TCM Prescription: Qing Nao An Shen Pills



Prescription Description
Prescription IDTCMF5435
Pinyin NameQing Nao An Shen Wan
Chinese Name清脑安神丸
English NameQing Nao An Shen Pills
Function Description惊悸, 怔仲, 不寐, 健忘, 眩晕, 耳鸣
IndicationsInducible palpitation disorder, Tinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Dizziness
Disease ICD-11 Category SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH916 Succinus 琥珀 TCMH916
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH324 Magnetitum 磁石 TCMH324
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1163 Rhizoma anemones altaicae 九节菖蒲 TCMH1163
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2551 Polygonatum odoratum 玉竹 TCMH2551 ITSAM921-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH2078 Acacia concinna 藤合欢 TCMH2078 GBVP7225-15, GBVP6411-15
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA, TRPV1 15.265
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 14.0052
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 13.0094
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FDPS, FUT7, GBA2, GLO1, HMGCR, PIM1, PPARA, TYR, XDH 12.4248
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9559
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 10.5785
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.172
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP2, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.8826
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 9.57577
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 9.17573
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 9.12566
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, KIT, MET, PPARA 9.07698
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PHF8, TYR, XDH 8.89947
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.85881
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.85881
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 8.65017
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, KIT, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.54777
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, NR3C1, PPARA, SLC6A4, SRC, TRPV1 8.12413
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.03096
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PPARA, SLC6A4, SRC, TRPV1 7.96547
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.8512
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TERT, TRPV1 7.45369
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, RORC, SLC6A4, SRC, TYR 7.33403
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 7.33282
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, RORC, SLC6A4, SRC, TRPV1, TYR 7.30439
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 7.26473
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.14189
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.02416
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.00758
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 6.8105
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.8105
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.7079
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 6.62515
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PPARA 6.62515
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 6.62126
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, GBA2, HMGCR, TYR 6.55901
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, RORC, SLC6A4, SRC, TRPV1 6.49636
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KCNH2, KDR, NR3C1, SLC6A2, SLC6A4, SRC, TRPV1 6.48864
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.48816
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.47289
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PHF8, PIM1, PPARA, PTPRS, RORC, SLC6A4, SRC, TERT, TNKS2, TOP2A, TYR 6.32343
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, RORC 6.0156
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.97708
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.94417
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.91189
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.63368
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.6106
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.48055
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 5.48048
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.42717
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR 5.31676
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TERT 5.30944
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1 5.14024
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.13778
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.12221
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.0557
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.05447
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2, TRPV1 5.03157
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.02375
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.95616
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.86106
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 4.8268
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR 4.80994
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TRPV1, TYR 4.76939
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.76549
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC, TRPV1 4.76217
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.76217
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PHF8, PPARA, PTPRS, SRC, TYR 4.76217
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.76217
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, RORC, SLC6A4, SRC, TOP2A 4.76217
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.74083
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.71588
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, KIT, PPARA, RORC, SRC 4.64611
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.64108
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FDPS, HMGCR 4.62775
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.62775
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.62548
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.50687
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.4219
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.39276
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.31146
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR 4.27231
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.23479
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TRPV1 4.22229
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, HMGCR, KDR, SLC6A4, SRC 4.22207
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.20873
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, HMGCR, SRC, TNKS, TNKS2, TRPV1 4.20394
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GBA2, GLO1, PIM1, PPARA, TYR 4.18214
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.15761
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.1142
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FDPS, FLT3, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 4.07981
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.05487
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, ALOX12, APP, CDK6, CYP19A1, DYRK1A, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.99834
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FDPS 3.96107
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 3.94221
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KCNH2, KDR, NR3C1, SRC, TRPV1 3.923
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.83274
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.76052
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FDPS, FLT3, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 3.72865
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIM1, SRC, TNKS 3.72283
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.68778
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.57097
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.57097
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.53015
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.53015
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F3, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 3.50453
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 3.48834
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.451
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.43655
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.40528
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, SLC6A4, SRC, TRPV1 3.37693
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, KIT, MMP2, PPARA, SLC6A4, SRC, TERT, TRPV1, TYR 3.36312
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT, TRPV1 3.35887
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.35887
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 3.35181
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.32705
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.32705
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.32175
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 3.264
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.23782
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.23007
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PHF8, PIM1, PPARA, PTPRS, RORC, SRC, TYR 3.21035
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.18949
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 3.10972
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIM1, PTPRS, SLC6A4, SRC, TERT, TNKS2, TRPV1, XDH 3.01637
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.00053
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.00053
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT, TRPV1 3.00053
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 2.99639
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.93578
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SLC6A4, SRC, TRPV1, TYR 2.91918
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.88498
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.88498
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.87017
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.87017
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 2.82398
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTPRS, RORC, SRC, TERT, TOP2A 2.77089
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.74054
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.72845
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.7113
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.68619
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC, TERT, TRPV1 2.68429
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIM1, SRC, TNKS 2.67962
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 2.65309
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 2.64101
[BP] GO:0009115 None AOX1, XDH 2.64101
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.64101
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.64101
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.64101
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.63983
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.63398
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 2.61487
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SLC6A4, SRC, TRPV1, TYR 2.61457
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.55624
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.55311
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, HMGCR, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 2.5421
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.5421
[BP] GO:0016125 None APP, CES1, CYP19A1, CYP1B1, FDPS, HMGCR 2.53663
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.52432
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, SLC6A4, SRC, TRPV1, TYR 2.51388
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4 2.50348
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, SRC, TRPV1 2.47165
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.47161
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR 2.46289
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.39801
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.39801
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, SLC6A4, SRC, TOP2A 2.39686
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CES1, CYP1B1, CYP3A4, FDPS, HMGCR 2.39403
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.39013
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.37517
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.36585
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.35814
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.35814
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 2.35715
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.33905
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.32782
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.3225
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.3225
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, FDPS, HMGCR 2.27546
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PHF8, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.2663
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.25333
[BP] GO:0046110 None AOX1, XDH 2.25333
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.25333
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.21963
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 2.2187
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.19435
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, SLC6A4 2.18853
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT, SLC6A4 2.18853
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.16596
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.16165
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.15404
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4, TRPV1 2.15202
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, SLC6A4, SRC, TRPV1 2.14542
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.14153
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.12521
[BP] GO:0050730 None ADORA1, ADRA2A, APP, FLT3, KIT, PTPN1, SRC 2.10241
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.10175
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.09115
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HMGCR, HSD11B2, SLC6A4, SRC, TRPV1, TYR 2.07877
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.07877
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, TRPV1 2.07877
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.0707
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.06217
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.06026
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.05659
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.02662
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.02662
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.01929
[BP] GO:0070213 None TNKS, TNKS2 2.01929
[BP] GO:0006145 None AOX1, XDH 2.01929
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.01929
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.01
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.00649
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.00268
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 3.66465
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.30352
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, PTPN1, PTPRS, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.13755
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP2, PHF8, PIM1, PTPN1, PTPRS, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 2.67962
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.42283
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F3, FLT3, GBA2, GLO1, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.21553
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.179
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, FLT3, GBA2, HMGCR, KDR, PTPN1, XDH 2.08688
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.01
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 22.9996
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 17.7797
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2618
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 16.1536
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 11.2171
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.9559
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PHF8, TYR, XDH 10.5785
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, PHF8, XDH 10.5785
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PPARA, PTPN1, RORC, TNKS 10.5785
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2595
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1162
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.8512
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.50507
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 6.96735
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 6.62515
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.54583
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.50305
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4 6.29774
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, PHF8, TYR 6.05244
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 5.6106
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.51064
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP3A4 5.51064
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 5.36082
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HMGCR, HSD11B2, HSD17B1, SRC, XDH 4.95616
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.76549
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.76217
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.67888
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.67888
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SLC6A4, SRC, TOP2A, TRPV1 4.49796
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.13216
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, HMGCR, IGF1R, KCNH2, KDR, KIT, MET, MMP9, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 3.83207
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.56205
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.53015
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TRPV1 3.31127
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, HMGCR, KCNH2, KIT, MET, NR3C1, PPARA, PTPN1, SLC6A4, SRC, TNKS2, TOP2A 3.3007
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.04079
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.99639
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIM1, SRC 2.93787
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.93578
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TRPV1 2.9234
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.8874
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.73436
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TRPV1 2.64101
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.64101
[MF] GO:0003845 None HSD11B1, HSD11B2 2.64101
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.64101
[MF] GO:0008389 None CYP2A13, CYP2A6 2.64101
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, TUBB3, XDH 2.33356
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.32782
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KCNH2, KDR, KIT, MET, PIM1, SRC 2.25333
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.25333
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.25333
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.25333
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.25333
[MF] GO:0005330 None SLC6A2, SLC6A4 2.25333
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.25333
[MF] GO:0047374 None CES1, CES2 2.25333
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, HMGCR, KCNH2, KIT, SLC6A4, TERT, TOP2A, TYR, XDH 2.2187
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, TUBB3, XDH 2.179
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TRPV1, TUBB3, XDH 2.1729
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TRPV1 2.15349
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.08223
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.01929
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.01929
[MF] GO:0032795 None ADORA1, ADRA2A 2.01929
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.01929
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PHF8, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, TUBB3, TYR, XDH 2.00548


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.313
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.5438
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP2C19, GBA2, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, FDPS, CBR1, TYR, CYP2A6, AKR1B10, CYP1A2, CYP1A1, ALPL, CES1 8.4427
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 8.4427
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.2596
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.4733
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.9722
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.4839
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, CYP2C19 3.9722
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 3.9311
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.9311
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.5699
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4, CYP2C19 3.848
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 3.2909
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7293
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 3.9722
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.2447
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.5802
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.5699
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.1774
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7652
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.7375
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 1.9245
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 1.8604
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, MET, IGF1R 1.7226
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.7226
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 1.9245
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.6
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.7226
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 1.7577
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7226
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2A 1.5047
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4836
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.4584
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.2108
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2545
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.0426
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0154
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 0.978
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 0.8365
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.0793
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.0426
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0154
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.8365
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.8365
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.7652
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.7905
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8324
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 0.8365
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8365
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.8972
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.7823
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.7312
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.0566
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.7731
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 0.9884
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7383
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.823
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7055
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7055
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7055
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.6817
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.639
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.6817
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6349
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.631
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.5367
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.52
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.4697
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1665
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.465
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2067
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.24
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2509
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2563
HTLV-I infection_Homo sapiens_hsa05166 FDPS, TERT 0.3892
Influenza A_Homo sapiens_hsa05164 FDPS 0.2509
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.24
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2903
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.2831
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2802
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2774
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2729
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.2903
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.2892
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.2882
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.2997
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.2997
Platelet activation_Homo sapiens_hsa04611 SRC 0.3146
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3156
Axon guidance_Homo sapiens_hsa04360 MET 0.3077
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3146
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.341
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3665
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3805
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3805
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.3888
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3805
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.3882
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.3883
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5047
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3886
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3885
Peroxisome_Homo sapiens_hsa04146 XDH 0.3978
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4326
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4117
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4316
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4439
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4577
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4577
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4577
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4451
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4577
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4633
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.4248
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4577
Shigellosis_Homo sapiens_hsa05131 SRC 0.4577
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4577
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.4759
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.4782
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.4778
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.412
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5025
Malaria_Homo sapiens_hsa05144 MET 0.5133
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.52
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5166
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.52
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.558
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5258
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5222
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.6977
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5532
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.634
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6196
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.639
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.7226
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6714
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6362
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6619
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.7731
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8365
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.0792


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)