Prescription Description
| Prescription ID | TCMF3493 |
| Pinyin Name | Bao Gu Huo Luo Wan |
| Chinese Name | 豹骨活络丸 |
| English Name | Bao Gu Huo Luo Pills |
| Function Description | 痹病 |
| Indications | Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | SkeletalMuscle, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH136 | Os pardi | 豹骨 | TCMH136 | |
| TCMH1518 | Chaenomeles sinensis | 木瓜 | TCMH1518 | GBVJ2053-11, GBVJ2052-11 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH118 | Angelica dahurica | 白芷 | TCMH118 | ITSAK3312-14 |
| TCMH2166 | Clematis chinensis | 威灵仙 | TCMH2166 | |
| TCMH1680 | Sinomenium acutum | 青风藤 | TCMH1680 | ITSAJ4218-14 |
| TCMH776 | Piper kadsura | 海风藤 | TCMH776 | EF450290 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH296 | Radix aconiti | 川乌 | TCMH296 | |
| TCMH222 | Aconitum carmichaelii | 草乌 | TCMH222 | ITSAH2410-14 |
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 131 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 67 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP3, MMP9, PRKCD, SRC | 4.85819 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTAFR, PTGS2, SRC | 3.00088 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD1, DRD2, DRD3, GRIK5, PTGS2, SLC1A1, SLC22A2, SLC22A3, TRPV1 | 5.39921 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 | 2.14416 |
| [BP] GO:0001659 | None | ADORA1, DRD1, DRD2, TRPV1 | 3.09749 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC | 4.47774 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1 | 6.64235 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, RORC, SRC, TRPV1 | 3.93476 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH | 4.6949 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH | 5.21267 |
Showing 1 to 10 of 520 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.4712 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SRC, MET, IGF1R | 3.1038 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.545 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PRKCA, PIK3CB | 2.1489 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCG, PRKCB, PRKCA | 2.9397 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 | 9.0717 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1, DRD2 | 0.6807 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCG, PRKCB, PRKCE, PRKCA | 2.9718 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB | 5.4067 |
| Amoebiasis_Homo sapiens_hsa05146 | PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB | 3.6297 |
Showing 1 to 10 of 171 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples