Prescription Description
| Prescription ID | TCMF2555 |
| Pinyin Name | Shu Gan San Jie Tang |
| Chinese Name | 疏肝散结汤 |
| English Name | Liver Soothing and Stagnation Desolving Decoction |
| Function Description | |
| Indications | None |
| Disease ICD-11 Category | |
| Human Tissues Associated with Indication | |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH228 | Bupleurum chinense | 柴胡 | TCMH228 | ITSAM2218-14 |
| TCMH1513 | Paeonia moutan | 牡丹皮 | TCMH1513 | |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH2161 | Vaccaria segetalis | 王不留行 | TCMH2161 | |
| TCMH2532 | Curcuma aromatica | 郁金 | TCMH2532 | ITSAF2298-14 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH1848 | Crataegus pinnatifida | 山楂 | TCMH1848 | ITSAH1684-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH188 | Mentha haplocalyx | 薄荷 | TCMH188 | HM595443 |
| TCMH1348 | Liquidambar formosana | 路路通 | TCMH1348 | ITSAM899-14 |
| TCMH1695 | Pericarpium citri reticulatae viride | 青皮 | TCMH1695 | |
| TCMH243 | Pericarpium citri reticulatae | 陈皮 | TCMH243 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 109 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
Showing 1 to 10 of 64 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC | 4.15298 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC | 3.30338 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT | 2.30254 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES | 3.43887 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH | 2.42219 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH | 2.94199 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC | 2.02293 |
| [BP] GO:0002320 | lymphoid progenitor cell differentiation | BCL2, FLT3, KIT | 2.94057 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC | 3.07582 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC | 2.80086 |
Showing 1 to 10 of 246 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.7077 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | MAP2K1, FLT3, KIT, PIM1, RELA | 4.4165 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, SRC, MAP3K7, MET, IGF1R | 4.0123 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA, RELA | 1.2498 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, CACNA1C | 0.8312 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3, RELA | 3.5442 |
| Alcoholism_Homo sapiens_hsa05034 | MAP2K1, MAOA | 0.7352 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | CACNA1C | 0.5271 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP, CACNA1C | 1.2747 |
| Amoebiasis_Homo sapiens_hsa05146 | RELA | 0.4936 |
Showing 1 to 10 of 173 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples