TCM Prescription: Quan Zhou Cha Bing



Prescription Description
Prescription IDTCMF5307
Pinyin NameQuan Zhou Cha Bing
Chinese Name泉州茶饼
English NameQuan Zhou Cha Bing
Function Description感冒, 积滞
IndicationsCommon cold disorder, Common cold, Dyspepsia
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationLung, Blood, Spleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH2276 Elsholtzia splendens 香薷 TCMH2276 ITSAM4603-14
TCMH1938 Quisqualis indica 使君子 TCMH1938 GENG1719-16
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH45 Lablab purpureus 白扁豆 TCMH45 ITSAM881-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1, TYR 14.6845
[BP] GO:0042221 response to chemical ABCB1, ABCG2, ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SRC, TERT, TOP1, TRPV1, TYR 13.9789
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 13.9789
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 13.579
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 10.9546
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 10.8319
[BP] GO:0042493 response to drug ABCB1, ABCG2, ADORA2A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TOP1, TRPV1 10.4193
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 10.3947
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PRKCE, PTGS2, RORC, SRC, TYR 9.74013
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 9.59579
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.3764
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.35369
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TOP2A, TRPV1, TYR 9.21343
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.13683
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 9.12748
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PRKCE, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 8.96301
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 8.32247
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 8.32247
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.20665
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HCAR2, HMGCR, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 7.78142
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.77529
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 7.77529
[BP] GO:0044281 small molecule metabolic process ABCG2, ADORA2A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, GLO1, HMGCR, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.75457
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TERT 7.74148
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.74148
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.71799
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, TERT, XDH 7.6282
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 7.39562
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, PRKCD, PRKCE, SRC 7.05739
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7, CNR1, CNR2, PRKCE 6.97111
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SRC, TERT, TNKS2, TOP2A, TYR 6.76155
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TRPV1 6.73237
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, XDH 6.73229
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 6.69235
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.66976
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.66564
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.55463
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 6.52807
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.49934
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 6.47012
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.47012
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 6.39699
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.38677
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 6.38677
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 6.37782
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 6.37588
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 6.36517
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SRC, TNKS2, TOP1, TRPV1, TYR 6.26438
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 6.14018
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.14018
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, F3, FLT3, HMGCR, HTR6, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, XDH 6.10811
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 6.08452
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TERT, TRPV1 6.06902
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 5.92245
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.87826
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 5.80196
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 5.77565
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.73546
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.64069
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.5925
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.59234
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1 5.57797
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SRC, TERT, TRPV1 5.57532
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.5361
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.51227
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.27448
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.26722
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, MPO, POLB, PRKCD, PTGS2, TERT 5.26425
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 5.25669
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.25669
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SRC, TERT 5.23983
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.20833
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.15996
[BP] GO:0006855 None ABCB1, ABCG2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 5.15529
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 5.14263
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.9717
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.93722
[BP] GO:0043065 positive regulation of apoptotic process ADORA2A, BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 4.92358
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2 4.89185
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F10, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS, TOP1, TOP2A 4.87736
[BP] GO:0043068 positive regulation of programmed cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 4.87736
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.86198
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HCAR2, HMGCR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TRPV1 4.84138
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC, TERT 4.84066
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TERT 4.84066
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1 4.81682
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.77981
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC, TERT 4.7201
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, MMP2, MPO, POLB, PPARA, PRKCB, PRKCE, PTGS2, SRC, TERT, TRPV1, TYR 4.69535
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, IDO1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 4.63238
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.62398
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, MPO, PRKCD, PTGS1, PTGS2, SRC 4.55904
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, POLA1, PRKCD, SRC, TYR 4.54088
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 4.51033
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TERT, TNKS2, TRPV1, XDH 4.49981
[BP] GO:0010942 positive regulation of cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 4.49981
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, PPARA, PRKCG, RORC, SRC, TOP1, TOP2A 4.49354
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.46004
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.41294
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.41294
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 4.40998
[BP] GO:0001775 cell activation ADORA2A, ALOX5, APP, AXL, BCL2, FLT3, FUT7, MMP9, MPO, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 4.37576
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 4.34447
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.3308
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.29089
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.28705
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, PRKCE, PTGS2 4.28705
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, PRKCE, PTGS2 4.28705
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.27444
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC 4.22606
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7, PRKCE 4.20179
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HCAR2, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TERT, TRPV1 4.20121
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.14975
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.14975
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.14939
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.14858
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.09613
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.08729
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.06465
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 4.05432
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, PRKCE, SRC, TNKS, TNKS2, TRPV1 4.04339
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.03804
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.03746
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 4.00338
[BP] GO:0050878 regulation of body fluid levels ADORA1, ADORA2A, AKR1B1, CHRM1, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.98222
[BP] GO:0015893 None ABCB1, ABCG2, CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.97362
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.92109
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.91927
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 3.91892
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 3.89753
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, PRKCE, SRC, TRPV1 3.87887
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.834
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.834
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.834
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.834
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.83141
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 3.81459
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SRC, TERT, TRPV1 3.80786
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.80638
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 3.77581
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 3.75636
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 3.75596
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, SRC, TRPV1, TYR 3.70472
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 3.67499
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.66707
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.59603
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.5774
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.57555
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.57555
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, PRKCE, PTGS2 3.5546
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.53435
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, CHRM1, CNR1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 3.52457
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.52225
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC 3.51844
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, ESRRB, HCAR2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 3.51844
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.47734
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45637
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 3.45037
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7, PRKCD 3.43844
[BP] GO:0007187 None ADORA1, ADORA2A, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR6 3.39681
[BP] GO:0050727 regulation of inflammatory response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PRKCD, PTGS2 3.39566
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.37842
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.3717
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.37001
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.3586
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.3586
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.34977
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 3.3271
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS1, PTGS2, TBXAS1 3.31704
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.31704
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 3.30191
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.291
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 3.28751
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.25641
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.25641
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, MPO, PTGS2, SRC, TRPV1, TYR 3.25364
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.15616
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.13408
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT, TNKS 3.10012
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 3.06812
[BP] GO:0007271 None ADORA2A, CHRM1, CHRM2, CHRM4 3.06552
[BP] GO:0042752 None ADORA1, ADORA2A, PPARA, PRKCG, RORC, TOP2A 3.05266
[BP] GO:0051172 None ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.05266
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.05266
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.02673
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, CHRM1, CNR1, MMP9, PRKCD, PRKCE, PTGS2 3.01852
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.01678
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.01678
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 3.01678
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.00451
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.00451
[BP] GO:0006954 inflammatory response ADORA1, ADORA2A, ADORA3, AXL, CNR2, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.00451
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.99642
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PRKCD, PTGS2, SRC 2.9964
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TERT 2.97877
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.97539
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 2.96543
[BP] GO:0032880 regulation of protein localization ACHE, ADORA2A, APP, BCL2, CHRM1, CNR1, CSNK2A1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT 2.95613
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.95001
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.94933
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.93464
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.93464
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.93313
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.93313
[BP] GO:0070201 None ACHE, ADORA2A, APP, BCL2, CHRM1, CNR1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.91913
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.86286
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.85864
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.85156
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, IDO1, MMP12, MPO, PRKCD, PTGS2, SRC, TRPV1, TYR 2.84924
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 2.84924
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 2.84045
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SRC, TERT, XDH 2.82476
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.82366
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.82366
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PRKCD, PTGS2, SRC 2.82366
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.79189
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.78442
[BP] GO:0044267 cellular protein metabolic process ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DYRK1A, ESR1, F10, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.75734
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 2.75085
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.74625
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 2.74625
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CNR2, CYP19A1, MMP12, PPARA, PRKCD 2.74625
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, ADORA2A, CNR2, CYP19A1, PPARA, PRKCD 2.74625
[BP] GO:0035408 None PRKCA, PRKCB 2.74625
[BP] GO:0009115 None AOX1, XDH 2.74625
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.74625
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.73054
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.73054
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TERT 2.69189
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.68359
[BP] GO:0030155 regulation of cell adhesion ADORA2A, BCL2, CDK6, CYP1B1, IDO1, KDR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SRC 2.6781
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.66679
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 2.64387
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.62939
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC 2.61494
[BP] GO:0051223 None ACHE, ADORA2A, APP, CHRM1, CNR1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.60684
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, IGF1R, MMP2, PRKCD, PRKCE, PTGS2, SRC, TRPV1 2.59495
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.57957
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC, TOP2A 2.57077
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, HCAR2, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 2.55951
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.55204
[BP] GO:1901215 negative regulation of neuron death ADORA2A, AXL, BCL2, PIK3CA, PPARA, PRKCG, TERT 2.54752
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.54386
[BP] GO:0010605 negative regulation of macromolecule metabolic process ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.54307
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TERT, TNKS, XDH 2.54307
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH 2.54225
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, TYR 2.5397
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 2.52579
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.48778
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 2.47972
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.4629
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.4629
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PTGS2, TRPV1, TYR 2.4628
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, MET, PIK3CA, PPARA, PRKCG 2.4628
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADORA2A, CNR1, CYP19A1, HCAR2, HMGCR, PRKCA, PRKCE 2.4628
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, ADORA2A, APP, BCL2, CHRM1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SRC 2.45824
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.45364
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.43798
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.43798
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PRKCD, PTGS2 2.41732
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, IGF1R, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.41492
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.40487
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.39733
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.39733
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.39684
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.39684
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.39684
[BP] GO:0043524 negative regulation of neuron apoptotic process ADORA2A, AXL, BCL2, PIK3CA, PRKCG, TERT 2.375
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SRC, TNKS, TNKS2 2.37124
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 2.36082
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.36082
[BP] GO:0046110 None AOX1, XDH 2.36082
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36082
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.35385
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, MMP9, PRKCE, PTGS2 2.34569
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.3413
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.3413
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.34125
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.33521
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F3, FABP4, IDO1, KDR, MET, PRKCA, PTGS2 2.33267
[BP] GO:0007610 None ADORA2A, APP, BCL2, CNR1, HMGCR, IDO1, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 2.32401
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DNMT1, DYRK1A, ESR1, F10, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.32401
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, PRKCA, TERT 2.30535
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.29306
[BP] GO:0002791 None ACHE, ADORA1, ADORA2A, CNR1, HCAR2, HMGCR, MMP12, PRKCA, PRKCE, SRC 2.29013
[BP] GO:0014074 response to purine-containing compound ADORA2A, APEX1, APP, PTGS2, TRPV1, TYR 2.27724
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.27724
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.27724
[BP] GO:0043279 None ADORA2A, CNR1, PRKCE, PRKCG, TRPV1 2.27709
[BP] GO:0008150 biological_process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 2.27518
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.26552
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DYRK1A, HMGCR, IGF1R, MET, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 2.26145
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, PRKCA, PRKCE, SRC, TERT 2.2427
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.2391
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.2391
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.2369
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, APP, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PRKCD, PRKCG, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.23156
[BP] GO:0050865 regulation of cell activation ADORA2A, APP, AXL, BCL2, CNR1, CNR2, IDO1, PIK3CA, PRKCA, PRKCD, SRC 2.22553
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.21731
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, PRKCA, TERT, TNKS, TOP2A 2.20778
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.20248
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.19704
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.19686
[BP] GO:0003014 None ADORA1, ADORA2A, AKR1B1, BCL2, HSD11B2 2.18417
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DYRK1A, ESR1, F10, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.16283
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DYRK1A, ESR1, F10, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.16283
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, HCAR2, MMP12, PRKCE, SRC, TRPV1 2.1621
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.1621
[BP] GO:0003018 None ADORA1, ADORA2A, CHRM1, HMGCR, PTGS2, SRC 2.1621
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.1621
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, PIK3CB, PRKCB, PRKCE, TRPV1 2.16041
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.1553
[BP] GO:0043086 negative regulation of catalytic activity ADORA2A, APP, CNR1, CNR2, CSNK2A1, FABP4, HMGCR, IGF1R, MMP9, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.1553
[BP] GO:0007188 None ADORA1, ADORA2A, CHRM1, CHRM2, CHRM4, CNR1 2.15196
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.13443
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.12629
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, IGF1R, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.12447
[BP] GO:1901374 None SLC22A1, SLC22A2 2.12447
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.12447
[BP] GO:0070213 None TNKS, TNKS2 2.12447
[BP] GO:0006145 None AOX1, XDH 2.12447
[BP] GO:0038171 None CNR1, CNR2 2.12447
[BP] GO:0015874 None SLC22A1, SLC22A2 2.12447
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12447
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.12447
[BP] GO:0051222 positive regulation of protein transport ACHE, ADORA2A, APP, CHRM1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SRC 2.11813
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.11813
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.11813
[BP] GO:0032094 None CYP1A1, HSD11B2, MPO 2.11813
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.11813
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, APP, BCL2, CA2, CA7, ESR1, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, TRPV1 2.11512
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.11358
[BP] GO:0006952 defense response ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CNR2, MPO, PIK3CA, PIK3CB, POLB, PRKCD, PTGS1, PTGS2, SRC, TRPV1 2.11358
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.10378
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TNKS 2.10084
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HMGCR, IDO1, KDR, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SRC, TERT, TNKS2, TRPV1, XDH 2.10002
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.09972
[BP] GO:0050730 None ADORA1, APP, FLT3, PRKCD, PRKCE, PTPN1, SRC 2.09659
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DYRK1A, HSD11B2, IDO1, KDR, MET, MMP1, MMP12, MPO, POLA1, PRKCD, SRC, TOP1 2.0845
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.08369
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, IDO1, KDR, PIM1, PRKCA, PRKCB, PTGS2, SRC, TERT 2.07699
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.07452
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.07452
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.07452
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.07452
[BP] GO:0071456 cellular response to hypoxia BCL2, PRKCE, PTGS2, SRC, TERT 2.06975
[BP] GO:0042391 None ADORA1, ADORA2A, APP, BCL2, CNR1, CNR2, KDR, SRC, TRPV1 2.05924
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.04999
[BP] GO:0035556 intracellular signal transduction ADORA2A, AKR1B1, AXL, BCL2, CYP1B1, DNMT1, IGF1R, KDR, MET, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.04415
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.03667
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.02576
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.02576
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.02576
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.02576
[BP] GO:0002683 negative regulation of immune system process ADORA1, ADORA2A, AXL, CDK6, CNR1, CNR2, CYP19A1, IDO1, MMP12 2.02089
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.02089
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, IDO1, PTGS2, TERT, XDH 2.01317
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, PRKCD, PTGS2, TRPV1, XDH 2.01256
[BP] GO:0050866 negative regulation of cell activation ADORA2A, AXL, CNR1, CNR2, IDO1, PRKCD 2.00054
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, GLO1, HCAR2, HTR6, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1 6.41333
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TRPV1, TYR 5.42201
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, HTR6, IGF1R, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TRPV1 3.99456
[CC] GO:0098590 plasma membrane region ABCB1, ABCG2, ADORA1, ADORA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, MET, PRKCG, PTGS2, SLC22A1, SRC, TRPV1 3.184
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TRPV1, TYR 3.11708
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, HTR6, IGF1R, KDR, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TRPV1 2.99899
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 2.99464
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, HMGCR, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.85156
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR6, IGF1R, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TRPV1 2.83131
[CC] GO:0009330 None TOP1, TOP2A 2.74625
[CC] GO:0043226 organelle ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR6, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.47082
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 2.421
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 2.37493
[CC] GO:0099056 None ADORA1, ADORA2A 2.36082
[CC] GO:0098889 None ADORA1, ADORA2A 2.36082
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.27709
[CC] GO:0031233 None CA4, F10, F3 2.1621
[CC] GO:0044456 None ACHE, ADORA1, ADORA2A, APP, CHRM1, CHRM2, CHRM4, CNR1, PRKCG, SLC22A2, SRC, TRPV1 2.04954
[CC] GO:0043227 membrane-bounded organelle ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.01216
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 14.8309
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 14.7203
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 13.5055
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.26155
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TNKS 8.87551
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.78013
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.55526
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 8.32247
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.16485
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.1183
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.85221
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 6.43995
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 6.18761
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 5.92245
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TERT, TOP1 5.86623
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 5.54161
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.54161
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1, XDH 5.54161
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.51116
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1, XDH 5.35709
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1, XDH 5.35709
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.20404
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 5.17785
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 5.01877
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.53772
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.53772
[MF] GO:0043168 anion binding ABCB1, ABCG2, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1, XDH 4.49981
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.4827
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 4.41294
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.3855
[MF] GO:0015238 None ABCB1, ABCG2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.1573
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.14858
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.14332
[MF] GO:0005524 ATP binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 3.97362
[MF] GO:1901363 heterocyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP1, TOP2A, TRPV1, XDH 3.97362
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 3.92583
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 3.8409
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADORA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SLC22A1, TERT, TOP2A, TRPV1, TYR, XDH 3.834
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.834
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 3.834
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.83141
[MF] GO:0030554 adenyl nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 3.7991
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.77348
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP1, TOP2A, TRPV1, XDH 3.75596
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, RORC, TRPV1 3.6603
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.59204
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.57555
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TOP1 3.52225
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PPARA, PRKCE, RORC, TRPV1 3.51512
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.43014
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.3717
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.31861
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, MPO, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 3.27976
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 3.184
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.12262
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.11871
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.06552
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.05266
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.05266
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.9718
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.9249
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.82366
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 2.74625
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.74625
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74625
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74625
[MF] GO:0035403 None PRKCA, PRKCB 2.74625
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.73054
[MF] GO:0019899 enzyme binding ADORA2A, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, ESR1, ESR2, ESRRB, F3, HMGCR, MET, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS2, TOP2A 2.70141
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F10, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP1 2.68359
[MF] GO:0032555 purine ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 2.61202
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR6 2.57957
[MF] GO:0017076 purine nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 2.57481
[MF] GO:0032553 ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1, TOP2A, TRPV1 2.56656
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.50007
[MF] GO:0003674 molecular_function ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH 2.4397
[MF] GO:0140097 None APEX1, DNMT1, POLA1, POLB, TERT, TOP1, TOP2A 2.41784
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.37493
[MF] GO:0015307 None SLC47A1, SLC47A2 2.36082
[MF] GO:1901375 None SLC22A1, SLC22A2 2.36082
[MF] GO:0004949 None CNR1, CNR2 2.36082
[MF] GO:0005333 None SLC22A1, SLC22A2 2.36082
[MF] GO:0005277 None SLC22A1, SLC22A2 2.36082
[MF] GO:0008513 None SLC22A1, SLC22A2 2.36082
[MF] GO:0004699 None PRKCD, PRKCE 2.36082
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.35395
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.3413
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.27724
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.1621
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12447
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, FUT7, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TERT, TNKS, TNKS2, TOP1 2.11559
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, TRPV1 2.11358
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, TRPV1 2.11358
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, AOX1, BCL2, FLT3, HMGCR, NQO2, PTGS2, SLC22A1, TERT, TOP2A, TYR, XDH 2.08711
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR6 2.04228


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 8.4523
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.9154
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM1, PIK3CA, PRKCB, CHRM4, BCL2, PRKCA, PIK3CB 8.2628
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3388
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 9.7757
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PIK3CA, PRKCB, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 8.0691
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.9194
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 7.6564
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, BCL2, MET 6.9642
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.0428
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, ADORA2A, PIK3CA, PRKCB, SRC, CNR1, KDR, PRKCA, PIK3CB, MET, IGF1R 6.9642
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.9642
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 6.4522
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, ESR2 6.4522
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 6.4522
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.4022
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 6.2928
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.1159
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, HTR6, PRKCB, ALOX5, PRKCA, PTGS2, PTGS1 6.1748
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADORA2A, PIK3CA, ADORA1, PIK3CB, PPARA 5.4033
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB 5.6214
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, PRKCA, PIK3CB 6.4522
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.58
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, CHRM1, ADORA2A, CNR2, CNR1, ADORA3, CHRM4, ADORA1, TRPV1 5.1837
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, IGF1R 5.3129
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.6214
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA 5.1794
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 4.4815
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.9927
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.9927
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 4.6312
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2 4.2204
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, KDR, PRKCA, PIK3CB, MET, IGF1R 4.1388
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.5467
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, CHRM1, ADORA2A, PRKCB, PRKCA 3.9337
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, ADORA2A, PRKCB, PRKCE, PRKCD, PRKCA 3.9469
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.2543
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.9551
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9469
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.0558
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1, HMGCR, ABCG2 3.9551
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 3.5253
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9097
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.6242
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.3903
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.3574
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, PTGS2 3.3454
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.714
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0098
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 2.769
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.8368
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5812
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PRKCE, ADORA1, PIK3CB 2.4984
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.3723
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.8732
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.0098
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.6178
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.4984
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.752
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.3112
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.1606
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.1708
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.6299
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.5882
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2493
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3373
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA 2.6299
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8005
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.4781
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.8887
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2256
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.232
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2455
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.2165
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.5654
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.5201
Phagosome_Homo sapiens_hsa04145 MPO 0.2696
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.2375
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.1706
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.2912
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9751
Axon guidance_Homo sapiens_hsa04360 MET 0.3231
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3308
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.0725
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.5264
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 3.9551
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3798
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.025
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3902
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.1314
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.025
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4085
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.614
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7338
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6313
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6124
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.9796
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.5659
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB 1.7476
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, PIK3CB 3.5082
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4245
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7706
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.427
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4257
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2763
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7752
Peroxisome_Homo sapiens_hsa04146 XDH 0.4449
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.2867
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.2763
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8069
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3402
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.3444
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.3859
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.3127
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.2763
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.3859
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 1.4087
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9104
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9212
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9212
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.5409
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5035
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5061
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7406
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 1.7342
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5256
Shigellosis_Homo sapiens_hsa05131 SRC 0.5253
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.7924
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5253
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.8383
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.0079
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0079
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.0932
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.0711
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1109
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.0932
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0932
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1149
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5797
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.0797
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.097
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.025
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.1726
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1448
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1908
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6057
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6057
Malaria_Homo sapiens_hsa05144 MET 0.6128
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2096
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2177
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6151
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6203
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6258
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6313
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3123
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.3876
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.4955
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6716
DNA replication_Homo sapiens_hsa03030 POLA1 0.7104
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7673
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.782
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.5158
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.782
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8139
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7744
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8049
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7924
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6891
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7476
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7342
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6696
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8791
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.002
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9492
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.051
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3615
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1314


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)