Prescription Description
| Prescription ID | TCMF516 |
| Pinyin Name | Jia Wei Zuo Jin Wan |
| Chinese Name | 加味左金丸 |
| English Name | Jia Wei Zuo Jin Pills |
| Function Description | 呃逆连声, 因情志不舒而诱发, 气冲引胁, 脘闷纳呆, 两胁胀痛, 咽中不利, 肠鸣矢气, 舌苔薄白, 脉弦 |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | Intestine, Stomach, Lung |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1064 | Coptis chinensis | 姜黄连 | TCMH1064 | ITSAO4469-14 |
| TCMH2216 | Evodia rutaecarpa | 吴茱萸 | TCMH2216 | |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH228 | Bupleurum chinense | 柴胡 | TCMH228 | ITSAM2218-14 |
| TCMH1533 | Saussurea lappa | 木香 | TCMH1533 | |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH2532 | Curcuma aromatica | 郁金 | TCMH2532 | ITSAF2298-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1695 | Pericarpium citri reticulatae viride | 青皮 | TCMH1695 | |
| TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
| TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 | |
| TCMH2376 | Corydalis yanhusuo | 延胡索 | TCMH2376 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
Showing 1 to 10 of 138 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
Showing 1 to 10 of 93 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC | 2.72856 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, HTR2A | 2.87113 |
| [BP] GO:0001662 | None | BCL2, DRD1, HTR1A, HTR2C | 2.91231 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC | 2.53304 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 | 7.56092 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH | 3.94905 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ADRA1A, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH | 4.5443 |
| [BP] GO:0001963 | None | DRD1, DRD2, DRD3 | 2.47634 |
| [BP] GO:0002031 | None | DRD2, DRD3, HTR2B | 2.82416 |
| [BP] GO:0002209 | None | BCL2, DRD1, HTR1A, HTR2C | 2.91231 |
Showing 1 to 10 of 419 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.5885 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | MAP2K1, FLT3, PIM1, RELA | 2.9702 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R | 4.7612 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA, RELA | 1.0658 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, CACNA1C, ADRA1A | 1.1302 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3, RELA | 3.0629 |
| Alcoholism_Homo sapiens_hsa05034 | MAP2K1, MAOA, DRD1, DRD2 | 1.5021 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.4274 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.6295 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP, CACNA1C | 0.587 |
Showing 1 to 10 of 185 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples