TCM Prescription: Jie Yu He Gan Pills



Prescription Description
Prescription IDTCMF4805
Pinyin NameJie Yu He Gan Wan
Chinese Name解郁和肝丸
English NameJie Yu He Gan Pills
Function Description胁痛, 腹胀
IndicationsHypochondrium pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach, Liver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6135
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PPARA, PTGES, TBXAS1 10.5927
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 10.1366
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, PTGES, RELA, RORC, SRC, TYR 10.0362
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.94155
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, RELA, RORC, SRC, TYR 9.66209
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 9.14287
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, POLB, PPARA, PTGES, RELA, RORC, SRC, TERT, TOP1, TYR 9.09938
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, POLB, PPARA, PTGES, RELA, RORC, SRC, TYR 9.0296
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.68693
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, HSD17B3, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.65456
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 8.49756
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MET, POLA1, POLB, PPARA, SRC, TERT, TNKS, TNKS2, XDH 8.40164
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 8.34823
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, POLB, PPARA, PTPRS, RELA, SRC, TYR 7.94485
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.75239
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 7.73867
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.73867
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, RELA, SRC, TERT 7.62072
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 7.46687
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGES, RELA, RORC, SRC, TYR 7.21597
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PIM1, PTGES, RELA, SRC, TERT, XDH 7.17881
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, RELA, RORC, SRC, TERT, TNKS2, TYR 6.78136
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.58866
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.54219
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 6.51754
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 6.4594
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 6.36322
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.35048
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TOP1, TYR 6.19255
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 6.18315
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIM1, POLB, PPARA, PTPRS, RELA, RORC, SRC, TYR 6.12769
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 5.96378
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.96378
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, PPARA, RELA, SRC 5.92581
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 5.84766
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.63516
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, RELA, SRC 5.5359
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.39133
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES, TBXAS1 5.37875
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA, PTGES, TBXAS1 5.35683
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.34799
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, XDH 5.34257
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 5.34257
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 5.30245
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.2451
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, XDH 5.01933
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.9894
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.94879
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 4.94879
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, POLB, RELA, SRC, TOP1 4.93747
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RELA, RORC, SRC, TERT 4.92203
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 4.89768
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.75877
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TNKS2, TOP1, TYR 4.70572
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, POLA1, POLB, PTPN1, RELA, RORC, SRC, TERT 4.58217
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, RELA, TERT 4.57938
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 4.54694
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RELA, RORC, SRC 4.52183
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.46471
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.41873
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.32782
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.27999
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SRC, TERT, XDH 4.27999
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, TERT 4.24839
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, HCAR2, KDR, SRC, TNKS, TNKS2 4.22154
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT 4.19794
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MAP2K1, MET, PIM1, POLA1, SRC, TYR 4.19794
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA, PTGES, TBXAS1 4.19794
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.18557
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, KDR, POLB, RELA, SRC 4.16949
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.14123
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.14063
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 4.13986
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.10692
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.08599
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HSD17B3, MAOA, TYR 4.0626
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.03654
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 4.03654
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.93582
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, RORC, SRC, TOP1 3.85159
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, RELA, SRC, TERT, XDH 3.84977
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.72297
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.72041
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 3.72041
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.7194
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 3.69389
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.69179
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.68109
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.66111
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.63617
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 3.48842
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.4043
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1 3.4043
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.3641
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.35168
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PTPRS, RELA, SRC, TERT, TNKS2, XDH 3.34455
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.33898
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, SRC 3.33898
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.2848
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.2848
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GBA2, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.28029
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 3.25753
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.24337
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.22807
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.19726
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, HCAR2, KIT, MAP3K7, MMP12, MMP2, PTPN1, PTPRS, RELA, SRC 3.15712
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.14674
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, RELA, SRC, TERT 3.13658
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 3.12333
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 3.11443
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.0775
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 3.0559
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC, SRC 3.03406
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.03406
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.97825
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, RELA, SRC 2.97606
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT 2.97263
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC, TERT 2.96746
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.96072
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.95131
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 2.94536
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DNMT1, ESR1, IGF1R, MMP2, MMP9, RELA, RORC, SRC 2.94416
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.93443
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.92866
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.91162
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.89639
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.89639
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.89639
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, KIT 2.89639
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, KIT 2.89639
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.89111
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.89111
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.89111
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.89111
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.89111
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.87977
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.87977
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.87595
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, MAP2K1, POLB, RELA, TERT 2.87299
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TERT 2.87011
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, MAP3K7, PIM1, RELA 2.86162
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, POLB, TYR 2.85359
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, POLB, PPARA, RELA, SRC, TERT, TYR 2.83419
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA 2.81213
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MAP3K7, MMP12, MMP2, PPARA, PTPN1, PTPRS, RELA, SRC 2.78971
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.77554
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.7705
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.7705
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.7705
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.75589
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 2.71553
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.71553
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, XDH 2.67537
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, RELA, SRC, TERT, XDH 2.65947
[BP] GO:0009115 None AOX1, XDH 2.65385
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.6526
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.623
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.59306
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1 2.57217
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.57217
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.57082
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.56744
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.55888
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.55397
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.53856
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 2.52291
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.49615
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.48787
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.48787
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.48787
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC 2.47611
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.47336
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.40367
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.36955
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.36955
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 2.36955
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.36253
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.33716
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.33176
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.33176
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, SRC, XDH 2.30793
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, RELA, SRC, TERT 2.30793
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.27276
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.25796
[BP] GO:0046110 None AOX1, XDH 2.25333
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.25333
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.23962
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, SRC 2.19141
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.19086
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, RELA, SRC 2.14019
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, TNKS, TNKS2 2.13984
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.12462
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2 2.10844
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, MAP2K1, PTGES, TERT, XDH 2.10844
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.09429
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.09012
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.07957
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.06828
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.0659
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, MMP12, PTPRS 2.0598
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.03085
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.03027
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.03027
[BP] GO:0070213 None TNKS, TNKS2 2.00219
[BP] GO:0006145 None AOX1, XDH 2.00219
[BP] GO:0038171 None CNR1, CNR2 2.00219
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.00219
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.11567
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, POLA1, PTGES, PTPN1, PTPRS, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.10687
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, TBXAS1 3.10687
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 3.03768
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.5488
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, GBA2, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TERT 2.4804
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.4444
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, TBXAS1 2.17037
[CC] GO:0031233 None CA4, F10, F3 2.07073
[CC] GO:0044422 organelle part AKR1B1, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR 2.0449
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 18.4362
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0857
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 16.0572
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 14.357
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.0096
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.9023
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.71802
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 8.10659
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 7.95807
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 7.88293
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.90971
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC, SHBG 6.86536
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.43189
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 6.36322
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.09761
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.96378
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.96378
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.42161
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.34257
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 4.89625
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.76473
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG 4.69774
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.672
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.45799
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.45115
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.41873
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1 4.41306
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.31151
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.2499
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 4.19794
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.08599
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 3.94069
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, POLB, SRC, TERT, TOP1 3.87332
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.52542
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.47392
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.33898
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 3.26959
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, RORC 2.98
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.96072
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPRS, RELA, SRC, TOP1, TUBB3, XDH 2.94416
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.91581
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.71553
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.65385
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.65385
[MF] GO:0003845 None HSD11B1, HSD11B2 2.65385
[MF] GO:0008389 None CYP2A13, CYP2A6 2.65385
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.5116
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.36955
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.33716
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TOP1 2.31728
[MF] GO:0004949 None CNR1, CNR2 2.25333
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.1034
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.1034
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.07073
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.00219
[MF] GO:0005497 None AR, SHBG 2.00219


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.1982
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 9.4289
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, MAOA, ALOX15, HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 7.4786
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.9686
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, RELA, IGF1R 5.2992
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.8887
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6142
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.7997
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3116
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.7997
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7997
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.1737
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.7997
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.1737
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, KIT, KDR, BCL2, MET, RELA, IGF1R 3.6891
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, CACNA1C 3.9326
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGES 4.0203
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.7518
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.5561
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, CNR1, KIT, KDR, MET, IGF1R 3.4152
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.4115
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.4115
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.1677
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, BCL2, CACNA1C 2.9914
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.8595
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 2.7825
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 2.5394
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 2.8245
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.7825
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8595
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 2.8052
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.4142
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8052
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.2373
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.2125
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.1545
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.3909
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.0536
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 1.8716
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.6629
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.6438
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 1.6156
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 1.8719
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 1.9401
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CNR2, CNR1, ADORA3, ADORA1 1.574
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 1.8716
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 1.769
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.427
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.8465
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5084
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC, RELA 1.4152
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.6156
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.4921
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3 1.5965
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.4456
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.4607
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.427
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3359
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.1927
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.3486
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3142
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2528
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.1902
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.1441
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.131
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.131
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5499
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.0995
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.056
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0284
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.275
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC 0.9069
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0215
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3002
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT, RELA 0.7605
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3388
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7703
Axon guidance_Homo sapiens_hsa04360 MET 0.356
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.7662
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7828
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.7747
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7662
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.7421
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6126
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.7533
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.7284
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7284
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.7421
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.7014
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.6133
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CACNA1C 0.6117
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7201
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.7138
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.389
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6117
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.694
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C 0.8897
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9318
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 0.9739
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4152
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4144
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4229
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4229
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4229
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4318
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.426
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4342
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4306
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4318
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9735
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9735
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4393
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.1902
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4406
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4406
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.083
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.1576
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.1902
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4564
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0404
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4406
Salmonella infection_Homo sapiens_hsa05132 RELA 0.449
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4505
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.131
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.0995
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.129
Peroxisome_Homo sapiens_hsa04146 XDH 0.4564
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.083
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.1424
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4572
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.129
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.035
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.122
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4564
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4681
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.0995
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.0955
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1655
Pertussis_Homo sapiens_hsa05133 RELA 0.4798
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.131
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.1876
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.482
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.131
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.482
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5049
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5022
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.2683
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5248
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5248
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.7997
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3136
Legionellosis_Homo sapiens_hsa05134 RELA 0.5766
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5766
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.5924
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.574
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5971
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6019
Malaria_Homo sapiens_hsa05144 MET 0.6068
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6117
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6117
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.5906
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6117
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5314
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4607
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6117
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6183
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6133
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6596
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7364
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6527
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.694
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7385
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7533
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7254
DNA replication_Homo sapiens_hsa03030 POLA1 0.6882
Base excision repair_Homo sapiens_hsa03410 POLB 0.7102
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7385
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7577
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7284
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7533
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7713
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8945
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8788
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9634
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1876


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)