TCM Prescription: Nao Ling Tablets



Prescription Description
Prescription IDTCMF4764
Pinyin NameNao Ling Pian
Chinese Name脑灵片
English NameNao Ling Tablets
Function Description健忘, 不寐, 眩晕, 心悸, 阳痿, 遗精
IndicationsInvoluntary ejaculation disorder, Impotence disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Palpitations, Dizziness, Sexual dysfunction
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC81.2 [Palpitations, 心悸 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1345 Pulvis cornu cervi 鹿角胶 TCMH1345
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, MET, PPARA, TRPV1 11.8157
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B1, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 11.4048
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 10.8701
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, HMGCR, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TEK, TRPV1 10.4745
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 10.083
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 9.96296
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.91935
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.90695
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 9.71691
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FDPS, HMGCR, HSD11B1, HSD17B1 9.6136
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 9.51527
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TEK, TRPV1 9.22015
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 9.22015
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 8.75515
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1 8.44352
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 8.30035
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 8.15509
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 8.05645
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.91207
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 7.8586
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.80211
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.78213
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.68287
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FDPS, FUT7, HMGCR, HSPA1A, PIM1, PPARA, XDH 7.38464
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.28711
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.2871
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 7.2871
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 7.24498
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 7.22017
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 7.22017
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TRPV1 7.1301
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 7.1277
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 7.10634
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 7.10634
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, FDPS, HMGCR 7.07987
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.07987
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.07987
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.97795
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 6.92938
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 6.84712
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.81082
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK 6.789
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 6.74532
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.69895
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, FDPS, HMGCR 6.67058
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.59698
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 6.59027
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, ESR1 6.57036
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.50328
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 6.49108
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 6.43303
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 6.39208
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.33895
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.26194
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.18991
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1 6.11634
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.07456
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FDPS, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 6.05437
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.00076
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 5.98959
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.98959
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR, SRC, TEK 5.9678
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, FDPS 5.95355
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.95355
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.93217
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.92269
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.91893
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, HMGCR, KDR, NR3C1, SRC, TRPV1 5.91893
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.85736
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.83231
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.83231
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.83231
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.79513
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.79293
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK 5.78993
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.78993
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 5.75791
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.75791
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK 5.74514
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HMGCR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 5.69956
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.69843
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3 5.69339
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.67937
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.65871
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HMGCR, HSPA1A, INSR, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 5.64789
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, SRC, TRPV1 5.64789
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.63573
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, SMAD3, TEK 5.62688
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 5.60918
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.59749
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 5.59409
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.57331
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 5.56949
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.56619
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.5471
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, HMGCR, KDR, SRC 5.51548
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.50419
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.50115
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.47025
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.45688
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40346
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1 5.40175
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.35965
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.35762
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 5.35632
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 5.34549
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.21775
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A 5.2026
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR 5.17623
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1, XDH 5.17151
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 5.15251
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR, SRC, TEK 5.14379
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 5.14014
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC, TRPV1 5.09561
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, SMAD3, TEK 5.09313
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.09313
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.07326
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 5.01617
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.93174
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 4.91747
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.90357
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.90029
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 4.82008
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 4.82008
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR 4.82008
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.80705
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.70596
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.62388
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.61813
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.59237
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.58164
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, DRD5, HMGCR 4.58164
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 4.56133
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, NR3C1, RORC, SRC 4.56117
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 4.56007
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.53529
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR 4.49957
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 4.48062
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.48062
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GPR35, HCAR2, SMAD3, TRPV1 4.46618
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 4.44518
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 4.44186
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 4.44186
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, SMAD3, TRPV1 4.43455
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1 4.40176
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.36251
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 4.34703
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.34334
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 4.28083
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 4.27516
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK 4.26995
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 4.26776
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, XDH 4.25422
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HMGCR, KDR, SRC, TEK 4.24987
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 4.22491
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD17B1 4.22247
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, DRD5, HMGCR, INSR 4.21327
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 4.21036
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.20088
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.14696
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, INSR, KDR, PPARA, SMAD3, SRC, TEK 4.14434
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.13574
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC, TRPV1 4.13161
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, RORC, SRC 4.10813
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 4.10411
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3, HMGCR 4.09969
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.05094
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 4.05094
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.99686
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 3.9732
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.94707
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.93161
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.90409
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.90409
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3, HMGCR 3.90371
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 3.88456
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.88456
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.86285
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.83655
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.83655
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.83655
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.83511
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 3.78833
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.78833
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.7801
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, FDPS, HMGCR 3.77535
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.7667
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR 3.75885
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.74745
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 3.72301
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HCAR2, INSR, SRC 3.72301
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.7181
[BP] GO:0072507 divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 3.70129
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.68429
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.67513
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.67065
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.67061
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.67061
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.66393
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.64928
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.64928
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 3.62562
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.59054
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, RORC, SRC 3.58819
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, SRC, TRPV1 3.55943
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.55943
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.55799
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC 3.55799
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.55799
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, RORC 3.55799
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 3.53438
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.51204
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC 3.50333
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.50056
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.50056
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 3.49309
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.48537
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.47954
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.45693
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.41482
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 3.41212
[BP] GO:0030003 cellular cation homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 3.40971
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.40802
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.39651
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.39651
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, PTPN1, SMAD3, SRC 3.39184
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.39011
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR, SRC, TEK, TRPV1 3.36799
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.34781
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.34475
[BP] GO:0006873 cellular ion homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 3.32311
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC 3.32051
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.29641
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, RORC, SRC 3.27721
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.26826
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 3.244
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 3.23941
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GPR35, HCAR2, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.22454
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 3.22196
[BP] GO:0006874 cellular calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 3.21934
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC, TRPV1 3.21167
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 3.18448
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.18448
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.18358
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 3.17703
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 3.17703
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.17562
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 3.14877
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, MET, NR3C1, PPARA, RORC, SMAD3, SRC, TRPV1 3.14664
[BP] GO:0055074 calcium ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 3.13161
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.12254
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, TEK, TRPV1 3.12254
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 3.11493
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 3.11493
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 3.10268
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 3.09962
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 3.0975
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 3.08927
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, F3, MET, XDH 3.08357
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.08357
[BP] GO:0060158 None DRD1, DRD2, DRD5 3.08357
[BP] GO:0046960 None DRD1, DRD5 3.07766
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.07766
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.07766
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.07766
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 3.07766
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, TEK 3.07434
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.07176
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.05969
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD5, EGFR, NR3C1 3.05014
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 3.05014
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 3.05014
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR, TRPV1 3.02783
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.02033
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.00645
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, SMAD3 3.00627
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.00492
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.00492
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, HSPA1A, MMP9, TRPV1, XDH 2.98637
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.97941
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.97941
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.97941
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.95832
[BP] GO:0040008 regulation of growth ALOX12, APP, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SMAD3 2.92983
[BP] GO:0055082 cellular chemical homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.92983
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.92165
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.90991
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.90911
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.89934
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, DRD5, EGFR, HMGCR, INSR, PPARA, TRPV1 2.89551
[BP] GO:0055065 metal ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, SMAD3, TRPV1 2.86369
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.84489
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.84489
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.84489
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.82094
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR 2.81839
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.81085
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.80338
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.77937
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, RORC, SRC 2.76538
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.76013
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.76013
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.75303
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.75303
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.75303
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.75303
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.74446
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.71692
[BP] GO:0019226 None CHRM5, DRD1, DRD5 2.70614
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.70614
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.70614
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, TEK 2.7036
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.69538
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.68206
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.67856
[BP] GO:0060160 None DRD2, DRD3 2.67856
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67856
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.64928
[BP] GO:0007617 None APP, DRD1, DRD5 2.64928
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.64471
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.64471
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.64063
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.61636
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.58854
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.58854
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 2.57119
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 2.57119
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.56246
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.56246
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.54988
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.53828
[BP] GO:0006875 cellular metal ion homeostasis APP, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.53694
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.53548
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.53548
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC 2.53534
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.5353
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.52746
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, FDPS, HMGCR 2.52676
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, GPR35, MMP9 2.52546
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.51903
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.51903
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.51282
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.48226
[BP] GO:0043086 negative regulation of catalytic activity APP, CSNK2A1, DRD2, DRD3, DRD5, DUSP3, FABP4, HMGCR, IGF1R, MMP9, PTPN1, SRC 2.48183
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.4752
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, EGFR, HMGCR 2.45143
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR 2.45143
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.4467
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC 2.43703
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, INSR, MMP2, MMP9, SRC 2.43491
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.43483
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43483
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.43276
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.43276
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 2.42882
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.41767
[BP] GO:0051894 None KDR, SMAD3, TEK 2.39363
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.39363
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.39363
[BP] GO:0061900 None APP, EGFR, TRPV1 2.39363
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.39363
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.39026
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.38632
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.38632
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, HMGCR, INSR, KDR, PIM1, SMAD3, SRC, TEK, XDH 2.36068
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.36062
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET 2.3509
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.3509
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, FDPS, HMGCR 2.34914
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.34914
[BP] GO:0050927 None F3, KDR, SMAD3 2.34875
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.3436
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.34329
[BP] GO:0051223 None ACHE, APP, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, PTPN1, SMAD3, SRC 2.33976
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.33678
[BP] GO:0019725 cellular homeostasis APP, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, SMAD3, TRPV1 2.3239
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.32372
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30778
[BP] GO:0050926 None F3, KDR, SMAD3 2.30778
[BP] GO:1903393 None KDR, SMAD3, TEK 2.30778
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.30355
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.28099
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, HMGCR, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK 2.26494
[BP] GO:0021853 None DRD1, DRD2 2.25571
[BP] GO:0046541 None CHRM1, CHRM3 2.25571
[BP] GO:0010641 None F3, SRC 2.25571
[BP] GO:0090325 None DRD2, DRD3 2.25571
[BP] GO:1904936 None DRD1, DRD2 2.25571
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.25571
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.25571
[BP] GO:0042321 None ADORA1, DRD2 2.25571
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.25333
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.25232
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5 2.24855
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, CA2, CYP1B1, DRD2, F3, HMGCR, INSR, KDR, PIM1, SMAD3, SRC, TEK 2.2446
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PTPN1, SRC 2.23989
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, NR3C1, SRC 2.23989
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.232
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.232
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.22309
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 2.21909
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.21903
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.21013
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, DRD1, DRD5, EGFR, ESR1, SRC 2.20887
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, PPARA 2.20558
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, MMP9 2.19346
[BP] GO:0019098 None APP, DRD1, DRD5 2.19346
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.19266
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.18716
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.18434
[BP] GO:0070201 None ACHE, APP, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, PTPN1, SMAD3, SRC 2.18262
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3 2.17544
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.17544
[BP] GO:0032845 None ADORA1, DRD2, HMGCR, SRC, TRPV1 2.15898
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.15898
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.15898
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.15898
[BP] GO:0046717 None CHRM5, DRD2, DRD3, TRPV1 2.15848
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, SRC, TEK 2.14119
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.14011
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3 2.14011
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.13853
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, PPARA, TRPV1 2.13004
[BP] GO:0051262 protein tetramerization ACHE, HMGCR, IGF1R, INSR, TRPV1 2.12744
[BP] GO:0042220 None DRD2, DRD3, DRD5 2.12744
[BP] GO:1901890 None KDR, SMAD3, TEK 2.12744
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.12744
[BP] GO:0045744 None DRD2, DRD3, MET 2.12744
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.12744
[BP] GO:0021843 None DRD1, DRD2 2.12442
[BP] GO:1990535 None APP, INSR 2.12442
[BP] GO:0021830 None DRD1, DRD2 2.12442
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.12442
[BP] GO:0021826 None DRD1, DRD2 2.12442
[BP] GO:0046958 None DRD1, DRD5 2.12442
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA 2.12281
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, MMP9, SMAD3, SRC, TEK 2.12119
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, DRD3, DRD5, EGFR, KDR 2.11548
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.11548
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.11548
[BP] GO:0035303 None ADORA1, CHRM5, DRD2, NUAK1, SMAD3 2.11548
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.11129
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.10838
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.10258
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.10258
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.10173
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HMGCR, SRC 2.10074
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, SRC 2.10038
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CYP1B1, DRD2, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.09379
[BP] GO:1903426 None EGFR, INSR, SMAD3, TRPV1 2.08507
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.08507
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD5, INSR, PPARA 2.07007
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.07007
[BP] GO:0010907 None INSR, PPARA, SRC 2.07007
[BP] GO:0106027 None APP, IGF1R, INSR 2.07007
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9 2.06941
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9 2.06941
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, TEK 2.06438
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, DRD5 2.06438
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR 2.06208
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, SRC 2.0532
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3 2.0532
[BP] GO:0071868 None APP, DRD1, DRD5 2.0387
[BP] GO:0071870 None APP, DRD1, DRD5 2.0387
[BP] GO:0045936 None DRD2, DRD3, DUSP3, FABP4, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.02413
[BP] GO:0010563 None DRD2, DRD3, DUSP3, FABP4, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.01957
[BP] GO:0042058 None ADORA1, APP, EGFR, MMP9 2.01957
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP9, SRC, TEK 2.01957
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2D6 2.01246
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2D6 2.01246
[BP] GO:0032880 regulation of protein localization ACHE, APP, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, PTPN1, SMAD3, SRC 2.00907
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, SRC, TRPV1 2.00411
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, MMP9, NUAK1, PTPN1, SMAD3, SRC, XDH 2.00411
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, NR3C1, PPARA, RORC 2.00324
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.00017
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 6.36467
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 5.98959
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK, TRPV1 5.19368
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, EGFR, INSR, MET, SRC, TEK, TRPV1 5.17623
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 5.07011
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 4.35515
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK, TRPV1 4.09672
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 3.78133
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.44791
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 2.93396
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 2.93396
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2 2.77889
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.66295
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.61636
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HMGCR, HSD11B1, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.33728
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.28099
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, SRC, TRPV1 2.14259
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.12442
[CC] GO:0097730 None DRD1, DRD2, DRD5 2.10258
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, PTPN1, SMAD3, SRC, TRPV1, XDH 2.03764
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 12.7094
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FDPS, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 12.4208
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 10.083
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.083
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 9.96296
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DUSP3, EGFR, F3, FDPS, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 9.6136
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 8.9956
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 8.86227
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 8.73132
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.47638
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, XDH 7.32576
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 7.10634
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 7.07987
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 7.07987
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH 6.97795
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.84712
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.84712
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.59698
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.50497
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.91893
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.72155
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.62688
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.53849
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3 5.46221
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.43333
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, XDH 5.26175
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.97945
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.83516
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3, DRD5 4.522
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, FDPS, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TRPV1, XDH 4.41855
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 4.35995
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.28878
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.27516
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 4.17693
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1, RORC 4.16717
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.1368
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 4.13378
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 3.94469
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.76936
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, RORC 3.707
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.52513
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.523
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.523
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.50333
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.47568
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 3.31528
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, SRC, XDH 3.23134
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.1975
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, XDH 3.18358
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.17703
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.14877
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.07766
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.07766
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.92409
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.86869
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.80338
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.77979
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.77979
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.68206
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.67856
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.67856
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.67856
[MF] GO:0042578 None ADORA1, ALPL, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.59206
[MF] GO:0019899 enzyme binding APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F3, HMGCR, HSPA1A, MET, NR3C1, PPARA, PTPN1, SMAD3, SRC, TEK 2.55397
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.54886
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GPR35, HCAR2 2.53578
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1 2.46597
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.45143
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.45143
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FDPS, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.43433
[MF] GO:0001588 None DRD1, DRD5 2.43276
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.43276
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.43276
[MF] GO:0051425 None APP, INSR 2.43276
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.43276
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1, XDH 2.42882
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.3239
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.30778
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.26321
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.26321
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.25571
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.25571
[MF] GO:0043559 insulin binding IGF1R, INSR 2.25571
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.19346
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.18262
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, SMAD3, TRPV1, XDH 2.17282
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.12744
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.126
[MF] GO:0004064 arylesterase activity CA1, CA2 2.12442
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.10258
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.04465
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.01957
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.01246
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1 2.01246
[MF] GO:0001609 None ADORA1, ADORA3 2.01246


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, CHRM5, TRPV1, NR3C1, ADORA3, ADORA1, DRD1, DRD2, DRD3, DRD5 9.1421
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9389
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8693
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.1013
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.497
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.93
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.1609
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, DRD1, DRD2, PPARA, DRD5 5.1808
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4072
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.0752
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2898
Metabolic pathways_Homo sapiens_hsa01100 FDPS, ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 4.4024
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1, EGFR, DRD5 4.4661
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.6733
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5622
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.4712
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3088
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0191
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, ALOX15, ALOX12 3.4712
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 3.1862
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0957
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.6613
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1862
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.5607
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.8567
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.4985
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6449
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3, DRD5 2.3358
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3557
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.24
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7102
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2067
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.2673
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9562
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1998
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1789
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2328
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1719
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8453
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9226
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, CYP3A4 2.1928
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5096
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7404
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.1789
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4693
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.604
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4527
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0957
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3281
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0986
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1101
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0538
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0744
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8489
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9337
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0937
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9337
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8601
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9337
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8489
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9266
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0962
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8489
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8489
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9073
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2261
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8489
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0639
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8489
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8489
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8225
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1904
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3173
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6615
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3479
Influenza A_Homo sapiens_hsa05164 FDPS, HSPA1A 0.7395
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8035
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7324
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2929
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3181
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3276
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3374
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3118
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3272
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3888
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3374
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3179
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3529
HTLV-I infection_Homo sapiens_hsa05166 FDPS, SMAD3 0.5522
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3602
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4016
Platelet activation_Homo sapiens_hsa04611 SRC 0.4247
Axon guidance_Homo sapiens_hsa04360 MET 0.4169
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4247
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3173
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3679
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4575
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4744
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4816
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4816
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4972
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5016
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.519
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5144
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5181
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5144
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5144
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5173
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5144
Peroxisome_Homo sapiens_hsa04146 XDH 0.519
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5522
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4907
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5302
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5361
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.561
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5759
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.574
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5799
Shigellosis_Homo sapiens_hsa05131 SRC 0.5779
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5272
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5969
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5882
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.62
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6229
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6409
Malaria_Homo sapiens_hsa05144 MET 0.6603
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6615
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6639
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8453
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7324
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7165
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7991
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7655
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8489
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.806
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.036
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8489
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8147
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8489
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.0646
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0395
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1207


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)