TCM-ID Prescription

Prescription Description

Prescription ID	TCMF3500
Pinyin Name	Shen Rong Bai Feng Wan
Chinese Name	参茸白凤丸
English Name	Shen Rong Bai Feng Pills
Function Description	月经失调, 痛经, 崩漏, 早产
Indications	Metrorrhagia disorder, Dysmenorrhea disorder, Irregular menstruation
Disease ICD-11 Category	SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1) ]; SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ]; GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with Indication	Uterus
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1721	Panax ginseng	人参	TCMH1721	GBVE1679-11
TCMH1349	Cervus elaphus	鹿茸	TCMH1349	ABMC060-05
TCMH981	Astragalus membranaceus	黄芪	TCMH981	ITSAK2981-14
TCMH426	Codonopsis pilosula	党参	TCMH426	ITSAL4530-14
TCMH421	Angelica sinensis	当归	TCMH421	ITSAF173-14
TCMH305	Cnidium officinale	川芎	TCMH305	ITSAP4207-14
TCMH1966	Rehmannia glutinosa	熟地黄	TCMH1966	ITSAH4578-14
TCMH104	Paeonia lactiflora	白芍	TCMH104	ITSAH2416-14
TCMH2376	Corydalis yanhusuo	延胡索	TCMH2376
TCMH909	Trigonella foenum -graecum	葫芦巴	TCMH909
TCMH2334	Dipsacus japonicus	续断	TCMH2334	ITSAC1509-14
TCMH120	Atractylodes macrocephala	白术	TCMH120	ITSAN4430-14
TCMH1803	Amomum villosum	砂仁	TCMH1803	ITSAD521-14
TCMH2473	Leonurus japonicus	益母草	TCMH2473	ITSAN1807-14
TCMH986	Scutellaria baicalensis	黄芩	TCMH986	ITSAP4211-14
TCMH1791	Loranthus parasiticus	桑寄生	TCMH1791
TCMH628	Glycyrrhiza uralensis	甘草	TCMH628	ITSAM892-14

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT100	TTR	Transthyretin	Unclassified	P02766
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT128	TNKS2	Tankyrase-2	Transferase	Q9H2K2
TCMT129	TNKS	Tankyrase-1	Transferase	O95271
TCMT13	APEX1	DNA-(apurinic or apyrimidinic site) lyase	Lyase	P27695
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT139	CA6	Carbonic anhydrase VI	Lyase	P23280
TCMT140	CA5B	Carbonic anhydrase VB	Lyase	Q9Y2D0
TCMT141	CA5A	Carbonic anhydrase VA	Lyase	P35218
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT160	HTR7	Serotonin 7 (5-HT7) receptor	GPCR	P34969
TCMT161	HCAR2	Hydroxycarboxylic acid receptor 2	GPCR	Q8TDS4
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT164	PTGS1	Cyclooxygenase-1	Oxidoreductase	P23219
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT189	DUSP3	Dual specificity protein phosphatase 3	Hydrolase	P51452
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT197	PDE4D	Phosphodiesterase 4D	Hydrolase	Q08499
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT209	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	Oxidoreductase	P80365
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT231	GBA2	Beta-glucosidase	Hydrolase	Q9HCG7
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT240	AMY1A	Salivary alpha-amylase	Unclassified	P04745
TCMT249	CDK6	Cyclin-dependent kinase 6	Kinase	Q00534
TCMT254	CBR1	Carbonyl reductase [NADPH] 1	Oxidoreductase	P16152
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT27	DRD1	Dopamine D1 receptor	GPCR	P21728
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT283	PTPRS	Receptor-type tyrosine-protein phosphatase S	Hydrolase	Q13332
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT313	HTR2B	Serotonin 2b (5-HT2b) receptor	GPCR	P41595
TCMT315	HTR6	Serotonin 6 (5-HT6) receptor	GPCR	P50406
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT329	NQO2	Quinone reductase 2	Oxidoreductase	P16083
TCMT332	AOC3	Amine oxidase, copper containing	Oxidoreductase	Q16853
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT36	HTR1A	Serotonin 1a (5-HT1a) receptor	GPCR	P08908
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT37	HTR2A	Serotonin 2a (5-HT2a) receptor	GPCR	P28223
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT38	DRD2	Dopamine D2 receptor	GPCR	P14416
TCMT384	GRK6	G protein-coupled receptor kinase 6	Kinase	P43250
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT44	GLO1	Glyoxalase I	Lyase	Q04760
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT506	PTK2B	Protein tyrosine kinase 2 beta	Kinase	Q14289
TCMT508	SYK	Tyrosine-protein kinase SYK	Kinase	P43405
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT558	TOP2A	DNA topoisomerase II alpha	Isomerase	P11388
TCMT560	F10	Coagulation factor X	Unclassified	P00742
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT615	SENP8	Sentrin-specific protease 8	Protease	Q96LD8
TCMT616	SENP7	Sentrin-specific protease 7	Protease	Q9BQF6
TCMT626	BRAF	Serine/threonine-protein kinase B-raf	Kinase	P15056
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT643	ADRA1A	Alpha-1a adrenergic receptor	GPCR	P35348
TCMT646	HTR5A	Serotonin 5a (5-HT5a) receptor	GPCR	P47898
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT651	DRD3	Dopamine D3 receptor	GPCR	P35462
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT690	HDAC3	Histone deacetylase 3	Hydrolase	O15379
TCMT698	PDE4B	Phosphodiesterase 4B	Hydrolase	Q07343
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT721	HSPA1A	Heat shock 70 kDa protein 1	Unclassified	P0DMV8
TCMT729	PIK3CA	PI3-kinase p110-alpha subunit	Transferase	P42336
TCMT730	PIK3CB	PI3-kinase p110-beta subunit	Transferase	P42338
TCMT734	MMP12	Matrix metalloproteinase 12	Hydrolase	P39900
TCMT737	APOBEC3G	DNA dC->dU-editing enzyme APOBEC-3G	Unclassified	Q9HC16
TCMT739	GPR35	G-protein coupled receptor 35	GPCR	Q9HC97
TCMT740	PIK3CG	PI3-kinase p110-gamma subunit	Transferase	P48736
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT753	SMAD3	Mothers against decapentaplegic homolog 3	Unclassified	P84022
TCMT755	PLK4	Serine/threonine-protein kinase PLK4	Kinase	O00444
TCMT756	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Kinase	P41279
TCMT771	ATR	Serine-protein kinase ATR	Kinase	Q13535
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT801	TUBB3	Tubulin beta-3 chain	Unclassified	Q13509
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT848	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	Kinase	O75460
TCMT853	SIGMAR1	Sigma opioid receptor	Unclassified	Q99720
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1170	Enterobacter cloacae
TCMT1172	Staphylococcus aureus subsp. aureus RN4220
TCMT1175	Human immunodeficiency virus
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1179	Escherichia coli ATCC 8739
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1182	Streptococcus sanguinis
TCMT1186	Plasmodium yoelii yoelii
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191	Bacillus megaterium
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1213	Neisseria gonorrhoeae
TCMT1214	Enterococcus faecium
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1217	Bacillus anthracis
TCMT1218	Staphylococcus aureus
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1227	Streptococcus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1234	Bacillus coagulans
TCMT1235	Clostridium sporogenes
TCMT1236	Mycobacterium bovis
TCMT1237	Mycobacterium kansasii
TCMT1238	Mycobacterium xenopi
TCMT1239	Mycobacterium marinum
TCMT1243	Aspergillus flavus
TCMT1245	Phytophthora cactorum
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1260	Streptococcus agalactiae
TCMT1284	Penicillium expansum
TCMT1286	Bacillus cereus
TCMT1289	Shigella dysenteriae
TCMT1292	Japanese encephalitis virus
TCMT1294	Human parainfluenza virus 3
TCMT1319	Corynebacterium xerosis
TCMT1321	Staphylococcus hominis
TCMT1322	Streptococcus mitis
TCMT1323	Corynebacterium pseudodiphtheriticum
TCMT1324	Corynebacterium diphtheriae
TCMT1336	Yellow fever virus
TCMT1337	Dengue virus type 4
TCMT1338	Rift Valley fever virus
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393	Vibrio sp.
TCMT1408	Colletotrichum gloeosporioides
TCMT1410	Listeria monocytogenes
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1457	Leishmania major
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value
[BP] GO:0010647	positive regulation of cell communication	ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	13.6322
[BP] GO:0023056	positive regulation of signaling	ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	13.6322
[BP] GO:0065008	regulation of biological quality	ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	12.574
[BP] GO:0006629	lipid metabolic process	ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2	11.759
[BP] GO:0009967	positive regulation of signal transduction	ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	10.7008
[BP] GO:0015701	bicarbonate transport	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	10.6681
[BP] GO:0042127	regulation of cell proliferation	ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH	10.6387
[BP] GO:0010033	response to organic substance	ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TYR	10.4112
[BP] GO:1901700	response to oxygen-containing compound	AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TEK, TYR	10.4076
[BP] GO:0042221	response to chemical	ABCB1, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TYR	10.3808
[BP] GO:0019748	secondary metabolic process	AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR	10.1945
[BP] GO:0044281	small molecule metabolic process	AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, GLO1, HSPA1A, HTR2B, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH	10.1945
[BP] GO:0008152	metabolic process	ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH	10.067
[BP] GO:1902533	positive regulation of intracellular signal transduction	ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	10.0614
[BP] GO:0006730	one-carbon metabolic process	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	10.0434
[BP] GO:0019369	arachidonic acid metabolic process	ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2	10.0434
[BP] GO:0010646	regulation of cell communication	ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	9.99041
[BP] GO:0023051	regulation of signaling	ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	9.80518
[BP] GO:0048522	positive regulation of cellular process	ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	9.68388
[BP] GO:1902531	regulation of intracellular signal transduction	ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	9.64756
[BP] GO:0032844	regulation of homeostatic process	ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2	9.05154
[BP] GO:0033559	unsaturated fatty acid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2	9.00691
[BP] GO:0048584	positive regulation of response to stimulus	ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	8.88973
[BP] GO:0043067	regulation of programmed cell death	ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH	8.80071
[BP] GO:0010941	regulation of cell death	ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH	8.72094
[BP] GO:0006690	icosanoid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2	8.72094
[BP] GO:0048518	positive regulation of biological process	ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	8.67348
[BP] GO:0014070	response to organic cyclic compound	ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGS2, SRC, TEK, TYR	8.61371
[BP] GO:0044237	cellular metabolic process	ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH	8.54848
[BP] GO:0009719	response to endogenous stimulus	ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK	8.54848
[BP] GO:0009725	response to hormone	ADRA1A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, INSR, PPARA, PTGS2, SRC, TEK	8.54341
[BP] GO:0032502	developmental process	ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR	8.52962
[BP] GO:0042981	regulation of apoptotic process	ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TOP2A, XDH	8.26958
[BP] GO:0008202	steroid metabolic process	AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2	8.13365
[BP] GO:0044255	cellular lipid metabolic process	ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2	7.9493
[BP] GO:0032879	regulation of localization	ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK	7.89869
[BP] GO:0008284	positive regulation of cell proliferation	AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK	7.89304
[BP] GO:0048583	regulation of response to stimulus	ABCB1, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	7.88527
[BP] GO:0051896	regulation of protein kinase B signaling	AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH	7.88207
[BP] GO:0055114	oxidation-reduction process	AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH	7.82067
[BP] GO:0042493	response to drug	ABCB1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD11B2, HTR2A, HTR2B, KDR, PTGS2, SRC	7.75822
[BP] GO:0001676	long-chain fatty acid metabolic process	ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2	7.66127
[BP] GO:0032501	multicellular organismal process	ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS2, TYR	7.37659
[BP] GO:0050896	response to stimulus	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR	7.33357
[BP] GO:0009966	regulation of signal transduction	ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH	7.15102
[BP] GO:0033993	response to lipid	ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PTGS2, SRC, TYR	7.12032
[BP] GO:0040012	regulation of locomotion	ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	7.12032
[BP] GO:1901568	fatty acid derivative metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2	7.09105
[BP] GO:0003018	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK	7.09105
[BP] GO:0048513	animal organ development	ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR	7.02786
[BP] GO:0006796	phosphate-containing compound metabolic process	ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH	6.99683
[BP] GO:2000145	regulation of cell motility	ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	6.98128
[BP] GO:0010562	positive regulation of phosphorus metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	6.96491
[BP] GO:0045937	positive regulation of phosphate metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	6.96491
[BP] GO:0019220	regulation of phosphate metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	6.96491
[BP] GO:0051174	regulation of phosphorus metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	6.88674
[BP] GO:0097756	None	ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	6.71043
[BP] GO:0010035	response to inorganic substance	AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC	6.69792
[BP] GO:0030334	regulation of cell migration	ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	6.69792
[BP] GO:0060548	negative regulation of cell death	ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK	6.68926
[BP] GO:0043069	negative regulation of programmed cell death	ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK	6.62231
[BP] GO:0042592	homeostatic process	ADORA1, ADRA1A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC	6.60753
[BP] GO:0032846	positive regulation of homeostatic process	AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2	6.58362
[BP] GO:0006793	phosphorus metabolic process	ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH	6.58362
[BP] GO:0007210	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.47917
[BP] GO:0098664	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.47917
[BP] GO:0051270	regulation of cellular component movement	ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	6.46128
[BP] GO:0015711	organic anion transport	ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA	6.42799
[BP] GO:0006631	fatty acid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2	6.35158
[BP] GO:0051173	positive regulation of nitrogen compound metabolic process	ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	6.20769
[BP] GO:0048856	anatomical structure development	ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TYR	6.20769
[BP] GO:0010817	regulation of hormone levels	ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A	6.19495
[BP] GO:0051897	positive regulation of protein kinase B signaling	AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK	6.13012
[BP] GO:0048878	chemical homeostasis	ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, PIK3CA, PIK3CB, SMAD3	6.07372
[BP] GO:0043066	negative regulation of apoptotic process	ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK	6.05692
[BP] GO:0003013	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK	6.02679
[BP] GO:2000021	regulation of ion homeostasis	ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC	5.96478
[BP] GO:0048585	negative regulation of response to stimulus	ADORA1, ADRA1A, ALOX15, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH	5.92555
[BP] GO:0010648	negative regulation of cell communication	ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH	5.83392
[BP] GO:0042325	regulation of phosphorylation	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH	5.82499
[BP] GO:0023057	negative regulation of signaling	ACHE, ADORA1, ADRA1A, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH	5.81666
[BP] GO:0031325	positive regulation of cellular metabolic process	ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	5.81666
[BP] GO:0042327	positive regulation of phosphorylation	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	5.77104
[BP] GO:0097746	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	5.76759
[BP] GO:0035296	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	5.76759
[BP] GO:0010604	positive regulation of macromolecule metabolic process	ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	5.76759
[BP] GO:0065009	regulation of molecular function	ABCB1, ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH	5.74161
[BP] GO:0032787	None	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PPARA, PTGS1, PTGS2	5.73474
[BP] GO:0009628	response to abiotic stimulus	ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR	5.69251
[BP] GO:0048523	negative regulation of cellular process	ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	5.69251
[BP] GO:0050880	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	5.55265
[BP] GO:0050790	regulation of catalytic activity	ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH	5.54311
[BP] GO:0035150	None	ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	5.53083
[BP] GO:0071704	organic substance metabolic process	ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH	5.51588
[BP] GO:0009698	phenylpropanoid metabolic process	CYP1A1, CYP2A13, CYP2A6, CYP2D6	5.51588
[BP] GO:0009804	coumarin metabolic process	CYP1A1, CYP2A13, CYP2A6, CYP2D6	5.51588
[BP] GO:0006468	protein phosphorylation	AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS	5.48575
[BP] GO:0009893	positive regulation of metabolic process	ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	5.48563
[BP] GO:0042445	hormone metabolic process	ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2	5.43485
[BP] GO:0001934	positive regulation of protein phosphorylation	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	5.42873
[BP] GO:0048519	negative regulation of biological process	ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	5.42732
[BP] GO:0043410	positive regulation of MAPK cascade	ADORA1, ADRA1A, ALOX15, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH	5.42186
[BP] GO:0070887	cellular response to chemical stimulus	AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC	5.36951
[BP] GO:0030335	positive regulation of cell migration	BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	5.35337
[BP] GO:0044238	primary metabolic process	ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH	5.35299
[BP] GO:0001932	regulation of protein phosphorylation	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	5.34078
[BP] GO:1901564	organonitrogen compound metabolic process	ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH	5.30189
[BP] GO:0051049	regulation of transport	ABCB1, ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC	5.29315
[BP] GO:0017144	drug metabolic process	ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A	5.25888
[BP] GO:0046777	protein autophosphorylation	AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK	5.23357
[BP] GO:2000147	positive regulation of cell motility	BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	5.18216
[BP] GO:0008217	None	ADORA1, ADRA1A, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3	5.17356
[BP] GO:0019373	epoxygenase P450 pathway	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6	5.16988
[BP] GO:0001666	response to hypoxia	ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK	5.12212
[BP] GO:0006820	anion transport	ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA	5.09593
[BP] GO:1903727	positive regulation of phospholipid metabolic process	FABP3, FLT3, HTR2A, HTR2B, SRC, TEK	5.07443
[BP] GO:0043408	regulation of MAPK cascade	ADORA1, ADRA1A, ALOX15, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH	5.07068
[BP] GO:0051272	positive regulation of cellular component movement	BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	5.05444
[BP] GO:0071310	cellular response to organic substance	AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC	5.03842
[BP] GO:0036293	response to decreased oxygen levels	ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK	5.00729
[BP] GO:0080134	regulation of response to stress	ABCB1, ADORA1, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH	4.91323
[BP] GO:0070372	regulation of ERK1 and ERK2 cascade	ADRA1A, ALOX15, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK	4.90416
[BP] GO:0040017	positive regulation of locomotion	BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK	4.88382
[BP] GO:0018958	None	AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR	4.86773
[BP] GO:1901615	organic hydroxy compound metabolic process	AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR	4.86366
[BP] GO:0006939	None	ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7	4.81429
[BP] GO:0016310	phosphorylation	AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS	4.79239
[BP] GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK	4.77829
[BP] GO:0050806	positive regulation of synaptic transmission	ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR, PTGS2	4.76781
[BP] GO:0048511	rhythmic process	AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC, TOP2A	4.76781
[BP] GO:0050801	ion homeostasis	ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	4.76367
[BP] GO:0010243	response to organonitrogen compound	AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR	4.75718
[BP] GO:0051247	positive regulation of protein metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	4.7326
[BP] GO:0045834	positive regulation of lipid metabolic process	FABP3, FLT3, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK	4.72501
[BP] GO:0044093	positive regulation of molecular function	ABCB1, ADORA1, ADRA1A, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH	4.71793
[BP] GO:0070482	response to oxygen levels	ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK	4.68133
[BP] GO:0009987	cellular process	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	4.66114
[BP] GO:0019216	regulation of lipid metabolic process	ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK	4.63486
[BP] GO:1902532	negative regulation of intracellular signal transduction	ADRA1A, BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH	4.62532
[BP] GO:0031399	regulation of protein modification process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	4.61086
[BP] GO:0032101	regulation of response to external stimulus	ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK	4.60319
[BP] GO:0032270	positive regulation of cellular protein metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	4.60167
[BP] GO:0009611	response to wounding	ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3	4.58585
[BP] GO:0007165	signal transduction	ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2	4.58352
[BP] GO:0050804	modulation of chemical synaptic transmission	ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, PTGS2	4.56027
[BP] GO:0099177	regulation of trans-synaptic signaling	ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, PTGS2	4.56027
[BP] GO:0051239	regulation of multicellular organismal process	ADORA1, ADORA3, ADRA1A, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH	4.5425
[BP] GO:0042310	None	ADRA1A, HTR1A, HTR2A, HTR2B, HTR7	4.5237
[BP] GO:0007187	None	ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7	4.52036
[BP] GO:0018108	peptidyl-tyrosine phosphorylation	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK	4.46501
[BP] GO:0018212	peptidyl-tyrosine modification	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK	4.40848
[BP] GO:0014065	phosphatidylinositol 3-kinase signaling	HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB	4.38403
[BP] GO:0009894	regulation of catabolic process	ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3	4.38403
[BP] GO:1901698	response to nitrogen compound	AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR	4.34858
[BP] GO:0051966	regulation of synaptic transmission, glutamatergic	ADORA1, DRD1, DRD2, EGFR, HTR2A, PTGS2	4.34856
[BP] GO:0043271	negative regulation of ion transport	ADORA1, BCL2, DRD2, DRD3, GPR35, HTR2A, MMP9, PTGS2	4.33068
[BP] GO:0007198	None	HTR1A, HTR5A, HTR7	4.32555
[BP] GO:0032847	regulation of cellular pH reduction	BCL2, CA2, CA7	4.32555
[BP] GO:0032228	regulation of synaptic transmission, GABAergic	ADORA1, ADRA1A, CA2, CA7, DRD2	4.32555
[BP] GO:0008610	lipid biosynthetic process	ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2	4.3239
[BP] GO:0001505	regulation of neurotransmitter levels	ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, PTGS2, SMAD3	4.31449
[BP] GO:0098771	inorganic ion homeostasis	ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	4.30575
[BP] GO:0070374	positive regulation of ERK1 and ERK2 cascade	ADRA1A, ALOX15, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK	4.28246
[BP] GO:0042446	hormone biosynthetic process	AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2	4.28025
[BP] GO:0032845	None	ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2	4.27976
[BP] GO:0010863	positive regulation of phospholipase C activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	4.27044
[BP] GO:0009636	response to toxic substance	AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC	4.2306
[BP] GO:0008283	cell proliferation	ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TEK, TYR	4.21879
[BP] GO:0007346	regulation of mitotic cell cycle	APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A	4.18125
[BP] GO:0050805	negative regulation of synaptic transmission	ACHE, ADORA1, DRD1, DRD2, HTR2A, PTGS2	4.17315
[BP] GO:0050795	None	ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B	4.17315
[BP] GO:0044092	negative regulation of molecular function	ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS	4.16544
[BP] GO:0001952	regulation of cell-matrix adhesion	BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK	4.16242
[BP] GO:0021885	forebrain cell migration	AXL, DRD1, DRD2, EGFR, HTR6	4.15777
[BP] GO:0019752	carboxylic acid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR	4.12353
[BP] GO:0007186	G-protein coupled receptor signaling pathway	ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SIGMAR1, SRC	4.11898
[BP] GO:0043405	regulation of MAP kinase activity	ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC	4.11284
[BP] GO:0051050	positive regulation of transport	ABCB1, ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, MMP12, PTGS2, SMAD3, SRC	4.11284
[BP] GO:1900274	regulation of phospholipase C activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	4.10608
[BP] GO:0072507	divalent inorganic cation homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	4.08412
[BP] GO:0007167	enzyme linked receptor protein signaling pathway	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK	4.08412
[BP] GO:0006979	response to oxidative stress	AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC	4.0836
[BP] GO:0051240	positive regulation of multicellular organismal process	ADRA1A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK	4.07777
[BP] GO:0032225	None	DRD1, DRD2, DRD3, PTGS2	4.06787
[BP] GO:0007188	None	ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7	4.06053
[BP] GO:0043085	positive regulation of catalytic activity	ADORA1, ADRA1A, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH	4.05295
[BP] GO:0034754	cellular hormone metabolic process	AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2	4.05295
[BP] GO:0034614	cellular response to reactive oxygen species	AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC	4.05295
[BP] GO:0051701	interaction with host	AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC	4.02788
[BP] GO:0051347	positive regulation of transferase activity	ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS	4.01495
[BP] GO:0035690	cellular response to drug	AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC	3.98613
[BP] GO:0031401	positive regulation of protein modification process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH	3.97151
[BP] GO:0031347	regulation of defense response	ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK	3.97108
[BP] GO:0051716	cellular response to stimulus	AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TOP2A	3.93165
[BP] GO:1903725	regulation of phospholipid metabolic process	FABP3, FLT3, HTR2A, HTR2B, SRC, TEK	3.92359
[BP] GO:0001503	ossification	ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK	3.91916
[BP] GO:0006805	xenobiotic metabolic process	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1	3.91916
[BP] GO:0010638	positive regulation of organelle organization	ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2	3.85581
[BP] GO:0051338	regulation of transferase activity	ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS	3.83399
[BP] GO:0048871	multicellular organismal homeostasis	ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA	3.82351
[BP] GO:0007193	None	ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7	3.79651
[BP] GO:0055080	cation homeostasis	ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.75996
[BP] GO:0000302	response to reactive oxygen species	AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC	3.74789
[BP] GO:0048148	None	DRD1, DRD2, DRD3, HTR2A	3.69675
[BP] GO:0006874	cellular calcium ion homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.69316
[BP] GO:0033674	positive regulation of kinase activity	ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK	3.68826
[BP] GO:0016477	cell migration	AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK	3.66922
[BP] GO:0051726	regulation of cell cycle	APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TNKS, TOP2A	3.61489
[BP] GO:0097164	None	ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A	3.61226
[BP] GO:0043436	oxoacid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR	3.61174
[BP] GO:0051130	positive regulation of cellular component organization	ALOX15, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2	3.59272
[BP] GO:0035556	intracellular signal transduction	ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK	3.5926
[BP] GO:0038083	peptidyl-tyrosine autophosphorylation	EGFR, IGF1R, INSR, KDR, SRC	3.58813
[BP] GO:0043549	regulation of kinase activity	ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK	3.58813
[BP] GO:0055082	cellular chemical homeostasis	ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CA, PIK3CB, SMAD3	3.58473
[BP] GO:0055074	calcium ion homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.5833
[BP] GO:1901701	cellular response to oxygen-containing compound	AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC	3.56012
[BP] GO:0010038	response to metal ion	ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2	3.56012
[BP] GO:0019222	regulation of metabolic process	ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	3.55238
[BP] GO:0030003	cellular cation homeostasis	ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.55056
[BP] GO:0009968	negative regulation of signal transduction	ADRA1A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH	3.54371
[BP] GO:0072503	cellular divalent inorganic cation homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.5433
[BP] GO:0010810	regulation of cell-substrate adhesion	ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK	3.53553
[BP] GO:0006082	organic acid metabolic process	ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR	3.53553
[BP] GO:0010518	positive regulation of phospholipase activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	3.5237
[BP] GO:0007200	None	ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B	3.50291
[BP] GO:0009891	positive regulation of biosynthetic process	AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, SRC, TNKS, TNKS2, TOP2A	3.50291
[BP] GO:0006873	cellular ion homeostasis	ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.45537
[BP] GO:0034599	cellular response to oxidative stress	AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC	3.44747
[BP] GO:0018193	peptidyl-amino acid modification	AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A	3.43661
[BP] GO:0008210	estrogen metabolic process	CYP19A1, CYP1B1, HSD17B1, HSD17B2	3.41552
[BP] GO:0007202	None	ADRA1A, EGFR, HTR2A, HTR2B	3.41552
[BP] GO:0009056	catabolic process	ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH	3.40907
[BP] GO:0009895	negative regulation of catabolic process	ADORA1, BCL2, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, SMAD3	3.39765
[BP] GO:0043406	positive regulation of MAP kinase activity	ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC	3.38578
[BP] GO:0019725	cellular homeostasis	ADRA1A, APEX1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CA, PIK3CB, SMAD3	3.37133
[BP] GO:0045859	regulation of protein kinase activity	ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC	3.35294
[BP] GO:0051940	None	DRD1, DRD2, DRD3	3.35239
[BP] GO:0051584	None	DRD1, DRD2, DRD3	3.35239
[BP] GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC	3.30109
[BP] GO:0032268	regulation of cellular protein metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	3.2865
[BP] GO:0045860	positive regulation of protein kinase activity	ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, PTPN1, SRC	3.28136
[BP] GO:0003014	None	ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2	3.27905
[BP] GO:1901652	response to peptide	AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK	3.2626
[BP] GO:0043269	regulation of ion transport	ABCB1, ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, MMP9, PTGS2	3.25982
[BP] GO:0071248	cellular response to metal ion	ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2	3.2537
[BP] GO:0071407	cellular response to organic cyclic compound	ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, SRC	3.24515
[BP] GO:0006950	response to stress	ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A	3.24392
[BP] GO:0040011	locomotion	AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK	3.23623
[BP] GO:0048870	cell motility	AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK	3.22343
[BP] GO:0032102	negative regulation of response to external stimulus	ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, PTPRS, SMAD3, TEK	3.21658
[BP] GO:0071073	None	FABP3, HTR2A, HTR2B	3.20033
[BP] GO:0003008	None	ADORA1, ADRA1A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PTGS2, SRC, TEK, TYR	3.18497
[BP] GO:0051828	entry into other organism involved in symbiotic interaction	AXL, EGFR, HSPA1A, HTR2A, MET, SRC	3.17528
[BP] GO:0051806	entry into cell of other organism involved in symbiotic interaction	AXL, EGFR, HSPA1A, HTR2A, MET, SRC	3.17528
[BP] GO:0030260	entry into host cell	AXL, EGFR, HSPA1A, HTR2A, MET, SRC	3.17528
[BP] GO:0044409	entry into host	AXL, EGFR, HSPA1A, HTR2A, MET, SRC	3.17528
[BP] GO:0010517	regulation of phospholipase activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	3.17382
[BP] GO:0031960	response to corticosteroid	ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC	3.14565
[BP] GO:0031328	positive regulation of cellular biosynthetic process	AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, SMAD3, SRC, TNKS, TNKS2, TOP2A	3.14219
[BP] GO:0080090	regulation of primary metabolic process	ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	3.13308
[BP] GO:0002682	regulation of immune system process	ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC	3.12113
[BP] GO:0048545	response to steroid hormone	ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC	3.11794
[BP] GO:0048015	phosphatidylinositol-mediated signaling	HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB	3.11282
[BP] GO:0090066	None	ADORA1, ADRA1A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2	3.08877
[BP] GO:0060193	positive regulation of lipase activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	3.08057
[BP] GO:0045787	positive regulation of cell cycle	APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC	3.07434
[BP] GO:2001225	regulation of chloride transport	ABCB1, CA2, CA7	3.07434
[BP] GO:0097267	omega-hydroxylase P450 pathway	CYP1A1, CYP1A2, CYP1B1	3.07434
[BP] GO:0035265	organ growth	ADRA1A, BCL2, CYP19A1, ESR1	3.07434
[BP] GO:0055065	metal ion homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	3.07373
[BP] GO:0006721	terpenoid metabolic process	AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR	3.05494
[BP] GO:0048869	cellular developmental process	ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HTR2B, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, SMAD3, SRC, TEK, TOP2A	3.05083
[BP] GO:0006811	None	ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA	3.04204
[BP] GO:0042542	response to hydrogen peroxide	AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC	3.03689
[BP] GO:0048017	inositol lipid-mediated signaling	HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB	3.02673
[BP] GO:0001659	None	ADORA1, DRD1, DRD2, HTR2A	3.02612
[BP] GO:0009892	negative regulation of metabolic process	ADORA1, APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH	3.00766
[BP] GO:0040008	regulation of growth	BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3, TNKS2	2.98866
[BP] GO:0051047	None	ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC	2.98435
[BP] GO:0022029	None	DRD1, DRD2, EGFR, HTR6	2.97967
[BP] GO:0002031	None	DRD2, DRD3, HTR2B	2.96058
[BP] GO:0019371	None	CBR1, PTGS1, PTGS2	2.96058
[BP] GO:0040014	regulation of multicellular organism growth	BCL2, DRD2, DRD3, PIK3CA, TNKS2	2.94392
[BP] GO:2000377	regulation of reactive oxygen species metabolic process	BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH	2.94369
[BP] GO:0019932	second-messenger-mediated signaling	ADRA1A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR	2.93488
[BP] GO:0010907	None	ESRRB, INSR, PPARA, SRC	2.93488
[BP] GO:0045907	None	ADRA1A, EGFR, HTR2A, PTGS2	2.93488
[BP] GO:0031323	regulation of cellular metabolic process	ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	2.92936
[BP] GO:0045913	None	ESRRB, HTR2A, INSR, PPARA, SRC	2.92204
[BP] GO:0031348	negative regulation of defense response	ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK	2.9203
[BP] GO:0071241	cellular response to inorganic substance	ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2	2.90514
[BP] GO:0045935	positive regulation of nucleobase-containing compound metabolic process	AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A	2.90499
[BP] GO:0030155	regulation of cell adhesion	ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK	2.90064
[BP] GO:0009115	None	AOX1, XDH	2.86614
[BP] GO:0030522	intracellular receptor signaling pathway	ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC	2.86614
[BP] GO:0006875	cellular metal ion homeostasis	ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, PIK3CB, SMAD3	2.86462
[BP] GO:0048732	gland development	BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR	2.86394
[BP] GO:0022414	reproductive process	AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A	2.84348
[BP] GO:0048010	vascular endothelial growth factor receptor signaling pathway	AXL, KDR, PIK3CA, PIK3CB, SRC	2.82064
[BP] GO:0046486	glycerolipid metabolic process	ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB	2.81177
[BP] GO:0051171	regulation of nitrogen compound metabolic process	ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	2.78278
[BP] GO:0032467	None	AURKB, CDC25B, DRD2, DRD3	2.7655
[BP] GO:0046456	icosanoid biosynthetic process	ALOX15, ALOX5, PTGS1, PTGS2	2.7655
[BP] GO:0006703	estrogen biosynthetic process	CYP19A1, HSD17B1, HSD17B2	2.7655
[BP] GO:0060134	None	DRD1, DRD2, DRD3	2.7655
[BP] GO:0032230	positive regulation of synaptic transmission, GABAergic	ADRA1A, CA2, CA7	2.7655
[BP] GO:0032355	response to estradiol	CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2	2.75266
[BP] GO:0060255	regulation of macromolecule metabolic process	ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	2.74277
[BP] GO:0071900	regulation of protein serine/threonine kinase activity	ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, PTPN1, SRC	2.74015
[BP] GO:0050678	None	CDK6, EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH	2.73922
[BP] GO:0006720	isoprenoid metabolic process	AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR	2.7385
[BP] GO:0010634	positive regulation of epithelial cell migration	KDR, MET, MMP9, PTGS2, SRC, TEK	2.7385
[BP] GO:0003006	developmental process involved in reproduction	ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC	2.73237
[BP] GO:0051952	None	ADORA1, DRD1, DRD2, DRD3, HTR2A	2.72657
[BP] GO:0048661	positive regulation of smooth muscle cell proliferation	AKR1B1, EGFR, MMP2, MMP9, PTGS2	2.72657
[BP] GO:0002793	None	ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC	2.72639
[BP] GO:0006694	steroid biosynthetic process	AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2	2.72443
[BP] GO:0051246	regulation of protein metabolic process	ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH	2.71117
[BP] GO:0051128	regulation of cellular component organization	ALOX15, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A	2.68714
[BP] GO:0060065	uterus development	CYP19A1, ESR1, SRC	2.67972
[BP] GO:0051580	None	DRD1, DRD2, DRD3	2.67972
[BP] GO:0051967	None	ADORA1, DRD2, HTR2A	2.67972
[BP] GO:0007166	cell surface receptor signaling pathway	ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2	2.65815
[BP] GO:0043401	steroid hormone mediated signaling pathway	ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC	2.65562
[BP] GO:0044057	None	ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, PTGS2, SMAD3	2.634
[BP] GO:0003012	None	ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, PIK3CA	2.63039
[BP] GO:0051098	regulation of binding	AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS	2.6271
[BP] GO:0010564	regulation of cell cycle process	APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS	2.62582
[BP] GO:1904407	positive regulation of nitric oxide metabolic process	EGFR, INSR, PTGS2, SMAD3	2.6136
[BP] GO:0045429	positive regulation of nitric oxide biosynthetic process	EGFR, INSR, PTGS2, SMAD3	2.6136
[BP] GO:0001963	None	DRD1, DRD2, DRD3	2.59488
[BP] GO:0033273	response to vitamin	ALPL, CYP1A1, EGFR, PTGS2, TYR	2.58631
[BP] GO:0045776	None	ADORA1, DRD2, DRD3, PPARA	2.57592
[BP] GO:0016042	lipid catabolic process	ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2	2.57099
[BP] GO:0071902	positive regulation of protein serine/threonine kinase activity	ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, PTPN1, SRC	2.55911
[BP] GO:0050890	None	ADORA1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2	2.55051
[BP] GO:0051781	None	AURKB, CDC25B, DRD2, DRD3, HTR2B	2.5413
[BP] GO:0006584	None	AKR1B1, DRD1, DRD2, DRD3	2.5413
[BP] GO:0009712	None	AKR1B1, DRD1, DRD2, DRD3	2.5413
[BP] GO:0060191	regulation of lipase activity	ADRA1A, EGFR, ESR1, HTR2A, HTR2B	2.51957
[BP] GO:2000811	negative regulation of anoikis	BCL2, PIK3CA, SRC	2.51957
[BP] GO:0071071	None	FABP3, HTR2A, HTR2B	2.51957
[BP] GO:0030540	female genitalia development	AXL, CYP19A1, ESR1	2.51957
[BP] GO:0019372	lipoxygenase pathway	ALOX15, ALOX5, PTGS2	2.51957
[BP] GO:0051384	response to glucocorticoid	ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2	2.51683
[BP] GO:0065007	biological regulation	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	2.50813
[BP] GO:0007610	None	BCL2, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, INSR, PPARA, PTGS2	2.5047
[BP] GO:0043434	None	APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK	2.49821
[BP] GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH	2.48173
[BP] GO:0001954	positive regulation of cell-matrix adhesion	CDK6, KDR, SMAD3, TEK	2.47579
[BP] GO:0046110	None	AOX1, XDH	2.46193
[BP] GO:0060160	None	DRD2, DRD3	2.46193
[BP] GO:0032849	positive regulation of cellular pH reduction	CA2, CA7	2.46193
[BP] GO:0002009	morphogenesis of an epithelium	BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC	2.46174
[BP] GO:0051302	None	AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B	2.46022
[BP] GO:1904355	positive regulation of telomere capping	AURKB, TNKS, TNKS2	2.45168
[BP] GO:0045931	positive regulation of mitotic cell cycle	APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR	2.44538
[BP] GO:2001023	None	DRD1, DRD2, DRD3, HTR2A, MET	2.44488
[BP] GO:0051480	regulation of cytosolic calcium ion concentration	ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, SMAD3	2.43551
[BP] GO:0009416	response to light stimulus	AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR	2.43551
[BP] GO:2000379	positive regulation of reactive oxygen species metabolic process	EGFR, INSR, PTGS2, SMAD3, XDH	2.42558
[BP] GO:0051054	positive regulation of DNA metabolic process	AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2	2.40558
[BP] GO:0019933	None	ADRA1A, DRD1, DRD2, DRD3, HTR5A	2.40558
[BP] GO:0006936	None	ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, PIK3CA	2.3954
[BP] GO:0016137	None	AKR1B1, AKR1B10, GBA2	2.38653
[BP] GO:0045821	None	ESRRB, HTR2A, INSR	2.38653
[BP] GO:0014821	None	DRD1, DRD2, HTR2B	2.38653
[BP] GO:0008150	biological_process	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	2.38235
[BP] GO:0045187	None	ADORA1, DRD2, DRD3	2.32002
[BP] GO:0051900	regulation of mitochondrial depolarization	BCL2, KDR, SRC	2.32002
[BP] GO:0051197	None	ESRRB, HTR2A, INSR	2.32002
[BP] GO:0031329	regulation of cellular catabolic process	APEX1, BCL2, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1	2.29939
[BP] GO:0006928	movement of cell or subcellular component	AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, TUBB3	2.29079
[BP] GO:0050727	regulation of inflammatory response	ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK	2.27456
[BP] GO:0042752	None	ADORA1, DRD2, DRD3, PPARA, TOP2A	2.26873
[BP] GO:1903530	regulation of secretion by cell	ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC	2.26869
[BP] GO:0050793	regulation of developmental process	AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH	2.26564
[BP] GO:0071495	cellular response to endogenous stimulus	AKR1B1, APEX1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC	2.26457
[BP] GO:1903428	positive regulation of reactive oxygen species biosynthetic process	EGFR, INSR, PTGS2, SMAD3	2.26387
[BP] GO:0010676	None	ESRRB, INSR, PPARA, SRC	2.26387
[BP] GO:0035813	None	ADORA1, DRD2, DRD3	2.26385
[BP] GO:2001242	regulation of intrinsic apoptotic signaling pathway	BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC	2.25506
[BP] GO:0031324	negative regulation of cellular metabolic process	APEX1, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH	2.23774
[BP] GO:0019935	None	ADRA1A, DRD1, DRD2, DRD3, HTR5A	2.23774
[BP] GO:0032210	regulation of telomere maintenance via telomerase	AURKB, SRC, TNKS, TNKS2	2.23774
[BP] GO:0019538	protein metabolic process	ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A	2.23711
[BP] GO:0071417	cellular response to organonitrogen compound	AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC	2.22981
[BP] GO:0007568	aging	ADRA1A, APEX1, AURKB, BCL2, CYP1A1, HTR2A, PTGS2	2.21746
[BP] GO:0051893	regulation of focal adhesion assembly	KDR, SMAD3, SRC, TEK	2.21321
[BP] GO:0090109	regulation of cell-substrate junction assembly	KDR, SMAD3, SRC, TEK	2.21321
[BP] GO:0048638	regulation of developmental growth	BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, PTPRS, TNKS2	2.21321
[BP] GO:0071498	cellular response to fluid shear stress	CA2, PTGS2, SRC	2.21321
[BP] GO:0051968	None	DRD1, EGFR, PTGS2	2.21321
[BP] GO:0042749	None	ADORA1, DRD2, DRD3	2.21321
[BP] GO:0033031	positive regulation of neutrophil apoptotic process	HCAR2, PIK3CB	2.21321
[BP] GO:0070213	None	TNKS, TNKS2	2.21321
[BP] GO:0006145	None	AOX1, XDH	2.21321
[BP] GO:0018894	dibenzo-p-dioxin metabolic process	CYP1A1, CYP1A2	2.21321
[BP] GO:0022900	electron transport chain	AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH	2.21178
[BP] GO:0072593	reactive oxygen species metabolic process	BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR	2.21178
[BP] GO:1900542	None	DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA	2.19517
[BP] GO:0032147	activation of protein kinase activity	ADORA1, DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC	2.19237
[BP] GO:0031623	None	ACHE, DRD2, DRD3, HTR2B	2.19237
[BP] GO:0050714	None	ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC	2.18892
[BP] GO:0007611	None	DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2	2.18892
[BP] GO:0090087	None	ACHE, ADORA1, CA2, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC	2.17927
[BP] GO:2000116	regulation of cysteine-type endopeptidase activity	CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH	2.17927
[BP] GO:0008285	negative regulation of cell proliferation	ADORA1, ADORA3, ADRA1A, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SMAD3, XDH	2.17867
[BP] GO:0051194	None	ESRRB, HTR2A, INSR	2.16458
[BP] GO:0030520	intracellular estrogen receptor signaling pathway	ESR1, ESR2, SRC	2.16458
[BP] GO:0002683	negative regulation of immune system process	ADORA1, ALOX15, AXL, CDK6, CYP19A1, DRD2, DUSP3, MMP12, PTPRS	2.16458
[BP] GO:0007613	None	DRD1, DRD2, HTR2A, INSR, PTGS2	2.16458
[BP] GO:0009755	hormone-mediated signaling pathway	ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC	2.15335
[BP] GO:0010811	positive regulation of cell-substrate adhesion	ALOX15, CDK6, KDR, SMAD3, TEK	2.14695
[BP] GO:1903391	regulation of adherens junction organization	KDR, SMAD3, SRC, TEK	2.14374
[BP] GO:0045428	regulation of nitric oxide biosynthetic process	EGFR, INSR, PTGS2, SMAD3	2.14374
[BP] GO:0001101	response to acid chemical	AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC	2.13255
[BP] GO:0006140	None	DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA	2.13255
[BP] GO:0043065	positive regulation of apoptotic process	BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH	2.12815
[BP] GO:0006464	cellular protein modification process	ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A	2.11905
[BP] GO:0036211	protein modification process	ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A	2.11905
[BP] GO:2000209	regulation of anoikis	BCL2, PIK3CA, SRC	2.11779
[BP] GO:0044062	None	ADORA1, DRD2, DRD3	2.11779
[BP] GO:0009404	toxin metabolic process	CYP1A1, CYP1A2, CYP1B1	2.11779
[BP] GO:0051336	regulation of hydrolase activity	ADRA1A, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH	2.10218
[BP] GO:0043068	positive regulation of programmed cell death	BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH	2.09786
[BP] GO:0034502	protein localization to chromosome	AURKB, ESR1, TNKS, TNKS2	2.09622
[BP] GO:0070988	demethylation	APEX1, CYP1A1, CYP1A2, CYP2D6	2.09622
[BP] GO:0044267	cellular protein metabolic process	ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A	2.09369
[BP] GO:1904951	positive regulation of establishment of protein localization	ACHE, BCL2, DRD2, EGFR, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC	2.08143
[BP] GO:1904356	regulation of telomere maintenance via telomere lengthening	AURKB, SRC, TNKS, TNKS2	2.07114
[BP] GO:0019229	None	ADRA1A, EGFR, HTR2A, PTGS2	2.07114
[BP] GO:0007204	positive regulation of cytosolic calcium ion concentration	ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B	2.07031
[BP] GO:0051894	None	KDR, SMAD3, TEK	2.07031
[BP] GO:1903409	reactive oxygen species biosynthetic process	CYP1A1, CYP1A2, CYP1B1	2.07031
[BP] GO:0050679	None	EGFR, F3, HTR2B, KDR, MMP12, TEK	2.06292
[BP] GO:0070301	cellular response to hydrogen peroxide	AKR1B1, APEX1, AXL, CYP1B1	2.04734
[BP] GO:0051046	None	ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC	2.03754
[BP] GO:0021853	None	DRD1, DRD2	2.03754
[BP] GO:0043696	None	CDK6, ESRRB	2.03754
[BP] GO:0043697	None	CDK6, ESRRB	2.03754
[BP] GO:0010641	None	F3, SRC	2.03754
[BP] GO:0090325	None	DRD2, DRD3	2.03754
[BP] GO:0007598	None	F10, F3	2.03754
[BP] GO:1904936	None	DRD1, DRD2	2.03754
[BP] GO:0042321	None	ADORA1, DRD2	2.03754
[BP] GO:0010513	None	HTR2A, HTR2B	2.03754
[BP] GO:0006650	glycerophospholipid metabolic process	ACHE, ALOX15, CSNK2A1, DRD2, EGFR, MET, PIK3CA, PIK3CB	2.03427
[BP] GO:0050794	regulation of cellular process	ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH	2.03238
[BP] GO:0050927	None	F3, KDR, SMAD3	2.02986
[BP] GO:1901699	cellular response to nitrogen compound	AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC	2.02855
[BP] GO:0050728	negative regulation of inflammatory response	ADORA1, CYP19A1, PPARA, SMAD3, TEK	2.01488
[BP] GO:0001525	angiogenesis	CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK	2.00379
[BP] GO:0009991	response to extracellular stimulus	ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR	2.00186
[CC] GO:0031226	intrinsic component of plasma membrane	ADORA1, ADORA3, ADRA1A, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK	5.45501
[CC] GO:0016020	membrane	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR	5.05444
[CC] GO:0005886	plasma membrane	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK	4.91935
[CC] GO:0044459	plasma membrane part	ABCB1, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, PTPRS, SIGMAR1, SRC, TEK	4.69643
[CC] GO:0044425	membrane part	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SRC, TEK, TYR	4.48428
[CC] GO:0005887	integral component of plasma membrane	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK	4.11453
[CC] GO:0044444	cytoplasmic part	ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH	3.92984
[CC] GO:0005789	endoplasmic reticulum membrane	BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, SIGMAR1	3.78471
[CC] GO:0044432	endoplasmic reticulum part	BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1	3.5833
[CC] GO:0043227	membrane-bounded organelle	ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR2A, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	2.98866
[CC] GO:0098590	plasma membrane region	ABCB1, ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, PTGS2, SIGMAR1, SRC, TEK	2.93739
[CC] GO:0005901	caveola	ADRA1A, HTR2A, INSR, PTGS2, SRC	2.84795
[CC] GO:0005783	None	ADORA1, APEX1, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH	2.59705
[CC] GO:0043226	organelle	ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, HTR2A, HTR5A, HTR6, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	2.5194
[CC] GO:0044853	plasma membrane raft	ADRA1A, HTR2A, INSR, PTGS2, SRC	2.40558
[CC] GO:0045121	membrane raft	ADRA1A, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK	2.36334
[CC] GO:0098857	membrane microdomain	ADRA1A, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK	2.3438
[CC] GO:0031233	None	CA4, F10, F3	2.26385
[CC] GO:0044464	cell part	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	2.19237
[MF] GO:0043167	ion binding	ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	17.5867
[MF] GO:0046914	transition metal ion binding	ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH	16.6847
[MF] GO:0004089	carbonate dehydratase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	16.0124
[MF] GO:0003824	catalytic activity	ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	14.6784
[MF] GO:0043169	cation binding	ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH	10.6387
[MF] GO:0016835	carbon-oxygen lyase activity	APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	10.0642
[MF] GO:0016836	hydro-lyase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	9.99041
[MF] GO:0008144	drug binding	ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP2A	9.55202
[MF] GO:0016491	oxidoreductase activity	AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH	9.39792
[MF] GO:0008270	zinc ion binding	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3, TNKS	8.55554
[MF] GO:0038023	signaling receptor activity	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK	8.47646
[MF] GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6	7.8725
[MF] GO:0060089	molecular transducer activity	ADORA1, ADORA3, ADRA1A, AXL, CDK6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK	7.6916
[MF] GO:0070405	ammonium ion binding	ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7	7.51934
[MF] GO:0016829	lyase activity	APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1	7.44382
[MF] GO:0004872	receptor activity	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK	7.33785
[MF] GO:0004871	signal transducer activity	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, SMAD3, TEK	7.07353
[MF] GO:0008227	None	ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.99683
[MF] GO:0005506	iron ion binding	ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH	6.98128
[MF] GO:0004714	transmembrane receptor protein tyrosine kinase activity	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK	6.74146
[MF] GO:0020037	heme binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC	6.73823
[MF] GO:0070330	aromatase activity	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6	6.56843
[MF] GO:0043176	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR7	6.56259
[MF] GO:0051378	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR7	6.56259
[MF] GO:0046906	tetrapyrrole binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC	6.48006
[MF] GO:0004993	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.47917
[MF] GO:0099589	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.47917
[MF] GO:0046872	metal ion binding	ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH	6.20297
[MF] GO:0030594	None	DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	6.19495
[MF] GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR	6.05692
[MF] GO:0019199	transmembrane receptor protein kinase activity	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK	6.03174
[MF] GO:0099600	transmembrane receptor activity	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK	6.03174
[MF] GO:0004888	transmembrane signaling receptor activity	ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK	6.03174
[MF] GO:0048037	cofactor binding	AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH	5.69251
[MF] GO:0004497	monooxygenase activity	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR	5.48563
[MF] GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH	5.46942
[MF] GO:0099528	None	HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7	5.36951
[MF] GO:0019825	oxygen binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6	4.9686
[MF] GO:0043560	insulin receptor substrate binding	IGF1R, INSR, PIK3CA, PIK3CB	4.68439
[MF] GO:0042165	neurotransmitter binding	ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7	4.63619
[MF] GO:0004713	protein tyrosine kinase activity	AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK	4.55406
[MF] GO:0004672	protein kinase activity	AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK	4.22512
[MF] GO:0008395	steroid hydroxylase activity	CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6	4.21115
[MF] GO:0097159	organic cyclic compound binding	ABCB1, ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TUBB3, XDH	4.03298
[MF] GO:0044877	macromolecular complex binding	ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC	3.98736
[MF] GO:0016773	phosphotransferase activity, alcohol group as acceptor	AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK	3.98736
[MF] GO:0032403	protein complex binding	ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC	3.93165
[MF] GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2	3.80059
[MF] GO:0016301	kinase activity	AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK	3.54883
[MF] GO:0042562	hormone binding	ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2	3.54799
[MF] GO:0005496	steroid binding	ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1	3.52599
[MF] GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	ESR1, ESR2, ESRRA, ESRRB, PPARA	3.5237
[MF] GO:0004879	nuclear receptor activity	ESR1, ESR2, ESRRA, ESRRB, PPARA	3.5237
[MF] GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	HSD11B1, HSD11B2, HSD17B1, HSD17B2	3.22828
[MF] GO:0043168	anion binding	ABCB1, ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, TUBB3, XDH	3.20887
[MF] GO:0004716	signal transducer, downstream of receptor, with protein tyrosine kinase activity	EGFR, INSR, KDR	3.20033
[MF] GO:0003707	steroid hormone receptor activity	ESR1, ESR2, ESRRA, ESRRB, PPARA	3.17382
[MF] GO:0036094	small molecule binding	ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH	3.12562
[MF] GO:0016229	steroid dehydrogenase activity	HSD11B1, HSD11B2, HSD17B1, HSD17B2	3.12315
[MF] GO:0009055	electron transfer activity	AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH	3.03689
[MF] GO:1901363	heterocyclic compound binding	ABCB1, ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TUBB3, XDH	2.99923
[MF] GO:0000166	nucleotide binding	ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH	2.98866
[MF] GO:1901265	nucleoside phosphate binding	ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH	2.98634
[MF] GO:0004930	None	ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1	2.92946
[MF] GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS1, PTGS2	2.86614
[MF] GO:0038052	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	ESR1, ESR2	2.86614
[MF] GO:0003845	None	HSD11B1, HSD11B2	2.86614
[MF] GO:0008389	None	CYP2A13, CYP2A6	2.86614
[MF] GO:0008289	lipid binding	ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA	2.86394
[MF] GO:0004952	None	DRD1, DRD2, DRD3	2.86394
[MF] GO:0016772	transferase activity, transferring phosphorus-containing groups	AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK	2.79134
[MF] GO:0035240	None	DRD1, DRD2, DRD3	2.7655
[MF] GO:0016903	None	AKR1B1, AKR1B10, AOX1, XDH	2.50962
[MF] GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15, PTGS2	2.46193
[MF] GO:0005524	ATP binding	ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A	2.42845
[MF] GO:0003674	molecular_function	ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH	2.38203
[MF] GO:0032559	adenyl ribonucleotide binding	ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A	2.30858
[MF] GO:0030554	adenyl nucleotide binding	ABCB1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A	2.27456
[MF] GO:1901338	None	DRD1, DRD2, DRD3	2.26385
[MF] GO:0034056	estrogen response element binding	ESR1, ESR2	2.21321
[MF] GO:0019902	phosphatase binding	BCL2, EGFR, MET, PPARA, PTPN1, SMAD3	2.18892
[MF] GO:0140096	catalytic activity, acting on a protein	AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK	2.12101
[MF] GO:0030284	estrogen receptor activity	ESR1, ESR2	2.03754
[MF] GO:0043559	insulin binding	IGF1R, INSR	2.03754
[MF] GO:0005518	collagen binding	ACHE, MMP12, MMP9, SMAD3	2.00738

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910	CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14	16.9805
Ovarian steroidogenesis_Homo sapiens_hsa04913	ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R	9.8567
Serotonergic synapse_Homo sapiens_hsa04726	HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, PTGS2, HTR5A, PTGS1	9.5589
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	GPR35, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3	7.702
Estrogen signaling pathway_Homo sapiens_hsa04915	PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A	7.5761
Steroid hormone biosynthesis_Homo sapiens_hsa00140	HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1	7.9226
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1	7.3548
Adherens junction_Homo sapiens_hsa04520	PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R	7.3548
Pathways in cancer_Homo sapiens_hsa05200	SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET	6.2103
Proteoglycans in cancer_Homo sapiens_hsa05205	PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R	6.2103
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1	6.8745
Chemical carcinogenesis_Homo sapiens_hsa05204	HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2	7.0454
Rap1 signaling pathway_Homo sapiens_hsa04015	PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R	6.1172
MicroRNAs in cancer_Homo sapiens_hsa05206	CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B	5.7375
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3	5.3092
cAMP signaling pathway_Homo sapiens_hsa04024	HCAR2, HTR6, PIK3CA, ADORA1, HTR1A, PIK3CB, DRD1, DRD2, PPARA	5.3568
Metabolic pathways_Homo sapiens_hsa01100	CBR1, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH	5.075
Gap junction_Homo sapiens_hsa04540	SRC, TUBB3, HTR2B, HTR2A, DRD1, DRD2, EGFR	5.6661
HIF-1 signaling pathway_Homo sapiens_hsa04066	PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R	5.2759
Ras signaling pathway_Homo sapiens_hsa04014	HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R	5.0173
Calcium signaling pathway_Homo sapiens_hsa04020	HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR	4.8182
PI3K-Akt signaling pathway_Homo sapiens_hsa04151	CDK6, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R	4.497
Melanoma_Homo sapiens_hsa05218	CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R	5.075
Focal adhesion_Homo sapiens_hsa04510	PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R	4.4812
Hepatitis B_Homo sapiens_hsa05161	CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9	4.4355
VEGF signaling pathway_Homo sapiens_hsa04370	PIK3CA, SRC, KDR, PIK3CB, PTGS2	4.2137
Glioma_Homo sapiens_hsa05214	CDK6, PIK3CA, PIK3CB, EGFR, IGF1R	4.1218
Bladder cancer_Homo sapiens_hsa05219	SRC, MMP1, MMP2, MMP9, EGFR	4.9957
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A	4.1407
Pancreatic cancer_Homo sapiens_hsa05212	CDK6, SMAD3, PIK3CA, PIK3CB, EGFR	4.1029
Arachidonic acid metabolism_Homo sapiens_hsa00590	CBR1, ALOX5, ALOX15, PTGS2, PTGS1	4.194
FoxO signaling pathway_Homo sapiens_hsa04068	SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R	3.7423
Prolactin signaling pathway_Homo sapiens_hsa04917	PIK3CA, SRC, PIK3CB, ESR1, ESR2	3.9442
Central carbon metabolism in cancer_Homo sapiens_hsa05230	PIK3CA, FLT3, PIK3CB, MET, EGFR	4.0842
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	PIK3CA, SRC, HTR2B, PIK3CB, HTR2A	3.3705
cGMP-PKG signaling pathway_Homo sapiens_hsa04022	PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA1A	3.2435
Prostate cancer_Homo sapiens_hsa05215	PIK3CA, BCL2, PIK3CB, EGFR, IGF1R	3.5588
Endocytosis_Homo sapiens_hsa04144	SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A	3.0827
Small cell lung cancer_Homo sapiens_hsa05222	CDK6, PIK3CA, BCL2, PIK3CB, PTGS2	3.6191
Insulin resistance_Homo sapiens_hsa04931	PTPN1, PIK3CA, INSR, PIK3CB, PPARA	3.1939
Toxoplasmosis_Homo sapiens_hsa05145	PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A	3.0615
Sphingolipid signaling pathway_Homo sapiens_hsa04071	PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB	3.0457
AMPK signaling pathway_Homo sapiens_hsa04152	PIK3CA, INSR, PIK3CB, ADRA1A, IGF1R	2.9884
Measles_Homo sapiens_hsa05162	CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A	2.8374
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R	2.7678
Jak-STAT signaling pathway_Homo sapiens_hsa04630	PIK3CA, BCL2, PIM1, AOX1, PIK3CB	2.5809
Oxytocin signaling pathway_Homo sapiens_hsa04921	PIK3CA, SRC, PIK3CB, PTGS2, EGFR	2.5809
Non-small cell lung cancer_Homo sapiens_hsa05223	CDK6, PIK3CA, PIK3CB, EGFR	3.2435
Acute myeloid leukemia_Homo sapiens_hsa05221	PIK3CA, FLT3, PIM1, PIK3CB	3.2237
Colorectal cancer_Homo sapiens_hsa05210	SMAD3, PIK3CA, BCL2, PIK3CB	3.1013
Chronic myeloid leukemia_Homo sapiens_hsa05220	CDK6, SMAD3, PIK3CA, PIK3CB	2.8993
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	PIK3CA, PIK3CB, CDC25B, IGF1R	2.4781
ErbB signaling pathway_Homo sapiens_hsa04012	PIK3CA, SRC, PIK3CB, EGFR	2.6419
Cholinergic synapse_Homo sapiens_hsa04725	ACHE, PIK3CA, BCL2, PIK3CB	2.303
Epstein-Barr virus infection_Homo sapiens_hsa05169	CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A	2.1794
TNF signaling pathway_Homo sapiens_hsa04668	PIK3CA, PIK3CB, PTGS2, MMP9	2.307
Longevity regulating pathway - mammal_Homo sapiens_hsa04211	PIK3CA, INSR, PIK3CB, IGF1R	2.5382
Retinol metabolism_Homo sapiens_hsa00830	CYP2A6, CYP1A2, CYP1A1, AOX1	3.0499
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	HSD11B2, PIK3CA, INSR, PIK3CB	3.7875
Platelet activation_Homo sapiens_hsa04611	PIK3CA, SRC, PIK3CB, PTGS1	2.1794
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	PIK3CA, SRC, PIK3CB, MET	2.8055
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	CYP2A6, CYP2D6, CYP1A2, AOX1	2.9846
Thyroid hormone signaling pathway_Homo sapiens_hsa04919	PIK3CA, SRC, PIK3CB, ESR1	2.2225
Hepatitis C_Homo sapiens_hsa05160	PIK3CA, PIK3CB, PPARA, EGFR	2.0543
Leukocyte transendothelial migration_Homo sapiens_hsa04670	PIK3CA, MMP2, PIK3CB, MMP9	2.2225
Phospholipase D signaling pathway_Homo sapiens_hsa04072	PIK3CA, INSR, PIK3CB, EGFR	1.9559
Insulin signaling pathway_Homo sapiens_hsa04910	PTPN1, PIK3CA, INSR, PIK3CB	2.0042
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	PIK3CA, INSR, PIK3CB, PPARA	1.9007
PPAR signaling pathway_Homo sapiens_hsa03320	FABP3, FABP4, MMP1, PPARA	2.9846
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	PIK3CA, BCL2, PIK3CB, ADRA1A	1.9255
Tryptophan metabolism_Homo sapiens_hsa00380	CYP1A2, CYP1A1, AOX1, CYP1B1	3.7557
Transcriptional misregulation in cancer_Homo sapiens_hsa05202	FLT3, MMP9, MET, IGF1R	1.6696
Viral carcinogenesis_Homo sapiens_hsa05203	CDK6, PIK3CA, SRC, PIK3CB	1.5056
Regulation of actin cytoskeleton_Homo sapiens_hsa04810	PIK3CA, SRC, PIK3CB, EGFR	1.449
Herpes simplex infection_Homo sapiens_hsa05168	CSNK2A1	0.234
Purine metabolism_Homo sapiens_hsa00230	XDH	0.2453
Hippo signaling pathway_Homo sapiens_hsa04390	SMAD3	0.2812
Phagosome_Homo sapiens_hsa04145	TUBB3	0.2812
MAPK signaling pathway_Homo sapiens_hsa04010	DUSP3, EGFR, CDC25B, HSPA1A	1.2535
Spliceosome_Homo sapiens_hsa03040	HSPA1A	0.3184
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	FLT3, KDR, MET, EGFR	1.2078
Apoptosis_Homo sapiens_hsa04210	PIK3CA, BCL2, PIK3CB	1.2987
GnRH signaling pathway_Homo sapiens_hsa04912	SRC, MMP2, EGFR	1.7102
Choline metabolism in cancer_Homo sapiens_hsa05231	PIK3CA, PIK3CB, EGFR	1.6139
Axon guidance_Homo sapiens_hsa04360	MET	0.3327
Neurotrophin signaling pathway_Homo sapiens_hsa04722	PIK3CA, BCL2, PIK3CB	1.4444
Oocyte meiosis_Homo sapiens_hsa04114	IGF1R	0.3404
Vascular smooth muscle contraction_Homo sapiens_hsa04270	ADRA1A	0.3457
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	SMAD3, PIK3CA, PIK3CB	1.5897
HTLV-I infection_Homo sapiens_hsa05166	SMAD3, PIK3CA, PIK3CB	0.762
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	BCL2, HSPA1A	0.6126
Influenza A_Homo sapiens_hsa05164	PIK3CA, PIK3CB, HSPA1A	1.0949
Cell cycle_Homo sapiens_hsa04110	CDK6, SMAD3, CDC25B	1.4166
Dopaminergic synapse_Homo sapiens_hsa04728	DRD1, DRD2, DRD3	1.3811
NF-kappa B signaling pathway_Homo sapiens_hsa04064	CSNK2A1, BCL2, PTGS2	1.6899
Tuberculosis_Homo sapiens_hsa05152	SRC, BCL2	0.5929
Chemokine signaling pathway_Homo sapiens_hsa04062	PIK3CA, SRC, PIK3CB	1.0333
Parkinson's disease_Homo sapiens_hsa05012	DRD1, DRD2	0.7165
Alcoholism_Homo sapiens_hsa05034	DRD1, DRD2	0.5929
Tight junction_Homo sapiens_hsa04530	CSNK2A1, SRC	0.7217
Glucagon signaling pathway_Homo sapiens_hsa04922	PPARA	0.4002
Melanogenesis_Homo sapiens_hsa04916	TYR	0.4002
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	PIK3CA, PIK3CB	0.7352
Wnt signaling pathway_Homo sapiens_hsa04310	SMAD3, CSNK2A1	0.7165
Osteoclast differentiation_Homo sapiens_hsa04380	PIK3CA, PIK3CB	0.7474
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	PTGS2	0.4002
Glycerophospholipid metabolism_Homo sapiens_hsa00564	ACHE	0.4105
Pancreatic secretion_Homo sapiens_hsa04972	CA2	0.4096
Hematopoietic cell lineage_Homo sapiens_hsa04640	FLT3	0.4305
Toll-like receptor signaling pathway_Homo sapiens_hsa04620	PIK3CA, PIK3CB	0.8837
GABAergic synapse_Homo sapiens_hsa04727	SRC	0.4305
Salivary secretion_Homo sapiens_hsa04970	ADRA1A	0.4305
Taste transduction_Homo sapiens_hsa04742	HTR1A	0.4412
TGF-beta signaling pathway_Homo sapiens_hsa04350	SMAD3	0.4397
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	CSNK2A1	0.4305
T cell receptor signaling pathway_Homo sapiens_hsa04660	PIK3CA, PIK3CB	0.8941
Renal cell carcinoma_Homo sapiens_hsa05211	PIK3CA, PIK3CB, MET	2.0459
Amoebiasis_Homo sapiens_hsa05146	PIK3CA, PIK3CB	0.9158
Peroxisome_Homo sapiens_hsa04146	XDH	0.4412
Phosphatidylinositol signaling system_Homo sapiens_hsa04070	PIK3CA, PIK3CB	0.927
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	PIK3CA, PIK3CB	0.9622
Morphine addiction_Homo sapiens_hsa05032	ADORA1, DRD1	0.9747
Rheumatoid arthritis_Homo sapiens_hsa05323	MMP1, TEK	0.9792
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	SRC, MET, EGFR	2.0154
Antigen processing and presentation_Homo sapiens_hsa04612	HSPA1A	0.4624
Leishmaniasis_Homo sapiens_hsa05140	PTGS2	0.476
Gastric acid secretion_Homo sapiens_hsa04971	CA2	0.4739
Adipocytokine signaling pathway_Homo sapiens_hsa04920	PPARA	0.4884
p53 signaling pathway_Homo sapiens_hsa04115	CDK6	0.4908
Amphetamine addiction_Homo sapiens_hsa05031	DRD1	0.4987
Renin secretion_Homo sapiens_hsa04924	ADORA1	0.507
B cell receptor signaling pathway_Homo sapiens_hsa04662	PIK3CA, PIK3CB	1.12
Endometrial cancer_Homo sapiens_hsa05213	PIK3CA, PIK3CB, EGFR	2.303
Shigellosis_Homo sapiens_hsa05131	SRC	0.507
Complement and coagulation cascades_Homo sapiens_hsa04610	F10, F3	1.0669
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	SMAD3	0.507
Long-term depression_Homo sapiens_hsa04730	IGF1R	0.528
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	PIK3CA, PIK3CB	1.163
Inositol phosphate metabolism_Homo sapiens_hsa00562	PIK3CA, PIK3CB	1.1376
Bile secretion_Homo sapiens_hsa04976	ABCB1, CA2	1.1376
Legionellosis_Homo sapiens_hsa05134	HSPA1A	0.5578
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	TUBB3	0.5578
mTOR signaling pathway_Homo sapiens_hsa04150	PIK3CA, PIK3CB	1.2535
Type II diabetes mellitus_Homo sapiens_hsa04930	PIK3CA, INSR, PIK3CB	2.3831
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	BCL2	0.5805
Malaria_Homo sapiens_hsa05144	MET	0.5929
Glycerolipid metabolism_Homo sapiens_hsa00561	AKR1B10, AKR1B1	1.2581
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	ESR1	0.5964
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	AOX1	0.5929
Sphingolipid metabolism_Homo sapiens_hsa00600	GBA2	0.5964
ABC transporters_Homo sapiens_hsa02010	ABCB1	0.6126
Cocaine addiction_Homo sapiens_hsa05030	DRD1, DRD2	1.3898
Carbohydrate digestion and absorption_Homo sapiens_hsa04973	PIK3CA, PIK3CB	1.4444
Pyruvate metabolism_Homo sapiens_hsa00620	GLO1	0.6465
Prion diseases_Homo sapiens_hsa05020	HSPA1A	0.6962
Drug metabolism - other enzymes_Homo sapiens_hsa00983	CYP2A6, XDH	1.432
Dorso-ventral axis formation_Homo sapiens_hsa04320	EGFR	0.7662
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	FUT7	0.7279
Base excision repair_Homo sapiens_hsa03410	APEX1	0.7165
Galactose metabolism_Homo sapiens_hsa00052	AKR1B10, AKR1B1	1.7212
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	AOX1	0.7474
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	FUT7	0.7744
Tyrosine metabolism_Homo sapiens_hsa00350	AOX1, TYR	1.6185
Linoleic acid metabolism_Homo sapiens_hsa00591	ALOX15, CYP1A2	1.7442
Fructose and mannose metabolism_Homo sapiens_hsa00051	AKR1B10, AKR1B1	1.683
Pentose and glucuronate interconversions_Homo sapiens_hsa00040	AKR1B10, AKR1B1	1.6052
Collecting duct acid secretion_Homo sapiens_hsa04966	CA2	0.7662
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	CA2, CA4	1.9255
Other glycan degradation_Homo sapiens_hsa00511	GBA2	0.9147
Folate biosynthesis_Homo sapiens_hsa00790	ALPL	0.997
Caffeine metabolism_Homo sapiens_hsa00232	CYP2A6, CYP1A2, XDH	5.075
Vitamin B6 metabolism_Homo sapiens_hsa00750	AOX1	1.3016

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway
5. Targets Expression Levels in Healthy Donor (mRNA Level)
6. Targets Expression Levels in Healthy Donor (Protein Level)

TCM Prescription: Shen Rong Bai Feng Pills