TCM Prescription: JY Roundworm Decoction



Prescription Description
Prescription IDTCMF2459
Pinyin NameDan Yi Tang
Chinese Name
English NameJY Roundworm Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1106 Fructus meliae toosendan 金铃子 TCMH1106
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1211 Melia azedarach 苦楝皮 TCMH1211 ITSAN2144-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1938 Quisqualis indica 使君子 TCMH1938 GENG1719-16
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1198 Serratia marcescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5839
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5839
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 13.4711
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCA, PTGS2, RORC, SRC, TOP1, TYR 10.9221
[BP] GO:0007187 None CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 9.15057
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 9.14627
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 8.96009
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 8.91716
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCA, PTGS2, RORC, SRC, TYR 8.44632
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.28158
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.25395
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, SRC, TOP1 7.94401
[BP] GO:0007193 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.69937
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 7.39252
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 7.35338
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP1, TYR 7.22233
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.84912
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.83108
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA 6.83108
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.79448
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.59841
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.55557
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5477
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 6.51349
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 6.44917
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 6.41751
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.41751
[BP] GO:0007188 None CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.41751
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.35618
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 6.25678
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.19864
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.14636
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 6.11346
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2 6.0255
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.95919
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.91444
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.91444
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.80368
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, XDH 5.78107
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.72744
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.63419
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.58908
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.57021
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, POLA1, SRC, TYR 5.5589
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, SRC 5.52429
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, SRC 5.52429
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 5.51987
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 5.51987
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.36699
[BP] GO:0003018 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.36699
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.26763
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC 5.26294
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.22361
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 5.16117
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 5.11096
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 5.11096
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.10043
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.10043
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.08699
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2 5.05444
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 5.05444
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.03607
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.01841
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.01841
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 5.01841
[BP] GO:0097746 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.00221
[BP] GO:0035296 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.00221
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.9462
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.91759
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.85453
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 4.82404
[BP] GO:0050880 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.8159
[BP] GO:0035150 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.79452
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SRC 4.76871
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.75477
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.6791
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 4.62496
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.49455
[BP] GO:0003013 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.48397
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.44053
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.43345
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.42284
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.32912
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31065
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, PTPRS, SRC, TYR 4.31065
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC 4.31065
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC 4.29609
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.25543
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.16891
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 4.1097
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.09322
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 4.08736
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.05974
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.04865
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.96305
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.96305
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.82559
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS 3.78808
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC, TNKS, TOP1 3.71722
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.679
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.66321
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 3.66317
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 3.6081
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 3.54628
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.5418
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 3.52619
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.49289
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.49289
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.48991
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.47274
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.47274
[BP] GO:0007154 None AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.45976
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.45134
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, PPARA, RORC, SRC, TOP1 3.43461
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42593
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, F10, HTR1D, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.34367
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.33033
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.31073
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, XDH 3.28053
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TNKS, TOP1 3.273
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 3.24286
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.16087
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 3.15565
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 3.07833
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.07612
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.07612
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.07612
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.07612
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.0181
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.012
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.012
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCA, PTPN1, SRC, XDH 3.012
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.9838
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.96209
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 2.95424
[BP] GO:0007267 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.93226
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.89219
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.85143
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.81474
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.79876
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.79876
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, POLB, PPARA, PTGS2, SRC, TYR 2.79876
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.75229
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.74159
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.73417
[BP] GO:0007208 None HTR2A, HTR2C 2.73417
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC 2.72294
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, HTR2A, HTR2B, HTR2C, KDR, PRKCA, PTPN1, SRC 2.71835
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.692
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.69167
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SRC 2.67216
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 2.66678
[BP] GO:0090066 None ALOX15, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.64812
[BP] GO:1903530 regulation of secretion by cell ACHE, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, SRC 2.62054
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.60439
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.56976
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH 2.55637
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC 2.55616
[BP] GO:0023052 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.53212
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 2.52939
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.50963
[BP] GO:0031401 positive regulation of protein modification process ALOX15, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.50963
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.50963
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.46967
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 2.46967
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 2.46967
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.45355
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.45355
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.45355
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.45355
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.45318
[BP] GO:0043408 regulation of MAPK cascade ALOX15, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PRKCA, PTPN1, SRC, XDH 2.44202
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.42352
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 2.42187
[BP] GO:0043269 regulation of ion transport ABCB1, BCL2, CA2, CA7, CHRM1, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.41959
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1A1, CYP1A2, ESR1, F10, FLT3, FUT7, HTR1A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.41769
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 2.41464
[BP] GO:0003008 None AKR1B1, BCL2, CHRM1, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 2.38766
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.38734
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.37389
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.37312
[BP] GO:0051046 None ACHE, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, SRC 2.36796
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PTGS2 2.36121
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.35265
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34812
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.33591
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 2.333
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HCAR2, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 2.33214
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TNKS, TOP1 2.27163
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.26594
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, SRC, TNKS, TOP1 2.26594
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.23316
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.20485
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.20029
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 2.1858
[BP] GO:0030334 regulation of cell migration ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.1858
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.17613
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.16296
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.15458
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.15458
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.15458
[BP] GO:0080134 regulation of response to stress ABCB1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.15458
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.15458
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.15458
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.15284
[BP] GO:0030335 positive regulation of cell migration BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.15215
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PRKCA, PTGS2, PTPRS 2.14725
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, XDH 2.14619
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.1396
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.13489
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC 2.1327
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.13188
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, HCAR2, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1 2.13178
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.1191
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.11521
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.11521
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.11521
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.11521
[BP] GO:0070213 None TNKS, TNKS2 2.11521
[BP] GO:0038171 None CNR1, CNR2 2.11521
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11521
[BP] GO:0014827 None HTR1D, HTR2B 2.11521
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.11309
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.10567
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.10567
[BP] GO:0009892 negative regulation of metabolic process AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, HCAR2, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.09255
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, HCAR2, HTR2B, MET, PIK3CA, PPARA 2.09255
[BP] GO:0046883 regulation of hormone secretion CNR1, CYP19A1, HCAR2, HTR1A, HTR2A, HTR2C, PRKCA 2.09255
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.08888
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.08888
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.08743
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.08511
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.08511
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.08511
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.08511
[BP] GO:2000147 positive regulation of cell motility BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.08511
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, SRC, TNKS, TOP1 2.08283
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.06783
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SRC 2.06565
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.06138
[BP] GO:0090087 None ACHE, CA2, CHRM1, CNR1, HCAR2, HTR2B, HTR2C, MMP12, PRKCA, PTGS2, PTPN1, SRC 2.05427
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.03933
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.03933
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.02901
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.02547
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F10, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.00946
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.00946
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.00488
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 6.5477
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TYR 6.23068
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, F10, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, PTPRS, SRC 6.00563
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 5.64488
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, PTPRS, SRC 5.13914
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TYR 5.03607
[CC] GO:0043005 None CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 2.11521
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, F10, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS, TBXAS1, TYR 2.08602
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.01757
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 19.5919
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0186
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5839
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5839
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.475
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.475
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.4711
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 13.0111
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 10.8732
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.751
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 9.87568
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.86566
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.2714
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 8.38643
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 7.75987
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.17364
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC, TOP1 7.15684
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 6.74698
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 6.51349
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.44917
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.44917
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.43174
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC 6.0255
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.00563
[MF] GO:0004930 None ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.43106
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PTPN1, RORC, TNKS 5.12829
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.90745
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 4.75527
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.73534
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.69009
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.3312
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.2504
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.99521
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.96305
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.82559
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48406
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.42593
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.39184
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.29392
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23618
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.1309
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.11779
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.88934
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC, TOP1 2.76792
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, SRC, TOP1 2.76269
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.73417
[MF] GO:0003845 None HSD11B1, HSD11B2 2.73417
[MF] GO:0071886 None HTR2A, HTR2C 2.73417
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.692
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1 2.69167
[MF] GO:1901363 heterocyclic compound binding ABCB1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP1, TUBB3, XDH 2.50036
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.4594
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1 2.36121
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.34812
[MF] GO:0004949 None CNR1, CNR2 2.34812
[MF] GO:0097159 organic cyclic compound binding ABCB1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP1, TUBB3, XDH 2.33265
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.33265
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.15458
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.10302


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.9927
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, HTR1E, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 13.2255
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.1292
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 9.1292
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8871
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.6876
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4 7.214
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 6.769
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PRKCA, PIK3CB 6.5751
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PRKCA, PIK3CB, HTR2A 5.6704
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 5.626
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.4492
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PRKCA, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.2561
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 5.4492
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 5.6209
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 4.8716
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PRKCA, PIK3CB, MET, IGF1R 4.7535
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB 4.6236
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, PRKCA, HTR2A 4.8716
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 4.6368
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 4.2013
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.0178
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.6368
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PRKCA, PIK3CB, MET, IGF1R 3.7036
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PRKCA, PIK3CB, MMP9 3.8097
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1119
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1231
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PRKCA, PIK3CB, IGF1R 3.4951
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.2561
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.2135
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.2561
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PRKCA, PIK3CB 3.2346
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 3.0682
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3719
Glioma_Homo sapiens_hsa05214 PIK3CA, PRKCA, PIK3CB, IGF1R 3.2133
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8821
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PRKCA, PIK3CB 3.9531
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2 2.8202
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.174
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1101
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.0973
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.8904
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB 2.8318
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.8128
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6722
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.8413
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9838
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1472
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5013
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5077
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3964
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.997
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.0915
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8187
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.8187
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.7135
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.7031
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 1.8179
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.1448
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8156
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.7622
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.7742
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.2701
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8179
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.7622
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2051
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.582
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1744
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PRKCA, PTGS2 1.7622
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5493
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2369
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4951
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PRKCA, PIK3CB 2.3486
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.446
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4796
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.4831
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4951
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4664
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4669
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2797
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3041
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.4669
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.4549
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.446
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3302
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4041
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.5065
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3928
Axon guidance_Homo sapiens_hsa04360 MET 0.3874
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3928
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.3849
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8962
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.3138
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6951
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB 0.919
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.3983
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4131
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCA, PIK3CB 1.2793
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6908
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.821
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4388
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4496
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.863
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2234
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4686
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4686
Morphine addiction_Homo sapiens_hsa05032 PRKCA 0.4783
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4795
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4807
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.4807
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0149
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4807
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.4887
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0255
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.0477
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0255
Peroxisome_Homo sapiens_hsa04146 XDH 0.4943
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5003
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5065
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.075
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5299
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5394
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5372
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1343
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5524
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5418
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.5498
Shigellosis_Homo sapiens_hsa05131 SRC 0.555
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.555
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.269
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.269
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.2623
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2793
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2793
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3198
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7345
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3045
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3276
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.3876
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6423
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6423
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4669
Malaria_Homo sapiens_hsa05144 MET 0.6515
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3967
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3, PRKCA 1.4447
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.497
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.5091
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5396
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6731
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6874
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7657
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8156
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7657
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8047
DNA replication_Homo sapiens_hsa03030 POLA1 0.7577
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8187
Base excision repair_Homo sapiens_hsa03410 POLB 0.7825
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7734
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7036
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8623
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8145
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.997
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8505
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0868
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.167


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)