TCM Prescription: Huan Gu Pills



Prescription Description
Prescription IDTCMF3996
Pinyin NameHuan Gu Wan
Chinese Name换骨丸
English NameHuan Gu Pills
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2112 Radix smilacis 铁丝威灵仙 TCMH2112
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1432 Vitex trifolia 蔓荆子 TCMH1432 ITSAO4721-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH940 Sophora japonica 槐角 TCMH940 ITSAN2377-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1533 Saussurea lappa 木香 TCMH1533
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 16.5719
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 13.5583
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 13.2714
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 13.2619
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 11.8577
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.8577
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 11.4482
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGS1, PTGS2 11.4331
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.8653
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 10.6718
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 10.6262
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 10.6262
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 10.4017
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 9.08252
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 8.60211
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH 8.1637
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 8.00178
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 7.99476
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 7.98302
[BP] GO:0032787 None AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 7.87973
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TRPV1, XDH 7.83911
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 7.83911
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 7.7475
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 7.48371
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR 7.43577
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.34961
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH 7.34961
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 7.3122
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 6.77691
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 6.7314
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.70687
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.65298
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.62521
[BP] GO:0014070 response to organic cyclic compound AKR1C3, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1, TYR 6.52666
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 6.52666
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.43574
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 6.40304
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.24491
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 6.18363
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF, PTGS1, PTGS2 6.18363
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 6.14762
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 5.9917
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.95083
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.95083
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.86314
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.84192
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 5.83488
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 5.82066
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 5.76892
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.76715
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 5.74437
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 5.71957
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 5.64265
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.62203
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.55792
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 5.29224
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 5.12128
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF, PTGS1, PTGS2 5.08168
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 4.89573
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CYP1B1, FLT3, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.89573
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.83336
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.83336
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TRPV1 4.67319
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 4.65211
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.59448
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 4.5797
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.54118
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MIF, PTGS1, PTGS2 4.51883
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 4.47729
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.47695
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.46251
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 4.45215
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TRPV1, TYR 4.44099
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.43563
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 4.43221
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR 4.43221
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SRC, TRPV1 4.40999
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 4.40999
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 4.40999
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF, PTGS1, PTGS2 4.36268
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 4.35496
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 4.33235
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, MIF, PIK3CB, PTGS2, SRC, TRPV1 4.24413
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 4.14657
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.10324
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 4.05169
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.0472
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.0368
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.00729
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.96654
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.94499
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.94499
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.88146
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.8524
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.85067
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 3.849
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4 3.84186
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 3.83009
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.77717
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.73098
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9, TRPV1 3.71801
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 3.71801
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.68012
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.67896
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 3.66072
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 3.66072
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 3.64595
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.61904
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.61904
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.58201
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.58201
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.58201
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 3.50163
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, ESRRB, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.46938
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.42739
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.36209
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.35625
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 3.3483
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.33927
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.32604
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.32564
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29304
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.2527
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 3.23677
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH 3.21643
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, MET, PIK3CA, PIK3CB, SRC, XDH 3.18094
[BP] GO:0019371 None AKR1C3, PTGS1, PTGS2 3.17705
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 3.15677
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.15213
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.1271
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.10845
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 3.08564
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TYR 3.08292
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.0759
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.0759
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, MIF, PTGS1, PTGS2 3.01956
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.01956
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.01956
[BP] GO:0006633 None ALOX12, ALOX15, MIF, PTGS1, PTGS2 3.00595
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 3.00595
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.99914
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.99914
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.9916
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9916
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.9916
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.9916
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, MET, PIK3CA, PIK3CB, SRC 2.97501
[BP] GO:0016488 None AKR1B10, AKR1C3 2.96148
[BP] GO:0016487 None AKR1B10, AKR1C3 2.96148
[BP] GO:0016107 None AKR1B10, AKR1C3 2.96148
[BP] GO:0009115 None AOX1, XDH 2.96148
[BP] GO:0006714 None AKR1B10, AKR1C3 2.96148
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.96148
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.96148
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.96148
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 2.95874
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.92546
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.85875
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.85867
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.85663
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.85663
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.85184
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75699
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.69526
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, PTGS2, SRC, TRPV1 2.69526
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, MIF, PTGS1, PTGS2 2.64838
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 2.64657
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TRPV1 2.64597
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, MIF, PTGS1, PTGS2 2.64597
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, XDH 2.64597
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.64204
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 2.64204
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.61928
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.6121
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.56037
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, SRC, TRPV1 2.56037
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.55649
[BP] GO:0046110 None AOX1, XDH 2.55649
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55649
[BP] GO:0016095 None AKR1B10, AKR1C3 2.55649
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.54241
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4 2.53294
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 2.50986
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2 2.4984
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.48958
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.47748
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.47254
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, TRPV1 2.45932
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.45932
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.43296
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 2.40828
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 2.40828
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40517
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.40427
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.37416
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35218
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, HCAR2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 2.35025
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.34983
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.33346
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 2.3147
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.3147
[BP] GO:0006145 None AOX1, XDH 2.3147
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3147
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3147
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.3147
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, FABP4, FLT3, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH 2.29373
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.28595
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.25077
[BP] GO:0048545 response to steroid hormone AKR1C3, CA2, FLT3, NR3C1, PTGS2, SRC 2.24834
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, ESR1, ESRRA, HCAR2, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.22712
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.22047
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CYP1B1, ESRRB, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TRPV1 2.21249
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 2.1838
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1 2.18097
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.17036
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, IGF1R, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 2.16815
[BP] GO:0071383 None AKR1C3, FLT3, NR3C1, SRC 2.15029
[BP] GO:0009058 None ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, MIF, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, TYR 2.14456
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.13876
[BP] GO:0033032 regulation of myeloid cell apoptotic process HCAR2, MIF, PIK3CB 2.13876
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.13876
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.13159
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.13159
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.13159
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.12911
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.12606
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.12282
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.11897
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, MIF, PIK3CB, PTPN1, SRC 2.11897
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.09577
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.08462
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.07298
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.06791
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.06736
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.05715
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.04914
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, MET, PIK3CA, PIK3CB 2.04914
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.03801
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.03771
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.03771
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.03771
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.03771
[BP] GO:0044249 None ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, HSD17B2, MIF, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, TYR 2.02095
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.02095
[BP] GO:0031960 response to corticosteroid AKR1C3, FLT3, NR3C1, PTGS2, SRC 2.02095
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, ESR1, FLT3, NR3C1, RORC, SRC 2.02045
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.01996
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SRC, TRPV1 2.01996
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 2.01223
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, ESR1, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.01043
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.01043
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.00998
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.00998
[BP] GO:0046113 None AOX1, XDH 2.00998
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.00998
[BP] GO:0016115 None AKR1B10, AKR1C3 2.00998
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.00582
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR, XDH 3.17705
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B2, PTGS1, PTGS2 2.55457
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.39885
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00998
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR 1.68388
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 21.6966
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 13.1358
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, TYR, XDH 13.0337
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 11.8577
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 11.2866
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 10.816
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.673
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 10.134
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 9.57826
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 9.37675
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TRPV1, TYR, XDH 9.29461
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 9.29461
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 9.28774
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TRPV1, TYR, XDH 8.86699
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC 8.48011
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 7.84103
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.30631
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.83653
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.70687
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.52666
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 6.39618
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.86431
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 5.64495
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.53512
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.53512
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 5.48947
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 5.22635
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.2485
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.68012
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.66072
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.60781
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.60781
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.60349
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.52391
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.49953
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.48611
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.42739
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.18925
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.17705
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.1553
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2, NR3C1 3.01956
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.96148
[MF] GO:0045550 None AKR1B10, AKR1C3 2.96148
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.96148
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.96148
[MF] GO:0008389 None CYP2A13, CYP2A6 2.96148
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.95874
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.88129
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.83332
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.64838
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.61928
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TRPV1, XDH 2.6121
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.55649
[MF] GO:0047718 None AKR1B10, AKR1C3 2.55649
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55649
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.55649
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.55649
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.52667
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.49513
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, TRPV1, TYR, XDH 2.45932
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.45932
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.4573
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3147
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3147
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3147
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.23871
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.22047
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.20949
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13159
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13159
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03771
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.01043
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH 2.00998
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00998
[MF] GO:0043546 None AOX1, XDH 2.00998
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.00998


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.5768
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 11.1838
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5768
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.6562
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1C3, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 7.1089
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 8.339
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.6003
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.4319
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.4453
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, ALOX12, PTGS2, PTGS1 6.2712
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.8471
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 4.8471
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.5528
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.5839
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.7474
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4 4.6478
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.5528
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 4.0426
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.6438
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.6438
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.556
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7181
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.273
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2517
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.5129
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.446
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.9241
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.961
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.8196
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.479
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3163
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8196
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.8196
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.6265
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7066
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.7397
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7397
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.7231
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.4806
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.4651
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.3659
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.3659
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.2866
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1852
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.0008
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4651
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.471
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 2.1563
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1763
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0969
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4608
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.9314
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 2.0008
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1825
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7481
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8716
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7555
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8259
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1 1.6751
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7555
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7481
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.817
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 3.095
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.7284
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.655
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.396
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4647
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2603
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3844
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.3163
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.3414
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3551
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3651
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3645
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1547
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4344
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6444
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4759
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4759
Axon guidance_Homo sapiens_hsa04360 MET 0.4706
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0254
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8841
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0267
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9918
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0083
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0447
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0576
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5442
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5442
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.1264
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2099
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2346
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2941
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2862
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5541
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2205
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5442
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5535
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2379
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2205
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5669
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2493
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5677
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5694
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5694
Gap junction_Homo sapiens_hsa04540 SRC 0.5694
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5686
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2862
Peroxisome_Homo sapiens_hsa04146 XDH 0.5814
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4845
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4521
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6238
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4521
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.622
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.493
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6366
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4647
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5602
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4647
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4845
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6584
Shigellosis_Homo sapiens_hsa05131 SRC 0.6584
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5388
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6788
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6584
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6059
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5685
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6558
Malaria_Homo sapiens_hsa05144 MET 0.756
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7109
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7481
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7652
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.8345
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7605
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0076
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8884
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9747
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4322
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1886
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9516
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9416
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9776
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.139
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4845


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)