TCM Prescription: Qian Jin Tea



Prescription Description
Prescription IDTCMF4997
Pinyin NameQian Jin Cha
Chinese Name千金茶
English NameQian Jin Tea
Function Description感冒, 中暑
IndicationsCommon cold disorder, Common cold, Sunstroke
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
NF01.0 [Heat stroke, 中暑 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2276 Elsholtzia splendens 香薷 TCMH2276 ITSAM4603-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH719 Dryopteris crassirhizoma 贯众 TCMH719 GBVM2585-11
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2548 Mussaenda hirsutissim 玉叶金花 TCMH2548
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 13.9826
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SRC, TYR 12.3141
[BP] GO:0042221 response to chemical ABCB1, ABCG2, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SRC, TERT, TOP1, TYR 11.6473
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, PIK3CA, POLB, PPARA, PTAFR, PTGS2, RORC, SRC, TYR 11.0734
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 10.7177
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.02925
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 9.02925
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 9.02925
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTAFR, PTGS2, RORC, SRC, TYR 8.73545
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.24457
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, GRM1, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.23624
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP1, TYR 8.23624
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.1953
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.03713
[BP] GO:0044281 small molecule metabolic process ABCG2, ADORA2A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FUT7, GBA2, HMGCR, PIK3CA, PIM1, PPARA, PTAFR, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.9377
[BP] GO:0042493 response to drug ABCB1, ABCG2, ADORA2A, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, KDR, POLB, PTAFR, PTGS2, SRC, TOP1 7.84087
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS1, PTGS2, SRC, TERT, XDH 7.75909
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.69442
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.68435
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 7.25243
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 7.20722
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTAFR, PTGS2, RORC, SRC, TYR 7.187
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 7.16573
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 7.14716
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 6.93284
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 6.87566
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, ADORA2A, CNR1, GRM1, GRM3, GRM5, GRM8, PTGS2 6.78746
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MMP2, PPARA, PTAFR, PTGS2, SRC 6.58125
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.58125
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.58125
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.58125
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.34069
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.24215
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RORC, SRC, TERT 6.10673
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 6.04141
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 6.01152
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 5.90881
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.84552
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, PIK3CA, PTAFR, PTGS2, RORC, SRC 5.74448
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 5.69043
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT 5.61821
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 5.61821
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7, CNR1, CNR2 5.61821
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.59734
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC, TERT 5.59734
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, PTAFR, PTGS2, SRC 5.59488
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.49761
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.455
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.39384
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.37841
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.3654
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.36134
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TNKS, TNKS2 5.36134
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 5.35955
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, TERT 5.32087
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TERT, TNKS2, TYR 5.3198
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 5.28512
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.27712
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2 5.26368
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.26139
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.26139
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, POLA1, POLB, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT 5.18371
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 5.16854
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLB, PTAFR, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 5.13381
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 5.0909
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 5.04066
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 5.00501
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.00501
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 4.94283
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.93845
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.93449
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTAFR, PTGS2, RORC, SRC 4.93449
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.91605
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.89846
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.89693
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SRC, TYR 4.89562
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, POLB, PPARA, SRC, TYR 4.81205
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.81041
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLB, PTAFR, PTGS2, PTPN1, SRC, TNKS, TOP1, XDH 4.80242
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.78748
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.74814
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7, GRM5, PTAFR 4.71275
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, PTGS2, RORC, SRC 4.69536
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.69536
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.67356
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.67082
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HMGCR, HSD11B2, KIT, MMP2, POLB, PPARA, PTAFR, PTGS2, SRC, TERT, TYR 4.64248
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.61758
[BP] GO:0007187 None ADORA1, ADORA2A, CHRM2, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8 4.52844
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.51832
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, PTGS2, SRC, TYR 4.50149
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 4.50027
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.41552
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 4.41552
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.39632
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 4.32397
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.3205
[BP] GO:0042391 None ADORA1, ADORA2A, APP, BCL2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.3159
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.3159
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.29006
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.28548
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.25026
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.24237
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 4.24237
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23495
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 4.22055
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.21393
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.15223
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC 4.12882
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.12882
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.08905
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 4.07145
[BP] GO:0007188 None ADORA1, ADORA2A, CHRM2, CNR1, GRM1, GRM3, GRM5, GRM8 4.0531
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 4.03095
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, GRM1, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, SLC1A1, SRC, TERT, TNKS2, XDH 4.03095
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.03049
[BP] GO:0006954 inflammatory response ADORA1, ADORA2A, ADORA3, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTAFR, PTGS1, PTGS2 3.99777
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, RORC, SRC, TOP1 3.99335
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP1, XDH 3.97737
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 3.96426
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.91347
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC, TERT 3.91347
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 3.86601
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 3.85171
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 3.79479
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, PTAFR, PTGS2, SLC1A1, SRC, TERT 3.78538
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 3.78538
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.77632
[BP] GO:0007193 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 3.76606
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.73745
[BP] GO:0060078 None ADORA1, ADORA2A, GRIA2, GRIA4, GRIK5, GRM5 3.73742
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, POLA1, SRC, TYR 3.68288
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.64241
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3, PTAFR 3.63456
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.60468
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 3.60468
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 3.60394
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.56903
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.56903
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, MMP12, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT 3.56744
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.5631
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.53119
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.53022
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, GRM1, GRM5, KIT, MET, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.49084
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.47865
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.47748
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.47748
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 3.47748
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.47748
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, PTAFR, TYR 3.46758
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 3.43617
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.43617
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.4118
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.41012
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.38894
[BP] GO:0043065 positive regulation of apoptotic process ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 3.36894
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.36414
[BP] GO:0043068 positive regulation of programmed cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 3.32678
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC 3.3251
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.31375
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTAFR, PTGS2, RORC, SRC 3.30271
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTAFR, PTGS1, PTGS2 3.24036
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.23715
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.20661
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.18924
[BP] GO:0043549 regulation of kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.15125
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTAFR, PTGS2, SRC 3.14715
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.13753
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTAFR, PTGS2, SRC 3.1345
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.13438
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.13438
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3, PTAFR 3.12867
[BP] GO:0099536 None ADORA2A, CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.04879
[BP] GO:0099537 None ADORA2A, CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.04879
[BP] GO:0010942 positive regulation of cell death ADORA2A, BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SRC, XDH 3.02766
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.00113
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTAFR, PTGS2, SRC 3.00113
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.00113
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, POLB, PTGS2, TERT 2.99321
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.97037
[BP] GO:0006940 None ADORA1, CHRM2, KIT, PTAFR, PTGS2 2.96427
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GBA2, PPARA, PTGS1, PTGS2, TBXAS1 2.96193
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.94685
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2 2.93132
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 2.90209
[BP] GO:0003008 None ADORA1, ADORA2A, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, KIT, PIK3CA, PTAFR, PTGS2, SRC, TYR 2.88871
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.88871
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 2.88871
[BP] GO:0060079 None ADORA1, ADORA2A, GRIA2, GRIA4, GRIK5 2.85406
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGS2, SRC 2.83125
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, PTGS2 2.77198
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.77198
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, PTAFR, SRC 2.77173
[BP] GO:0009115 None AOX1, XDH 2.76649
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, GRM1, GRM5, KIT, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 2.76181
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.74422
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, CNR1, GRM5, MMP9, PTAFR, PTGS2 2.74255
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, HMGCR, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 2.74034
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.69538
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.68224
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.68224
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, KIT, PIK3CB, PTPN1, SRC 2.67131
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.64458
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.64458
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.63365
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.62342
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, MMP12, PTAFR, PTGS2, SRC, TERT 2.59708
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.59198
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59145
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.57104
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTAFR, PTGS2 2.51027
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.50985
[BP] GO:0045776 None ADORA1, CNR1, PPARA, PTAFR 2.50814
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.50814
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.5044
[BP] GO:0007154 None ADORA1, ADORA2A, AXL, BCL2, CHRM2, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1 2.50054
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, KIT, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TERT 2.49545
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTAFR, PTGS2 2.48342
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.47578
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.46494
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP1 2.45987
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTAFR, PTGS2, SRC 2.45987
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, SRC 2.44321
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.44191
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.43845
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.43845
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.41216
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.37057
[BP] GO:0007268 None ADORA2A, CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.36783
[BP] GO:0098916 None ADORA2A, CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.36783
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.36747
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, KIT, MMP12, PTAFR, PTGS2, SRC, TYR 2.36747
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.3669
[BP] GO:0099566 None GRM1, GRM5 2.36659
[BP] GO:0046110 None AOX1, XDH 2.36659
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36659
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.3614
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.34307
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, PTAFR, PTGS2, SRC 2.32901
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.32332
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.31962
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DYRK1A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.31071
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.30963
[BP] GO:0050727 regulation of inflammatory response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.30256
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.28985
[BP] GO:0048167 None ADORA1, ADORA2A, APP, GRM5, KIT, PTGS2 2.28579
[BP] GO:0003018 None ADORA1, ADORA2A, HMGCR, PTAFR, PTGS2, SRC 2.27213
[BP] GO:0003014 None ADORA1, ADORA2A, AKR1B1, BCL2, HSD11B2 2.27213
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.266
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTAFR, PTGS2, SRC 2.266
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, GRM5, IGF1R, MMP2, PTAFR, PTGS2, SRC 2.25382
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25214
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.23122
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, KIT, PTPN1, SRC 2.21336
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.21336
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.21336
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 2.21336
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.21218
[BP] GO:0035249 None ADORA2A, GRIA2, GRIK5 2.19442
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.19123
[BP] GO:0019233 None CNR1, CNR2, GRM1, PTGS2 2.19123
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.19123
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.19123
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity ADORA2A, CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.16944
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 2.16503
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.15497
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.15237
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14126
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.14126
[BP] GO:0001775 cell activation ADORA2A, ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, RORC, SRC 2.12911
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TYR 2.12911
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.12911
[BP] GO:0070213 None TNKS, TNKS2 2.12911
[BP] GO:0006145 None AOX1, XDH 2.12911
[BP] GO:0038171 None CNR1, CNR2 2.12911
[BP] GO:1901529 None ABCB1, PTAFR 2.12911
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12911
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.12674
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTAFR, PTGS2, SRC 2.1255
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.12032
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.11512
[BP] GO:0044057 None ADORA1, ADORA2A, ADORA3, CHRM2, GRM1, HCAR2, KIT, PTAFR, PTGS2, SLC1A1 2.10271
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.10271
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.10271
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.10271
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CNR2, CYP19A1, MMP12, PPARA 2.0947
[BP] GO:0007267 None ADORA1, ADORA2A, CHRM2, CNR1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.08979
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.08979
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.08979
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, PTPN1, SRC 2.07171
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.061
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.06033
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTAFR, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.0598
[BP] GO:2000117 negative regulation of cysteine-type endopeptidase activity ADORA2A, CSNK2A1, MMP9, PTGS2, SRC 2.05798
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.05595
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.05595
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, GRM5, IGF1R, MMP2, PTAFR, PTGS2, SRC 2.05563
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.0535
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 2.04483
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.02841
[BP] GO:0051172 None ADORA2A, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.02322
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, RORC, SRC, TERT, TNKS, TNKS2 2.00912
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.00717
[BP] GO:0048015 phosphatidylinositol-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.00511
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 5.61821
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, SLC1A1, SRC, TERT 5.40837
[CC] GO:0098590 plasma membrane region ABCB1, ABCG2, ADORA1, ADORA2A, CA2, CA4, CA9, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 5.35955
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TBXAS1, TYR 4.8863
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM2, CNR1, CNR2, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PTAFR, PTGS2, SLC1A1, SRC 4.61758
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA4, CHRM2, CNR1, CNR2, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 4.60146
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.21497
[CC] GO:0043005 None ADORA1, ADORA2A, APP, BACE1, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 4.05241
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 3.77632
[CC] GO:0044456 None ACHE, ADORA1, ADORA2A, APP, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.43617
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CHRM2, CNR1, CNR2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1 3.30617
[CC] GO:0120025 None ADORA1, ADORA2A, AKR1B1, APP, BACE1, CA2, CDK6, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 3.18924
[CC] GO:0097060 None CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.16905
[CC] GO:0042995 cell projection ADORA1, ADORA2A, AKR1B1, APP, BACE1, CA2, CDK6, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.89504
[CC] GO:0097458 None ADORA1, ADORA2A, APP, BACE1, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SRC, TOP1 2.8397
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.80555
[CC] GO:0014069 None ADORA1, ADORA2A, GRIK5, GRM1, GRM3, GRM5, SRC 2.55784
[CC] GO:0099572 None ADORA1, ADORA2A, GRIK5, GRM1, GRM3, GRM5, SRC 2.55784
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.50814
[CC] GO:0099056 None ADORA1, ADORA2A 2.36659
[CC] GO:0098889 None ADORA1, ADORA2A 2.36659
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PTAFR, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.31071
[CC] GO:0031233 None CA4, F10, F3 2.19442
[CC] GO:0043227 membrane-bounded organelle ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.00511
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 13.4896
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 11.2621
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 11.2621
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.28095
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PTAFR, RORC 7.98942
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.60417
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, AXL, CDK6, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PTAFR, RORC 7.30063
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.17006
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PTAFR, RORC 6.99006
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.49592
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, TNKS 6.49592
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PTAFR, RORC 6.1531
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.04793
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.9605
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.74391
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.64075
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 5.5907
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.39189
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 5.36134
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 5.04086
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PTAFR 5.04066
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PTAFR 5.04066
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR 5.02189
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TBXAS1, XDH 4.93449
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.7242
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.7242
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.67356
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.60253
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TBXAS1, TYR 4.33509
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.3159
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.21497
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TERT, TOP1 4.01337
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SLC1A1, SRC, TOP1, XDH 3.98993
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADORA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, TERT, TYR, XDH 3.93438
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.78538
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 3.6882
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.67893
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.64241
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.60093
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PTAFR, RORC 3.5462
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.50052
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.45127
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.43133
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3, PTAFR 3.30218
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, XDH 3.23715
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, XDH 3.23657
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.17885
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.11589
[MF] GO:0043168 anion binding ABCB1, ABCG2, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTAFR, SLC1A1, SRC, TOP1, XDH 3.09066
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.07132
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.0154
[MF] GO:0030594 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.99962
[MF] GO:0019899 enzyme binding ADORA2A, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, KIT, MET, POLA1, POLB, PPARA, PTAFR, PTGS2, PTPN1, SRC, TNKS2 2.98389
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.88871
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.76649
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.76649
[MF] GO:0003845 None HSD11B1, HSD11B2 2.76649
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.44321
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.41149
[MF] GO:0004949 None CNR1, CNR2 2.36659
[MF] GO:0099583 None GRM1, GRM5 2.36659
[MF] GO:1901363 heterocyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP1, XDH 2.29125
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.25214
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.25214
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.19442
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12911
[MF] GO:0004971 None GRIA2, GRIA4 2.12911
[MF] GO:0003674 molecular_function ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.11512
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TERT, TOP1, XDH 2.11415


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GRIK5, PTAFR, GRM1, GRM3, GRM5, ADORA2A, CNR2, CNR1, ADORA3, GRM8, ADORA1, GRIA4 8.743
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5256
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.0523
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.1104
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.3261
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 6.3261
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.983
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.4807
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.7375
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.3588
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, ADORA2A, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 5.394
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.4807
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 5.252
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.2664
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, KIT, GRM8, PIK3CB, GRM1 4.4015
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, PTGS2, GRM1, GRIA4 4.2664
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.6931
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.2664
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 3.852
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.1788
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 3.8952
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 3.9987
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.8847
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.7025
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.5677
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.863
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 3.8739
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.1254
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.6254
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.9961
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.0112
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 2.6474
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.0112
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5561
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.0531
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7025
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.5563
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, ADORA2A, PTAFR, GRM1 2.3314
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7192
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.4293
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0112
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.7525
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.3584
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2803
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.2859
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, ABCG2 2.8979
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9344
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.1519
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.2603
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.2025
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.2025
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2025
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.1479
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.0678
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.061
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8254
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.0073
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.8626
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.791
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7135
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.5709
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.4977
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1665
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.1927
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.7781
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.0678
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1302
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 1.959
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7135
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.6767
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2349
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2441
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.061
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.061
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.2509
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2649
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.0971
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4776
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7162
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.3012
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.7703
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.3149
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3457
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.061
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3149
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.3872
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.3492
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.2817
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3012
Axon guidance_Homo sapiens_hsa04360 MET 0.3452
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.353
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.2881
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A 0.3585
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.5561
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0148
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6392
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0899
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4007
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4113
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6377
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.64
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6607
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4271
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4262
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7924
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7783
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4396
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4407
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7983
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8294
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8083
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4407
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4585
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4407
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4407
Peroxisome_Homo sapiens_hsa04146 XDH 0.4585
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9374
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.963
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.963
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 0.959
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9481
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0025
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9481
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9706
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0152
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9901
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.033
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4968
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4946
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5093
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5119
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5312
Shigellosis_Homo sapiens_hsa05131 SRC 0.5312
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1659
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1082
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5312
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2136
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1836
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.217
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5789
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2136
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2921
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.3761
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3012
Malaria_Homo sapiens_hsa05144 MET 0.6275
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6377
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6325
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3872
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4103
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6377
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4223
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.64
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4653
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4522
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.4776
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5423
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7335
DNA replication_Homo sapiens_hsa03030 POLA1 0.7215
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7752
Base excision repair_Homo sapiens_hsa03410 POLB 0.7533
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7924
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6375
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7018
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6194
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7924
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8167
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.782
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8083
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9234
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.978
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8784
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9481
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0227
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.32


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)