Prescription Description
| Prescription ID | TCMF2979 |
| Pinyin Name | Ba Ji Bu Shen Wan |
| Chinese Name | 巴戟补肾丸 |
| English Name | Ba Ji Bu Shen Pills |
| Function Description | 阳痿, 眩晕, 耳鸣, 腰痛 |
| Indications | Involuntary ejaculation disorder, Lumbago disorder, Tinnitus disorder, Vertigo disorder, Tinnitus, Dizziness, Sexual dysfunction, Lumbago |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; MC41 [Tinnitus, 耳鸣 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ]; ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ]; |
| Human Tissues Associated with Indication | Uterus |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH31 | Morinda officinalis | 巴戟天 | TCMH31 | ITSAJ4459-14 |
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH1663 | Semen euryales | 芡实 | TCMH1663 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH2581 | Alisma orientale | 泽泻 | TCMH2581 | KC573871 |
| TCMH693 | Cudrania cochinchinensis | 狗脊 | TCMH693 | |
| TCMH2149 | Cuscuta australis | 菟丝子 | TCMH2149 | ITSAP4209-14 |
| TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
| TCMH524 | Eucommia ulmoides | 杜仲 | TCMH524 | ITSAM1588-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1156 | Semen allii tuberosi | 韭菜子 | TCMH1156 | |
| TCMH1740 | Cistanche deserticola | 肉苁蓉 | TCMH1740 | ITSAM2511-14 |
| TCMH2086 | Trichosanthes kirilowii | 天花粉 | TCMH2086 | ITSAO4359-14 |
| TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 140 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
Showing 1 to 10 of 78 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.69418 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.10524 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.84765 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 | 2.67809 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 4.21866 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 6.39353 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 2.03293 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.75058 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.38425 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK | 4.11456 |
Showing 1 to 10 of 475 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.2416 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2572 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4939 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.2733 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 5.3559 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, INSR, PIK3CB | 3.8318 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.2566 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9465 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.1979 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, HMGCR, IGF1R | 3.0171 |
Showing 1 to 10 of 176 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples