Prescription Description
| Prescription ID | TCMF3454 |
| Pinyin Name | Shen Qi Xiao Ke Ke Li |
| Chinese Name | 参芪消渴颗粒 |
| English Name | Shen Qi Xiao Ke Granules |
| Function Description | 消渴 |
| Indications | Wasting thirst disorder, Diabetes |
| Disease ICD-11 Category |
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1)
]; 5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ]; |
| Human Tissues Associated with Indication | Pancreas, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH2551 | Polygonatum odoratum | 玉竹 | TCMH2551 | ITSAM921-14 |
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH1562 | Arctium lappa | 牛蒡子 | TCMH1562 | ITSAI1776-14 |
| TCMH1060 | Bombyx batryticatus | 僵蚕 | TCMH1060 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 116 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 61 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC | 2.4917 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.68604 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, EGFR, MMP2, MMP9, TEK | 3.35069 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3, TRPV1 | 4.17982 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.4909 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 3.25598 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 5.93406 |
| [BP] GO:0001775 | cell activation | ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TRPV1 | 2.4512 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.29698 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.59346 |
Showing 1 to 10 of 444 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.583 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 8.0626 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5769 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 0.8881 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, PIM1, PIK3CB | 3.7587 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.9031 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.1246 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.3839 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, HMGCR, IGF1R | 3.3844 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6874 |
Showing 1 to 10 of 164 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples