TCM Prescription: Wan Ying Tea



Prescription Description
Prescription IDTCMF5392
Pinyin NameWan Ying Cha
Chinese Name万应茶
English NameWan Ying Tea
Function Description积滞, 腹痛, 呕吐, 腹泻, 腹胀, 痢疾, 类霍乱
IndicationsDysentery disorder, Abdominal pain disorder, Severe vomiting and diarrhoea disorder, Diarrhea, Dyspepsia, Cholera, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
SD92 [Severe vomiting and diarrhoea disorder (TM1), 霍乱 (TM1) ];
ME05.1 [Diarrhoea, 腹泻 ];
MD92 [Dyspepsia, 消化不良 ];
1A00 [Cholera, 霍乱 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach, Spleen
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1499 Changium smyrnioides 明党参 TCMH1499
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH45 Lablab purpureus 白扁豆 TCMH45 ITSAM881-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH2276 Elsholtzia splendens 香薷 TCMH2276 ITSAM4603-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2671 Polyporus umbellatus 猪苓 TCMH2671 NOBAS3307-16
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1312 Enterococcus durans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 24.4862
[BP] GO:0042221 response to chemical ABCB1, ABCG2, ADORA2A, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 16.9969
[BP] GO:0007187 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 16.173
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1, TYR 15.6747
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 15.658
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 15.6275
[BP] GO:0010033 response to organic substance ADORA2A, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 15.4426
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8339
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8339
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.3946
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.2778
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.1703
[BP] GO:0007188 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 14.0407
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 13.3343
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 13.33
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 13.0114
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB2, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 12.125
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.1182
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 11.8357
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 11.749
[BP] GO:0042493 response to drug ABCB1, ABCG2, ADORA2A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 11.6232
[BP] GO:0003018 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 11.5762
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 11.5666
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 11.5013
[BP] GO:0099536 None ADORA2A, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 11.4484
[BP] GO:0099537 None ADORA2A, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 11.4484
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, ADRB2, APP, BACE1, CA2, CA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PRKCE, PTGS2 11.4117
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, ADRB2, APP, BACE1, CA2, CA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PRKCE, PTGS2 11.4117
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.3823
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.0851
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.0489
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.9276
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.8335
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.8241
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 10.7997
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 10.7578
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, ADRB2, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 10.6696
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 10.664
[BP] GO:0007268 None ADORA2A, CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 10.664
[BP] GO:0098916 None ADORA2A, CHRM1, CHRM2, CHRM4, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 10.664
[BP] GO:0097746 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.5641
[BP] GO:0035296 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.5641
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.4502
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.4502
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, ADORA2A, CNR1, EGFR, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 10.3583
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1, TYR 10.2386
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 10.2386
[BP] GO:0050880 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.2274
[BP] GO:0035150 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.1875
[BP] GO:0007154 None ADORA1, ADORA2A, ADRB1, ADRB2, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 10.0287
[BP] GO:0007267 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1, TEK 9.99552
[BP] GO:0003013 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 9.91655
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 9.86268
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 9.37846
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 9.33792
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.27988
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.27648
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE, SLC22A1 9.24367
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.12012
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.11141
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.09291
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 9.08131
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 9.05285
[BP] GO:0023052 None ADORA1, ADORA2A, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1, TEK 9.05119
[BP] GO:0010243 response to organonitrogen compound ADORA2A, ADRB2, AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 9.05119
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 9.03001
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PRKCE, PTGS2, RORC, SRC, TYR 8.75788
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 8.75788
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.75348
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.72184
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.72184
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HTR1B, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 8.70522
[BP] GO:0044281 small molecule metabolic process ABCG2, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.63551
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, ADRB2, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 8.62776
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.4864
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 8.40577
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRB2, ALOX15, APP, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 8.40484
[BP] GO:1901698 response to nitrogen compound ADORA2A, ADRB2, AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 8.36744
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 8.28069
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 8.1858
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.08102
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRB2, ALOX15, APP, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 8.04914
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.04179
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.01809
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.99215
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, ADRB2, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.90473
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 7.87269
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.86027
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 7.8177
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.80617
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.71772
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, ADRB2, ALOX15, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 7.68114
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 7.66847
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 7.66651
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.64052
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, HTR1B, HTR1D, KDR, POLB, PRKCD, PRKCE, SRC 7.58457
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 7.55355
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, ADRB2, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 7.55355
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.54222
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.54222
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.53256
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.50357
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, PRKCE, SRC, TNKS, TNKS2, TRPV1 7.50357
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.4321
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 7.38523
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.32678
[BP] GO:0090066 None ADORA1, ADORA2A, ADRB1, ADRB2, ALOX15, CHRM1, EGFR, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 7.28207
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 7.27797
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.24176
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH 7.23694
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.20866
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2, TBXAS1 7.16594
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.14454
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 7.10284
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 7.03257
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.96658
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.95317
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, ADRB1, ADRB2, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 6.94907
[BP] GO:0003008 None ADORA1, ADORA2A, ADRB1, ADRB2, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 6.78258
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.77777
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 6.70104
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.60419
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 6.55676
[BP] GO:0007610 None ADORA2A, APP, BCL2, CNR1, EGFR, GRM1, GRM5, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 6.45838
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, ADRB2, APP, BCL2, CA2, CA7, CHRM1, CNR1, GPR35, GRM5, HTR1A, HTR1B, HTR2A, MIF, MMP9, PRKCD, PRKCE, PTGS2 6.38702
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 6.32888
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, PTPN1, SRC, TEK 6.31829
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.29749
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.17358
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.17358
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRB2, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 6.11205
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, ADRB2, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.10491
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 6.07844
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.07028
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC 6.05221
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK 6.05221
[BP] GO:0043549 regulation of kinase activity ADORA1, ADORA2A, ADRB2, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 6.05221
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.018
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, ADRB2, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.98541
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 5.97724
[BP] GO:0044057 None ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, EGFR, GPR35, GRM1, HCAR2, HTR2A, HTR2C, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 5.9765
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, ADORA2A, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.96761
[BP] GO:0050795 None ADORA1, ADORA2A, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.96595
[BP] GO:0006855 None ABCB1, ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 5.96595
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, ADRB2, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.95497
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 5.95064
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, ADRB2, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 5.94685
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.93808
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 5.92569
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.89707
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 5.83604
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 5.83542
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, ADORA2A, CYP1B1, EGFR, GRIK5, HTR1A, INSR, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 5.81505
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.80359
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRB2, BCL2, CNR2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.78393
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.78393
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.78318
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRB2, BCL2, CNR2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.75938
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, ADRB2, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT, TRPV1 5.75927
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 5.7522
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.69601
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.69136
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1 5.67869
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 5.63998
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC, TEK 5.61039
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 5.61039
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.53158
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.50981
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.46044
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, HTR1B, MMP2, MMP9, PTGS2, TERT 5.43511
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, MIF, POLB, PRKCD, PTGS2, TERT 5.3853
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.3853
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 5.3853
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.38224
[BP] GO:0035556 intracellular signal transduction ADORA2A, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 5.36732
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3, TRPV1 5.36301
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HTR1B, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.35897
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.35143
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.33462
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.32967
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 5.31569
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.29123
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.25937
[BP] GO:0042391 None ADORA1, ADORA2A, ADRB2, APP, BCL2, CNR1, CNR2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 5.25541
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.22813
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7, GRM5, MIF, PRKCD 5.21703
[BP] GO:0051046 None ACHE, ADORA1, ADORA2A, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC, TRPV1 5.20342
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 5.15993
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.15577
[BP] GO:0032787 None ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PPARA, PTGS1, PTGS2, TBXAS1 5.03422
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, ADRB2, APP, CA2, CA7, EGFR, PRKCE, PTGS2 5.03341
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADORA2A, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.03341
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, GRM5, HTR2A, HTR2B, HTR2C 5.0321
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.03172
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.03172
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADORA2A, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 5.02924
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, GRM5, HTR1B, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 5.0211
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 5.00314
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.00192
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 4.99353
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.92754
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.91605
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.90509
[BP] GO:0055080 cation homeostasis ABCG2, APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.88082
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADORA2A, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE 4.8539
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.81025
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRB2, DUSP3, EGFR, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC 4.78384
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.76646
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.75778
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.75778
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.75778
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, ADORA2A, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.72079
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.67863
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.6735
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 4.65769
[BP] GO:0001775 cell activation ADORA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 4.64471
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.63567
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.60885
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.59808
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.55852
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.55741
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.55297
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, MIF, PRKCD, PRKCE, PTPN1, SRC 4.55297
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.54103
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, HTR7, PPARA, PRKCG, RORC, SRC, TOP2A 4.54049
[BP] GO:0051172 None ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, HTR1B, HTR1E, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.54049
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 4.54049
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.52523
[BP] GO:1900542 None ADORA2A, ADRB1, ESRRB, GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA 4.50902
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.50375
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.49774
[BP] GO:0043065 positive regulation of apoptotic process ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.43924
[BP] GO:0006140 None ADORA2A, ADRB1, ESRRB, GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA 4.38917
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 4.38917
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.38917
[BP] GO:0043068 positive regulation of programmed cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.38583
[BP] GO:0015893 None ABCB1, ABCG2, CA2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.37949
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, ADORA2A, ADRB2, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.37949
[BP] GO:0055065 metal ion homeostasis ABCG2, APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.37941
[BP] GO:0008217 None ADORA1, ADRB1, ADRB2, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 4.35933
[BP] GO:0009266 None ADORA1, ADRB1, ADRB2, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 4.33625
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.30303
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 4.30289
[BP] GO:0060078 None ADORA1, ADORA2A, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.28942
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.27694
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.25646
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 4.23037
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, ADORA2A, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 4.2028
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.18204
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 4.16494
[BP] GO:0043393 regulation of protein binding ADRB2, APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 4.15798
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC, TERT 4.15798
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.13323
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, ADRB2, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 4.12974
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.12231
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADORA2A, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.11879
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7, PRKCE 4.09785
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 4.08521
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, PRKCG, SMAD3 4.06123
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PIK3CB, PTPN1, SRC 4.04644
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.0281
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.02504
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, ADORA2A, APP, BCL2, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 4.01706
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TNKS, TOP2A 4.00527
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 4.00007
[BP] GO:0010942 positive regulation of cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.99124
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, ADRB1, ADRB2, APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.98644
[BP] GO:0001659 None ADORA1, ADRB1, ADRB2, HTR2A, TRPV1 3.97911
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.97911
[BP] GO:0002791 None ACHE, ADORA1, ADORA2A, CNR1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 3.97911
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 3.97687
[BP] GO:0050727 regulation of inflammatory response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.97519
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.97081
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 3.95978
[BP] GO:0050890 None ADORA1, APP, CHRM1, CNR1, EGFR, GRM5, HMGCR, HTR2A, INSR, PRKCG, PTGS2 3.94297
[BP] GO:0030155 regulation of cell adhesion ADORA2A, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.93424
[BP] GO:0070201 None ACHE, ADORA2A, APP, BCL2, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.93244
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.92235
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, HTR1B, MMP2, MMP9, PTGS2, TERT 3.90051
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 3.88733
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, ALOX15, APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.86907
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.86475
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.78631
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 3.78631
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.78631
[BP] GO:0051098 regulation of binding ADRB2, APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, TNKS 3.77899
[BP] GO:0010638 positive regulation of organelle organization ADRB2, ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.7658
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.75737
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 3.7519
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.74697
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.74461
[BP] GO:0008150 biological_process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.71217
[BP] GO:0051222 positive regulation of protein transport ACHE, ADORA2A, APP, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.69683
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRB2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, MIF, PIK3CB, PTPN1, SRC 3.69027
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 3.69027
[BP] GO:0032880 regulation of protein localization ACHE, ADORA2A, APP, BCL2, CHRM1, CNR1, CSNK2A1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 3.69027
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADORA2A, ADRB1, ADRB2, APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.68324
[BP] GO:0051223 None ACHE, ADORA2A, APP, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.66864
[BP] GO:0031329 regulation of cellular catabolic process ADRB2, APEX1, BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.66208
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, PPARA, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 3.65741
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 3.6535
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 3.6535
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 3.62855
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.62014
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT 3.55444
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, ADRB2, APP, BCL2, PIK3CA, TNKS2 3.54076
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.53151
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.5194
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.5194
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.5168
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, PRKCE, SRC 3.5096
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, ADRB1, ADRB2, APP, AURKB, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.4986
[BP] GO:0050793 regulation of developmental process ADRB1, ADRB2, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 3.49638
[BP] GO:0006954 inflammatory response ADORA1, ADORA2A, ADORA3, ALOX15, AXL, CNR2, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.48861
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.48068
[BP] GO:0060079 None ADORA1, ADORA2A, GRIA2, GRIA4, GRIK5, TRPV1 3.47787
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9, TRPV1 3.46074
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.42318
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.42318
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.41385
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.41385
[BP] GO:1900543 None GRM3, GRM8, HTR1B, HTR1E, PPARA, PRKCA 3.41385
[BP] GO:0002793 None ACHE, ADORA1, ADORA2A, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 3.41244
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A 3.41242
[BP] GO:0045980 None GRM3, GRM8, HTR1B, HTR1E, PPARA, PRKCA 3.38156
[BP] GO:0045776 None ADORA1, ADRB1, ADRB2, CNR1, PPARA 3.37784
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.36631
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC, TRPV1 3.35614
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 3.35122
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.34881
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 3.3204
[BP] GO:0009968 negative regulation of signal transduction ADRB2, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.31818
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.31134
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.31134
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.31134
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PRKCD, SRC 3.30511
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.29809
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B, TERT 3.29182
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.28034
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.248
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.248
[BP] GO:0030814 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, HTR1E, PRKCA 3.23578
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.22522
[BP] GO:0050878 regulation of body fluid levels ADORA1, ADORA2A, AKR1B1, CHRM1, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.17744
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.17082
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.15972
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.15514
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.14637
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.14209
[BP] GO:0031649 None ADRB1, ADRB2, TRPV1 3.12733
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.12109
[BP] GO:0030815 None GRM3, GRM8, HTR1B, HTR1E, PRKCA 3.12109
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.12109
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ADORA2A, CNR2, CYP19A1, HMGCR, MIF, PPARA, PRKCD, SMAD3, TEK 3.11105
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 3.11105
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.08317
[BP] GO:0032098 None HTR2C, HTR4, PPARA, SLC22A3 3.08317
[BP] GO:0061900 None ADORA2A, APP, EGFR, TRPV1 3.08317
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.05286
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, HTR1A, TYR 3.0469
[BP] GO:0030800 None GRM3, GRM8, HTR1B, HTR1E, PRKCA 3.04183
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3, TRPV1 3.0392
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.0239
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.00804
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.00804
[BP] GO:0048143 None ADORA2A, APP, EGFR 2.97532
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 2.97532
[BP] GO:0002024 None ADRB1, ADRB2, TRPV1 2.97532
[BP] GO:0050877 None ADORA1, ADORA2A, APP, CHRM1, CNR1, CNR2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, HTR2A, INSR, PRKCG, PTGS2, TRPV1, TYR 2.9752
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.97084
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 2.97084
[BP] GO:0050708 None ACHE, ADORA2A, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, PRKCA, PRKCE, SRC 2.96001
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 2.96001
[BP] GO:0006693 None CES2, MIF, PTGS1, PTGS2 2.96001
[BP] GO:0006692 None CES2, MIF, PTGS1, PTGS2 2.96001
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, GPR35, HMGCR, HSPA1A, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 2.95939
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.95461
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.95461
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.95409
[BP] GO:0051094 positive regulation of developmental process ADRB2, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, HTR2A, HTR2C, INSR, KDR, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT 2.94617
[BP] GO:0050714 None ACHE, ADORA2A, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.93731
[BP] GO:0007611 None APP, CNR1, EGFR, GRM5, HMGCR, HTR2A, INSR, PRKCG, PTGS2 2.93731
[BP] GO:0033555 multicellular organismal response to stress ADRB1, BCL2, HTR1A, HTR2C, PRKCG 2.90525
[BP] GO:0007271 None ADORA2A, CHRM1, CHRM2, CHRM4 2.90525
[BP] GO:1904646 cellular response to amyloid-beta ADRB2, APP, GRM5, IGF1R 2.90525
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.89679
[BP] GO:0043279 None ADORA2A, CNR1, HTR1B, PRKCE, PRKCG, TRPV1 2.87011
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B, TERT 2.87008
[BP] GO:0032409 None ABCB1, ADRB2, APP, BCL2, GPR35, GRM5, MMP9, PRKCD, PRKCE 2.84759
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.84759
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 2.84759
[BP] GO:0050873 None ADRB1, ADRB2, FABP4, PTGS2 2.84759
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 2.84759
[BP] GO:0044267 cellular protein metabolic process ADORA2A, ADRB2, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.81916
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.81902
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.80205
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.80205
[BP] GO:0045936 None ADORA2A, DUSP3, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.80198
[BP] GO:0010563 None ADORA2A, DUSP3, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.79489
[BP] GO:0007205 None ADORA2A, CHRM1, HTR1B, HTR2B 2.79317
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 2.79317
[BP] GO:0009896 positive regulation of catabolic process ADRB2, CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.78642
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TRPV1, TYR 2.74619
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.74568
[BP] GO:1904645 response to amyloid-beta ADRB2, APP, GRM5, IGF1R 2.74568
[BP] GO:0030799 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, HTR1E, PRKCA 2.74568
[BP] GO:0007208 None HTR2A, HTR2C 2.74568
[BP] GO:0035408 None PRKCA, PRKCB 2.74568
[BP] GO:0009115 None AOX1, XDH 2.74568
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.74568
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRB2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.73922
[BP] GO:2001233 regulation of apoptotic signaling pathway ADORA2A, BCL2, HSPA1A, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 2.73773
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.73724
[BP] GO:0030817 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, PRKCA 2.72045
[BP] GO:0042752 None ADORA1, ADORA2A, PPARA, PRKCG, RORC, TOP2A 2.72045
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.69727
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.68644
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.68644
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.68644
[BP] GO:0014074 response to purine-containing compound ADORA2A, APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.68048
[BP] GO:0009410 None ADORA2A, CNR1, CNR2, EGFR, HTR1B, PRKCE, PRKCG 2.68048
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.67709
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 2.65986
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.65738
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.65738
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.65738
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.65738
[BP] GO:0045934 None APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, MMP12, PPARA, PRKCA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 2.65122
[BP] GO:0042596 None ADRB1, BCL2, HTR1A, HTR2C 2.65122
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.65021
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.63305
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.63305
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.63305
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.60289
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.60289
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.60075
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.60075
[BP] GO:0050678 None CDK6, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.58419
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.58419
[BP] GO:0006940 None ADORA1, ADRB2, CHRM1, CHRM2, PTGS2 2.57063
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK 2.55261
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.53062
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.53062
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.53062
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.53024
[BP] GO:0002683 negative regulation of immune system process ADORA1, ADORA2A, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, MIF, MMP12 2.52149
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, PRKCE, TERT, TNKS 2.51985
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.51985
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ADRB1, ADRB2, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR2B, KDR, MET, MIF, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.51874
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.51659
[BP] GO:0051234 None ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADRB2, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TRPV1, XDH 2.50246
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.49125
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ADRB2, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.48616
[BP] GO:0006464 cellular protein modification process ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.48419
[BP] GO:0036211 protein modification process ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.48419
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 2.47062
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.47062
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.46216
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.444
[BP] GO:1990845 None ADRB1, ADRB2, TRPV1 2.444
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.444
[BP] GO:1903524 None ADRB1, EGFR, HTR2A, PTGS2, SLC1A1 2.43675
[BP] GO:0051128 regulation of cellular component organization ADRB2, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.4348
[BP] GO:0007190 None ADORA3, ADRB1, ADRB2, PRKCA 2.43065
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.38752
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.38737
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.38501
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CHRM1, CHRM2, EGFR, HTR2A, PTGS2, SLC1A1 2.37994
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.36311
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.36311
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.36311
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.36311
[BP] GO:0046890 None FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.36311
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.36311
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.35222
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.35222
[BP] GO:1903532 None ACHE, ADORA2A, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.34984
[BP] GO:0099566 None GRM1, GRM5 2.34613
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.34613
[BP] GO:0046110 None AOX1, XDH 2.34613
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34613
[BP] GO:0002025 None ADRB1, ADRB2 2.34613
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.32929
[BP] GO:0022898 None ABCB1, ADRB2, APP, BCL2, GPR35, GRM5, MMP9, PRKCE 2.32834
[BP] GO:0030802 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, PRKCA 2.3231
[BP] GO:0010605 negative regulation of macromolecule metabolic process ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.30542
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.3013
[BP] GO:0051952 None ADORA1, ADORA2A, CNR1, HTR1B, HTR2A 2.29975
[BP] GO:0060401 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.29975
[BP] GO:0043412 macromolecule modification ADRB2, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.29975
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.29975
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.29975
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.29975
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.29975
[BP] GO:0070920 None EGFR, ESR1, TERT 2.29975
[BP] GO:0045986 None ADORA1, ADRB2, PTGS2 2.29975
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.29975
[BP] GO:0051179 None ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADRB2, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.29931
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC 2.29398
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.29373
[BP] GO:0006952 defense response ADORA1, ADORA2A, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, MIF, PIK3CA, PIK3CB, POLB, PRKCD, PTGS1, PTGS2, SRC, TRPV1 2.28669
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, PRKCE, RORC, SRC 2.28122
[BP] GO:0098657 import into cell ACHE, ADORA1, ADORA2A, ADRB2, ALOX15, APP, AXL, HTR1B, HTR2B, SLC1A1, SLC22A3, TRPV1 2.28014
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK 2.26719
[BP] GO:1903793 None ABCB1, ADORA2A, MIF, PRKCD 2.25437
[BP] GO:0019932 second-messenger-mediated signaling ADORA2A, ADRB1, ADRB2, EGFR, GRM5, HTR2B, HTR5A, KDR 2.25403
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.24209
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 2.24161
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 2.23081
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.22901
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.22901
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 2.22658
[BP] GO:0006810 None ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADRB2, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TNKS, TRPV1, XDH 2.21811
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.21286
[BP] GO:0030818 None GRM3, GRM8, HTR1B, PRKCA 2.18499
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.1771
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.16769
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.16769
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.16769
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.16264
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.16264
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.16264
[BP] GO:1900371 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, PRKCA 2.16264
[BP] GO:0009889 regulation of biosynthetic process ADORA2A, ADORA3, ADRB1, ADRB2, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.16042
[BP] GO:0051248 None ADORA2A, APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH 2.15595
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.15526
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.14767
[BP] GO:0030808 None ADORA2A, ADRB1, GRM3, GRM8, HTR1B, PRKCA 2.14767
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA2A, ADORA3, ADRB1, ADRB2, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, HTR2A, IGF1R, INSR, MET, MMP12, PIK3CA, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.13289
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.13092
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.12887
[BP] GO:1901215 negative regulation of neuron death ADORA2A, AXL, BCL2, PIK3CA, PPARA, PRKCG, TERT 2.12887
[BP] GO:0090342 None CDK6, MIF, NUAK1, TERT 2.12439
[BP] GO:0030803 None GRM3, GRM8, HTR1B, PRKCA 2.12439
[BP] GO:0043086 negative regulation of catalytic activity ADORA2A, APP, CNR1, CNR2, CSNK2A1, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.12439
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ESR1, GPR35, GRM1, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.12051
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.10874
[BP] GO:0001936 None F3, HTR2B, KDR, PRKCA, TEK, XDH 2.10464
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.10464
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.10464
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.10464
[BP] GO:1901374 None SLC22A1, SLC22A2 2.10114
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.10114
[BP] GO:0070213 None TNKS, TNKS2 2.10114
[BP] GO:0006145 None AOX1, XDH 2.10114
[BP] GO:0038171 None CNR1, CNR2 2.10114
[BP] GO:0015874 None SLC22A1, SLC22A2 2.10114
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.10114
[BP] GO:0014827 None HTR1D, HTR2B 2.10114
[BP] GO:0050433 None ADORA2A, CNR1, HTR1B, HTR2A 2.10114
[BP] GO:0001938 None F3, HTR2B, KDR, PRKCA, TEK 2.0969
[BP] GO:0031331 positive regulation of cellular catabolic process ADRB2, ESRRB, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PRKCD, PTPN1 2.05475
[BP] GO:0051341 None CNR1, CNR2, EGFR, HTR2B, TERT 2.05279
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.04916
[BP] GO:0035249 None ADORA2A, GRIA2, GRIK5 2.04916
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.04563
[BP] GO:0043523 regulation of neuron apoptotic process ADORA2A, AXL, BCL2, GRIK5, PIK3CA, PRKCG, TERT 2.03996
[BP] GO:1900372 None GRM3, GRM8, HTR1B, PRKCA 2.03996
[BP] GO:0030809 None GRM3, GRM8, HTR1B, PRKCA 2.03996
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.03996
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.03996
[BP] GO:2001023 None ADORA2A, CNR1, HTR1B, HTR2A, MET 2.03666
[BP] GO:0043524 negative regulation of neuron apoptotic process ADORA2A, AXL, BCL2, PIK3CA, PRKCG, TERT 2.03632
[BP] GO:0050865 regulation of cell activation ADORA2A, APP, AXL, BCL2, CNR1, CNR2, DUSP3, MIF, PIK3CA, PRKCA, PRKCD, SRC 2.02652
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, CHRM1, EGFR, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT 2.02128
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.02128
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.01772
[BP] GO:0051588 None ADORA2A, GRIK5, HTR1A, HTR1B, HTR2C 2.01772
[BP] GO:0097755 None ADORA2A, ADRB1, ADRB2, EGFR 2.01076
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1 15.3514
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 14.7417
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 13.2101
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, APP, AXL, BACE1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 13.1594
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR 11.7314
[CC] GO:0098590 plasma membrane region ABCB1, ABCG2, ADORA1, ADORA2A, ADRB2, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 9.5476
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TEK, TRPV1, TYR 9.38728
[CC] GO:0043005 None ADORA1, ADORA2A, APP, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PRKCG, PTGS2, SRC 5.31501
[CC] GO:0031224 None ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 5.29746
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 5.2905
[CC] GO:0044456 None ACHE, ADORA1, ADORA2A, APP, CHRM1, CHRM2, CHRM4, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 4.91605
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.77648
[CC] GO:0120025 None ADORA1, ADORA2A, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PRKCG, PTGS2, SRC, TEK 4.58596
[CC] GO:0016021 None ABCB1, ABCG2, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 4.52404
[CC] GO:0042995 cell projection ADORA1, ADORA2A, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PRKCG, PTGS2, SRC, TEK 4.17493
[CC] GO:0097458 None ADORA1, ADORA2A, APP, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TRPV1 4.09928
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 3.72018
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES2, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, HSPA1A, HTR5A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.69683
[CC] GO:0014069 None ADORA1, ADORA2A, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.45469
[CC] GO:0099572 None ADORA1, ADORA2A, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 3.45469
[CC] GO:0043235 receptor complex ABCG2, ADRB2, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.31818
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 3.25419
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.95461
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.93599
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 2.51985
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.45775
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.38315
[CC] GO:0098589 membrane region APP, BACE1, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.3633
[CC] GO:0099056 None ADORA1, ADORA2A 2.34613
[CC] GO:0098889 None ADORA1, ADORA2A 2.34613
[CC] GO:0032589 None ADORA1, ADORA2A, INSR, TRPV1 2.29224
[CC] GO:0044463 None ADORA1, ADORA2A, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SRC, TRPV1 2.18873
[CC] GO:0120038 None ADORA1, ADORA2A, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SRC, TRPV1 2.18873
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.12887
[CC] GO:0031233 None CA4, F10, F3 2.04916
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM4, EGFR, GRIA2, HTR2B 2.00894
[MF] GO:0008227 None ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.6363
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.5171
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.2062
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 16.9969
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 15.4426
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 15.2635
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 15.2635
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 15.2144
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.9459
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.9459
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8339
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8339
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.345
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK, TRPV1 14.0407
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK, TRPV1 14.0407
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.1635
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 11.0227
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.4564
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.43369
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.14925
[MF] GO:0004930 None ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.55509
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.0432
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 7.76004
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.25136
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.23694
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.6728
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.61714
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.17358
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.05221
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.98541
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 5.9765
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 5.96761
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.92106
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 5.84845
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.78393
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.69694
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 5.57531
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.49524
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.38532
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.3441
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.32674
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, ADRB1, ADRB2, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 5.31699
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.19586
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR 5.15692
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 5.06725
[MF] GO:0019899 enzyme binding ADORA2A, ADRB1, ADRB2, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 4.9913
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.91605
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.91387
[MF] GO:0015238 None ABCB1, ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.79931
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.76835
[MF] GO:1901363 heterocyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 4.74855
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.65116
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.57609
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 4.54103
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADORA2A, ADRB2, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.37818
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.26092
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.26092
[MF] GO:0005524 ATP binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.19382
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.13323
[MF] GO:0043168 anion binding ABCB1, ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 4.08143
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.02287
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.00007
[MF] GO:0030554 adenyl nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.97911
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.83511
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.78631
[MF] GO:0003674 molecular_function ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.69683
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.5194
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.3204
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.31134
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.248
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.16715
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRB2, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.06104
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.01073
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 2.97532
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 2.97532
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 2.97532
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.94335
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.90525
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.79317
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 2.77524
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.74568
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74568
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74568
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74568
[MF] GO:0035403 None PRKCA, PRKCB 2.74568
[MF] GO:0071886 None HTR2A, HTR2C 2.74568
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.73724
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.73298
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, BACE1, GRIA2, INSR 2.71802
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.63305
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.55546
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.51588
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.45037
[MF] GO:0032555 purine ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.43193
[MF] GO:0017076 purine nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.41506
[MF] GO:0032553 ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.4107
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.4034
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.34613
[MF] GO:0015307 None SLC47A1, SLC47A2 2.34613
[MF] GO:1901375 None SLC22A1, SLC22A2 2.34613
[MF] GO:0004949 None CNR1, CNR2 2.34613
[MF] GO:0004939 None ADRB1, ADRB2 2.34613
[MF] GO:0005333 None SLC22A1, SLC22A2 2.34613
[MF] GO:0005277 None SLC22A1, SLC22A2 2.34613
[MF] GO:0099583 None GRM1, GRM5 2.34613
[MF] GO:0008513 None SLC22A1, SLC22A2 2.34613
[MF] GO:0004699 None PRKCD, PRKCE 2.34613
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.22901
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.22901
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.18499
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADORA2A, ADRB1, ADRB2, AOX1, AXL, BCL2, EGFR, FLT3, HMGCR, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH 2.16502
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.16264
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, ADRB2, AOX1, BCL2, FLT3, HMGCR, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH 2.12887
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.10464
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.10464
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.10114
[MF] GO:0004971 None GRIA2, GRIA4 2.10114
[MF] GO:0051425 None APP, INSR 2.10114
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.06679
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.05279
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.04916


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM1, CHRM4, GRIK5, HTR2B, HTR2C, ADRB1, HTR2A, ADRB2, HTR4, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, GRIA4, HTR1E, GPR35, HTR1D, HTR1A, HTR1B, TRPV1, HTR5A, ADORA2A 25.6119
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, HTR1E, PRKCB, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 19.4424
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM1, PRKCB, HTR2B, HTR2C, PRKCA, ADRB1, HTR2A, ADRB2, HTR5A, HTR4, GRM1, EGFR, HTR6, GRM5, HTR7, ADORA2A 14.2528
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, CHRM1, HTR1E, HTR1D, HTR1A, HTR1B, ADRB1, PIK3CB, ADRB2, HTR4, HCAR2, HTR6, ADORA2A, PIK3CA, ADORA1, PPARA, GRIA4 13.5988
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 10.3076
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.0903
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.2205
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, HTR2B, HTR2C, PRKCA, ADRB1, HTR2A, GRM1, EGFR 9.6014
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.1406
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.9626
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, ADORA2A, PIK3CA, CNR1, KDR, TEK, MET 8.9626
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.6594
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, ADRB1, PIK3CB, ADRB2, PTGS2, PTGS1 8.9626
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 8.1417
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM1, PIK3CA, PRKCB, CHRM4, BCL2, PRKCA, PIK3CB 7.6028
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 7.3695
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 7.8972
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 9.6866
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.3695
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.1667
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, HTR7, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.7688
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 6.8945
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, CNR1, PRKCA, PTGS2, GRM1, GRIA4 6.8945
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.6499
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.484
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.3508
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, CDK6, PIK3CA, KDR, BCL2, TEK, MET 5.7783
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.7688
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 7.3695
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.3358
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PRKCA, PIK3CB, GRM1, EGFR 5.684
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 6.3683
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.5674
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.8286
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.1345
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 4.9504
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 4.479
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.2972
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, ADRB1, PIK3CB, ADRB2 4.3315
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.3685
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 4.9469
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5699
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 3.8242
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.3685
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.0572
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 4.7352
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.0229
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 3.9512
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5098
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, ADORA2A, PRKCB, PRKCE, PRKCD, PRKCA 3.4391
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB, EGFR 2.9314
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, ADRB1, PIK3CB, ADRB2 2.9948
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.8419
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, GRM1 3.2502
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.1348
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.0096
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.5219
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.6735
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 2.5394
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.73
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.6572
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.1846
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 3.6572
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.5746
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.9598
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA, ADRB1, ADRB2 3.1348
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.9314
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1492
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1564
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.1617
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.6282
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.1978
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.2151
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 2.5487
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2285
Axon guidance_Homo sapiens_hsa04360 MET 0.2411
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1, HMGCR, ABCG2 3.5436
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2479
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 2.5011
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.427
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.2923
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.5699
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4229
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3019
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 3.7889
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.3505
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.3505
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3187
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.4584
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.4743
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4544
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.4752
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3336
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.3336
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3336
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3462
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3336
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.2844
Peroxisome_Homo sapiens_hsa04146 XDH 0.3477
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.1869
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6052
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.0164
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 0.9226
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.3702
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.7962
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 1.9052
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4001
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7277
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 1.7781
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.7378
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.0777
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4026
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.5439
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, TERT, PIK3CB 1.4318
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.3828
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 1.8874
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.0114
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.1727
Shigellosis_Homo sapiens_hsa05131 SRC 0.4209
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.6061
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.2573
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.2201
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.7156
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.1456
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.7693
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.1995
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.5327
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8339
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.4229
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.2323
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.3055
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.1961
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.4685
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.375
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.6189
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.4728
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.4728
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.7051
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.777
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9197
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.4899
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 0.969
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 2.9104
Malaria_Homo sapiens_hsa05144 MET 0.502
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 0.9867
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.5791
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.507
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.512
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.738
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.7989
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5256
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0503
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.8225
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.1842
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.7989
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.767
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, ADRB2 1.8551
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 1.7894
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1181
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5675
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6105
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.0859
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2253
DNA replication_Homo sapiens_hsa03030 POLA1 0.6052
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6552
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.2535
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7014
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.4391
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.2323
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6757
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.3325
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7104
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.2152
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6651
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3991
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7014
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.5011
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6103
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.5011
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4778
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5458
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5675
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6347
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7688
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8652
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7989
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8447
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9363
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2644
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9069


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)