TCM Prescription: Headach Syrup



Prescription Description
Prescription IDTCMF2348
Pinyin NameTou Tong Ting Tang Jiang
Chinese Name头痛定糖浆
English NameHeadach Syrup
Function Description头痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBrain
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1036 Spatholobus suberectus 鸡血藤 TCMH1036 ITSAK2607-14
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH320 Tribulus terrestris 刺蒺藜 TCMH320 ITSAJ4258-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.0653
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0638
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1166
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FUT7, GLO1, NISCH, PIM1, PPARA, TYR, XDH 9.58791
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 8.837
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 8.78602
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 8.56924
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.39345
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.99549
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 6.71436
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.69447
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.6302
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, HSD17B1, HSD17B2 6.40092
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.40092
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 6.34603
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 6.31922
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KCNH2, KDR, MAOA, MET, NISCH, PPARA, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.14563
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TNKS2, TOP2A, TYR 6.04776
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 5.88697
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.87626
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, PPARA 5.84854
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 5.81462
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, F10, FLT3, HASPIN, IGF1R, KDR, MET, SRC, TNKS, TOP2A 5.74135
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 5.67278
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.67278
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SLC6A4, SRC, TYR 5.4582
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 5.37264
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.35989
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.35936
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRB1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.3342
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TYR 5.3342
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 5.114
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.04529
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A4, SRC, TYR 5.02234
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, RORC 4.97862
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC, TERT 4.97023
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.94177
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.94177
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.89704
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 4.85632
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 4.84404
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 4.79147
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC, TERT 4.78293
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.73209
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.7253
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 4.69472
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PHF8, PPARA, SRC, TYR 4.62464
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2 4.56653
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, PPARA, SLC6A4, SRC 4.54737
[BP] GO:0032787 None ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GLO1, PPARA 4.53543
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC 4.47403
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, ERBB2, F10, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SRC, TERT 4.39677
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 4.39476
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC, TERT 4.37919
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT, TNKS, TNKS2 4.34405
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.33421
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 4.3236
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 4.29285
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 4.28218
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.14656
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, EGFR, MAOA 4.12983
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 4.11822
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, RORC, SLC6A4, SRC, TYR 4.10173
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.09932
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.08882
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.08882
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.0485
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.86217
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.81041
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRB1, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.80019
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.80019
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC, TERT 3.80019
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 3.78228
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.72682
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PHF8, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.6563
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.64534
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.62627
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.60297
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRB1, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.52636
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRB1, AURKB, CDC25B, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.48158
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.46785
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A 3.45752
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, SLC6A2, SLC6A4, SRC 3.36627
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.35252
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.35252
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, APEX1, AURKB, AXL, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ERBB2, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR 3.35119
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 3.32531
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.32531
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 3.30393
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.30155
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KCNH2, KDR, SRC 3.2966
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.29489
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, ADRB1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, SRC, TERT 3.28139
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PHF8, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.27411
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PHF8, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.17931
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, GLO1, HASPIN, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.1623
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DYRK1A, DYRK3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.04489
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DYRK1A, DYRK3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.03233
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.02498
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.98301
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALOX5, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 2.97634
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, AURKB, DYRK1B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PHF8, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.97237
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.95955
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.9273
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2C19, MAOA 2.89104
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.88646
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 2.86221
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.85917
[BP] GO:0010907 None DYRK2, ESRRB, PPARA, SRC 2.81273
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, CDK6, CYP19A1, DYRK1A, DYRK3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.80454
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 2.78726
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AXL, CYP1B1, EGFR, ERBB2, F10, FLT3, KDR, MET, PTPN1, SRC, XDH 2.73188
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 2.70145
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.6918
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, MMP2, MMP9, RORC, SLC6A4, SRC 2.67307
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.65459
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 2.65459
[BP] GO:0009115 None AOX1, XDH 2.65459
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.63766
[BP] GO:0008283 cell proliferation ACHE, AURKB, CLK1, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 2.61445
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.60752
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.60416
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.55444
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.50797
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.45271
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.44297
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, MET, SRC, XDH 2.4275
[BP] GO:0051937 None NISCH, SLC6A2, SLC6A4 2.42648
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.42648
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, DYRK1A, DYRK3, EGFR, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.40553
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PHF8, PIM1, PPARA, RORC, SRC, TYR 2.36958
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.34678
[BP] GO:0070920 None EGFR, ESR1, TERT 2.34678
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, MET, SRC 2.28913
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.28383
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.28152
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.27159
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, EGFR, ERBB2, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT 2.26118
[BP] GO:0003018 None ADORA1, ADRA2A, ADRB1, EGFR, SLC6A4, SRC 2.26118
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 2.26118
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.25985
[BP] GO:0046110 None AOX1, XDH 2.25578
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.25578
[BP] GO:0010906 None DYRK2, ESRRB, PPARA, RORC, SRC 2.24352
[BP] GO:0006464 cellular protein modification process AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KCNH2, KDR, MET, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.232
[BP] GO:0036211 protein modification process AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KCNH2, KDR, MET, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.232
[BP] GO:0044267 cellular protein metabolic process AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.21604
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.20534
[BP] GO:1901184 None ADORA1, ADRA2A, EGFR, ERBB2, MMP9 2.18982
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, CES1, CYP19A1, CYP1A1, CYP1B1, MAOA, TYR 2.18771
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.18142
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.17587
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, AXL, CBR1, CDC25B, CDK6, CES1, CYP1A1, DYRK3, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, RORC, SRC, TERT, TOP2A 2.17027
[BP] GO:0019538 protein metabolic process ACHE, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.16698
[BP] GO:0010676 None DYRK2, ESRRB, PPARA, SRC 2.1637
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.1637
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.13297
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CA7, CACNA1C, CYP19A1, DYRK2, EGFR, ERBB2, HCAR2, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 2.12959
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.07213
[BP] GO:0015844 None NISCH, SLC6A2, SLC6A4 2.05241
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.0503
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.03934
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, IGF1R, PTPN1, SRC 2.03668
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, APEX1, AURKB, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.02483
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4 2.02483
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, F10, IGF1R, KDR, MET, MMP9, SRC, TERT 2.02483
[BP] GO:0070213 None TNKS, TNKS2 2.02483
[BP] GO:0006145 None AOX1, XDH 2.02483
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.02483
[BP] GO:0015874 None NISCH, SLC6A2 2.02483
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.02483
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.02483
[BP] GO:0060969 None ESR1, PHF8, TERT 2.02483
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.02483
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.02483
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.02483
[BP] GO:0043412 macromolecule modification APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KCNH2, KDR, MET, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.01751
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.01751
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, ERBB2, PPARA 2.0038
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.00121
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRB1, AXL, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, HCAR2, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, TNKS2, XDH 2.00058
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.00058
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, AOX1, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.9967
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KCNH2, KDR, MAOA, MMP2, MMP9, NISCH, PIM1, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.82711
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, ERBB2 2.73034
[CC] GO:0043226 organelle ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, AOX1, APEX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.28152
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, CA4, CA5A, CA5B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, MAOA, MMP12, MMP2, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.03144
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 18.8328
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.461
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, F10, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.9594
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.1844
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3075
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, RORC, TNKS 9.41842
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.00245
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 8.9589
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.78602
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.69108
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 7.69108
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC 7.60478
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PHF8, XDH 7.14767
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TOP2A 6.74759
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC 6.40092
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.17427
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC 5.87626
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TERT 5.54861
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 5.49823
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.45133
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, PHF8, TYR 5.114
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.05679
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 4.92126
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.88824
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 4.85086
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.75038
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.75038
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 4.69472
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 4.47403
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.45736
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.34405
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SRC 4.33421
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.14686
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, F10, FLT3, HASPIN, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 3.80019
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, SRC, XDH 3.75725
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.64986
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.49253
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.48255
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NISCH, SLC6A4, TERT, TOP2A, TYR, XDH 3.30155
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, PIM1 3.2775
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 3.23073
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 3.12111
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.03233
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.00462
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.89104
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.85048
[MF] GO:0000166 nucleotide binding ALDH2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.7307
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.73034
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.73034
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.69514
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.65459
[MF] GO:0008389 None CYP2A13, CYP2A6 2.65459
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.59436
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NISCH, PPARA, RORC 2.48787
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NISCH, PIM1, SRC, TOP2A, XDH 2.33752
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRB1, ALDH2, AOX1, APEX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 2.33318
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.28152
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.28152
[MF] GO:0005330 None SLC6A2, SLC6A4 2.25578
[MF] GO:0047374 None CES1, CES2 2.25578
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.11227
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, PPARA, RORC 2.1107
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.02483
[MF] GO:0032795 None ADORA1, ADRA2A 2.02483


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.639
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.9859
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 6.2016
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.2016
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.1624
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.5315
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 5.9281
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.5315
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, CYP2C19, CYP19A1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 4.5161
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.021
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 4.3642
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.4279
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 3.9408
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.4734
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, CACNA1C, CYP2C19, SLC6A4 3.0402
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 2.8529
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.4279
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 2.8592
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8867
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8251
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.3944
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C, ADRA2A 2.4204
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.4681
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8529
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, ADRB1, CACNA1C, PPARA 2.1119
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.0443
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.0786
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.0786
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9594
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5632
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0412
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 1.9527
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, EGFR 1.6529
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.869
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, CYP2C19 1.9927
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 1.9662
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.6712
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9278
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 1.6645
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6529
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, MET, EGFR, IGF1R 1.3887
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.5452
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 1.668
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.3626
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.5467
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.2006
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1898
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRB1, ADRA2A 1.1563
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.1563
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.8207
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.7326
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8371
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 0.7683
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7757
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7347
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.8959
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9066
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7347
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7326
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.6962
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.6962
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7158
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6962
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6921
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.994
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6824
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6784
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6299
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.6664
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1832
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1618
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4946
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4753
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.1077
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1944
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2447
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2642
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2711
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2538
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2711
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2711
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2638
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.2815
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3115
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.3237
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3292
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3252
Platelet activation_Homo sapiens_hsa04611 SRC 0.3608
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3608
Axon guidance_Homo sapiens_hsa04360 MET 0.3558
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3608
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3832
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3627
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.374
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3653
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4097
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4097
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4097
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4097
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4122
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4122
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4122
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4143
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.2779
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4117
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4122
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4149
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4156
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4097
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4234
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4156
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4183
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4156
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.3033
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4234
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4176
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4438
Peroxisome_Homo sapiens_hsa04146 XDH 0.4234
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4281
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4234
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.427
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4438
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4494
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.4598
Bile secretion_Homo sapiens_hsa04976 CA2 0.4479
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4598
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4598
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4438
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4509
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4753
Shigellosis_Homo sapiens_hsa05131 SRC 0.4598
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4598
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.458
Legionellosis_Homo sapiens_hsa05134 CLK1 0.4965
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.514
Malaria_Homo sapiens_hsa05144 MET 0.5328
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.5328
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.429
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5328
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.536
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6444
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.6529
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5574
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5988
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.5907
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7905
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6962
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6749
Base excision repair_Homo sapiens_hsa03410 APEX1 0.659
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.765
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9788
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.6749
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6962
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6824
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6784
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6962
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.6962
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8083
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1829


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)