TCM Prescription: Diabetes Relieving Decorction



Prescription Description
Prescription IDTCMF2369
Pinyin NameJiang Tang Yin
Chinese Name姜糖饮
English NameDiabetes Relieving Decorction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH923 Radix trichosanthis 花粉 TCMH923
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1806 Radix glehniae 沙参 TCMH1806
TCMH800 Herba ecliptae prostratae 旱莲草 TCMH800
TCMH2553 Scrophularia ningpoensis 元参 TCMH2553 ITSAO4295-14
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH2241 Panax quinquefolium 西洋参 TCMH2241 KY120319
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 12.8376
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, KDR, MET, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 11.4756
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 9.6596
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 9.01853
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, HSD11B1, HSD17B1, MET, PPARA, TRPV1 8.28903
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 8.28612
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 8.28612
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 8.2
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 8.2
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 7.63146
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PPARA, SLC6A3, SRC, TRPV1 7.44849
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.33316
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.33316
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, FABP3, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PPARA, SLC6A3, SRC, TRPV1 7.17304
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.14543
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.14543
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, SLC6A2, SLC6A3, SRC, TRPV1 7.0443
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 6.76568
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.66256
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 6.50147
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 6.34942
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1 6.28804
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 6.28708
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.24331
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.24331
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 6.23281
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM1, GRM5, GRM8, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SRC, TRPV1 5.88239
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 5.79006
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, NR3C1, SLC6A3, SRC, TRPV1 5.7814
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, KDR, NR3C1, SLC6A2, SLC6A3, SRC, TRPV1 5.71711
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.68106
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3, TRPV1 5.67015
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TRPV1 5.66163
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A3, SRC, TRPV1, XDH 5.43433
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.43433
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TRPV1 5.2956
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, PIM1, PPARA, XDH 5.17275
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 5.1551
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA 5.12311
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.10542
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, MET, PPARA 5.10229
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.10229
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 5.08514
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, SLC6A3, SRC 4.95743
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, SLC6A3 4.8368
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, KDR, MET, MMP9, SRC, XDH 4.79829
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, KDR, MET, MMP9, SRC, XDH 4.77877
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, SLC6A3 4.75664
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1 4.75497
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.666
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.65636
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, SRC, TRPV1 4.6483
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.62984
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1 4.59899
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 4.54174
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 4.48364
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1, TRPV1 4.4832
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.45778
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, SRC, TRPV1 4.34213
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.32189
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.32189
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.30103
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 4.28363
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC, TRPV1 4.27676
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 4.22719
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM5 4.22678
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 4.20962
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TRPV1 4.17073
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 4.12707
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HCAR2, HSD11B1, HSD17B1 4.10119
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 4.09687
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 4.09687
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 4.05772
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, XDH 4.05772
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TRPV1 4.05772
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, SRC, TRPV1, XDH 4.05623
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.05623
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, SLC1A1, SLC6A3, TRPV1, XDH 4.05623
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1, TRPV1 4.05474
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.04137
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.00257
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, SRC, TRPV1 3.96852
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.93473
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, SRC, XDH 3.92716
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.92716
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.92716
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 3.92716
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, SRC, XDH 3.92716
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, SRC, XDH 3.89195
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, SRC, XDH 3.8364
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 3.78702
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, SRC, TRPV1 3.78702
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TRPV1 3.75919
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.70743
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 3.6937
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.68409
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.68053
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 3.65656
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.64001
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.64001
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.63493
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.63134
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, SRC 3.62664
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD2, MET, TRPV1 3.61229
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD2, DRD3, HCAR2, KDR, SRC, TRPV1 3.59222
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA 3.56337
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.56337
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.55809
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, SRC, TRPV1, XDH 3.54898
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.50363
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.49241
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.44254
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, IGF1R, KDR, MET, MMP9, SRC 3.44254
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.43756
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.43756
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, SLC6A2, SLC6A3, SRC, TRPV1 3.3869
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.37789
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.37789
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.37789
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.34924
[BP] GO:0042391 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.3467
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, MET, SLC6A3, XDH 3.3467
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3, TRPV1 3.33362
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.28574
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 3.26468
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.26468
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 3.25652
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 3.17807
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 3.15662
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.15662
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 3.15662
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, IGF1R, KDR, MET, MMP9, SRC, XDH 3.15333
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TRPV1 3.13921
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 3.11017
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1 3.10548
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, DRD4, FLT3, GRM1, KDR, MET, SRC, XDH 3.08134
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 3.06158
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, MMP9, PPARA, SRC, TRPV1 3.04246
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 3.03411
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.00082
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.00082
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.00082
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.97484
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, KDR, MET, MMP9, SRC, XDH 2.95843
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, SLC6A3 2.946
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.92969
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, NR3C1, SRC 2.91364
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC 2.89713
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, HCAR2, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TRPV1 2.89713
[BP] GO:0051937 None CHRM5, SLC6A2, SLC6A3 2.89326
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.87529
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA 2.87529
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, HSD11B1, KDR, MMP9, PIM1, PPARA, SLC6A3, SRC 2.84024
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CHRM1, CSNK2A1, DRD2, DRD3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 2.83334
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.81991
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.81991
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, SRC, TRPV1 2.75862
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.74236
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, PPARA 2.73574
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.73574
[BP] GO:0046942 None DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 2.73574
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.72727
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.6994
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.68738
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, SRC, TRPV1 2.67763
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.67763
[BP] GO:0015849 None DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, TRPV1 2.66709
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.65911
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.65911
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD2, DRD3, PPARA, SLC6A3 2.65256
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, GRM1, HCAR2, KDR, MET, MMP9, PIM1, SLC1A1, SLC6A3, SRC, TRPV1, XDH 2.64363
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC, TRPV1 2.62994
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.62994
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, FLT3, GRM1, KDR, SRC, XDH 2.62905
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.62905
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, PPARA, SRC 2.62357
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, SLC6A3 2.62357
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, SLC1A1 2.62357
[BP] GO:0099566 None GRM1, GRM5 2.62357
[BP] GO:0051944 None DRD2, DRD4 2.62357
[BP] GO:0060160 None DRD2, DRD3 2.62357
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62357
[BP] GO:0051586 None DRD2, DRD4 2.62357
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, FLT3, HSD11B1, KDR, MET, MMP2, MMP9, PIM1, PPARA, SLC6A3, SRC 2.60243
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.60243
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, PIM1, SRC 2.59623
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.58998
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.58998
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.55731
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD2, DRD3, DRD4, HCAR2, SRC, TRPV1 2.55096
[BP] GO:0015844 None CHRM5, SLC6A2, SLC6A3 2.53532
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.53532
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, DRD4 2.53221
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, GRM1, GRM5, TRPV1 2.53063
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.51646
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.49348
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.49165
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TRPV1, XDH 2.45741
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.45741
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.43009
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.43009
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.43009
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43009
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, MET, SRC, XDH 2.42996
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.42596
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.42596
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.42237
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD2, DRD3, GRM1, MMP2, PPARA, SRC, TRPV1 2.41226
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.40937
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.38666
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.38666
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.38411
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.38411
[BP] GO:0051582 None DRD2, DRD4 2.38411
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.38411
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC 2.37996
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA 2.36317
[BP] GO:0007589 None CHRM1, CHRM3, SLC6A3, XDH 2.32427
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, DRD4, FLT3, GRM1, IGF1R, KDR, SRC, XDH 2.31964
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 2.30858
[BP] GO:0003008 None ADORA1, AKR1B1, CHRM1, CHRM3, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, SLC6A3, SRC, TRPV1 2.30858
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30858
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.30858
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.30858
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.30858
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, FLT3, GRM1, KDR, MET, MMP2, MMP9, SRC, XDH 2.30814
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2 2.30814
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.29171
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, DRD4, MMP9 2.28028
[BP] GO:0030799 None DRD2, DRD3, DRD4, GRM3, GRM8 2.26939
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, SRC, TRPV1 2.26234
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, XDH 2.24892
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, XDH 2.24468
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, SLC6A3, TRPV1 2.24433
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, SRC 2.24134
[BP] GO:1900542 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.2412
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, GRM3, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, SLC6A3, SRC, TRPV1, XDH 2.2412
[BP] GO:0032413 None DRD2, DRD3, DRD4, MMP9 2.2412
[BP] GO:0009410 None DRD2, DRD3, DRD4, NR3C1, SLC6A3 2.22746
[BP] GO:0051952 None ADORA1, DRD2, DRD3, DRD4 2.22267
[BP] GO:0046541 None CHRM1, CHRM3 2.21638
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.21638
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.21638
[BP] GO:0042321 None ADORA1, DRD2 2.21638
[BP] GO:0090325 None DRD2, DRD3 2.21638
[BP] GO:0015893 None CA2, CHRM5, SLC1A1, SLC6A2, SLC6A3 2.21121
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.21121
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.20354
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.20354
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 2.19546
[BP] GO:0006140 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 2.1941
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CHRM1, DRD2, DRD3, DRD4, GRM5, MMP9 2.19085
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, FLT3, NR3C1, SRC, TRPV1 2.18381
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.12802
[BP] GO:0045744 None DRD2, DRD3, MET 2.12802
[BP] GO:0001659 None ADORA1, DRD2, TRPV1 2.12802
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.12802
[BP] GO:0010039 response to iron ion CYP1A1, DRD2, SLC6A3 2.12802
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.12075
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, SRC, XDH 2.11196
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, SRC, XDH 2.11196
[BP] GO:0032410 None DRD2, DRD3, DRD4, MMP9 2.10519
[BP] GO:1904063 None DRD2, DRD3, DRD4, MMP9 2.10519
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.09477
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD2, DRD3, FABP4, KDR, MET, PPARA, SLC6A3 2.08044
[BP] GO:0032415 None DRD3, DRD4 2.08044
[BP] GO:0051934 None SLC6A2, SLC6A3 2.08044
[BP] GO:0021984 None DRD2, SLC6A3 2.08044
[BP] GO:0090494 None SLC6A2, SLC6A3 2.08044
[BP] GO:0090493 None SLC6A2, SLC6A3 2.08044
[BP] GO:0051583 None SLC6A2, SLC6A3 2.08044
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.08044
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.08044
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, SRC, XDH 2.0778
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA 2.07096
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.07096
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.06615
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.06069
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD2, DRD3, DRD4, GRM1, GRM5, TRPV1 2.05122
[BP] GO:0060359 None DRD2, DRD3, DRD4, SLC6A3 2.03158
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.0167
[BP] GO:2001023 None DRD2, DRD3, DRD4, MET 2.01491
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA 2.01389
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM5, TRPV1 2.00288
[BP] GO:0051588 None DRD2, DRD3, DRD4, GRIK5 2.00072
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.00041
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC, TRPV1 8.499
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 8.36281
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 8.33918
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 8.19039
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 8.02314
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 7.66183
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 7.33316
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, IGF1R, KDR, MET, MMP2, PIM1, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 5.98532
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 5.32698
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 5.24348
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1 5.09488
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 4.40542
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 4.40542
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.94548
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC, TRPV1 3.90369
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 3.88755
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.68409
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.63556
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 3.3789
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC, TRPV1 3.3789
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 3.08096
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.83502
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.63783
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.57329
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.5431
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.32427
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1 2.28028
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TRPV1 2.2331
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.05275
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 11.3433
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1756
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 9.5472
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, XDH 9.01853
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 8.69618
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 8.69618
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 8.62434
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.52538
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 8.42372
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 8.02314
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TRPV1, XDH 7.44771
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, XDH 7.34257
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC, TRPV1 7.22533
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 7.04723
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71859
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.66256
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.86305
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD2, DRD3, DRD4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1, XDH 5.74768
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.54466
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, XDH 4.96277
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FLT3, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, SRC, XDH 4.8368
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.78967
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 4.59899
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 4.48364
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, SRC 4.30103
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.27676
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.24622
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 4.17277
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 4.11343
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 4.05623
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.84016
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.68409
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.64001
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.63653
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.53516
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.50363
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP3A4 3.34924
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, SLC6A2, SLC6A3, TRPV1, XDH 3.34924
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.26468
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.17755
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.15662
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 3.13153
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 3.0388
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.00082
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.83492
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 2.78445
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.71387
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.62905
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.62905
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.62357
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.62357
[MF] GO:0005330 None SLC6A2, SLC6A3 2.62357
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.62357
[MF] GO:0099583 None GRM1, GRM5 2.62357
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA 2.54194
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.42596
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.38411
[MF] GO:0004971 None GRIA2, GRIA4 2.38411
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.38411
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD17B1, XDH 2.33366
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.30858
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.26939
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.26939
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.2412
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.21638
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.09477
[MF] GO:0005329 None SLC6A2, SLC6A3 2.08044
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08044
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.00288
[MF] GO:0003676 nucleic acid binding NR3C1, PPARA 2.1553


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 16.8722
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.757
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.2883
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.7852
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.2883
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.8545
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0086
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 5.6832
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.5351
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, CYP2A6, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.8844
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.8496
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.7794
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.6133
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1248
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.8844
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.5933
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.5369
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.361
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.934
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.458
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 3.1092
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.934
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.7203
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.7082
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.3717
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.4309
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4888
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 1.9582
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.3919
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1413
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9935
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.3971
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.934
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.9935
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.3717
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.7815
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.66
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.8529
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.4713
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2914
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1697
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1127
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0393
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1697
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.352
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4199
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.2302
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3064
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4713
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3315
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1461
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4664
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.349
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8844
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2721
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.9348
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8986
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0069
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.1454
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3315
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0129
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.908
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8035
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.7652
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3369
Purine metabolism_Homo sapiens_hsa00230 XDH 0.363
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3357
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3478
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3543
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.506
Tuberculosis_Homo sapiens_hsa05152 SRC 0.363
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3953
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4032
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3543
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4206
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4278
Platelet activation_Homo sapiens_hsa04611 SRC 0.4486
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3953
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4206
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.506
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4712
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4712
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.506
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4317
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4965
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4486
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4541
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.506
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4486
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4868
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.506
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4896
Axon guidance_Homo sapiens_hsa04360 MET 0.4441
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4541
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5036
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.506
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.506
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.506
Peroxisome_Homo sapiens_hsa04146 XDH 0.506
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.506
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5036
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5036
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5414
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.506
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5653
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.547
Glioma_Homo sapiens_hsa05214 IGF1R 0.5653
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5646
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7228
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5653
Shigellosis_Homo sapiens_hsa05131 SRC 0.5653
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.581
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6334
Malaria_Homo sapiens_hsa05144 MET 0.6436
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8139
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4639
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7635
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.141
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7997
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8514
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0731


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)