TCM Prescription: Tian Ma Shou Wu Tablets



Prescription Description
Prescription IDTCMF5439
Pinyin NameTian Ma Shou Wu Pian
Chinese Name天麻首乌片
English NameTian Ma Shou Wu Tablets
Function Description眩晕, 头痛, 耳鸣, 耳聋, 健忘, 白发症
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Headache, Alopecia
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ];
ED70 [Alopecia or hair loss, 脱发 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1797 Morus alba 桑叶 TCMH1797 ITSAL1073-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 16.3465
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.4395
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSPA1A, NISCH, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 13.3161
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 12.4991
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MAOA, MCL1, MET, NISCH, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.6859
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, HIF1A, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 10.653
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1449
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.1449
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.1226
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.0781
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, HIF1A, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 9.80894
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GBA, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 9.5421
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.43053
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.42936
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.29944
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.20233
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.03216
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.03216
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.01881
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 8.82232
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.75636
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 8.75636
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK 8.70892
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.59099
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.5644
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 8.44296
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 8.43884
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.31883
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.31883
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD11B2, INSR, PPARA, PTGS2, SLC6A4, SRC, TEK 8.28101
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT 8.23799
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.21922
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 8.19331
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 8.14225
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, GAA, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 8.14225
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.13466
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK, TERT 8.1158
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.0851
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD17B2, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 8.05354
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK, TERT 7.87205
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.80713
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F3, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.79557
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.68721
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GBA, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.68054
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD11B2, HSD17B2, PTGS2, RORC, SLC6A4, SRC, TYR 7.66979
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GBA, HSD11B2, PTGS2, RORC, SLC6A4, SRC, TEK, TYR 7.61986
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK, TERT 7.50257
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK, TERT 7.47993
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 7.42485
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.33333
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.10166
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.96385
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC 6.93647
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.75988
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.75284
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK2, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 6.70738
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP9, PTGS2, SRC, TERT 6.70738
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, F10, F3, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 6.70738
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GBA, HIF1A, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MCL1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.69794
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, NQO2, PTGS1, RORC 6.66946
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, KCNH2, MCL1, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 6.60952
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.60869
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.60156
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 6.57332
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 6.57332
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUCA1, FUT7, GBA, GBA2, GLO1, HASPIN, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 6.52996
[BP] GO:0032787 None ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, HIF1A, PPARA, PTGS1, PTGS2 6.52996
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TERT, XDH 6.52307
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TERT, XDH 6.49875
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.49713
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, EGFR, F10, F3, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.42793
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.39554
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NISCH, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.38201
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HIF1A, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.32864
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GAA, GBA, HIF1A, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR 6.32069
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GBA2, HSPA1A, MAOA, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 6.26298
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.20028
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.19167
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.18832
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2 6.0175
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.00638
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HIF1A, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.94224
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.88637
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HIF1A, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.79512
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.78098
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, HASPIN, HCAR2, HIF1A, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.7305
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, HCAR2, HIF1A, HSPA1A, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NISCH, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.62368
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.61121
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 5.60324
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.5871
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.57582
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, HIF1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.55503
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 5.53972
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, GBA, HSD11B2, KCNH2, KDR, PTGS2, SLC6A2, SLC6A4, SRC 5.4228
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.34122
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, DYRK3, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, SRC, XDH 5.34122
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA, GBA2 5.16757
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 5.08485
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 5.02163
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, GBA2, HIF1A, MAOA, TYR 4.94383
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, GAA, GBA2, HIF1A, HSD11B1, HSD17B2, INSR, KDR, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 4.94383
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.88548
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, DYRK3, EGFR, HIF1A, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 4.78295
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.75032
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HSD11B2, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.70221
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, GBA, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 4.68935
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.67936
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.67936
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.67936
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 4.60758
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.5689
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 4.49212
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 4.46581
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, HIF1A, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT 4.37189
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, FABP3, GBA2, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR 4.36043
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GAA, GBA, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.35343
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, GBA, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.26947
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.22168
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 4.16828
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2, TNKS, TNKS2 4.16568
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.1441
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 4.13138
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.09144
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.07654
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.07528
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CA7, CYP19A1, DYRK2, EGFR, GPR35, HCAR2, HIF1A, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.06935
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 4.06103
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.03848
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT, TNKS, TNKS2 3.96035
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 3.93538
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 3.91673
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.88082
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, DAO, EGFR, HSPA1A, MAOA 3.80941
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.75158
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.74834
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.74437
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGS2, TERT 3.73511
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.73511
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.71292
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HCAR2, HIF1A, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.65969
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.65621
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HIF1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.65496
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MCL1, MET, PIK3CA, PPARA, SMAD3 3.64579
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.64234
[BP] GO:0045913 None DYRK2, ESRRB, HIF1A, INSR, PPARA, SRC 3.6411
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, GBA, HIF1A, HSD11B2, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 3.60111
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.60111
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.60111
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HIF1A, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.59706
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, HSD11B2, PTGS2, SRC 3.59154
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA, GBA2 3.56104
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC, TERT 3.55068
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, GBA, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.55068
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, HASPIN, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.55068
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TYR 3.54855
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC 3.54199
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.53657
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.52001
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CLK1, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.48233
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, DYRK3, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HIF1A, KDR, MCL1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.44259
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, HSD11B2, PTGS2, SRC 3.43821
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.4238
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HIF1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.4238
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.42374
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.42374
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.40195
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 3.35265
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.35265
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.34577
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.34561
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.29238
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SMAD3, SRC 3.2841
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.28207
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.27416
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.27416
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.27416
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A 3.27267
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.27267
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.26565
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.25492
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.2524
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.2524
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23235
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, NISCH, PTGS2, SLC6A4 3.21819
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, NISCH, PTGS2, SLC6A4 3.21819
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.21819
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 3.20878
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.18988
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.16858
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.16063
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.16063
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.12306
[BP] GO:0016139 None FUCA1, GBA, GBA2 3.10756
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HIF1A, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.098
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, GBA, HCAR2, HIF1A, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 3.09421
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, DAO, FABP3, FABP4, FUCA1, GAA, GBA, GBA2, HSPA1A, MAOA, MGAM, PIK3CB, SRC, XDH 3.0867
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.08469
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, APP, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.08044
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.07902
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.07902
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.07902
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.05242
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.0487
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.02685
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GBA2, HSPA1A, MAOA, MGAM, XDH 3.02283
[BP] GO:0046466 None CYP1B1, FUCA1, GBA, GBA2 3.00833
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.00833
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 3.00833
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, HSD11B2, PTGS2 3.00667
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, PTGS2, SLC6A2, SLC6A4, SMAD3 3.00667
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.00138
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, GPR35, KCNH2, MMP9, PTGS2 2.97102
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.97102
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.94996
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SLC6A4, SMAD3, TNKS2 2.93075
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HIF1A, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A 2.92297
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.92277
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.92277
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.87381
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.8714
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.85281
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.84175
[BP] GO:0008217 None ADORA1, HSD11B2, NISCH, PPARA, PTGS1, PTGS2, SMAD3 2.84175
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.84175
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.83337
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 2.81152
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.7624
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, HIF1A, KDR, PTGS2, TEK, TERT 2.76063
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.75245
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 2.74827
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 2.73896
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, HASPIN, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.7355
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 2.73095
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.72949
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.71911
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, INSR, PTGS2, SRC 2.71887
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, GBA, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 2.71887
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.71887
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.71735
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.71292
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.71236
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DYRK2, EGFR, HASPIN, IGF1R, INSR, KCNH2, KDR, MCL1, MET, NISCH, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.71236
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 2.70757
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.69636
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.69636
[BP] GO:0006680 None GBA, GBA2 2.69636
[BP] GO:0009115 None AOX1, XDH 2.69636
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUCA1, FUT7, GBA, GBA2, GLO1, HASPIN, HIF1A, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.6831
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 2.67692
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.64486
[BP] GO:2001240 None BCL2, HSPA1A, MCL1, TERT 2.63217
[BP] GO:1901099 None BCL2, HSPA1A, MCL1, TERT 2.63217
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.63177
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DYRK2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.59194
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.59194
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, DAO, MAOA 2.58357
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.58357
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK 2.5635
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.55875
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HASPIN, HCAR2, HIF1A, IGF1R, INSR, KCNH2, KDR, MCL1, MET, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 2.5468
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.54662
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GBA, MMP12, PPARA, SMAD3, TEK 2.53656
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.51309
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA, GBA2 2.50698
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.50302
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, HIF1A, INSR, PPARA, RORC, SRC 2.49357
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, HIF1A, KDR, PTGS2, TEK, TERT 2.47902
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.4582
[BP] GO:0019377 None FUCA1, GBA, GBA2 2.4582
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.4582
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.4582
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK 2.44788
[BP] GO:0043467 regulation of generation of precursor metabolites and energy DYRK2, ESRRB, HIF1A, INSR, PIK3CA, PPARA 2.44184
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.44038
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.42904
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.42563
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.40722
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 2.39039
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 2.39015
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA, MAOA 2.38944
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.37861
[BP] GO:0051937 None NISCH, SLC6A2, SLC6A4 2.37861
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.37861
[BP] GO:0018958 None AKR1B1, BCL2, DAO, MAOA, TYR 2.37344
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.35091
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.35091
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.34223
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.34053
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, GBA, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.31483
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, KCNH2, PIK3CB, SMAD3 2.31483
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.31483
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.31402
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, SLC6A4, TEK, TYR 2.31402
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.30954
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.30954
[BP] GO:0070920 None EGFR, ESR1, TERT 2.30954
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.30954
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.30954
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 2.30886
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.30568
[BP] GO:0000023 None GAA, MGAM 2.30568
[BP] GO:0046110 None AOX1, XDH 2.30568
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30568
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.30568
[BP] GO:0050678 None CDK6, EGFR, F3, HIF1A, KDR, MMP12, SMAD3, TEK, XDH 2.30218
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, HIF1A, PIK3CB 2.30207
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.30207
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.301
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.301
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.2667
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.25759
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.24975
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.2457
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.24131
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.24055
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.23555
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.23555
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.22061
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.22061
[BP] GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand BCL2, HSPA1A, MCL1, TERT 2.20101
[BP] GO:0045821 None ESRRB, HIF1A, INSR 2.18276
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.16629
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.14866
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.14655
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, BCL2, CA2, CA7, GPR35, KCNH2, MMP9, PTGS2, SLC6A4 2.14406
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, EGFR, GAA, GBA, GPR35, HCAR2, KCNH2, PTGS2, SMAD3 2.13539
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.13539
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 2.13024
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.12654
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.12108
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.12108
[BP] GO:0051197 None ESRRB, HIF1A, INSR 2.12108
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, SRC, TNKS, TNKS2 2.12064
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.12013
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.10139
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, HIF1A, MCL1, PIK3CA, PPARA, TERT 2.10139
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.10082
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, DYRK2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.10082
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, SLC6A4, TEK, TYR 2.09392
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.09131
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.06855
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.0661
[BP] GO:0001892 None EGFR, ESRRB, HIF1A 2.0661
[BP] GO:0098908 None GBA, GPR35 2.06408
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.06408
[BP] GO:0070213 None TNKS, TNKS2 2.06408
[BP] GO:0006145 None AOX1, XDH 2.06408
[BP] GO:0015874 None NISCH, SLC6A2 2.06408
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06408
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HIF1A, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.05525
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, HASPIN, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.0498
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.03518
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.03518
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.03456
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.03456
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.01996
[BP] GO:0015844 None NISCH, SLC6A2, SLC6A4 2.01996
[BP] GO:0019318 None AKR1B1, FUCA1, FUT7, GAA, NISCH, PIK3CA 2.0102
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.00699
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MCL1, MGAM, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.32038
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MAOA, MCL1, MGAM, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.6142
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MCL1, MGAM, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.66022
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 3.65621
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.29238
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.27416
[CC] GO:0044446 intracellular organelle part AKR1B1, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, HASPIN, HIF1A, HSD11B1, HSD11B2, HSD17B2, HSPA1A, INSR, MAOA, MCL1, MGAM, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR 3.10756
[CC] GO:0044422 organelle part AKR1B1, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, HASPIN, HIF1A, HSD11B1, HSD11B2, HSD17B2, HSPA1A, INSR, MAOA, MCL1, MGAM, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR 3.08094
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, EGFR, ESR1, F10, F3, FLT3, FUT7, GAA, GBA, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MGAM, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 3.07661
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GAA, GBA2, GLO1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MGAM, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.77417
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA2, GLO1, HASPIN, HIF1A, HSPA1A, IGF1R, KDR, MAOA, MCL1, MMP12, MMP2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.72949
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.71887
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, HASPIN, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MGAM, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.68088
[CC] GO:0031974 None ALOX5, APP, BACE1, CA5A, CA5B, CES1, CES2, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.67537
[CC] GO:0043233 None ALOX5, APP, BACE1, CA5A, CA5B, CES1, CES2, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.67537
[CC] GO:0070013 None ALOX5, APP, BACE1, CA5A, CA5B, CES1, CES2, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 2.67537
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, KCNH2, MET, SLC6A2, TEK 2.53823
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.34053
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.08583
[CC] GO:0031233 None CA4, F10, F3 2.0661
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 22.2021
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DNMT1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 17.4388
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.5491
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.5061
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.42936
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.33908
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 8.96763
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 8.95331
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS 8.86501
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TEK, TOP2A 8.52873
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 8.3254
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 7.76348
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DNMT1, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.61399
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DNMT1, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.4429
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 7.08847
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 6.85818
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 6.52996
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.36716
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2, SRC 6.26679
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2, SRC 5.97957
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.94831
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.70512
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.60324
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PTGS1, PTGS2, TYR 5.55277
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH 5.42816
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 5.06139
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 5.02163
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 4.98164
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 4.98017
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.962
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DAO, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, XDH 4.88996
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 4.74996
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.64848
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 4.59235
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK 4.39931
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.38612
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.38575
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.38575
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.31214
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.30078
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.22168
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.17926
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.13219
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MCL1, MET, MMP9, NISCH, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 4.09144
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.08935
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.96035
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 3.85438
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIK3CA, PIM1 3.79822
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HIF1A, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.68727
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HIF1A, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.53029
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.36095
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.16858
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HIF1A, HSPA1A, KCNH2, MET, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A 3.16587
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 2.97102
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.95351
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.94621
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A 2.90372
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DAO, EGFR, FLT3, HIF1A, KCNH2, MCL1, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.88344
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.85281
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.84573
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.7983
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, PPARA, RORC 2.78984
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.75821
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.74932
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DAO, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GBA2, GLO1, GPR35, HASPIN, HCAR2, HIF1A, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.72949
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.69636
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.69636
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69636
[MF] GO:0003845 None HSD11B1, HSD11B2 2.69636
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69636
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, MCL1, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.67835
[MF] GO:0015926 None GAA, GBA2, MGAM 2.4582
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.4562
[MF] GO:0016798 None APEX1, FUCA1, GAA, GBA, GBA2, MGAM 2.31402
[MF] GO:0005330 None SLC6A2, SLC6A4 2.30568
[MF] GO:0032450 None GAA, MGAM 2.30568
[MF] GO:0004348 None GBA, GBA2 2.30568
[MF] GO:0047374 None CES1, CES2 2.30568
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.26359
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.24975
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.24975
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 2.24131
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.0661
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, FUT7, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TNKS, TNKS2 2.06408
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06408
[MF] GO:0032795 None ADORA1, ADRA2A 2.06408
[MF] GO:0051425 None APP, INSR 2.06408
[MF] GO:0004558 None GAA, MGAM 2.06408
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 2.02792


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.3853
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.332
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, GBA, AKR1B1, PTGS2, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, CBR1, MGAM, GAA, TYR, CYP2A6, DAO, AKR1B10, CYP1A2, CYP1A1, ALPL, CES1 7.8598
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.0638
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 7.6264
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.5581
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 6.6358
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET, MCL1 6.8251
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 6.371
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.8392
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.473
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 5.9307
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.8345
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.7726
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, MCL1, IGF1R 4.708
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.708
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 4.7683
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.708
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, PTGS2, CYP2C19, PTGS1, SLC6A4 4.708
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.0049
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.0049
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 3.7678
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 3.8918
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.708
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 3.8122
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.6904
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.83
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.7945
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, CYP2C19, PTGS1 3.8817
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.395
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.6525
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB, MCL1 3.043
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 3.7286
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.284
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.3199
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA2A 2.9446
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 2.9237
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.7757
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 2.8111
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.8111
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 2.7867
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.5814
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.0087
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.5127
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.3224
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 2.9893
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.8784
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 3.8918
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.6786
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 2.8111
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8111
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.2702
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.547
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.432
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.3224
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.2292
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.1072
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.1149
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.5814
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.9551
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 1.9702
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 1.9792
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.2987
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.0184
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7635
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 1.8162
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 1.9666
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.8713
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.8196
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.7138
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 1.7794
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.3236
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2053
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.493
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2045
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2045
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.2783
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2408
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2765
Axon guidance_Homo sapiens_hsa04360 MET 0.2875
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.2854
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.087
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2947
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.493
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.076
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0495
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.2953
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.1066
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.2772
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5666
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, ADRA2A 1.0089
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.4377
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2728
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5539
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3548
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3548
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 0.9759
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5324
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.3548
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.5539
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3644
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3636
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.5464
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6535
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.9201
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.3761
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6444
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.6688
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3821
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6774
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3821
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3925
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.381
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8038
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8139
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 1.9846
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.8386
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.42
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8499
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4332
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.8847
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4312
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4454
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9014
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4477
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8687
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 0.9144
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.4554
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.1354
Shigellosis_Homo sapiens_hsa05131 SRC 0.4636
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4664
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9508
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.0287
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.487
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9763
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.0671
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.046
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.046
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0896
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.2283
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5418
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.2884
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1569
Malaria_Homo sapiens_hsa05144 MET 0.5539
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.5539
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5547
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.2036
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5539
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.1938
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5737
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5682
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOA 1.2708
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA, GBA2 1.2974
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6075
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6535
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5706
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6853
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7307
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6688
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOA 1.4191
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7053
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.739
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.568
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6951
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.493
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.6451
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7307
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.768
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8196
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA, GBA2 3.284
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.7683
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8884
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9508
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.243


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)