TCM Prescription: Ning Shen Pills



Prescription Description
Prescription IDTCMF4915
Pinyin NameNing Shen Wan
Chinese Name宁神丸
English NameNing Shen Pills
Function Description多梦, 惊悸, 不寐
IndicationsInducible palpitation disorder, Insomnia disorder, Insomnia
Disease ICD-11 Category SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH1626 Fritillaria ussuriensis 平贝母 TCMH1626 ITSAM1620-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8729
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8577
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 11.0455
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.5655
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA 9.60832
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, HMGCR, PPARA, TYR, XDH 9.43071
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.71065
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.13808
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, TYR 6.44494
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.22431
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.11228
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.10834
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.71796
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, TYR 5.47144
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, MMP1, MMP2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 5.08706
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.02061
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.99692
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.97206
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.56953
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TNKS, TNKS2, XDH 4.40021
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38701
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HMGCR, HSD11B2, HSD17B2, MMP2, PPARA, TYR 4.32261
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA 4.16467
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, HMGCR, PPARA 4.07954
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.82182
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, TYR 3.77054
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.68272
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.61411
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, HMGCR, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, TYR 3.59679
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.59679
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.59679
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, XDH 3.58065
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, HMGCR, MMP9, PTPN1, TNKS, TNKS2, XDH 3.53326
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, HMGCR, MMP9, PTPN1, TNKS, TNKS2, XDH 3.52243
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, TYR 3.30092
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, MMP2, PPARA 3.29993
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21376
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR 3.18497
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16264
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, HMGCR, MMP2, MMP9, XDH 2.94821
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, HCAR2, HMGCR, TNKS, TNKS2 2.87137
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81241
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.7501
[BP] GO:0009115 None AOX1, XDH 2.71822
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, MMP2, MMP9, PPARA, TNKS2, TYR 2.71822
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.71822
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, HCAR2, HMGCR, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 2.6956
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.67121
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.65046
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.46475
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.44238
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HCAR2, HMGCR, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 2.3045
[BP] GO:0046110 None AOX1, XDH 2.30142
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30142
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.30142
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.22393
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 2.16085
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14777
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.10933
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.10396
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10396
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, MMP1, MMP2, MMP9, PPARA, TNKS2, TYR 2.10101
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA 2.07605
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, MMP9, PPARA, TYR 2.06705
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, TNKS, TNKS2 2.06705
[BP] GO:0070213 None TNKS, TNKS2 2.06705
[BP] GO:0006145 None AOX1, XDH 2.06705
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06705
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, XDH 2.05382
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.86261
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.7968
[CC] GO:0031233 None CA4, F10, F3 2.3045
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 2.06705
[CC] GO:0000242 None TNKS, TNKS2 0.897192
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.288
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TYR, XDH 17.2098
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9359
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7438
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 9.60832
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 9.60832
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HMGCR, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 7.36247
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 7.20662
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.13808
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.12199
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.97394
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 6.88899
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 6.40951
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.51768
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.33124
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.12766
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.72926
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, XDH 4.52207
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.22269
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.16895
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.04848
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.02798
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.02798
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.65306
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.53186
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.41691
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.37048
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.29993
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.21376
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.18497
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.7697
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.71822
[MF] GO:0003845 None HSD11B1, HSD11B2 2.71822
[MF] GO:0008389 None CYP2A13, CYP2A6 2.71822
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.57552
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06705


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.963
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.9821
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.8735
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.9389
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.564
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.8554
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.3591
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.5615
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5043
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 2.9318
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8579
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, MMP9, CDC25B 2.1309
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.2234
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.8365
Pathways in cancer_Homo sapiens_hsa05200 CDK6, MMP1, MMP2, BCL2, MMP9 1.743
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.743
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.564
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.2996
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.2996
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4235
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2996
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.397
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7862
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.743
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.564
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.564
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2996
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9622
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0349
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2996
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7557
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2031
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0374
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2594
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7418
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1524
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9303
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0094
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9813
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8356
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8239
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7249
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.5805
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.5297
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.534
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.534
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5287
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.534
Glioma_Homo sapiens_hsa05214 CDK6 0.582
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.507
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5774
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5283
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.534
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4634
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.534
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.582
Melanoma_Homo sapiens_hsa05218 CDK6 0.5805
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5283
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3122
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4634
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5264
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4912
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.416
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4903
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4634
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5297
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5774
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4634
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4079
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5852
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4634
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR 0.4832
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4509
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4912
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5297
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4533
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3775
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4634
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.378
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.582
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4079
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4079
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4031
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5805
Peroxisome_Homo sapiens_hsa04146 XDH 0.5388
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6185
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5805
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6664
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6488
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6655
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6664
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7249
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8049
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8239
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8239
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8327
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8265
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8834
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9477
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0215
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2996


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)