Prescription Description
| Prescription ID | TCMF2770 |
| Pinyin Name | Jing Jie Lian Qiao Tang |
| Chinese Name | 荊芥连翘汤 |
| English Name | Schizonepeta and Forsythia Decoction |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Current Kampo Medicine |
| Reference Book/link | ISSN 1559-033X |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1141 | Schizonepeta tenuifolia | 荆芥 | TCMH1141 | ITSAL858-14 |
| TCMH1272 | Forsythia suspensa | 连翘 | TCMH1272 | ITSAJ4444-14 |
| TCMH562 | Saposhnikovia divaricata | 防风 | TCMH562 | ITSAE3225-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH228 | Bupleurum chinense | 柴胡 | TCMH228 | ITSAM2218-14 |
| TCMH2618 | Citrus aurantium | 枳壳 | TCMH2618 | ITSAA1279-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH1856 | Gardenia jasminoides | 山栀 | TCMH1856 | ITSAJ4473-14 |
| TCMH118 | Angelica dahurica | 白芷 | TCMH118 | ITSAK3312-14 |
| TCMH1080 | Platycodon grandiflorum | 桔梗 | TCMH1080 | ITSAJ4293-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 118 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
Showing 1 to 10 of 85 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.094 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.0064 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT | 2.81934 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 | 5.46589 |
| [BP] GO:0002320 | lymphoid progenitor cell differentiation | BCL2, FLT3, KIT | 2.81133 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC | 2.033 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TBXAS1, TYR | 2.4263 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.01184 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.25776 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 | 4.30787 |
Showing 1 to 10 of 218 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.5882 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, KIT, PIM1 | 2.0333 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 3.7873 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4974 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.331 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.3094 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.6212 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6218 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.3627 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.5588 |
Showing 1 to 10 of 142 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples