Prescription Description
| Prescription ID | TCMF2569 |
| Pinyin Name | Jia Jian Qing Hai Wan |
| Chinese Name | 加减清海丸 |
| English Name | Plus and Minus Sea Cleansing Bolus |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 | |
| TCMH1862 | Cornus officinalis | 山茱萸 | TCMH1862 | ITSAO2979-14 |
| TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
| TCMH541 | Colla corii asini | 阿胶 | TCMH541 | |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH147 | Glehnia littoralis | 北沙参 | TCMH147 | ITSAF389-14 |
| TCMH120 | Atractylodes macrocephala | 白术 | TCMH120 | ITSAN4430-14 |
| TCMH1797 | Morus alba | 桑叶 | TCMH1797 | ITSAL1073-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1933 | Herba dendrobii | 石斛 | TCMH1933 | |
| TCMH1321 | Os draconis | 龙骨 | TCMH1321 | |
| TCMH1525 | Crassostrea gigas | 牡蛎 | TCMH1525 | BCMOL364-12 |
| TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
| TCMH800 | Herba ecliptae prostratae | 旱莲草 | TCMH800 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT11 | HIF1A | Hypoxia-inducible factor 1 alpha | Transcription factor | Q16665 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
Showing 1 to 10 of 141 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
Showing 1 to 10 of 60 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000023 | None | GAA, MGAM | 2.51955 |
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 3.81861 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.88138 |
| [BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 2.98727 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A3 | 2.51352 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A3, SMAD3, TRPV1 | 8.03203 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.78135 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT | 6.08119 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 5.40974 |
| [BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TRPV1 | 4.2331 |
Showing 1 to 10 of 627 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6423 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.1615 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2523 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.4974 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.2768 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 4.2288 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2, SLC6A3 | 0.6194 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.5855 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6423 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 0.9416 |
Showing 1 to 10 of 178 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples