TCM Prescription: Qi and Liver Modulating Decoction



Prescription Description
Prescription IDTCMF2546
Pinyin NameYi Qi Tiao Jiang Ya Tang
Chinese Name益气调肝降脂汤
English NameQi and Liver Modulating Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH810 Paeonia albiflora 杭芍 TCMH810 MF096543
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH695 Uncaria rhynchophylla é’©è—¤ TCMH695 ITSAM939-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH2121 Semen astragali complanati 潼蒺藜 TCMH2121
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.7675
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.885
[BP] GO:0044281 small molecule metabolic process AKR1B1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, NISCH, PIK3CA, PPARA, PTGS1, PTGS2, XDH 10.0029
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, FABP3, FABP4, FDPS, FUT7, HSD17B1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.31455
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 8.09407
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FABP3, FABP4, FDPS, FUT7, HASPIN, HSD17B1, MAOA, MMP1, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, XDH 8.01715
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.97935
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.82229
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.76417
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALPL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FABP3, FABP4, FDPS, FUT7, HASPIN, HSD17B1, MAOA, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, XDH 6.70076
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FDPS, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.38448
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC 6.30014
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.65819
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.19262
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.12976
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.02473
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FDPS, HSD17B1 4.83571
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, NISCH 4.7932
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 4.78681
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, PTGS2, RORC 4.44861
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36173
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 4.26927
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F10, FABP3, FABP4, HCAR2, HSD17B1, MAOA, NISCH, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, XDH 4.22899
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, MMP2, PIK3CA, PPARA, PTGS2, RORC 4.19256
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 3.98988
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 3.94353
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MMP9, PTGS2 3.71711
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.6686
[BP] GO:0055114 oxidation-reduction process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, MAOA, NQO2, PTGS1, PTGS2, XDH 3.5579
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.55546
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.55546
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.54862
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 3.46564
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC 3.44356
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, PTGS2 3.43443
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 3.415
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD17B1 3.415
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, HCAR2, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 3.39774
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, PPARA, PTGS2 3.3047
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 3.3047
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, NISCH, PTGS2 3.28419
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, NISCH, PTGS2 3.28419
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, FDPS, MAOA 3.24884
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, MMP2, PPARA, PTGS2 3.21489
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14146
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN 3.14146
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOA 3.14146
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 3.14146
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, BCL2, CA3, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FDPS, HASPIN, PIK3CA, PIK3CB, PTGS2, XDH 3.1281
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, HCAR2, PIK3CB, PTGS2 3.0991
[BP] GO:0008217 None ADORA1, DRD2, NISCH, PPARA, PTGS1, PTGS2 3.02037
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, PTGS2, RORC 3.01186
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN 2.9913
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, PIK3CB, XDH 2.88986
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, BCL2, CA3, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FDPS, HASPIN, PIK3CA, PIK3CB, PTGS2, XDH 2.8786
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HCAR2, PIK3CB, PTGS2 2.84637
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 2.82239
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.81561
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.81561
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, HCAR2, PPARA, PTGS2, RORC 2.79554
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, MMP9, NISCH, PTGS2 2.7756
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2 2.7756
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, PIK3CA, PIK3CB 2.7343
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.73059
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2 2.71414
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.65189
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, F10, HCAR2, MMP9, NISCH, PIK3CA, PIK3CB, PTGS2, XDH 2.62793
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, MAOA 2.62013
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.60778
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.6033
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, MMP9, NISCH, PTGS2 2.57685
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, PPARA, RORC 2.57685
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD1, DRD2, MAOA 2.5754
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, F10, HCAR2, MMP9, NISCH, PIK3CA, PIK3CB, PTGS2, XDH 2.57481
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2 2.5583
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2 2.52578
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, NISCH, PPARA 2.49579
[BP] GO:0051271 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.48643
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 2.47991
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, PIK3CA 2.43841
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, F10, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.42399
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, PTGS2 2.38253
[BP] GO:0040013 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2, NISCH 2.37764
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2 2.36411
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.36254
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, MMP9, NISCH, PTGS2 2.31624
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, MMP9, NISCH, PTGS2 2.30666
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, PTGS2 2.28579
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, F10, FABP3, HCAR2, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, XDH 2.27973
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20871
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, MMP2, MMP9, PIK3CA, PTGS2, RORC 2.20488
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, ESR1, F10, FABP3, FABP4, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC 2.16616
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.16616
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16616
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK2, F10, HCAR2, MMP9, NISCH, PIK3CB, PPARA, PTGS2 2.14986
[BP] GO:0006979 response to oxidative stress AKR1B1, BCL2, CA3, CYP1B1, MMP9, PTGS1, PTGS2 2.14973
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MMP9, PTGS2 2.13626
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK3, ESR1, FABP4, FUT7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RORC 2.13626
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALPL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FABP3, FABP4, FDPS, FUT7, HASPIN, HCAR2, HSD17B1, MAOA, MMP1, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, XDH 2.13619
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.12416
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12416
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, PTGS2, RORC 2.10698
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.05447
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.03125
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, MMP9, PIK3CA, PPARA, PTGS2, RORC 2.0209
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, PIK3CA, PIK3CB 2.00795
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.00795
[BP] GO:0042417 None DRD1, DRD2, MAOA 2.00795
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, PTGS1, PTGS2 1.65177
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK2, DYRK3, ESR1, F10, FABP3, FABP4, FDPS, FUT7, HSD17B1, MAOA, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, XDH 1.48523
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, FABP3, FABP4, FDPS, FUT7, HASPIN, MAOA, MMP2, MMP9, NISCH, NQO2, PIK3CB, PPARA, PTGS1, PTGS2, RORC, XDH 1.32517
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, F10, PTGS1, PTGS2 1.22752
[CC] GO:0031233 None CA4, F10 1.01145
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 21.191
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.885
[MF] GO:0046914 transition metal ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, RORC, XDH 13.5747
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4663
[MF] GO:0043167 ion binding ACHE, ALPL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FABP3, FABP4, FDPS, HASPIN, HSD17B1, MMP1, MMP2, MMP9, NISCH, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, XDH 12.391
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALPL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FDPS, FUT7, HASPIN, HSD17B1, MAOA, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, XDH 9.0577
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.33498
[MF] GO:0043169 cation binding ACHE, ALPL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DRD2, DYRK2, DYRK3, ESR1, F10, FDPS, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, RORC, XDH 8.01715
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, RORC 7.40825
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.01905
[MF] GO:0046872 metal ion binding ALPL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, F10, FDPS, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, RORC, XDH 6.12623
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.72881
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.50409
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.47499
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.15324
[MF] GO:0016491 oxidoreductase activity AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, MAOA, NQO2, PTGS1, PTGS2, XDH 4.43998
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.43083
[MF] GO:0008144 drug binding ACHE, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, NQO2, PIK3CA, PIK3CB, PPARA 4.41372
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 4.26927
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.14686
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.96336
[MF] GO:0005506 iron ion binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 3.92404
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.14499
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.7343
[MF] GO:0008389 None CYP2A13, CYP2A6 2.7343
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.58218
[MF] GO:0004674 protein serine/threonine kinase activity CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIK3CA 2.2463


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.5779
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.2596
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 5.2185
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.4256
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA 4.7251
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9698
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5921
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 4.0338
Metabolic pathways_Homo sapiens_hsa01100 FDPS, MAOA, AKR1B1, PTGS2, CYP19A1, PTGS1, CYP2A6, FUT7, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.7055
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.2198
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.7055
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.1071
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB 2.8716
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1071
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4283
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.8105
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.8105
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8105
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2185
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.73
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.4552
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8274
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.4552
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.3017
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.267
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4552
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.7082
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1 2.3215
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.0671
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.419
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 2.3595
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.1136
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.9714
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.914
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0722
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, PTGS2, PTGS1 1.8928
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.8517
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.8517
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.833
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8422
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2 1.786
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.719
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 1.719
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7421
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7592
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6796
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6895
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.6501
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.6501
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.5604
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.5484
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.4865
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, PIK3CB, DRD2 1.4483
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 1.2907
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5604
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6501
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6008
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, PIK3CB 1.3128
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.5296
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.5936
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.3706
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.3128
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3335
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.5339
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.3303
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5296
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3454
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5239
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.786
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, BCL2, PIK3CB 1.0567
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4903
Purine metabolism_Homo sapiens_hsa00230 XDH 0.416
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4254
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.0933
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.299
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4097
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.416
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.416
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.127
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.416
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3128
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4903
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.5296
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.1663
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.1258
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1188
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.5009
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3019
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.5296
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.5296
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.1008
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2805
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 1.0933
Gap junction_Homo sapiens_hsa04540 DRD1, DRD2 1.3669
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.087
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2907
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5009
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2907
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4881
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4835
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.857
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.4483
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.8841
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, PIK3CB 0.8225
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6895
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7176
Arachidonic acid metabolism_Homo sapiens_hsa00590 PTGS2, PTGS1 1.5484
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.9359
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6031
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.708
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.6031
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6169
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6162
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.63
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6312
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6321
Peroxisome_Homo sapiens_hsa04146 XDH 0.6558
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6718
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.694
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.694
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.694
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7022
Bile secretion_Homo sapiens_hsa04976 CA2 0.7001
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1136
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7307
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.7282
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7597
Legionellosis_Homo sapiens_hsa05134 CLK1 0.7844
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.8114
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.8156
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8336
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8884
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9838
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9743
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.9355
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.965
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9281
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9897
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0273
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9838
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0157
Histidine metabolism_Homo sapiens_hsa00340 MAOA 1.0567
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 1.0848
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.1578
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2308


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)