | 2.47983 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5 | 2.47983 |
[BP] GO:0031099 | regeneration | AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG | 2.47074 |
[BP] GO:0003008 | None | ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD3, EGFR, GRM1, GRM5, GRM8, HSD11B2, INSR, SRC, TEK, TRPV1, TYR | 2.47074 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, PPARG, SRC, TRPV1, TYR | 2.45503 |
[BP] GO:0030818 | None | DRD3, GRM3, GRM8, PRKCA | 2.45272 |
[BP] GO:0018210 | peptidyl-threonine modification | BCL2, CSNK2A1, PRKCA, PRKCD, TNKS | 2.45107 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.44711 |
[BP] GO:0060748 | None | AR, PGR | 2.44711 |
[BP] GO:0046110 | None | AOX1, XDH | 2.44711 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.44711 |
[BP] GO:0070201 | None | ACHE, APP, BCL2, CHRM1, DRD3, EGFR, HCAR2, HSP90AB1, MIF, PRKCA, PRKCD, PTPN1, SMAD3, SRC | 2.43857 |
[BP] GO:0048145 | None | CDK6, EGFR, ESR1, MIF, PPARG | 2.43633 |
[BP] GO:0071902 | positive regulation of protein serine/threonine kinase activity | ADORA1, EGFR, FLT3, GRM1, HSP90AB1, INSR, MIF, PTPN1, SRC | 2.43633 |
[BP] GO:0032868 | None | FABP3, HSD11B2, INSR, PPARA, PPARG, SRC | 2.43576 |
[BP] GO:0051384 | response to glucocorticoid | ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 | 2.43576 |
[BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.42778 |
[BP] GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | BCL2, CYP1B1, PRKCD | 2.41931 |
[BP] GO:1904355 | positive regulation of telomere capping | AURKB, TNKS, TNKS2 | 2.41931 |
[BP] GO:0048729 | tissue morphogenesis | AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.40426 |
[BP] GO:0055080 | cation homeostasis | APP, BCL2, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.39746 |
[BP] GO:0030803 | None | DRD3, GRM3, GRM8, PRKCA | 2.39626 |
[BP] GO:0045893 | None | APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TOP2A | 2.39429 |
[BP] GO:1903508 | None | APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TOP2A | 2.39429 |
[BP] GO:1902680 | None | APP, AR, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SMAD3, SRC, TNKS, TOP2A | 2.39111 |
[BP] GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH | 2.38912 |
[BP] GO:0032103 | positive regulation of response to external stimulus | EGFR, F3, FABP4, KDR, MET, MIF, PRKCA, SMAD3 | 2.38066 |
[BP] GO:0070848 | response to growth factor | APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 | 2.38066 |
[BP] GO:2000146 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF, PPARG | 2.37076 |
[BP] GO:0045321 | leukocyte activation | ALOX5, AXL, BCL2, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PRKCD, RORC, SMAD3, TRPV1 | 2.36268 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, GBA2 | 2.35506 |
[BP] GO:0090330 | regulation of platelet aggregation | ALOX12, PRKCA, PRKCD | 2.35506 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1, TRPV1 | 2.34708 |
[BP] GO:0014074 | response to purine-containing compound | APEX1, APP, PPARG, TEK, TRPV1, TYR | 2.33742 |
[BP] GO:0030815 | None | DRD3, GRM3, GRM8, PRKCA | 2.33729 |
[BP] GO:2001234 | negative regulation of apoptotic signaling pathway | AR, BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC | 2.33551 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.30923 |
[BP] GO:1900372 | None | DRD3, GRM3, GRM8, PRKCA | 2.30716 |
[BP] GO:0030809 | None | DRD3, GRM3, GRM8, PRKCA | 2.30716 |
[BP] GO:0035306 | None | ADORA1, HSP90AB1, PRKCD, SMAD3 | 2.30716 |
[BP] GO:0035303 | None | ADORA1, CHRM5, HSP90AB1, NUAK1, PRKCD, SMAD3 | 2.29659 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.2958 |
[BP] GO:0010632 | regulation of epithelial cell migration | KDR, MET, MMP9, PPARG, PRKCA, SRC, TEK | 2.29335 |
[BP] GO:0030800 | None | DRD3, GRM3, GRM8, PRKCA | 2.27858 |
[BP] GO:0055082 | cellular chemical homeostasis | APP, BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 | 2.26597 |
[BP] GO:0051179 | None | ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PPARA, PPARG, PRKCD, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH | 2.25814 |
[BP] GO:0033043 | regulation of organelle organization | ALOX15, AURKB, BCL2, DRD3, GRIK5, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A | 2.25293 |
[BP] GO:0010906 | None | ESRRB, INSR, PPARA, RORC, SRC | 2.24849 |
[BP] GO:0006807 | nitrogen compound metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 2.23169 |
[BP] GO:0051271 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF, PPARG | 2.23063 |
[BP] GO:0045766 | positive regulation of angiogenesis | ALOX12, CYP1B1, F3, KDR, PRKCA, TEK | 2.23063 |
[BP] GO:0010676 | None | ESRRB, INSR, PPARA, SRC | 2.22174 |
[BP] GO:0050994 | None | ADORA1, HCAR2, PPARA, PRKCD | 2.22174 |
[BP] GO:0003018 | None | ADORA1, CHRM1, CHRM3, EGFR, SRC, TEK | 2.21857 |
[BP] GO:0010556 | regulation of macromolecule biosynthetic process | ADORA3, APEX1, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 | 2.21558 |
[BP] GO:0042307 | positive regulation of protein import into nucleus | APP, EGFR, HSP90AB1, PRKCD, SMAD3 | 2.21515 |
[BP] GO:0006874 | cellular calcium ion homeostasis | APP, BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.21515 |
[BP] GO:2001233 | regulation of apoptotic signaling pathway | AR, BCL2, HSPA1A, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC | 2.21515 |
[BP] GO:0051047 | None | ACHE, ADORA1, CYP19A1, DRD3, EGFR, HCAR2, MIF, SRC, TRPV1 | 2.20743 |
[BP] GO:0030003 | cellular cation homeostasis | APP, BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.20735 |
[BP] GO:1905323 | None | HSP90AA1, HSP90AB1 | 2.20735 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.20735 |
[BP] GO:0006145 | None | AOX1, XDH | 2.20735 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.20735 |
[BP] GO:0048146 | positive regulation of fibroblast proliferation | CDK6, EGFR, ESR1, MIF | 2.20392 |
[BP] GO:0032210 | regulation of telomere maintenance via telomerase | AURKB, SRC, TNKS, TNKS2 | 2.20392 |
[BP] GO:2001242 | regulation of intrinsic apoptotic signaling pathway | BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC | 2.19009 |
[BP] GO:1904591 | positive regulation of protein import | APP, EGFR, HSP90AB1, PRKCD, SMAD3 | 2.19009 |
[BP] GO:0000904 | cell morphogenesis involved in differentiation | AR, AXL, MET, SRC, TEK | 2.19009 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.17851 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.17851 |
[BP] GO:0051090 | regulation of DNA binding transcription factor activity | ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, PIM1, PPARG | 2.17527 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.17527 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.17527 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.17527 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.17527 |
[BP] GO:0051222 | positive regulation of protein transport | ACHE, APP, CHRM1, EGFR, HCAR2, HSP90AB1, MIF, PRKCD, SMAD3, SRC | 2.15596 |
[BP] GO:0051223 | None | ACHE, APP, CHRM1, DRD3, EGFR, HCAR2, HSP90AB1, MIF, PRKCA, PRKCD, PTPN1, SMAD3, SRC | 2.15275 |
[BP] GO:0006810 | None | ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PPARA, PPARG, PRKCD, SLC1A1, SRC, TNKS, TRPV1, XDH | 2.14532 |
[BP] GO:0000122 | None | AR, AURKB, DRD3, ESR1, ESR2, ESRRA, HSPA1A, NR3C1, PPARA, PPARG, RORC, SMAD3, TRPV1 | 2.14346 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 2.14257 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.14215 |
[BP] GO:0055074 | calcium ion homeostasis | APP, BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.14141 |
[BP] GO:0019725 | cellular homeostasis | APEX1, APP, BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 | 2.13664 |
[BP] GO:0006873 | cellular ion homeostasis | APP, BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.13664 |
[BP] GO:0051234 | None | ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9, PPARA, PPARG, PRKCD, SLC1A1, SRC, TNKS, TRPV1, XDH | 2.13571 |
[BP] GO:0040013 | None | ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF, PPARG | 2.13102 |
[BP] GO:0044089 | positive regulation of cellular component biogenesis | ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK | 2.12973 |
[BP] GO:1900542 | None | DRD3, ESRRB, GRM3, GRM8, INSR, PPARA, PRKCA | 2.11461 |
[BP] GO:0018105 | peptidyl-serine phosphorylation | AURKB, BCL2, PRKCA, PRKCD, SRC, TNKS | 2.10745 |
[BP] GO:0072503 | cellular divalent inorganic cation homeostasis | APP, BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 | 2.10745 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.10621 |
[BP] GO:2000116 | regulation of cysteine-type endopeptidase activity | CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH | 2.09727 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.09527 |
[BP] GO:0010811 | positive regulation of cell-substrate adhesion | ALOX15, CDK6, KDR, SMAD3, TEK | 2.09527 |
[BP] GO:0051704 | multi-organism process | APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DRD3, EGFR, HSD11B2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP1, PRKCD, SMAD3, SRC | 2.08332 |
[BP] GO:0032368 | None | CYP19A1, MIF, PPARA, PPARG, PRKCD | 2.07921 |
[BP] GO:0045936 | None | DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH | 2.07437 |
[BP] GO:0010563 | None | DRD3, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH | 2.06882 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, EGFR, HSD11B2, PPARG, SRC, TRPV1, TYR | 2.06255 |
[BP] GO:0034502 | protein localization to chromosome | AURKB, ESR1, TNKS, TNKS2 | 2.05846 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP3A4 | 2.05846 |
[BP] GO:0006140 | None | DRD3, ESRRB, GRM3, GRM8, INSR, PPARA, PRKCA | 2.05134 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.05058 |
[BP] GO:0035902 | response to immobilization stress | CYP1A1, CYP1A2, PPARG | 2.05058 |
[BP] GO:0061900 | None | APP, EGFR, TRPV1 | 2.05058 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.05058 |
[BP] GO:2000026 | regulation of multicellular organismal development | ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, INSR, KDR, PIM1, PPARG, PRKCA, SMAD3, SRC, TEK, XDH | 2.05038 |
[BP] GO:0033554 | cellular response to stress | AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, PPARG, PRKCD, PTPN1, SRC, TOP2A, TRPV1 | 2.04347 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC | 2.04229 |
[BP] GO:1904356 | regulation of telomere maintenance via telomere lengthening | AURKB, SRC, TNKS, TNKS2 | 2.04169 |
[BP] GO:0008285 | negative regulation of cell proliferation | ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, PPARG, SMAD3, XDH | 2.04169 |
[BP] GO:0046541 | None | CHRM1, CHRM3 | 2.04169 |
[BP] GO:0043696 | None | CDK6, ESRRB | 2.04169 |
[BP] GO:0043697 | None | CDK6, ESRRB | 2.04169 |
[BP] GO:0010641 | None | F3, SRC | 2.04169 |
[BP] GO:0007598 | None | F10, F3 | 2.04169 |
[BP] GO:0032800 | receptor biosynthetic process | ACHE, PPARG | 2.04169 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.04169 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.04169 |
[BP] GO:0010891 | None | PPARA, PPARG | 2.04169 |
[BP] GO:0021700 | developmental maturation | APP, AXL, CDC25B, MMP2, PGR, PPARG | 2.04169 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 | 2.04169 |
[BP] GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ADORA1, FLT3, GRM5, MIF, PTPN1, SRC | 2.02917 |
[BP] GO:0050927 | None | F3, KDR, SMAD3 | 2.01446 |
[BP] GO:0034110 | regulation of homotypic cell-cell adhesion | ALOX12, PRKCA, PRKCD | 2.01446 |
[BP] GO:1903827 | regulation of cellular protein localization | APP, AR, BCL2, CHRM1, CSNK2A1, EGFR, HSP90AB1, PRKCD, PTPN1, SMAD3, SRC | 2.0073 |
[BP] GO:0050679 | None | AR, EGFR, F3, KDR, PRKCA, TEK | 2.00619 |
[BP] GO:1904018 | positive regulation of vasculature development | ALOX12, CYP1B1, F3, KDR, PRKCA, TEK | 2.00619 |
[CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, SLC1A1, SRC, TEK, TRPV1 | 7.53734 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PRKCD, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 | 6.8423 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIM1, PRKCA, PRKCD, PTPN1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR | 6.51678 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 | 5.63255 |
[CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK, TRPV1 | 5.61691 |
[CC] GO:0097060 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 | 5.42849 |
[CC] GO:0044456 | None | ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 | 4.34942 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 | 4.3164 |
[CC] GO:0043235 | receptor complex | APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, NR3C2, SMAD3 | 4.15186 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C2, PTPN1, SLC1A1, SRC, TEK, TRPV1, TYR | 4.01268 |
[CC] GO:0045211 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 | 3.94161 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 3.91738 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, TEK | 3.45347 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.02009 |
[CC] GO:0044463 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 | 2.85315 |
[CC] GO:0120038 | None | ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 | 2.85315 |
[CC] GO:0048471 | perinuclear region of cytoplasm | ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PPARG, PRKCA, PRKCD, SRC, TNKS2, TYR | 2.84901 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTPN1 | 2.83411 |
[CC] GO:0005654 | None | AKR1B1, ALOX5, APEX1, AR, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, MIF, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TNKS, TOP2A | 2.73226 |
[CC] GO:1904813 | None | ALOX5, HSP90AA1, HSP90AB1, HSPA1A, MIF, MMP9 | 2.66245 |
[CC] GO:0045202 | None | ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 | 2.54601 |
[CC] GO:0005789 | endoplasmic reticulum membrane | BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2 | 2.48793 |
[CC] GO:0014069 | None | ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.47048 |
[CC] GO:0099572 | None | ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.47048 |
[CC] GO:0005783 | None | ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, HSPA1A, KDR, PRKCA, PRKCD, PTPN1, XDH | 2.39746 |
[CC] GO:0044464 | cell part | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 2.34188 |
[CC] GO:0030054 | cell junction | ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, KDR, PRKCD, TEK, TRPV1 | 2.26423 |
[CC] GO:0031233 | None | CA4, F10, F3 | 2.23439 |
[CC] GO:1903561 | None | AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, MMP9, PRKCA, PRKCD, SLC1A1, SRC | 2.1966 |
[CC] GO:0043230 | None | AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, MMP9, PRKCA, PRKCD, SLC1A1, SRC | 2.19541 |
[CC] GO:0005829 | cytosol | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, DUSP3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, MIF, NR3C1, NR3C2, PGR, PIM1, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, TYR, XDH | 2.1928 |
[CC] GO:0043005 | None | ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC | 2.10621 |
[CC] GO:0098793 | None | ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 | 2.09727 |
[CC] GO:0031253 | None | ADORA1, CA4, CA9, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 | 2.09289 |
[CC] GO:0043227 | membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH | 2.0489 |
[CC] GO:0044428 | nuclear part | AKR1B1, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, INSR, MIF, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A | 2.04874 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH | 20.7574 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 | 13.5496 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 13.3934 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 | 12.379 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TEK, TRPV1 | 12.0361 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SMAD3, TEK, TRPV1 | 11.5875 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 11.3931 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCD, PTPN1, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH | 10.9683 |
[MF] GO:0003707 | steroid hormone receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC | 10.9683 |
[MF] GO:0005496 | steroid binding | AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC | 10.7173 |
[MF] GO:0008270 | zinc ion binding | AR, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARG, PRKCA, PTPN1, RORC, SMAD3, TNKS | 10.5195 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 9.7043 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD3, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1 | 8.91774 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARG, RORC | 8.82001 |
[MF] GO:0004879 | nuclear receptor activity | AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, PPARG, RORC | 8.82001 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 8.40531 |
[MF] GO:0008289 | lipid binding | ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, TRPV1 | 8.01232 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH | 7.88415 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 7.79652 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.7207 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 | 7.54474 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 | 7.54474 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH | 7.54474 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 7.37704 |
[MF] GO:0030594 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 7.2533 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 | 7.06415 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.67474 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 6.51392 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK | 6.34447 |
[MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.21687 |
[MF] GO:0019899 | enzyme binding | APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PPARG, PRKCA, PRKCD, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A | 6.04784 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 5.93328 |
[MF] GO:0042562 | hormone binding | ACHE, AR, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 | 5.71072 |
[MF] GO:0030235 | nitric-oxide synthase regulator activity | EGFR, ESR1, HSP90AA1, HSP90AB1 | 5.48972 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 5.39573 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH | 5.36118 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK | 5.35038 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 | 5.33163 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 4.92623 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 4.50963 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK | 4.35409 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC | 4.29394 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 | 4.15364 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR | 3.95517 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK | 3.88935 |
[MF] GO:0042802 | identical protein binding | ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MIF, MMP9, PGR, PPARG, SMAD3, TOP2A, TRPV1, TYR, XDH | 3.85522 |
[MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.83195 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.72234 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.7067 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC | 3.6976 |
[MF] GO:0043168 | anion binding | ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, PRKCD, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH | 3.6097 |
[MF] GO:0036094 | small molecule binding | ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, PRKCA, PRKCD, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH | 3.52678 |
[MF] GO:0019900 | None | AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, PRKCD, PTPN1, SMAD3, SRC, TOP2A | 3.35489 |
[MF] GO:0048037 | cofactor binding | AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B2, HSD17B1, SRC, XDH | 3.35489 |
[MF] GO:0019901 | None | CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, PRKCD, PTPN1, SMAD3, SRC, TOP2A | 3.2904 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.18506 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.17561 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.17561 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 3.06941 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK | 3.0601 |
[MF] GO:0005524 | ATP binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1 | 3.04513 |
[MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.02684 |
[MF] GO:0031072 | heat shock protein binding | ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 | 3.01531 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, INSR, PRKCD | 2.92022 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 | 2.90789 |
[MF] GO:0032559 | adenyl ribonucleotide binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1 | 2.90623 |
[MF] GO:0030554 | adenyl nucleotide binding | AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1 | 2.86693 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.84901 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.84901 |
[MF] GO:0003845 | None | HSD11B1, HSD11B2 | 2.84901 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.84901 |
[MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.66802 |
[MF] GO:0000166 | nucleotide binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH | 2.57092 |
[MF] GO:1901265 | nucleoside phosphate binding | AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH | 2.56967 |
[MF] GO:0019904 | None | APP, AR, BCL2, DRD3, ESRRA, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARA, PPARG, SRC | 2.56741 |
[MF] GO:0003674 | molecular_function | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH | 2.53128 |
[MF] GO:0016903 | None | AKR1B1, AKR1B10, AOX1, XDH | 2.45272 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.44711 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.44711 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.44711 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.44711 |
[MF] GO:0035258 | None | ESR1, FLT3, PPARG, SMAD3, SRC | 2.39746 |
[MF] GO:0008081 | None | ADORA1, APEX1, CHRM1, CHRM3, CHRM5 | 2.34058 |
[MF] GO:0005231 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.33729 |
[MF] GO:0042578 | None | ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 | 2.32305 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.2958 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.2958 |
[MF] GO:0097159 | organic cyclic compound binding | ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 2.27934 |
[MF] GO:0004930 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 2.22961 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.20735 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.20735 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.20735 |
[MF] GO:0051425 | None | APP, INSR | 2.20735 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.20735 |
[MF] GO:1901363 | heterocyclic compound binding | ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH | 2.14257 |
[MF] GO:0000978 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 | 2.13571 |
[MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 2.10621 |
[MF] GO:0008134 | transcription factor binding | APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, PPARG, SMAD3, SRC | 2.09109 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, AOX1, CYP19A1, CYP1A2, XDH | 2.06259 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.04169 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.04169 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.04169 |
[MF] GO:0000987 | None | AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 | 2.02917 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD3, GRIA4 | 11.5591 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | HSP90AA1, HSP90AB1, SRC, MMP2, PRKCD, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A | 9.8894 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 | 11.9481 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R | 8.3612 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.3212 |
Pathways in cancer_Homo sapiens_hsa05200 | HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PRKCA, MMP9, EGFR, IGF1R, AR, CDK6, BCL2, PPARG, MET | 7.501 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 | 6.9876 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, PRKCA, EGFR, IGF1R, CDK6, KDR, BCL2, TEK, MET | 6.6586 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 7.1593 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.1593 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.8965 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PRKCD, BCL2, PIM1, PRKCA, F3 | 4.9893 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, EGFR, IGF1R | 4.9863 |
Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, PRKCA | 4.8083 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH | 4.6142 |
Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PRKCA, GRM1, EGFR | 4.5079 |
Prostate cancer_Homo sapiens_hsa05215 | AR, HSP90AA1, HSP90AB1, BCL2, EGFR, IGF1R | 4.3069 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R | 4.0671 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, INSR, GRM8, PRKCA, GRM1, EGFR | 4.18 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 4.7115 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | CDK6, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B | 3.8877 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | INSR, BCL2, PRKCA, TEK, EGFR, IGF1R | 4.0038 |
cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 | 3.4207 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R | 3.395 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 | 3.8861 |
Hepatitis B_Homo sapiens_hsa05161 | CDK6, SMAD3, SRC, BCL2, PRKCA, MMP9 | 3.3047 |
Ras signaling pathway_Homo sapiens_hsa04014 | INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R | 3.1605 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARG, PPARA | 3.777 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, PRKCD, PRKCA, EGFR | 3.3047 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC, PRKCD, PRKCA, ALOX12, TRPV1 | 3.1784 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | HSP90AA1, HSP90AB1, PGR, CDC25B, IGF1R | 3.1784 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, PRKCA, GRM1, EGFR | 3.346 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, PRKCA, GRM1, GRIA4 | 3.1415 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 2.8788 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, ALOX15, PRKCA, ALOX12 | 2.9547 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, INSR, PRKCA, NR3C2 | 3.5553 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR | 2.5943 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, INSR, GRM1, EGFR, IGF1R | 2.6938 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, AOX1, CYP1B1 | 3.5275 |
Glioma_Homo sapiens_hsa05214 | CDK6, PRKCA, EGFR, IGF1R | 2.8788 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, PRKCA, GRM1, IGF1R | 2.9702 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, PPARG, MMP9, MET, IGF1R | 2.1433 |
Melanoma_Homo sapiens_hsa05218 | CDK6, MET, EGFR, IGF1R | 2.7737 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, PRKCA, GRM1 | 2.8652 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15, ALOX12 | 2.9378 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, INSR, PRKCD, PPARA | 2.1324 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, AOX1, CYP3A4 | 2.8013 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, BCL2, ADORA1, PRKCA | 2.0059 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, PRKCA, DRD3, GRIA4 | 1.9101 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, PRKCA, EGFR, CDC25B, HSPA1A | 1.6326 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC, PRKCD, PRKCA | 1.8386 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSP90AA1, HSP90AB1, BCL2, HSPA1A | 1.5971 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR, PRKCA | 1.9535 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC, PRKCA, EGFR | 1.6167 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | CDK6, PRKCA, EGFR | 2.043 |
Pancreatic cancer_Homo sapiens_hsa05212 | CDK6, SMAD3, EGFR | 1.8801 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, INSR, ADORA1 | 2.043 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | INSR, IGF1R, HSPA1A | 1.9101 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | INSR, PPARG, IGF1R | 1.5502 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC, ESR1, ESR2 | 1.8102 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, PRKCA, GRIA4 | 1.8765 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, PRKCA, GRIA4 | 1.5439 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET, EGFR | 1.8765 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC, PRKCA, ESR1 | 1.3282 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3 | 0.1401 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, PRKCA, MMP9 | 1.3282 |
Oocyte meiosis_Homo sapiens_hsa04114 | AR, PGR, IGF1R | 1.2989 |
Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2, PRKCA | 1.7905 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5, BCL2, HSPA1A | 1.3282 |
AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, PPARG, IGF1R | 1.2989 |
Measles_Homo sapiens_hsa05162 | CDK6, CSNK2A1, HSPA1A | 1.2161 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.2177 |
Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2, PRKCA | 1.5375 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2286 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.1013 |
Cell cycle_Homo sapiens_hsa04110 | CDK6, SMAD3, CDC25B | 1.2989 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, ESRRB, IGF1R | 1.1878 |
Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.239 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 1.8655 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1, PRKCA | 1.1878 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.2631 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | BCL2, PIM1, AOX1 | 1.0995 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1, HSPA1A | 1.7493 |
Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.2869 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.2954 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC, PRKCA, EGFR | 1.0995 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PRKCA | 0.2954 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PPARG | 0.2972 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, INSR, ADORA1 | 1.0492 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3067 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.3168 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, BCL2, HSPA1A | 0.9094 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.3475 |
Viral carcinogenesis_Homo sapiens_hsa05203 | CDK6, SRC | 0.4889 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5, PPARG | 0.52 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.5527 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3 | 0.3634 |
Influenza A_Homo sapiens_hsa05164 | PRKCA, HSPA1A | 0.558 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.3705 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC, PRKCD | 0.5322 |
Amoebiasis_Homo sapiens_hsa05146 | PRKCA | 0.3712 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, PRKCA | 0.6517 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | INSR, PPARA | 0.6415 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, INSR | 0.684 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PRKCA | 0.3754 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.3832 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PRKCD, BCL2 | 0.7525 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA, EGFR | 0.7049 |
Vascular smooth muscle contraction_Homo sapiens_hsa04270 | PRKCD, PRKCA | 0.7525 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4014 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4149 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.3991 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4002 |
Melanogenesis_Homo sapiens_hsa04916 | PRKCA, TYR | 0.8735 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PRKCD, PRKCA | 0.9126 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.4163 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PRKCA, EGFR | 0.87 |
Taste transduction_Homo sapiens_hsa04742 | CHRM3, GRM1 | 0.9622 |
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.4222 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, PRKCA | 0.9208 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 0.9252 |
Salivary secretion_Homo sapiens_hsa04970 | CHRM3, PRKCA | 0.9296 |
Insulin secretion_Homo sapiens_hsa04911 | CHRM3, PRKCA | 0.9481 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2 | 0.9126 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC, PRKCA | 0.9344 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, CYP3A4, XDH | 2.255 |
Small cell lung cancer_Homo sapiens_hsa05222 | CDK6, BCL2 | 0.9477 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.0012 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | CDK6, SMAD3 | 1.048 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4689 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PRKCA | 0.4738 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10, F3 | 0.9957 |
Thyroid hormone synthesis_Homo sapiens_hsa04918 | PRKCA | 0.4666 |
p53 signaling pathway_Homo sapiens_hsa04115 | CDK6 | 0.4713 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.4819 |
Bile secretion_Homo sapiens_hsa04976 | CA2, CYP3A4 | 1.0609 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.4847 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.4874 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PRKCA | 0.5056 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.112 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, BCL2 | 1.1447 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.1925 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.5322 |
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | HSP90AA1, HSP90AB1 | 1.1925 |
Endometrial cancer_Homo sapiens_hsa05213 | EGFR | 0.5445 |
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | PRKCA | 0.5322 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.1793 |
Vibrio cholerae infection_Homo sapiens_hsa05110 | PRKCA | 0.5488 |
Malaria_Homo sapiens_hsa05144 | MET | 0.558 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2, BCL2 | 1.262 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | PRKCA, ESR1 | 1.2989 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | INSR, PRKCD | 1.2989 |
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | AOX1 | 0.5596 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.2893 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA2 | 0.5646 |
Tyrosine metabolism_Homo sapiens_hsa00350 | AOX1, MIF, TYR | 2.5943 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 2.8002 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.4066 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.6672 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.6242 |
African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.6672 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.6043 |
Thyroid cancer_Homo sapiens_hsa05216 | PPARG | 0.719 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7025 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.7409 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.684 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.5626 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.488 |
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | AOX1 | 0.719 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.7491 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.7089 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 1.7972 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.7409 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 4.8283 |
Phenylalanine metabolism_Homo sapiens_hsa00360 | MIF | 0.902 |
Other glycan degradation_Homo sapiens_hsa00511 | GBA2 | 0.8821 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 0.9481 |
Vitamin B6 metabolism_Homo sapiens_hsa00750 | AOX1 | 1.2216 |