TCM Prescription: Qiang Li Tian Ma Du Zhong Capsules



Prescription Description
Prescription IDTCMF5177
Pinyin NameQiang Li Tian Ma Du Zhong Jiao Nang
Chinese Name强力天麻杜仲胶囊
English NameQiang Li Tian Ma Du Zhong Capsules
Function Description中风, 痹病, 头痛, 眩晕, 风痱
IndicationsVertigo disorder, Arthritis, Dizziness, Stroke
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain, SkeletalMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH670 Ligusticum sinense 藁本 TCMH670 ITSAP3226-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH289 Cyathula officinalis 川牛膝 TCMH289 ITSAF2788-14
TCMH906 Viscum coloratum 槲寄生 TCMH906 LT599683
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0587
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0669
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 10.2254
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 10.036
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 9.25643
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 9.05738
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, RORC, SRC, TEK, TYR 8.56628
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 8.54065
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.06046
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.02292
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.00481
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 7.83656
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, SMAD3, SRC, TEK, XDH 7.36176
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD3, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.63854
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.62617
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 6.54067
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.50289
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.39408
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD11B1, HSD17B1, HSD17B2 6.35371
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.14485
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.10507
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA 6.10507
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TOP2A 5.98875
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.9881
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FLT3, RORC, SRC, TEK, TYR 5.96693
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.91517
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.91517
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.89639
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.89639
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.89639
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 5.83207
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 5.82543
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.80335
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.62295
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 5.62295
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.49508
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.42883
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.42883
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 5.36761
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 5.35778
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.31607
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 5.29095
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.26964
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 5.24446
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 5.1724
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.16168
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, XDH 5.03884
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.01412
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.00253
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA 5.00253
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD3, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.95055
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.94466
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 4.94466
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.90585
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.85377
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.80961
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 4.77652
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.72654
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.65034
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 4.65034
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 4.65034
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.64518
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.64413
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.5656
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 4.5333
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.38838
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.36489
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD3, EGFR, HSPA1A, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.34397
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.34397
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 4.29306
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 4.28565
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.28565
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.23371
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 4.18067
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.16251
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.08273
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 4.06633
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.00868
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, INSR, SRC 3.99232
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.94858
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.93378
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 3.92408
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 3.92408
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, TBXAS1 3.91782
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.81791
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD3, KDR, POLB, SRC 3.70742
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2 3.67579
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.67579
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 3.6656
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63543
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.63017
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.62406
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.62406
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 3.60403
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.59752
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.49694
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.49694
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 3.49694
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.45443
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.4456
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD3, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.42411
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.40214
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.40214
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.38436
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.3803
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD3, DUSP3, EGFR, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.36539
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.3535
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 3.33641
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.28977
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.28191
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.26489
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.26489
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.26489
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.20409
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.20342
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.20342
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17667
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD3, EGFR, PPARA, RORC, SRC, TOP2A 3.1004
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 3.08517
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.08517
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.05575
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, KDR, POLB, SRC 3.04005
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.04005
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.01449
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TOP2A 3.00656
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.99912
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.9897
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 2.95298
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 2.93804
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8502
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.84749
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DRD3, TYR 2.84095
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.83185
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD3, EGFR, HSPA1A 2.83185
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.83185
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 2.8149
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.8113
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 2.80885
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.79997
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.79704
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.78563
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.76772
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.72362
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD3, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.71476
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.70748
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.70021
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 2.65353
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.63761
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD3, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 2.63559
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.6295
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.6295
[BP] GO:0042752 None ADORA1, DRD3, PPARA, RORC, TOP2A 2.60723
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD3, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.58946
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.57825
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD3, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.57825
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.55978
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.55978
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.55978
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.55978
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.5419
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.5419
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.53049
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.52509
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.50588
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.45289
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD3, EGFR, HCAR2, KDR, SRC 2.45289
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.44084
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.44084
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.44084
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44084
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.44084
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.44084
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.44084
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.41413
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.41035
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, INSR 2.37769
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, POLA1, POLB, PTPN1, SRC, TOP2A 2.36546
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.36252
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.3533
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD3, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 2.34408
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.3407
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, HCAR2, MMP12, SRC 2.3407
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.32675
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, DRD3, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.32409
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.32051
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.30718
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.27029
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.27029
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.27029
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.26621
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.2598
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.25878
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD3, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.23022
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.22861
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22519
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD3, EGFR, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.22313
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.20718
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.20718
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.20718
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20718
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.20438
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.19796
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.19796
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.19414
[BP] GO:0051894 None KDR, SMAD3, TEK 2.1902
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1902
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR 2.1902
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR 2.1902
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.17711
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.17711
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD3, KDR, SRC 2.17711
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.17603
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.13979
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.13771
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.13438
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD3, EGFR, HCAR2, MMP12, PTPN1, SMAD3, SRC 2.12274
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.11825
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.11737
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.11481
[BP] GO:1903393 None KDR, SMAD3, TEK 2.11051
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.10703
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.0795
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.0795
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2 2.07021
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.06241
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.04595
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.04385
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.04361
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, HCAR2 2.0186
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.37376
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, PIM1, POLA1, PTPN1, SMAD3, SRC, TBXAS1, TOP2A, TYR, XDH 2.0795
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD3, EGFR, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 1.91551
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.90915
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.71267
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.1644
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 17.0918
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 15.1635
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, EGFR, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 13.4547
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 13.0718
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0669
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 10.036
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD3, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 8.56628
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TYR, XDH 7.52875
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.46014
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.87886
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.84967
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.69339
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.68144
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.66967
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.14485
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 5.63267
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.38204
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.3391
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.33281
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.13744
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.80961
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.42207
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.22145
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.08506
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.03265
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.8862
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.63939
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.4456
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30307
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.10504
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.09187
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 3.01252
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.8502
[MF] GO:0008389 None CYP2A13, CYP2A6 2.83185
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 2.41936
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD3, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.32078
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.28188
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.22758
[MF] GO:0051425 None APP, INSR 2.20718
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.17471
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.15363
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.07021
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.0619
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04361


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.7011
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5181
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2729
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.5511
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.2517
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.39
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2747
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2517
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.1854
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1165
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6117
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.66
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3292
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0482
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1323
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.4936
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.5391
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.4238
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.2434
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.595
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2278
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2551
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.162
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1 2.1843
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1379
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0963
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1351
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.1595
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8768
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8318
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.7438
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6872
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4755
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.6659
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4326
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4045
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD3 1.3876
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2962
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.1488
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0798
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2741
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2997
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.023
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.077
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.337
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0486
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8884
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2701
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1513
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0785
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0756
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8938
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8312
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8884
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3179
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8416
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8271
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2741
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8884
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.823
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.823
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2421
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8219
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8271
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.806
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7836
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6496
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7317
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.649
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6312
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5528
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4755
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3512
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3351
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3406
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3409
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3432
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3512
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3668
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3348
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3743
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4161
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7455
Axon guidance_Homo sapiens_hsa04360 MET 0.4281
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4359
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.426
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4656
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4471
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4656
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4857
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4787
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4857
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.486
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4857
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.49
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4787
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4984
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4899
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4942
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5033
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5033
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.513
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7615
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5029
Peroxisome_Homo sapiens_hsa04146 XDH 0.5136
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5504
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5516
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5493
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5528
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5381
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2517
Bile secretion_Homo sapiens_hsa04976 CA2 0.5528
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5685
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5717
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5882
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7151
Shigellosis_Homo sapiens_hsa05131 SRC 0.5701
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5797
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7007
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6607
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6108
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9201
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6135
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6312
Malaria_Homo sapiens_hsa05144 MET 0.6455
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.649
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7135
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7426
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7082
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8176
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7426
DNA replication_Homo sapiens_hsa03030 POLA1 0.7361
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.782
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8219
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7849
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8176
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.994


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)