Prescription Description
| Prescription ID | TCMF5500 |
| Pinyin Name | Wei Tian Mei Jiang Tang Cha |
| Chinese Name | 维甜美降糖茶 |
| English Name | Wei Tian Mei Jiang Tang Tea |
| Function Description | 消渴 |
| Indications | Wasting thirst disorder, Diabetes |
| Disease ICD-11 Category |
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1)
]; 5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ]; |
| Human Tissues Associated with Indication | Pancreas, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH147 | Glehnia littoralis | 北沙参 | TCMH147 | ITSAF389-14 |
| TCMH2551 | Polygonatum odoratum | 玉竹 | TCMH2551 | ITSAM921-14 |
| TCMH2086 | Trichosanthes kirilowii | 天花粉 | TCMH2086 | ITSAO4359-14 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH2503 | Goodyera hachijoensis yatabe | 银线莲 | TCMH2503 | |
| TCMH677 | Pueraria lobata | 葛根 | TCMH677 | ITSAJ4206-14 |
| TCMH1121 | Cardiospermum halicacabum | 金丝苦楝 | TCMH1121 | GENG634-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH1683 | Canarium album | 青果 | TCMH1683 | ITSAM870-14 |
| TCMH1848 | Crataegus pinnatifida | 山楂 | TCMH1848 | ITSAH1684-14 |
| TCMH2101 | Eupatorium rebaudianum | 甜叶菊 | TCMH2101 | |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH226 | Camellia sinensis | 茶叶 | TCMH226 | ITSAG2924-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
Showing 1 to 10 of 121 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
Showing 1 to 10 of 54 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 4.10802 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.49558 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.21574 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, ADORA2A, CYP1B1, DRD1, EGFR, HTR1A, INSR, SMAD3, TRPV1 | 3.91706 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT | 3.87202 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.47119 |
| [BP] GO:0001775 | cell activation | ADORA2A, ALOX5, APP, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 | 3.20052 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADORA2A, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, F2, FABP4, FLT3, HTR2B, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 4.11132 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, F2, FLT3, HTR2B, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH | 3.25416 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, KDR, SMAD3, SRC, TEK | 2.4233 |
Showing 1 to 10 of 494 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6218 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.2331 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.6653 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5068 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.331 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, BCL2, PIM1 | 2.4135 |
| Alcoholism_Homo sapiens_hsa05034 | ADORA2A, DRD1 | 0.6218 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.6472 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6472 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5198 |
Showing 1 to 10 of 155 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples