TCM Prescription: Gou Qi Yi Yuan Wine



Prescription Description
Prescription IDTCMF3318
Pinyin NameGou Qi Yi Yuan Jiu
Chinese Name枸杞益元酒
English NameGou Qi Yi Yuan Wine
Function Description眩晕, 视瞻昏渺, 腰痛
IndicationsLumbago disorder, Vertigo disorder, Dizziness, Lumbago
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ];
Human Tissues Associated with IndicationBrain, Kidney, Bladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1185 Lycium chinense 枸杞 TCMH1185 ITSAO4545-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH2056 Cynomorium songaricum 锁阳 TCMH2056 ITSAO3649-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH876 Semen oryzae cum monasco fermentatum 红曲 TCMH876
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0494
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2149
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, SRC, TERT, XDH 10.042
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 9.90054
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, GRIK5, GRM5, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, RORC, SRC, TYR 9.32813
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.12093
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PPARG, PTGS2, RORC, SRC, TYR 8.75922
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PPARG, PTGS2, RORC, SRC, TERT, TYR 8.47654
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR, XDH 8.12144
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.02547
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 7.66645
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARG, PTGS2, RORC, SRC, TERT 7.34215
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 7.20905
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 7.17467
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 7.14038
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 6.8479
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 6.8479
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARG, PTGS2, RORC, SRC 6.8479
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 6.59844
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, XDH 6.49931
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 6.35427
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 6.32428
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 6.24446
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, FABP3, FLT3, GRM5, IGF1R, KIT, MMP2, PPARA, PPARG, PTGS2, SRC 6.2013
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.19838
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 6.10703
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PIK3CA, PIK3CB, PPARG, SRC, TERT 6.0828
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.04932
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DNMT1, ESR1, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARG, PTGS1, PTGS2, SRC, TERT, XDH 6.02083
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 6.01473
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HSP90AB1, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.97368
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HSP90AB1, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 5.94467
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PPARG, PTGS2, RORC, SRC, TYR 5.93675
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, RORC, SRC, TYR 5.90339
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR, XDH 5.89054
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 5.88068
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.86871
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, HSD17B2 5.83798
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.8069
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.76137
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TYR 5.74074
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.64079
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT 5.63624
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.56147
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.43415
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR, XDH 5.30931
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.28935
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, NQO2, PTGS1, RORC 5.28935
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PPARG, PTGS2, RORC, SRC 5.23922
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR 5.22394
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 5.16597
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.10867
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 5.10154
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTPN1, RORC, SRC 5.04804
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.04804
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PPARG, PTGS2, RORC, SRC 5.02469
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.99645
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, KIT, PPARA, PPARG, PTGS2, SRC 4.98635
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 4.95077
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.94344
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.89938
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, GRM1, HSP90AA1, HSP90AB1, KIT, MMP2, PPARA, PPARG, PTGS2, SRC, TERT, TYR 4.85426
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.84885
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH 4.81645
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TYR, XDH 4.7687
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.75317
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.73124
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, FABP4, FLT3, FUT7, HSD17B2, HSP90AB1, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, RORC, SRC, TERT, TYR 4.72302
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT 4.60086
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC, TERT 4.59015
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8, PTGS2 4.58911
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, PPARG, PTGS2, RORC, SRC 4.54617
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.54006
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, KIT, PIK3CA, PPARA, PPARG, SRC, TYR 4.54006
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.53163
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TERT, XDH 4.47313
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, KIT, PPARA, PPARG, RORC, SRC 4.44652
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.44286
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.43972
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, FLT3, HSD17B2, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, RORC, SRC, TYR 4.41818
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 4.41061
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HSP90AB1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.40912
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PTGS2 4.38948
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.38948
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, FLT3, GRM1, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.38463
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.38201
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.38201
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38201
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.38201
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.38201
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.38201
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1 4.35629
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.33459
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.31093
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.31093
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GRM1, HSP90AB1, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.30454
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 4.29505
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 4.27392
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 4.27363
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, FLT3, GRM1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.24304
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, FLT3, GRM1, GRM5, HSP90AB1, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 4.24304
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 4.24304
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KIT, PIK3CA, PIK3CB, PPARG, PTPN1, SRC 4.20848
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.20197
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC 4.19692
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 4.1884
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 4.09662
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PPARG, PTGS2, SRC 4.05833
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 4.05426
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.9855
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.9843
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 3.97378
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.97378
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, PPARG 3.95094
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.93266
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 3.88763
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.88686
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC, TERT 3.85255
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.78686
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, KIT, PPARG, SRC 3.77838
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.77011
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.72627
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.72345
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR 3.67746
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 3.65544
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, TERT 3.63193
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.61834
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.61834
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PPARG, PTGS2, SRC, TERT 3.59597
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.59597
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.59597
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT 3.59172
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 3.57774
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, ESR1, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TERT, XDH 3.57774
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.56574
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARG, PTGS2, SRC, TERT 3.56574
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.56574
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PIK3CA, PIK3CB, PPARG, SRC 3.56384
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.55693
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.53841
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC 3.50984
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.48668
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 3.47691
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.43828
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DYRK1A, ESR1, FABP4, HSP90AA1, HSP90AB1, IGF1R, MET, MMP2, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 3.42364
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.38096
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, PTGS2, SRC, TYR 3.36099
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSP90AB1, KIT, PPARG, PTGS2, SRC 3.34339
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.25866
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, HCAR2, HSP90AB1, PPARG, PTGS2, SRC, TERT 3.25451
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SRC 3.25349
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.21506
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.21253
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 3.18938
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, HSP90AB1, KDR, PPARG, PTGS2, SRC 3.18887
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.17407
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.17274
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14138
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.05307
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 3.05215
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, PPARG, RORC 3.02992
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.01622
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.01582
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, SRC 3.01321
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, PPARG, PTGS2, SRC 3.01045
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, GRM1, GRM5, HSP90AB1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.99101
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 2.98426
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT 2.97746
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.95982
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARG, PTGS2, TERT 2.9413
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.91306
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.90843
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 2.90277
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.89178
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.85259
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, PPARG, PTGS2, SRC 2.85259
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FABP4, FLT3, GRM1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 2.85259
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82442
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 2.81963
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC 2.78984
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.78237
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARG, PTGS2, TYR 2.78237
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.77107
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, HSP90AB1, KIT, MMP2, MMP9, PPARG, PTGS2, SRC 2.76429
[BP] GO:0051896 regulation of protein kinase B signaling AXL, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 2.74001
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73483
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 2.70324
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, HSP90AA1, HSP90AB1, KIT, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.70133
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.66546
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC 2.64575
[BP] GO:0042391 None ADORA1, APP, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.60633
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, GRM1, HCAR2, HSP90AB1, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARG, PTGS2, SLC1A1, SRC, TERT, XDH 2.60411
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HSP90AA1, KDR, SRC 2.59271
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, KIT, MET, PIK3CA, PIK3CB, SRC 2.57767
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.57354
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.57354
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57354
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 2.56916
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 2.55636
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.54309
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 2.53904
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP9, PPARA, PPARG, SLC1A1, SRC, TERT, XDH 2.53544
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, KIT, PTPN1, SRC 2.52306
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.52149
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.51579
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, KIT, PTGS2, SLC1A1 2.51049
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP9, PPARA, PPARG, SLC1A1, SRC, TERT, XDH 2.4902
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PTGS2 2.45997
[BP] GO:0099566 None GRM1, GRM5 2.4408
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4408
[BP] GO:0051099 positive regulation of binding APP, HSP90AB1, MET, MMP9, PPARG, TERT 2.43772
[BP] GO:0007004 None HSP90AA1, HSP90AB1, TERT 2.43772
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSP90AA1, HSP90AB1, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SRC, TERT 2.42766
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, GRM5, IGF1R, MMP2, PPARG, PTGS2, SRC 2.41612
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.38512
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, GRM1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 2.37639
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37639
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, KIT, MMP9, PPARA, PPARG, SLC1A1, SRC, XDH 2.36789
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, HSP90AA1, HSP90AB1, PTGS2, XDH 2.36532
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSP90AA1, HSP90AB1, KIT, MMP9, SLC1A1, XDH 2.36375
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, IGF1R, KIT, PIK3CB, PTPN1, SRC 2.34018
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.33927
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, PTPN1, SRC 2.31768
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.30525
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, HSP90AA1, HSP90AB1, PTGS2, SLC1A1 2.29408
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.29249
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.29249
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.28294
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TYR, XDH 2.27449
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, FABP4, GRM3, GRM8, HSP90AB1, IGF1R, MET, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.26836
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.26594
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HSP90AB1, KIT, PIK3CB, PTPN1, SRC 2.2637
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, HCAR2, HSP90AB1, MET, PIK3CA, PPARA 2.22562
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, KIT, PIK3CB, PTPN1, SRC 2.21671
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.21324
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21324
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, ESR1, HCAR2, HSP90AA1, HSP90AB1, KIT, MMP2, PIK3CA, PIK3CB, PPARG, PTPN1, SRC 2.21163
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.20885
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.20021
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.20021
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20021
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CHRM3, CYP1B1, HCAR2, KDR, KIT, MET, MMP9, PIM1, PPARG, PTGS2, SLC1A1, SRC, TERT 2.20021
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, GRM1, GRM5, GRM8, KIT, PIK3CA, PTGS2, SRC, TYR 2.18302
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, HSP90AB1, PIK3CA, PPARA, TERT 2.18137
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.17481
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.17262
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17262
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.17105
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.16244
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.1529
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.12499
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12499
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.11167
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GRIK5, HSP90AB1, PIK3CA, PPARA, TERT 2.11167
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.10718
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.10369
[BP] GO:0043523 regulation of neuron apoptotic process AXL, BCL2, GRIK5, HSP90AB1, PIK3CA, TERT 2.10182
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, GRM1, IGF1R, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 2.0999
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, XDH 2.09873
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SRC, TERT, XDH 2.09528
[BP] GO:0048169 None APP, GRM5, KIT 2.08341
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HSP90AB1, KDR, PTGS2, SRC 2.08337
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PTGS2, SLC1A1 2.05871
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.05454
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SRC, XDH 2.0461
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 2.04544
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CHRM1, GRM5, MMP9, PTGS2 2.04275
[BP] GO:0010833 None HSP90AA1, HSP90AB1, TERT 2.04254
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PPARG, PTGS2, PTPN1, SRC, TERT, XDH 2.03459
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SRC, XDH 2.03459
[BP] GO:0071453 cellular response to oxygen levels BCL2, PPARG, PTGS2, SRC, TERT 2.03459
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, KIT, PIM1, PPARG 2.03459
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, HSP90AA1, HSP90AB1, IGF1R, PIK3CA, PPARG, SRC 2.03459
[BP] GO:0046541 None CHRM1, CHRM3 2.03459
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.03459
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.03459
[BP] GO:0010891 None PPARA, PPARG 2.03459
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SRC, XDH 2.02952
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.01752
[BP] GO:0006278 None HSP90AA1, HSP90AB1, TERT 2.01752
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.01752
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, HSP90AB1, PTGS2, SRC, TERT 2.00796
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC 2.00796
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, SRC 2.00796
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HSP90AB1, IGF1R, KIT, PIK3CB, PTPN1, SRC 2.00793
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PPARG, PTGS2, SRC, XDH 2.00658
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, PTGS2, SLC1A1, SRC 7.66645
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC, TERT 5.56261
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.27532
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TYR 5.04804
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, PTGS2, SLC1A1, SRC 4.99645
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 4.73078
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 4.72147
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SRC 4.15356
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.93956
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 3.6262
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.61834
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC 3.42213
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, PTGS1, SRC 3.42213
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.29208
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.93082
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.89178
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 2.89178
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SRC 2.6625
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS1, PTGS2, SRC 2.60633
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GRIK5 2.39814
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.25538
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, HSP90AB1 2.18137
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.15089
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.12032
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GRIA2, HSD17B2, PTGS1, PTGS2, PTPN1 2.03459
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.4495
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTPN1, RORC, TYR, XDH 14.6484
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2149
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, ESR1, ESR2, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TYR, XDH 10.0127
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 10.0102
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.13237
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.8891
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1, RORC 7.41534
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, SRC 7.41534
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG, RORC 7.29493
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.4804
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG, RORC 6.35427
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.35427
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.19838
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG, RORC 6.14406
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TERT, TYR, XDH 6.10703
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.02083
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.90339
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.82503
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARA, PPARG, RORC 5.73252
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.44416
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARG 5.43415
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PPARG 5.43415
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TERT, TYR, XDH 5.21224
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.18543
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.11692
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, SRC 4.98635
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.67034
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.47831
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, MMP9, NQO2, PPARG, PTGS2, TERT, TYR, XDH 4.38948
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.38201
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.18114
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.00275
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.9843
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.88763
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.72345
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.72345
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.66257
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.59597
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.56384
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.3887
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, XDH 3.30916
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.21253
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.17407
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, HSP90AA1, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 3.02992
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.01622
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.01582
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.85259
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85259
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85259
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85259
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2 2.71505
[MF] GO:0099583 None GRM1, GRM5 2.4408
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.37639
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.37639
[MF] GO:0043621 protein self-association ACHE, DYRK1A, FLT3, PPARG 2.33379
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.31768
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.29249
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.25969
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20021
[MF] GO:0004971 None GRIA2, GRIA4 2.20021
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CSNK2A1, DYRK1A, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, XDH 2.15702
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.0746
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.06162
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03459
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, XDH 2.02486
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, XDH 2.02322
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.01752
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.01752
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.01752
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.01752


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.9151
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, ESR2 9.421
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0675
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, IGF1R, PIK3CA, KIT, BCL2, PPARG, MET 7.983
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 8.7493
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, BCL2, PIK3CB 6.5349
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.5102
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 5.9133
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 5.9133
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.8996
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.9133
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.5885
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.8996
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, PIK3CA, BCL2, PIK3CB, IGF1R 4.9083
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, KIT, GRM8, PIK3CB, GRM1 4.8794
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R 4.7135
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.0911
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.6398
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5147
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.0099
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.0937
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.3333
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.2183
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, MET, IGF1R 4.0034
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 3.994
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.196
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.2073
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.6467
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.2903
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.4694
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.6467
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 2.969
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.3162
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.9658
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.119
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PPARG, PIK3CB, IGF1R 2.7093
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9735
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.5929
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8453
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.994
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.5907
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5033
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5085
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.4837
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3821
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4269
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4269
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4269
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PPARG, PIK3CB, IGF1R 2.3645
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, IGF1R 2.2793
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0734
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0734
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0734
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.0011
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.756
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.8228
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.296
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9408
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2434
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2476
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6182
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PPARG, PIK3CB 1.5258
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8732
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2793
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5258
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.9337
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.511
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4931
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4517
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2018
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2392
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2392
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4962
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.4868
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2883
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4496
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3007
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.2793
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2434
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4408
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.3366
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3657
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4055
Axon guidance_Homo sapiens_hsa04360 MET 0.4001
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4055
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7084
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1765
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2678
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4713
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.7033
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7457
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.9893
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7542
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4905
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7794
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8948
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.909
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5033
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5046
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5046
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5046
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5046
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5112
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9355
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5046
Peroxisome_Homo sapiens_hsa04146 XDH 0.517
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0758
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1394
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.1059
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0867
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1524
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1059
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1268
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1019
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0867
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5619
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1141
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.1262
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5748
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.2125
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1746
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2979
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2979
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6
Shigellosis_Homo sapiens_hsa05131 SRC 0.6
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3335
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2912
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3397
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3117
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.3366
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3117
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.2678
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3335
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3261
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4122
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4908
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4496
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.4408
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4212
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4962
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5141
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5572
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5258
Malaria_Homo sapiens_hsa05144 MET 0.7009
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7113
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5445
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.6594
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7312
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7254
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.644
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8505
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8775
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7206
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8105
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8083
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8567
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8775
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.909
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0457
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8668
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8969
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1944
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1262


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)