TCM Prescription: Gan Mao Jie Du Tablets



Prescription Description
Prescription IDTCMF3729
Pinyin NameGan Mao Jie Du Pian
Chinese Name感冒解毒片
English NameGan Mao Jie Du Tablets
Function Description感冒, 风温
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1130 Lonicera maackii 金银忍冬叶 TCMH1130 ITSAH388-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, HMGCR, IDO1, PIM1, PPARA, PTGS2, XDH 9.21498
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 8.04141
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.4528
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 7.13705
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 7.13705
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, GSK3B, HMGCR, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC 7.13705
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 6.86
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 6.85343
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HMGCR, MET, PPARA, PTGS2 6.6988
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SRC 6.57688
[BP] GO:0042221 response to chemical AKR1B1, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TERT 6.45531
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DHFR, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 6.33925
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CNR1, CYP1B1, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 6.18373
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, KDR, MET, PPARA, PTGS2, SRC, TERT, XDH 6.18373
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 6.09062
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 6.01619
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 5.92278
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, GSK3B, HMGCR, IDO1, PTGS2, XDH 5.89465
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1B1, CYP2A13, CYP2A6 5.76044
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.75349
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CYP1B1, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 5.74667
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 5.71942
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 5.71942
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 5.70106
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.69236
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HMGCR, MET, PPARA, PTGS2 5.58588
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS2 5.5133
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CYP1B1, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.40128
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 5.26699
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 5.17714
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 5.1736
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KDR, PTGS2, SRC 5.17351
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 4.88591
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 4.87739
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2 4.83267
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CNR1, CYP1B1, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.70042
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 4.62783
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS2 4.47194
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR1, CNR2, CYP1A1, FABP3, FLT3, IDO1, PTGS2, RORC, SRC 4.40525
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP2A6, CYP3A4, HMGCR 4.33173
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.2577
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1B1, CYP2A13, CYP2A6 4.20949
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGS2 4.20781
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.19409
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS2 4.18962
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.18962
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CNR1, CNR2, CYP19A1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.15411
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CNR1, CYP19A1, CYP1B1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 4.14908
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT 4.11024
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 4.09356
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CNR1, CNR2, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 4.08344
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 4.08195
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 4.08046
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CNR1, CNR2, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 4.06295
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1B1, CYP2A13, CYP3A4, RORC 4.03492
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.92034
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 3.9179
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.91402
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.90964
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.90964
[BP] GO:0043393 regulation of protein binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.80763
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.79335
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.78573
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 3.76563
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.75892
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2 3.63627
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 3.63218
[BP] GO:0051716 cellular response to stimulus AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TERT 3.57177
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AXL, CNR1, CNR2, CYP19A1, CYP1B1, FABP4, HMGCR, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC 3.56207
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC, TERT 3.50951
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.50951
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.49868
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, HMGCR, KDR, PTGS2, SRC 3.39092
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.38698
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CNR1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TERT 3.38698
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.36081
[BP] GO:0006082 organic acid metabolic process ALOX5, CES2, CYP1A1, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.28507
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, HMGCR, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.24145
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.24145
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.22281
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CNR1, CNR2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.19743
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR 3.18354
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CNR1, CNR2, DHFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.17593
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.15994
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.15597
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 3.12796
[BP] GO:0050999 None CNR1, CNR2, DHFR, TERT 3.11917
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, FABP4, IDO1, PPARA, PTGS2 3.11917
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CNR1, CYP19A1, GSK3B, HMGCR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 3.08562
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1B1, CYP2A6, CYP3A4, DHFR, IDO1 3.08562
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1B1, CYP2A13, CYP2A6, PTGS2 3.0852
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, IDO1, PTGS2, SRC 3.08119
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 3.08119
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.99848
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.99848
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CDC25B, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.99848
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.99344
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CNR1, CNR2, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.97918
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.97096
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.97096
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HMGCR 2.97096
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.97096
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.97096
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, IDO1, PTGS2, SRC 2.93858
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, CA2, CA9, CNR2, CYP1A1, CYP1B1, DHFR, GSK3B, IDO1, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 2.92974
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.91852
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.90799
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, PTGS2 2.90748
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, PTGS2 2.90748
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CNR1, CYP1A1, CYP1B1, DHFR, FLT3, PTGS2, RORC, SRC 2.90048
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, CDC25B, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.86632
[BP] GO:0032768 None CNR1, CNR2, DHFR, TERT 2.82057
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CNR1, CYP1B1, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.77148
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 2.76963
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, MMP2, PTGS2, SRC 2.73702
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.73702
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GSK3B, IDO1, XDH 2.71969
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1B1, CYP3A4, HMGCR 2.71207
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.71207
[BP] GO:0043065 positive regulation of apoptotic process CNR1, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.70025
[BP] GO:0043068 positive regulation of programmed cell death CNR1, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.66927
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, CNR1, FABP3, FABP4, FLT3, MET, SRC, TERT 2.65802
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, CDC25B, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.64947
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.63438
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.6115
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.6115
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.61056
[BP] GO:0051098 regulation of binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT 2.60544
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 2.59212
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.59202
[BP] GO:0007568 aging AURKB, CNR1, CYP1A1, HMGCR, PTGS2, TERT 2.578
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.57063
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.57043
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, GSK3B, HMGCR, MMP12, PTGS2, PTPN1, SRC 2.55545
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, HMGCR, MMP2, PPARA, PTGS2, SRC, TERT 2.5299
[BP] GO:0080135 regulation of cellular response to stress DHFR, GSK3B, HMGCR, IGF1R, MET, PTGS2, PTPN1, TERT, XDH 2.52613
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CDC25B, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.49571
[BP] GO:0010942 positive regulation of cell death CNR1, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.47137
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.42107
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.4102
[BP] GO:1902532 negative regulation of intracellular signal transduction HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.40197
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.36523
[BP] GO:0038171 None CNR1, CNR2 2.36523
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, DHFR, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.35602
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.30566
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.28772
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.28457
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.28457
[BP] GO:0043086 negative regulation of catalytic activity CNR1, CNR2, FABP4, GSK3B, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC 2.28457
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.28457
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.27733
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DHFR, HMGCR 2.27586
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.25317
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.22232
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.2214
[BP] GO:0002683 negative regulation of immune system process ADORA1, AXL, CNR1, CNR2, CYP19A1, IDO1, MMP12 2.2214
[BP] GO:0006066 None AKR1B1, AKR1B10, CYP1B1, CYP3A4, DHFR, HMGCR 2.2214
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.2214
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, FABP3, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.2214
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CYP1A1, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.21761
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, FABP4, IDO1, KDR, MET, PTGS2 2.20043
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.20043
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA 2.19359
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, PTGS2, SRC 2.18543
[BP] GO:0051341 None CNR1, CNR2, DHFR, TERT 2.17233
[BP] GO:0031349 positive regulation of defense response CNR1, FABP4, IDO1, MMP12, MMP2, PTGS2, SRC 2.16642
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.16642
[BP] GO:0046165 None AKR1B1, CYP3A4, DHFR, HMGCR 2.1596
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CNR1, CYP1B1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, XDH 2.13052
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.12596
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DHFR, PPARA 2.11664
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, FLT3, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.09384
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MMP9, PTGS2, PTPN1, SRC 2.06165
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.05623
[BP] GO:0032229 None ADORA1, CNR2 2.05623
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.05623
[BP] GO:0010906 None GSK3B, PPARA, RORC, SRC 2.05623
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, GSK3B, MMP12, PTGS2, SRC, TERT 2.04753
[BP] GO:0030335 positive regulation of cell migration IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 2.04753
[BP] GO:0032091 negative regulation of protein binding AURKB, GSK3B, MET, PPARA 2.0274
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.02167
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, CNR1, DHFR, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.01978
[BP] GO:0030198 extracellular matrix organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.01978
[BP] GO:0043062 extracellular structure organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.01621
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.01621
[BP] GO:0009968 negative regulation of signal transduction GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.00685
[CC] GO:0005783 None ADORA1, CA4, CES2, CYP19A1, FLT3, HMGCR, KDR, PTGS2, PTPN1, XDH 2.1109
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.05623
[CC] GO:0044432 endoplasmic reticulum part CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, HMGCR, PTGS2, PTPN1 1.77552
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES2, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 1.56577
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, FLT3, GSK3B, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TERT 1.33046
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, XDH 10.7941
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.6608
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES2, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, XDH 9.97279
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, XDH 8.59226
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.25503
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.13705
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.13705
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.03859
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.24007
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HMGCR, IDO1, PTGS2, XDH 6.01619
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HMGCR, IDO1, PTGS2, SRC, XDH 6.00299
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP3A4 5.79074
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 5.59407
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 5.06757
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, XDH 4.96991
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 4.7251
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP3A4, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.72088
[MF] GO:0046872 metal ion binding ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, XDH 4.53902
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP3A4 4.51912
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2 4.47194
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.39848
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.07556
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.95243
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.50951
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 3.04699
[MF] GO:0008389 None CYP2A13, CYP2A6 2.9889
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.6115
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.6115
[MF] GO:0004949 None CNR1, CNR2 2.6115
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.58122
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.50774
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.3718
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.33132
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.19417
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.19417
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05623
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.01621


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.2275
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 6.9543
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.8116
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 4.1394
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A1, CYP1B1, CYP3A4 4.6202
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1967
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.919
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2 4.1394
Metabolic pathways_Homo sapiens_hsa01100 DHFR, CYP2A6, AKR1B10, ALOX5, CYP1A1, AKR1B1, HMGCR, PTGS2, CYP3A4, CYP19A1, XDH, IDO1 3.6251
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP3A4, CYP19A1 3.8425
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.5461
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.2322
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.6251
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 3.0539
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 3.0086
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1, IDO1 3.0539
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.5822
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.6686
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3229
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A1, CYP3A4 2.5232
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0714
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.4319
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.9698
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8554
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1 1.7757
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.4925
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.306
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4943
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.412
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3995
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4925
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3991
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4118
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.2031
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.4639
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.2673
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1987
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2756
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2087
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2591
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP3A4 1.4116
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.344
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2031
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.1525
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PTGS2 1.1468
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.1248
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1248
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1248
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.115
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 1.0748
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 1.0308
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 1.115
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.965
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.1037
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 1.0382
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 1.0476
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 1.0116
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9901
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9543
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8554
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8938
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.8595
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.6998
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9255
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1425
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3436
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B 0.4099
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3975
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4085
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4505
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4505
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4778
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4501
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.4595
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4857
Measles_Homo sapiens_hsa05162 GSK3B 0.5174
Tight junction_Homo sapiens_hsa04530 SRC 0.5131
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B 0.5092
Platelet activation_Homo sapiens_hsa04611 SRC 0.5432
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5219
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5445
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5659
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5432
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.5293
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5867
Melanogenesis_Homo sapiens_hsa04916 GSK3B 0.5896
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5928
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5468
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5964
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5896
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5995
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6035
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5995
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5867
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5964
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.6035
Gap junction_Homo sapiens_hsa04540 SRC 0.6035
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6035
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PTGS2 0.5964
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5964
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6488
Peroxisome_Homo sapiens_hsa04146 XDH 0.6077
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6482
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6488
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6751
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6554
Glioma_Homo sapiens_hsa05214 IGF1R 0.6751
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6751
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6741
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6751
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6751
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6751
Shigellosis_Homo sapiens_hsa05131 SRC 0.6751
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.7162
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6998
Malaria_Homo sapiens_hsa05144 MET 0.7289
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7265
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8595
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP3A4 0.9161
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9083
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9397
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, XDH 3.2862
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 1.0308
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 1.0063
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.1248


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)