TCM Prescription: Pill for Restoring Yang



Prescription Description
Prescription IDTCMF2582
Pinyin NameHuan Shao Dan
Chinese Name还少丹
English NamePill for Restoring Yang
Function Description腰痛, 阳痿, 遗精, 耳鸣, 眩晕
IndicationsInvoluntary ejaculation disorder, Impotence disorder, Lumbago disorder, Tinnitus disorder, Vertigo disorder
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
Human Tissues Associated with IndicationBrain, Kidney, Bladder
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH267 Fructus broussonetiae 楮实 TCMH267
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH237 Acorus calamus 菖蒲 TCMH237 ITSAI4402-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MTNR1B, PPARA, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 15.7289
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PTGES, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 12.7557
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGES, RORC, SLC6A3, SRC, TEK, TRPV1, TYR 12.74
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GRM1, GRM3, GRM5, GRM8, MTNR1A, MTNR1B 12.3407
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 11.7929
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PTGES, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 11.4473
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GRM1, GRM3, GRM5, GRM8 10.8172
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 10.2147
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FLT3, NR3C1, PTGES, RORC, SLC6A3, SRC, TEK, TRPV1, TYR 9.84247
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2 9.53267
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2 9.53267
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2 9.44163
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2 9.44163
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 9.43721
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, GRIK5, INSR, MAOA, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1 9.30499
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 8.61695
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.61695
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.582
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 8.52115
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 8.39801
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 8.38392
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 8.38392
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 8.38392
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.11748
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 8.06011
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH 8.06011
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 8.05796
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.97623
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, SMAD3, TRPV1 7.86787
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, SMAD3, SRC, TRPV1 7.73083
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2, TEK 7.64674
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, HMGCR, MAOA, SLC6A3, TYR 7.58786
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 7.4333
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 7.38534
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, FABP3, HMGCR, KDR, NR3C1, SLC6A2, SLC6A3, SRC, TRPV1 7.37551
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 7.3151
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, ESR1, GRM5 7.08742
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.08118
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.06055
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8 7.0507
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2, TEK, TRPV1 7.01091
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, RORC, SMAD3, SRC, TRPV1 7.00431
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, SLC6A2, TEK 6.97718
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.91109
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 6.86543
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGES, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, TYR 6.86543
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CDK6, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.85672
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 6.7401
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 6.68055
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CDK6, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, RORC, SMAD3, SRC, TRPV1 6.6616
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, DRD4, MAOA, SLC6A3 6.58082
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, DRD4, MAOA, SLC6A3 6.58082
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.51251
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 6.50588
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, MTNR1B 6.47782
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TRPV1, TYR 6.4409
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FUT7, HMGCR, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 6.4166
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGES, TBXAS1 6.31921
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.30873
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, HSPA1A, MAOA, SLC6A3 6.2982
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.24907
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, DRD4, MAOA, SLC6A3, TYR 6.22453
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.22191
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 6.22084
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 6.22084
[BP] GO:0042417 None DRD1, DRD2, DRD3, DRD4, MAOA, SLC6A3 6.21915
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, SLC6A3, SRC 6.20984
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.1507
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.1507
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.13966
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD4, DRD5, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.11488
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD4, DRD5, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 6.11488
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGES, RORC, SRC, TYR 6.08221
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, HMGCR, KDR, SLC6A3, SRC 6.07776
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TRPV1, TYR 6.00508
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.99182
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 5.94217
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.92536
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC 5.88031
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, DRD1, DRD5, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 5.81464
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.70793
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DRD5, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 5.70793
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, DRD4, MAOA, SLC6A3 5.68404
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.66228
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, MTNR1A, MTNR1B, SRC 5.64408
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.63368
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.47762
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.4714
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.4553
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.40813
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 5.38
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 5.38
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 5.3686
[BP] GO:0051940 None DRD1, DRD2, DRD3, DRD4 5.33225
[BP] GO:0051584 None DRD1, DRD2, DRD3, DRD4 5.33225
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 5.27436
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, SRC, TRPV1 5.26296
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.25295
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TRPV1 5.21748
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CDK6, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 5.21444
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.21344
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR, SRC, TEK 5.21344
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 5.12141
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.10634
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.096
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.0586
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 5.04638
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, SLC6A3, SMAD3, TEK 5.03758
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 5.03334
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 5.01335
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 4.98505
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.98243
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, MTNR1A 4.97023
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1 4.96919
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 4.92646
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, SLC6A3, SMAD3, TEK 4.89857
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.87305
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, SLC1A1, SMAD3, TRPV1 4.85454
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC, TEK 4.85131
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, HMGCR 4.8258
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD4, DRD5 4.82394
[BP] GO:0030335 positive regulation of cell migration ALOX12, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.82153
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 4.82153
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.79489
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, INSR, MTNR1A, PPARA 4.79489
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.75084
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, MTNR1A 4.74052
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, MTNR1A 4.71726
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 4.6956
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, INSR, MTNR1A, PPARA 4.69348
[BP] GO:0007610 None DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, GRM1, GRM5, HMGCR, INSR, MTNR1A, PPARA, SLC6A3, TRPV1 4.6827
[BP] GO:2000147 positive regulation of cell motility ALOX12, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.67287
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.62885
[BP] GO:0015872 None CHRM5, DRD1, SLC6A2, SLC6A3 4.60818
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.57466
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.56518
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 4.55643
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.54818
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.53696
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.51176
[BP] GO:0060134 None DRD1, DRD2, DRD3, SLC6A3 4.469
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8, MTNR1A 4.46022
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 4.43996
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.43756
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8 4.4117
[BP] GO:0040017 positive regulation of locomotion ALOX12, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.39594
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.38702
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 4.38627
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, NR3C1, SLC6A3 4.38586
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.34923
[BP] GO:0051580 None DRD1, DRD2, DRD3, DRD4 4.34923
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR, SRC, TEK 4.31996
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 4.30104
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.29107
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.29021
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC, TRPV1 4.27556
[BP] GO:0050890 None ADORA1, CHRM1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR 4.27543
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.27176
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.23746
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.23746
[BP] GO:0051937 None CHRM5, DRD1, SLC6A2, SLC6A3 4.23746
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.23066
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 4.22652
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, SLC6A3, TRPV1, TYR 4.22172
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.19806
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 4.17587
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, NR3C1, SRC, TRPV1 4.15909
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD4, DRD5 4.14359
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.13841
[BP] GO:0032225 None DRD1, DRD2, DRD3, DRD4 4.13841
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, SLC6A3, TYR 4.09414
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD4, DRD5 4.09179
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 4.0553
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.05395
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.05341
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, RORC 4.03687
[BP] GO:0003008 None ADORA1, AKR1B1, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, SLC6A3, SRC, TEK, TRPV1, TYR 4.02939
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.02735
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 4.00364
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD4, DRD5, GRM3, GRM8 3.99338
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 3.94513
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.9447
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1 3.92934
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 3.92934
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.91728
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 3.8992
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.8933
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, DRD4, EGFR 3.88639
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, PTGES 3.88295
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1, TRPV1 3.87819
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.86797
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 3.84819
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 3.83894
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 3.83714
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 3.83434
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 3.83434
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 3.83434
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.83126
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.82282
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.79629
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.79629
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.79629
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.79421
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.79246
[BP] GO:0048148 None DRD1, DRD2, DRD3, DRD4 3.79018
[BP] GO:0045761 None DRD2, DRD3, DRD4, DRD5, GRM3 3.78676
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD4, DRD5 3.78676
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES, SLC6A3 3.75742
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.75283
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.74496
[BP] GO:0042391 None ADORA1, DRD1, DRD4, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.73673
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, F10, F3, MET, SLC6A3, XDH 3.73673
[BP] GO:0015844 None CHRM5, DRD1, SLC6A2, SLC6A3 3.71478
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.7106
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.70581
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.69884
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 3.68906
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, HMGCR 3.66878
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.66757
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, DRD5, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 3.65647
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.63
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.63
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.63
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC 3.63
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.62196
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, MTNR1A, MTNR1B, PPARA, RORC 3.62134
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, GRM5, HMGCR, INSR 3.62134
[BP] GO:0060359 None DRD1, DRD2, DRD3, DRD4, DRD5, SLC6A3 3.61082
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.60747
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, TYR, XDH 3.6013
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.60129
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK 3.59348
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.58644
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.58644
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.5669
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.5669
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.54365
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51759
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.50112
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.46404
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.45957
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.41608
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC 3.36774
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.31856
[BP] GO:0055065 metal ion homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.28299
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 3.27375
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, HCAR2, INSR, SMAD3, SRC, TRPV1 3.27336
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.26727
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.23759
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.23156
[BP] GO:0031279 None DRD2, DRD3, DRD4, DRD5, GRM3 3.2116
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 3.19553
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.18207
[BP] GO:0051339 None DRD2, DRD3, DRD4, DRD5, GRM3 3.18207
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.16268
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.15022
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.13715
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.13715
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.13715
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13715
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5 3.1259
[BP] GO:0042220 None DRD2, DRD3, DRD5, SLC6A3 3.10621
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.10621
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGES, TBXAS1 3.09465
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.09465
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.09024
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, HMGCR, INSR 3.08194
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.05872
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.05872
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 3.05789
[BP] GO:0006875 cellular metal ion homeostasis DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 3.05369
[BP] GO:0019725 cellular homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3, TRPV1 3.05265
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.0459
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2D6, CYP3A4, MAOA, SLC6A3 3.04399
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.04399
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.03111
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.02577
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 3.00336
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, RORC, SRC 2.99529
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.99313
[BP] GO:0045936 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.97549
[BP] GO:0010563 None DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.97298
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 2.97298
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.97298
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.95866
[BP] GO:0007626 None DRD1, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.94447
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5, HMGCR 2.94447
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DRD4, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PTPN1, SRC 2.9328
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.92958
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, DRD2, DRD3, DRD4, EGFR, HCAR2, HMGCR, MTNR1B, PTPN1, SMAD3, SRC 2.92283
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.92283
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.92071
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, HSPA1A, MMP9, SLC1A1, SLC6A3, TRPV1, XDH 2.91707
[BP] GO:0046960 None DRD1, DRD5 2.91517
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.91517
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.91517
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.91517
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, DRD4, DRD5, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.91001
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.89397
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 2.89205
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.86379
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.85156
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 2.85156
[BP] GO:0032413 None DRD2, DRD3, DRD4, GPR35, MMP9 2.85156
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.83335
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8322
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.8322
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, DRD4 2.8292
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.8292
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, DRD5, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.81499
[BP] GO:0042060 None ALOX15, DRD5, EGFR, PPARA, SMAD3 2.80494
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, DRD4, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.78304
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, RORC, SRC 2.77441
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.77441
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, HMGCR, MTNR1B, SRC, TRPV1 2.77123
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.75836
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.75361
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 2.74434
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.74434
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74434
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.73433
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.72455
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, EGFR, HMGCR, KDR, SRC, TEK 2.7234
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.69837
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.69837
[BP] GO:0032410 None DRD2, DRD3, DRD4, GPR35, MMP9 2.66563
[BP] GO:1904063 None DRD2, DRD3, DRD4, GPR35, MMP9 2.66563
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, EGFR, HCAR2, HMGCR, MTNR1B, SRC 2.6374
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.62086
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, DRD4, GPR35, MMP9 2.5963
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57506
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.57506
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.57342
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR, SLC1A1 2.57342
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 2.55856
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.5494
[BP] GO:2001023 None DRD1, DRD2, DRD3, DRD4, MET 2.53135
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.51401
[BP] GO:0051588 None DRD1, DRD2, DRD3, DRD4, GRIK5 2.51119
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.51119
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.50647
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.50647
[BP] GO:0099566 None GRM1, GRM5 2.50647
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.50647
[BP] GO:0051944 None DRD2, DRD4 2.50647
[BP] GO:0060160 None DRD2, DRD3 2.50647
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50647
[BP] GO:0051586 None DRD2, DRD4 2.50647
[BP] GO:0015893 None CA2, CHRM5, DRD1, SLC1A1, SLC6A2, SLC6A3 2.50647
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.50647
[BP] GO:0043279 None DRD2, DRD3, DRD5, SLC6A3, TRPV1 2.50631
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.50304
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, SMAD3 2.49317
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC, TRPV1 2.48721
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, HMGCR, MTNR1B, SRC 2.47693
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.47521
[BP] GO:0008542 None DRD1, DRD2, DRD3, HMGCR 2.46905
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.46905
[BP] GO:0019226 None CHRM5, DRD1, DRD5 2.45155
[BP] GO:0034766 None DRD2, DRD3, DRD4, GPR35, MMP9 2.45067
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, DRD1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.44905
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.40518
[BP] GO:0042053 None DRD1, DRD4, SLC6A3 2.39161
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.39161
[BP] GO:0042069 None DRD1, DRD4, SLC6A3 2.39161
[BP] GO:0007617 None DRD1, DRD5, MTNR1A 2.39161
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.38106
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.34875
[BP] GO:0034763 None DRD2, DRD3, DRD4, GPR35, MMP9 2.33793
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, DRD4, EGFR, GRM1, INSR, PTPN1, SRC 2.33167
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.32803
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.32628
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.32628
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.32628
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.32628
[BP] GO:0007632 None DRD1, DRD2, DRD3, HMGCR 2.32628
[BP] GO:0015696 None CHRM5, DRD1, SLC6A2, SLC6A3 2.32628
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.32628
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, DRD3, DRD5, EGFR, GRM5, KDR 2.31561
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.30313
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.298
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.298
[BP] GO:0001952 regulation of cell-matrix adhesion CDK6, KDR, SMAD3, SRC, TEK 2.29081
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.27523
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.27523
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.27209
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.27209
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.26752
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, RORC, SRC 2.26453
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.26341
[BP] GO:0051582 None DRD2, DRD4 2.26341
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26341
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.2478
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.2478
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.24701
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.23052
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.22961
[BP] GO:0072347 None DRD2, DRD3, DRD5, SLC6A3 2.22961
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.22961
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.22961
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.22563
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.2135
[BP] GO:0050708 None ACHE, DRD2, DRD3, DRD4, EGFR, HCAR2, HMGCR, MTNR1B, SRC 2.20719
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.19339
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD4, DRD5, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, SLC6A2, SMAD3, SRC, TEK, TRPV1 2.19212
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGES, TBXAS1, TYR 2.19129
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.19033
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.18479
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.18479
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.18479
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18479
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.18342
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.1829
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.14244
[BP] GO:0045927 positive regulation of growth ALOX12, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.13613
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, MTNR1A, NR3C1, PPARA, RORC, SMAD3, SRC, TRPV1 2.13543
[BP] GO:0051894 None KDR, SMAD3, TEK 2.13403
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.13403
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.10884
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTGES 2.10853
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.10685
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, MTNR1A, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TRPV1, XDH 2.08521
[BP] GO:0050927 None F3, KDR, SMAD3 2.08486
[BP] GO:0040008 regulation of growth ALOX12, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A3, SMAD3 2.08347
[BP] GO:0043086 negative regulation of catalytic activity CSNK2A1, DRD2, DRD3, DRD4, DRD5, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PTPN1, SRC 2.08347
[BP] GO:0021853 None DRD1, DRD2 2.08347
[BP] GO:0046541 None CHRM1, CHRM3 2.08347
[BP] GO:0010641 None F3, SRC 2.08347
[BP] GO:0090325 None DRD2, DRD3 2.08347
[BP] GO:0007598 None F10, F3 2.08347
[BP] GO:1904936 None DRD1, DRD2 2.08347
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.08347
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.08347
[BP] GO:0042321 None ADORA1, DRD2 2.08347
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, MTNR1B 2.07415
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, DRD4, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.07183
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.06998
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.06998
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.06259
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.05522
[BP] GO:0050926 None F3, KDR, SMAD3 2.05522
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.05522
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.05522
[BP] GO:1903393 None KDR, SMAD3, TEK 2.05522
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.05303
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.05303
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, SRC, TEK 2.04814
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 2.04189
[BP] GO:0046942 None DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 2.02917
[BP] GO:0051223 None ACHE, CHRM1, DRD2, DRD3, DRD4, EGFR, HCAR2, HMGCR, MTNR1B, PTPN1, SMAD3, SRC 2.02524
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.01803
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.01167
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.00608
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 11.3406
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TRPV1 9.70941
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, SLC6A2, SLC6A3, TEK, TRPV1 9.47885
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TRPV1 9.44163
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 9.06887
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TEK, TRPV1, TYR 7.982
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR 7.96171
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC, TRPV1 6.27222
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TEK, TRPV1, TYR 5.95542
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 5.83303
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TEK, TRPV1, TYR 4.90712
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.23601
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD3, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 4.03687
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC, TEK 3.83894
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.61092
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.5669
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.5669
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 3.38671
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD5, GRIA2, GRIA4, GRIK5, GRM3, INSR, SRC, TRPV1 3.38671
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.18207
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 3.11886
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC, TRPV1 3.0364
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, MTNR1A, SMAD3 2.97298
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 2.85769
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, SLC6A2, SLC6A3, SRC, TRPV1 2.50749
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.45289
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGES, PTPN1, TBXAS1 2.4444
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, HMGCR, HSD11B1, HSD17B2, PTGES, TBXAS1 2.43503
[CC] GO:0031233 None CA4, F10, F3 2.32803
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.27209
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.09019
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.07183
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.04832
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 15.0085
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 13.8904
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, TEK, TRPV1 13.55
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 13.1397
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 12.9798
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 12.7391
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 12.2767
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 12.2767
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.811
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 11.66
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SLC6A3, SRC, TEK, TRPV1 10.2147
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TEK, TYR, XDH 8.52115
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD4, DRD5, SLC6A3 8.14511
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.89642
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 7.4333
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, ESR1, ESR2, F10, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TBXAS1, TRPV1, TYR, XDH 7.27198
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.26319
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, XDH 7.17653
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2, NR3C1 7.17266
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD4, DRD5, SLC6A3 7.01575
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.91016
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.67086
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD4, DRD5 6.4409
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3, DRD4, DRD5, SLC6A3 6.41574
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.3749
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.33007
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.30873
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.20585
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR 5.64408
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, MTNR1A, MTNR1B 5.64221
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, SMAD3 5.37222
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.07452
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC, TBXAS1 4.76159
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.71726
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC, TBXAS1 4.54624
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HMGCR, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 4.43996
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR 4.22172
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, F10, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TBXAS1, TRPV1, TYR, XDH 4.16496
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.94261
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.83714
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 3.75371
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 3.70041
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1, RORC 3.65393
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 3.62134
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.42685
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.34261
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, RORC 3.27375
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.26908
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.26908
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.15152
[MF] GO:0019902 phosphatase binding EGFR, HMGCR, MET, PPARA, PTPN1, SLC6A3, SMAD3 3.14528
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.05872
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 2.97298
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2 2.95478
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91517
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.91517
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.81371
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.70821
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SMAD3, SRC 2.64034
[MF] GO:0008502 None MTNR1A, MTNR1B 2.50647
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50647
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.50647
[MF] GO:0005330 None SLC6A2, SLC6A3 2.50647
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.50647
[MF] GO:0099583 None GRM1, GRM5 2.50647
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SLC6A3, SMAD3, SRC 2.47455
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.46905
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.44029
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.44029
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SLC1A1, SRC, TEK, TRPV1, XDH 2.40518
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.39161
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.39161
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.26341
[MF] GO:0001588 None DRD1, DRD5 2.26341
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26341
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.26341
[MF] GO:0004971 None GRIA2, GRIA4 2.26341
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.26341
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DRD5, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGES, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR, XDH 2.24701
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, SMAD3, TRPV1, TYR, XDH 2.24684
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.21813
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08347
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08347
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08347
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.07633
[MF] GO:0019903 protein phosphatase binding EGFR, HMGCR, MET, PTPN1, SLC6A3 2.07183
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.05522
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.05303
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.01467
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.01467
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.01467


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, MTNR1A, MTNR1B, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD4, DRD5, GRIA4 20.2328
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.6838
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5675
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.1523
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3787
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, DRD1, DRD2, DRD3, SLC6A3, DRD4, DRD5, GRIA4 6.8016
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 6.5086
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD1, DRD2, PPARA, DRD5, GRIA4 6.4145
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.1342
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, DRD1, GRM1, EGFR, DRD5 5.8069
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.2911
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2, SLC6A3 5.9066
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4703
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.9722
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.3725
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1, EGFR 4.5546
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9352
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.7799
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, DRD1, SLC6A3, GRIA4 3.997
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 4.14
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.346
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.5134
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.0601
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0363
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.6325
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, CYP2D6, ALOX5, ALOX15, ALOX12 3.0588
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.6519
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.7747
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.756
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.6328
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.8147
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8499
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, CYP3A4 2.8735
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.3603
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, GRIA4 2.4368
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8735
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.3603
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.1045
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.3397
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, MMP9 1.9112
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9801
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2, SLC6A3 1.6332
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.115
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9801
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0497
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6325
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6544
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 1.9796
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9796
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9112
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.5991
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9702
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 1.9801
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4955
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9606
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2252
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.275
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2, SLC6A3 1.2346
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.3735
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9165
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1901
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3735
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.1019
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1637
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2346
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2408
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2493
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2553
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2489
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2493
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2406
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.2724
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2791
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3174
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9059
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7809
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7916
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7916
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5284
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7841
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9614
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.9508
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7176
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7916
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5227
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7176
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7364
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.9923
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6801
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9278
Axon guidance_Homo sapiens_hsa04360 MET 0.3317
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7149
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6529
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3391
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7149
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9473
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9508
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.0705
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3732
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9165
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3893
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3963
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3963
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0654
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0297
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3963
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4084
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4127
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0252
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4219
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4231
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4219
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4219
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4222
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4219
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4219
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8499
Peroxisome_Homo sapiens_hsa04146 XDH 0.424
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4211
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1901
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4478
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2265
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.2346
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1509
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4795
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4815
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4946
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2108
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4992
Shigellosis_Homo sapiens_hsa05131 SRC 0.4969
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5077
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5424
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5605
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5643
Malaria_Homo sapiens_hsa05144 MET 0.5724
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5683
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3735
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5766
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.581
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4712
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.647
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6544
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6801
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6407
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.5618
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6225
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5452
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7506
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7153
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7575
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7176
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8652
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7506
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7815
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7943
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8969
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9508
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9606


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)