TCM Prescription: Augmented Restore the Spleen Decoction



Prescription Description
Prescription IDTCMF2768
Pinyin NameJia Wei Gui Pi Tang
Chinese Name加味归脾汤
English NameAugmented Restore the Spleen Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1329 Arillus longan 龙眼肉 TCMH1329
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1856 Gardenia jasminoides 山栀 TCMH1856 ITSAJ4473-14
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 13.7194
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 13.2939
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.1322
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.1322
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.4492
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1763
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.7749
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.7749
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 10.7555
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.6212
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3521
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, HMGCR, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.27
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TEK, TYR 10.27
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TOP1, TYR 10.2382
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.1413
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 10.0678
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.4558
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.28624
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.19863
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.94664
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.76946
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 8.71904
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.62422
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.62422
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.42621
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.42621
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.2375
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 8.20327
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.16318
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.16318
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.76516
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, KIT, PPARA, PTGS2, SRC, TEK 7.67119
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.61966
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS, TOP1 7.60933
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.60933
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 7.60933
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, TOP1, XDH 7.60933
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.55663
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.48086
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.46295
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.41761
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.36096
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.34024
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 7.32424
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 7.32424
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 7.31825
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.27169
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.25233
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 7.25233
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.24807
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.24705
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, TOP1, XDH 7.21929
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGS2, SRC, TYR 7.18204
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.12164
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.12164
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.07076
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP1, TYR 7.07076
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.06688
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.97404
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC, TERT 6.94344
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS, TOP1 6.91228
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.87616
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.86698
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.81794
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.74377
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.56943
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TNKS2, TYR 6.56736
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 6.38678
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, SRC, TEK, TYR 6.38395
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.3643
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.16823
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.15631
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 6.13932
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.10274
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.10149
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.84761
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.83202
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.83202
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, SMAD3, SRC 5.81948
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.80266
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, HSPA1A, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 5.7884
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.65507
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.64939
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.64939
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.63103
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.61957
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.61042
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.60987
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.60009
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.55527
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.53838
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.43575
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.40953
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.3704
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.33125
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.29671
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.2931
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.20543
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.19423
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 5.18681
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.06791
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.05226
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.05226
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.0023
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.96309
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.93766
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, SMAD3, SRC, TERT 4.93141
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.82968
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KDR, PTGS2, SRC, TOP1 4.82655
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.82651
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.81602
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.80497
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.80307
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.75858
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.72393
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 4.71602
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.69059
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.68535
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.61328
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP1 4.56795
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.48009
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 4.45828
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 4.45819
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.45324
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.4311
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 4.4311
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 4.40283
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, HMGCR, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 4.39836
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37935
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.37708
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 4.37593
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.35118
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, SRC, TOP1 4.26773
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 4.26773
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 4.26366
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.25545
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, PTGS2, SRC, TEK 4.22283
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.19989
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.19296
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.13483
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.12216
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1 4.1102
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.09441
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HMGCR, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 4.05494
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 4.05494
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.03163
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.99088
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.98836
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 3.98778
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 3.92181
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 3.91464
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.88555
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, HMGCR 3.87411
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.85301
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.81138
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 3.81075
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.79089
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.77845
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, XDH 3.76442
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.74509
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC 3.71518
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.71504
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.62538
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.60583
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 3.56064
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.55917
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.55917
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.51567
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48478
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC, TERT 3.46375
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.45395
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.41753
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.40622
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.38583
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.37408
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, PTGS2, SRC 3.36722
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.32861
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.32614
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.27968
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.27968
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.23876
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.23876
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 3.22032
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.21674
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.1934
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.19312
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.17774
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC 3.17774
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.16761
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.14093
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.1308
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, KIT, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3.12689
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.11864
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.11206
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10457
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10457
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS 3.09769
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, XDH 3.07924
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.06572
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.06572
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.05105
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.04676
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 3.04137
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT 3.04137
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.04137
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 3.03284
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, TYR 3.0043
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.0043
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.0043
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.99376
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.98872
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.94154
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 2.92158
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.92158
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.90574
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.90574
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.87073
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, EGFR, HSPA1A 2.87073
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.86776
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.86776
[BP] GO:0009115 None AOX1, XDH 2.85439
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.85137
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.85137
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 2.84959
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.84248
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.83388
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.81095
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.80833
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 2.80226
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.80178
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.80178
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.80178
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8013
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.78697
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.78697
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.75574
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.74554
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.73273
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70925
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.69484
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.68462
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.68462
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.66895
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 2.66895
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.66475
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.66285
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.66285
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.66285
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 2.64725
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HMGCR, KIT, PTGS2, TYR 2.64577
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.63405
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.62189
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.61107
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 2.60852
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2 2.60852
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.5976
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.5976
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.56955
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56743
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56743
[BP] GO:0070920 None EGFR, ESR1, TERT 2.56743
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.56436
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.56436
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.54619
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.54619
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.53351
[BP] GO:0008217 None ADORA1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 2.53351
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, SRC, TNKS, TNKS2 2.53351
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.53351
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, F3, HMGCR, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.52365
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.51955
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, PTGS2, SMAD3, TERT, XDH 2.50422
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50063
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.48092
[BP] GO:0046110 None AOX1, XDH 2.47091
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47091
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.46881
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 2.4682
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.4682
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK 2.45375
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.43366
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.43183
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.42933
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.42638
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.42638
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.42292
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.42118
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.4201
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.41808
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.41644
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.41511
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.41384
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 2.40208
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.39869
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.38704
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.38704
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37902
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.36824
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 2.36702
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.36702
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.36547
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.36526
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.36526
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.36526
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.36465
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36027
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.36027
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36027
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.36027
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.34212
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.34148
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.3409
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CYP1A1, DYRK1A, EGFR, HSD11B2, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC, TOP1 2.33646
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.31925
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.31925
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.31925
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.31925
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.298
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT, XDH 2.28996
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.27502
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.27342
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.27046
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.25759
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, XDH 2.25637
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, XDH 2.25637
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.24691
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.24691
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.24217
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.24217
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.24217
[BP] GO:0070213 None TNKS, TNKS2 2.24217
[BP] GO:0006145 None AOX1, XDH 2.24217
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24217
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.2304
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2304
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3, TNKS2 2.20975
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.20409
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.19604
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.18754
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.17814
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17814
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17048
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.17048
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.14424
[BP] GO:0050900 leukocyte migration FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.14424
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.14073
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 2.12947
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12947
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12947
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.12783
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.11843
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.10654
[BP] GO:0050927 None F3, KDR, SMAD3 2.08697
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08019
[BP] GO:0050890 None ADORA1, APP, EGFR, HMGCR, INSR, KIT, PTGS2 2.05977
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.05977
[BP] GO:0043696 None CDK6, ESRRB 2.05977
[BP] GO:0043697 None CDK6, ESRRB 2.05977
[BP] GO:0010641 None F3, SRC 2.05977
[BP] GO:0007598 None F10, F3 2.05977
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.05977
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 2.05203
[BP] GO:0050926 None F3, KDR, SMAD3 2.04924
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04924
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04924
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.04244
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.04186
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, HCAR2, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.03241
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.02083
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.02083
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.01811
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.0095
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.00681
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HMGCR, KDR, SRC, TEK 2.0005
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.0005
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 4.80497
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 3.70463
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.53082
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 3.484
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 3.34953
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR 2.74473
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 2.59024
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.58023
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.56571
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.49577
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MMP12, MMP2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.35869
[CC] GO:0031233 None CA4, F10, F3 2.33094
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TYR, XDH 2.31496
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, TEK 2.21552
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.12486
[CC] GO:0044446 intracellular organelle part AKR1B1, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSPA1A, INSR, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR 2.11595
[CC] GO:0044422 organelle part AKR1B1, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSPA1A, INSR, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR 2.10812
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.10812
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 19.4254
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 18.6904
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TYR, XDH 16.852
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.6515
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3256
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3, TNKS 9.4558
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.11442
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.62422
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.42621
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 8.2375
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP1 8.16318
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.13852
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 8.00268
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.60933
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.17521
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 7.12164
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TOP1 7.03192
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.97478
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 6.91721
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.85142
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 6.67291
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.47404
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.35874
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 6.09804
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.81948
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.80266
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.7849
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TOP1 5.73844
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 5.64487
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 5.28077
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 5.27971
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.17923
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.17061
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.80176
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1, XDH 4.63345
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.34908
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP1, XDH 4.3316
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK, TOP1 4.3316
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP1, XDH 4.06017
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.99795
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.96931
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TYR, XDH 3.88555
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.8204
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 3.78301
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.70693
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.68118
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.63385
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.63385
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, KIT, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2 3.4363
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.34497
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 3.29983
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29983
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.27968
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1894
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.18845
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.17774
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.16834
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.07843
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.00286
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 2.97927
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.87073
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85439
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85439
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85439
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85439
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.78081
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 2.68047
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.65088
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, SMAD3, TEK 2.63405
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.6329
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.62655
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.62001
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP1 2.61107
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.59236
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.33094
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TNKS, TNKS2, TOP1 2.32778
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24217
[MF] GO:0051425 None APP, INSR 2.24217
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, TOP1 2.12221
[MF] GO:0042803 protein homodimerization activity ACHE, AOX1, BCL2, FLT3, HMGCR, KIT, NQO2, PTGS2, SMAD3, TERT, TYR, XDH 2.1066
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.10391
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.1019
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05977
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05977
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.04924


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.5177
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.3329
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, KIT, BCL2, MET 7.5424
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.8665
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.2185
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.5683
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 7.0872
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.0877
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.6162
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.5021
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7508
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 5.668
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.4622
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 5.6144
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.3716
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.1452
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.5839
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 5.4473
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.3445
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.8019
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.7169
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.1431
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.5567
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4276
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.3242
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.3411
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.223
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.3072
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.1431
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.967
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.7701
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.8294
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.3731
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, PTGS2, PTGS1 3.329
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.2444
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2209
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 3.1749
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 3.0268
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.3897
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PIK3CB, EGFR 2.9393
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.9582
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.7802
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.7802
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.2512
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.6872
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 3.0478
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.8013
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2035
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6469
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1 3.1328
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6992
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4679
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.965
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9582
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.475
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.3984
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.3849
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1328
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9337
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3587
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3984
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3984
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.2353
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0684
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.9423
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1787
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8306
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6786
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6207
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8395
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3992
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2655
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2747
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2708
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.3875
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4208
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.7791
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.7488
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3143
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5777
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3722
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3536
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7247
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.2147
Axon guidance_Homo sapiens_hsa04360 MET 0.3684
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3762
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5498
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8306
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.8251
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1554
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6981
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.671
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.699
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4406
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8321
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8251
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8173
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4406
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8058
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4537
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4528
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1885
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4661
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9796
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4724
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9863
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4862
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0119
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4712
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0119
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0194
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0553
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR 2.1172
Peroxisome_Homo sapiens_hsa04146 XDH 0.4877
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.4319
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1642
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0724
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0856
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0856
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5123
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5261
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.524
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5387
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5411
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2147
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.2531
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1568
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5605
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2578
Shigellosis_Homo sapiens_hsa05131 SRC 0.5605
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.228
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.5109
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5605
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5817
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6119
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3536
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6381
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3627
Malaria_Homo sapiens_hsa05144 MET 0.6505
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6605
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6554
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6605
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6733
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.671
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5498
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7547
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5378
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8321
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8002
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8173
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8306
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8173
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7249
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8365
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7841
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7118
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8321
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0316
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9017
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9796
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0595
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2373
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3687


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)