TCM Prescription: Wu Li Hui Chun Pills



Prescription Description
Prescription IDTCMF5483
Pinyin NameWu Li Hui Chun Wan
Chinese Name五粒回春丸
English NameWu Li Hui Chun Pills
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH718 Aristolochia manshuriensis 关木通 TCMH718 GBVE2055-11
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH396 Semen sojae praeparata 淡豆豉 TCMH396
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH2225 Cacumen tamaricis 西河柳 TCMH2225
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2596 Fritillaria verticillata 浙贝母 TCMH2596
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT640 CTSD Cathepsin D Unclassified P07339
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.4629
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.4629
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSD17B1, HSPA1A, INSR, KDR, KIT, MET, NR1H4, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 11.3898
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 11.1892
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.1892
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 11.1478
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 11.1098
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, THRA, TNKS, TNKS2, XDH 10.6859
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, FABP3, FUT7, HMGCR, HSPA1A, IDO1, NR1H4, PIM1, PPARA, PTGS2, XDH 10.6859
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, THRA, TNKS, TNKS2, XDH 10.6694
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, THRA, TNKS, TNKS2, XDH 10.5829
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, KIT, MET, NR1H4, PPARA, PTGS2 10.4366
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.2398
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 10.1093
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP1 10.0955
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, TEK 9.80524
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 9.79834
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, CYP19A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 9.40193
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.35942
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.2741
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 9.05676
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 9.05676
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9, DHFR 8.87304
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, THRA, TNKS, TNKS2, XDH 8.77262
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.77262
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, THRA 8.77262
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NR1H4, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 8.77262
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DHFR, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.59951
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESRRA, FABP3, GSK3B, HMGCR, IDO1, IGF1R, INSR, MMP2, MMP9, NR1H4, PPARA, PTGS2, RORC, SRC, TEK 8.44946
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, PTGS2, PTPN1, SRC, TEK, XDH 8.39298
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.38323
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, NR1H4, PPARA, PTGS2, SMAD3, SRC, TEK 8.36235
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.35945
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 8.35718
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.31428
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 8.31428
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.31205
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 8.1058
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.85663
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.85663
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.8225
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, THRA, XDH 7.8225
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.78874
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA, PTGS2 7.78578
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 7.78578
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 7.76434
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 7.66404
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.64882
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, GSK3B, HMGCR, HSD17B1, IDO1, PTGS2, XDH 7.57733
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 7.51009
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.51009
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, IDO1, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS2, TOP1 7.49527
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.38747
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 7.34379
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.32677
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR1H4, PTGS2, RORC, SMAD3, SRC, TERT 7.32233
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, DRD1, DUSP3, EGFR, ESR1, ESR2, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.32233
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 7.32233
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PIM1, PPARA, RORC, SRC, THRA, THRB 7.31782
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.30092
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, KIT, NR1H4, PPARA, PTGS2, RORC, SRC, TEK, THRA 7.08206
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 6.92051
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD17B1, NR1H4 6.91533
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, DHFR, DRD1, EGFR, HSPA1A, IDO1 6.89252
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.88471
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.87886
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.87886
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DRD1, DUSP3, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.87886
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.87886
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS2, XDH 6.76676
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 6.76451
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, TOP1 6.75496
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.67563
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 6.66979
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CDC25B, CSNK2A1, DHFR, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.62787
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.61221
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DRD1, DUSP3, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.46016
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, KIT, PPARA, PTGS2, SRC, TEK 6.46016
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.42849
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 6.38007
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, NR1H4, PPARA, PTGS2, PTPRS, SMAD3, TEK 6.19625
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MMP2, NR1H4, PTGS2, RORC, SMAD3, SRC 6.15784
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2 6.13125
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, EGFR, GPR35, GSK3B, HMGCR, HSPA1A, INSR, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, THRA 6.10073
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 5.96766
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, INSR, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS2 5.9652
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 5.90844
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR1H4, NUAK1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT 5.89571
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 5.82243
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, XDH 5.81522
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.77621
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.77341
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, EGFR, HMGCR, KDR, NR1H4, PTGS2, SRC, TNKS, TNKS2 5.74972
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, NR1H4, PPARA, PTGS2 5.71438
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK, THRA 5.66237
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.60201
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK 5.59905
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2, SRC, TEK 5.53176
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NR1H4, SRC, TEK, TNKS, TOP1 5.51458
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK, XDH 5.50778
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.43846
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 5.42822
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 5.42822
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HMGCR, HSD17B1, NR1H4 5.41993
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC, TEK 5.41063
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DHFR, EGFR, ESR1, ESR2, F3, FLT3, GSK3B, HSPA1A, INSR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.40819
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, EGFR, FLT3, HMGCR, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 5.40819
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 5.32332
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 5.32332
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.29923
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 5.21348
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IDO1, NR1H4, PTGS2, RORC, SRC 5.19149
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, NR1H4, PPARA, PTGS2, SRC, TEK 5.159
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, CA2, CYP1B1, EGFR, ESRRB, F3, HMGCR, HSPA1A, IDO1, KDR, KIT, MET, MMP12, MMP9, NR1H4, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 5.159
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESRRA, FLT3, PTGS2, RORC, SRC, TEK 5.159
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 5.03784
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DUSP3, EGFR, ESR1, ESR2, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.02199
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2 4.93826
[BP] GO:0050793 regulation of developmental process ADRA2C, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GSK3B, HMGCR, IDO1, INSR, KDR, KIT, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, TNKS2, XDH 4.92729
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.90565
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.80762
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 4.80392
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.76614
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, DRD1, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, NR1H4, PTGS2, SMAD3, SRC 4.73299
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, EGFR, HMGCR, HSPA1A, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, THRA 4.73299
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.71003
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DHFR, DRD1, HMGCR, NR1H4 4.70812
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.67347
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC, TEK, TNKS 4.67347
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA 4.67347
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 4.65747
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 4.61414
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2, SRC, TEK 4.61414
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, EGFR, ESR1, F3, FLT3, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.57875
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 4.56914
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.56914
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.55541
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, THRA 4.55098
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.54664
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DHFR, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, INSR, KIT, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.48736
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.47708
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, GSK3B, KIT, PPARA, RORC, SRC, TOP1 4.44948
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.42216
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2 4.41164
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.39542
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, DRD1, EGFR, FABP3, HMGCR, KDR, PTGS2, SRC, TOP1 4.38397
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.36551
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, DRD1, EGFR, GSK3B, INSR, MMP12, NR1H4, PTGS2, SMAD3, SRC, TERT 4.32549
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2 4.31518
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, EGFR, NR1H4, PTGS2, TNKS, TNKS2 4.30391
[BP] GO:0080135 regulation of cellular response to stress DHFR, DUSP3, EGFR, GSK3B, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.27814
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, NR1H4, PTGS2, RORC, SRC 4.26902
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.26648
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, CSNK2A1, DHFR, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.26557
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 4.26204
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DHFR, DRD1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, NR1H4, PPARA, PTGS2, SRC, TEK 4.22708
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC, TEK 4.21567
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, NR1H4, SMAD3, SRC, TERT 4.18729
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 4.18114
[BP] GO:0010605 negative regulation of macromolecule metabolic process AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.17507
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, NR1H4, PPARA, PTGS2, SMAD3, TEK 4.16855
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, DHFR, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.16221
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR1H4, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 4.15091
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.11247
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DHFR, EGFR, PPARA, SMAD3 4.0618
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AXL, CA2, CYP1B1, ESRRB, F3, HMGCR, IDO1, INSR, KDR, KIT, NR1H4, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, THRA 4.05347
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 4.05347
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2 4.04973
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2 4.04973
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 4.02815
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 3.9719
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.96459
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, CA2, EGFR, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SMAD3, SRC, THRA 3.91078
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.88272
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2 3.88049
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.87708
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, HMGCR, PTGS2 3.863
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EGFR, GSK3B, HSPA1A, IDO1, KIT, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, THRA 3.863
[BP] GO:1901698 response to nitrogen compound AKR1B1, DHFR, DRD1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, NR1H4, PPARA, PTGS2, SRC, TEK 3.863
[BP] GO:0048869 cellular developmental process ACHE, AXL, CBR1, CDC25B, CYP1A1, DRD1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB 3.83939
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.83939
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 3.82929
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.82486
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.78507
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, F3, GSK3B, HMGCR, IDO1, INSR, KDR, KIT, NR1H4, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 3.70641
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TNKS, TNKS2 3.70618
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.70201
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.65374
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.65374
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, HMGCR, NR1H4, PPARA, PTPRS, SMAD3, TEK 3.64373
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, IDO1, INSR, KIT, MMP2, MMP9, PTGS2, SRC, THRA, THRB 3.64373
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, NR1H4, PPARA 3.61604
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 3.60615
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.58896
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.56439
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.52769
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.50757
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.49391
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.41293
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 3.39319
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.38927
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK, TNKS 3.35829
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, CSNK2A1, DHFR, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.35829
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DAO, DHFR, HMGCR 3.35147
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.34518
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, KIT, PTPN1, SRC 3.32845
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, GSK3B, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 3.32752
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.31763
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, GSK3B, IGF1R, INSR, MMP2, NR1H4, PTGS2, SRC 3.31538
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.3008
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, GPR35, GSK3B, HMGCR, HSPA1A, MMP9, NR1H4, PTGS2, THRA 3.25365
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 3.24712
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.23385
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, NR1H4, PPARA, SMAD3, TEK 3.21683
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, KIT, PTGS2 3.20668
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 3.20502
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.20502
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, NR1H4, SMAD3 3.20088
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, EGFR, FABP3, KDR, MMP2, NR1H4, PTGS2, SRC 3.19499
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, KIT, PTPN1, SRC 3.19327
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.18772
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18772
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK, THRA 3.18749
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT 3.16874
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, NR1H4, PPARA, SMAD3, TEK 3.16874
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.15921
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 3.09891
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, EGFR, GPR35, KIT, PTGS2, SMAD3, THRA, THRB 3.09678
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.09192
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.09192
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, DRD1, EGFR, INSR, PTGS2, SMAD3 3.05932
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, EGFR, PTGS2 3.05409
[BP] GO:0010675 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.05409
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, EGFR, GSK3B, IGF1R, INSR, MMP2, NR1H4, PTGS2, SRC 3.05347
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.04642
[BP] GO:0051098 regulation of binding AURKB, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.00469
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.98074
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2 2.96558
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.96363
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.95707
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.95707
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GSK3B, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.95364
[BP] GO:0010628 positive regulation of gene expression DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, GSK3B, HSPA1A, INSR, KIT, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS 2.95235
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 2.93685
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.91475
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.91475
[BP] GO:0019538 protein metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.91475
[BP] GO:0008050 None THRA, THRB 2.91475
[BP] GO:0009115 None AOX1, XDH 2.91475
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIM1, SRC, TEK 2.91475
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC, TEK 2.91475
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.91461
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, XDH 2.90505
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AXL, CYP1A1, DRD1, EGFR, ESR1, KIT, PTGS2, SRC, THRA, THRB 2.90426
[BP] GO:0050890 None ADORA1, DRD1, EGFR, HMGCR, INSR, KIT, PTGS2, THRA 2.89569
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, THRA, TNKS, TNKS2 2.89038
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.87557
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DAO, HSPA1A, IDO1, XDH 2.87118
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.84277
[BP] GO:0045934 None ADRA2A, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.8397
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, EGFR, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SMAD3, SRC, THRA 2.83752
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, CSNK2A1, EGFR, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TERT, THRA 2.83417
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.82736
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 2.79545
[BP] GO:0043393 regulation of protein binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 2.78622
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.77915
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, GSK3B, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3, THRA 2.77915
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.77664
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, EGFR, PTGS2, THRA, THRB 2.77119
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.77119
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.77119
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 2.74632
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.70207
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.69676
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.69676
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.69676
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.69676
[BP] GO:0032845 None ADORA1, ADRA2A, HMGCR, SRC, TNKS, TNKS2 2.69383
[BP] GO:0051254 None EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS 2.66391
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, EGFR, GSK3B, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SMAD3, SRC, THRA 2.63299
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.62845
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, EGFR, KIT, PTGS2 2.62845
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, EGFR, KIT, PTGS2 2.62845
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.62845
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.62845
[BP] GO:0070920 None EGFR, ESR1, TERT 2.62845
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.62845
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.62845
[BP] GO:1900180 regulation of protein localization to nucleus EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT, THRA 2.61476
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.56774
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.55274
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.55274
[BP] GO:0006464 cellular protein modification process AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.5425
[BP] GO:0036211 protein modification process AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.5425
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.53103
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, IDO1, KIT, MMP12, MMP2, NR1H4, PTPN1, PTPRS, SMAD3, SRC 2.51711
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, EGFR, INSR, KIT, PTPN1, SRC 2.51711
[BP] GO:0046110 None AOX1, XDH 2.51689
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51689
[BP] GO:0044267 cellular protein metabolic process AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NR1H4, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.51232
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, HSPA1A, IDO1, MMP12, NR1H4, PTGS2, PTPRS, SMAD3, SRC 2.51026
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.49939
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, GSK3B, HSPA1A, IDO1, SRC, XDH 2.49857
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.48975
[BP] GO:0007611 None DRD1, EGFR, HMGCR, INSR, KIT, PTGS2, THRA 2.47544
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NR1H4, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.46704
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.46615
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.46615
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.4593
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, XDH 2.45431
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, NR1H4, PTGS2, SRC 2.45007
[BP] GO:0045893 None EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS 2.43918
[BP] GO:1903508 None EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS 2.43918
[BP] GO:0007617 None DRD1, THRA, THRB 2.43918
[BP] GO:1902680 None EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS 2.43918
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.43918
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.43918
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.43918
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.43918
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.43918
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.43918
[BP] GO:0050994 None ADORA1, ADRA2A, PPARA, THRA 2.43918
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.43918
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, DRD1, GSK3B, SRC, TNKS, TOP1 2.4328
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.40865
[BP] GO:0001952 regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, SRC, TEK 2.40509
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT, XDH 2.39739
[BP] GO:0060341 regulation of cellular localization ADRA2A, CSNK2A1, DRD1, EGFR, GSK3B, HMGCR, NR1H4, PTGS2, PTPN1, SMAD3, SRC, TERT, THRA 2.39416
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.38625
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.38625
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, TEK 2.35539
[BP] GO:0007610 None DRD1, EGFR, HMGCR, IDO1, INSR, KIT, PPARA, PTGS2, THRA, THRB 2.34795
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.32735
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.32735
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GSK3B, INSR, PPARA, RORC, SRC 2.32232
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.32232
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 2.30874
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 2.30576
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.30428
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.30428
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, GSK3B, HSPA1A, INSR, KDR, PPARA, PTPN1 2.28499
[BP] GO:0000122 None AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, THRA, THRB 2.28499
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.28499
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28499
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, PTGS2 2.28499
[BP] GO:0035625 None ADRA2A, ADRA2C 2.28499
[BP] GO:0032811 None ADRA2A, ADRA2C 2.28499
[BP] GO:0070213 None TNKS, TNKS2 2.28499
[BP] GO:0006145 None AOX1, XDH 2.28499
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28499
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28499
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.27134
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, EGFR, PTGS2 2.26374
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, KIT, PTPN1, SRC 2.25782
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, EGFR, HMGCR, MMP12, NR1H4, SRC 2.24823
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1 2.24038
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.24009
[BP] GO:0019229 None ADRA2A, ADRA2C, EGFR, PTGS2 2.24009
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, DAO 2.23933
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CYP19A1, EGFR, HMGCR, NR1H4 2.23892
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.23892
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23892
[BP] GO:0018209 peptidyl-serine modification AURKB, DRD1, GSK3B, SRC, TNKS, TOP1 2.22123
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.21786
[BP] GO:0051894 None KDR, SMAD3, TEK 2.18707
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.18707
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18707
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, SRC, TEK 2.175
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, HMGCR 2.16988
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, PTGS2 2.14608
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.14608
[BP] GO:0050927 None F3, KDR, SMAD3 2.14143
[BP] GO:0045932 None ADORA1, ADRA2C, PTGS2 2.14143
[BP] GO:0006766 vitamin metabolic process AOX1, CBR1, CYP1A1, CYP3A4, DHFR 2.13485
[BP] GO:0090066 None ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, EGFR, HMGCR, PTGS2 2.13177
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.12458
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, NR1H4, PTGS2, SRC 2.11947
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 2.11947
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.11151
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, DRD1, EGFR, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTPN1, SRC, TEK 2.11151
[BP] GO:0035624 None ADRA2A, ADRA2C 2.11151
[BP] GO:0010641 None F3, SRC 2.11151
[BP] GO:0007598 None F10, F3 2.11151
[BP] GO:0060509 None THRA, THRB 2.11151
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.11151
[BP] GO:0014060 None ADRA2A, ADRA2C 2.11151
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.11151
[BP] GO:0050926 None F3, KDR, SMAD3 2.11151
[BP] GO:0005979 None ESRRB, GSK3B, INSR 2.11151
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.11151
[BP] GO:1903393 None KDR, SMAD3, TEK 2.11151
[BP] GO:0010962 None ESRRB, GSK3B, INSR 2.11151
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, RORC, SMAD3, SRC 2.11151
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.10702
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, XDH 2.10512
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HMGCR, KDR, SRC, TEK 2.09682
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, NR1H4, PTPN1, SRC 2.09625
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.09335
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, SRC, TEK 2.09133
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRA2C, AXL, EGFR, GPR35, GSK3B, IDO1, NR1H4, PTGS2, PTPRS, SMAD3, TEK, TERT, XDH 2.08381
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1 2.08164
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.07659
[BP] GO:1900078 None ESRRA, NR1H4, SRC 2.07319
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07319
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, NR1H4, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.07091
[BP] GO:2001233 regulation of apoptotic signaling pathway GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.07046
[BP] GO:0003006 developmental process involved in reproduction AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, INSR, KIT, PTGS2, SRC 2.05962
[BP] GO:0043412 macromolecule modification AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.04684
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.03306
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, PTGS2, SMAD3, SRC, TERT 2.03134
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, CYP1B1, ESR1, ESR2, HSPA1A, KIT, NR1H4, PIM1 2.02545
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.02198
[BP] GO:0051253 None AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, PPARA, RORC, SMAD3, SRC, TERT, THRA, THRB 2.00246
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, AOX1, AURKB, AXL, CA1, CA2, CA4, CA6, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 3.53876
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, AOX1, AURKB, AXL, CA1, CA2, CA4, CA6, CA9, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 3.19104
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.01402
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA4, CA9, DRD1, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PTGS2, PTPRS, SRC, TEK 2.76623
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, INSR, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, THRA, TNKS, TNKS2, TOP1, XDH 2.55398
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, EGFR, ESR1, F10, F3, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT 2.55052
[CC] GO:0044454 None AURKB, CSNK2A1, ESR1, NR1H4, SMAD3, TERT, THRB, TNKS, TNKS2, TOP1 2.39416
[CC] GO:0031233 None CA4, F10, F3 2.38665
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA4, DRD1, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, TEK 2.27737
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, DRD1, EGFR, INSR, MET, PTGS2, SRC, TEK 2.04485
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TNKS, TNKS2, TOP1, TUBB3, XDH 18.2217
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, PIM1, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TNKS, XDH 18.2217
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DUSP3, EGFR, F10, F3, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TUBB3, XDH 14.5926
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.8157
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR1H4, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TNKS 9.79834
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.40193
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.40193
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 8.77262
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.59667
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.37599
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.31019
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, IDO1, PTGS2, XDH 8.18622
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.78874
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.6378
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.61842
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, TERT, THRA, THRB, TNKS, TNKS2, XDH 7.58383
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, IDO1, PTGS2, SRC, XDH 7.36831
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.35399
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DHFR, DRD1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1 7.34992
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 7.30092
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.08748
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.94821
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.6844
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 6.31497
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR1H4, RORC 6.24633
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, SMAD3, TEK, THRA, THRB 6.15784
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.07396
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, NR1H4, PPARA, RORC, TEK, THRA, THRB 6.06612
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, ADRA2C, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TOP1, TUBB3, XDH 5.7341
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.71891
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CSNK2A1, DAO, DHFR, EGFR, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIM1, PTPRS, SRC, TEK, TOP1, TUBB3, XDH 5.57545
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.30339
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.26618
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, THRA, THRB 5.01869
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, DAO, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NR1H4, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.96856
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, THRA 4.81797
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, NR1H4, PPARA, RORC 4.78196
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.73299
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.71913
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, THRA 4.68025
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NR1H4, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, THRA, THRB, TOP1, TUBB3, XDH 4.55541
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2 4.47589
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.46533
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.29325
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GSK3B, HMGCR, HSPA1A, KIT, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, THRB, TNKS2 4.27103
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT, TOP1 4.07356
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DAO, DHFR, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.05347
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DAO, DHFR, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 4.05347
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 3.98766
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD17B1, XDH 3.81057
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 3.70641
[MF] GO:0004887 None NR1H4, THRA, THRB 3.65374
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.46153
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.39672
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.31575
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.3008
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91475
[MF] GO:0008389 None CYP2A13, CYP2A6 2.91475
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.69383
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SMAD3, TERT, XDH 2.66904
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.66391
[MF] GO:0008134 transcription factor binding ESR1, ESRRB, FLT3, GSK3B, NR1H4, PIM1, PPARA, SMAD3, SRC, TERT, THRA 2.66391
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.57917
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.54885
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.51689
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.51689
[MF] GO:0004938 None ADRA2A, ADRA2C 2.51689
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, TEK 2.49577
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, TEK 2.49577
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.43918
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1 2.38665
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.38665
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28499
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28499
[MF] GO:0032795 None ADORA1, ADRA2A 2.28499
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28499
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.16988
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.16988
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1 2.1641
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.1209
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.11151
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.11151
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11151
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.0857
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.07477
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.04485
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRA2C, AOX1, AXL, DAO, EGFR, FLT3, HMGCR, KIT, PTGS2, SMAD3, TERT, XDH 2.04485
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.03811
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.03134


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.7176
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.721
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4828
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.2452
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.2389
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.4608
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, PTGS2, CYP3A4, CYP19A1, DHFR, CYP2A6, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, XDH, IDO1 5.1291
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, EGFR, IGF1R 5.0671
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 5.4768
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.6861
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.0671
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.5929
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0671
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.0196
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, GPR35, ADORA3, ADORA1, DRD1, ADRA2C, ADRA2A 3.8356
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.1547
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 3.6423
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.5417
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.2827
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4, HMGCR, CYP3A4 4.0196
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, THRB, THRA, SRC, ESR1 3.1233
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, EGFR, IGF1R 3.011
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.2648
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.1233
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 3.543
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.0132
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 2.9543
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2C, ADRA2A 2.5456
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.4486
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.011
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, EGFR 2.6482
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.011
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4291
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, INSR, PPARA 2.3496
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0661
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, ESRRB, IGF1R 1.9952
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.8013
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0868
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.16
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0492
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6964
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9523
Prostate cancer_Homo sapiens_hsa05215 GSK3B, EGFR, IGF1R 1.7153
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC, EGFR 1.7333
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6977
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9952
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, PTGS2 1.4936
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2804
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.3909
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, HSPA1A 1.3002
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR 1.318
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.3909
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.2804
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, INSR 1.2902
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.263
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.2716
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA 1.2342
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.2074
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, HSPA1A 0.988
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, PPARA 0.9983
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, TERT 0.8145
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8598
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9367
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT 0.9266
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2466
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9722
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8184
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8225
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8225
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9634
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2733
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2803
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9751
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2891
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.745
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9872
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, DRD1 0.7807
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2803
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.7875
Alcoholism_Homo sapiens_hsa05034 DRD1 0.2803
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.6942
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 0.9634
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0522
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.2891
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.6189
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6885
Influenza A_Homo sapiens_hsa05164 GSK3B, HSPA1A 0.63
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3122
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3351
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.0154
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3511
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.6043
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0482
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5541
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, EGFR 1.2902
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1849
Platelet activation_Homo sapiens_hsa04611 SRC 0.3766
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.379
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3766
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1788
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9512
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4027
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3 1.2074
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4224
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4267
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4267
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4224
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4282
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.433
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4324
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4267
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1849
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2342
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4542
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4647
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4533
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4594
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5068
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5068
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5068
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4935
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.505
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5126
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5281
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5258
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5328
Shigellosis_Homo sapiens_hsa05131 SRC 0.5305
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5541
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5737
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5771
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5771
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5771
Malaria_Homo sapiens_hsa05144 MET 0.6038
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6038
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6033
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6043
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6043
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6033
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6043
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6788
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6192
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5418
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6554
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6326
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6906
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6906
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6492
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8508
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7617
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7228
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.6906
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7414
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7683
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0671
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7319
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7617
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8383
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8184
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 0.9634
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2342


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)