Prescription ID | TCMF2315 |
Pinyin Name | Bao Gu Jiu |
Chinese Name | 豹骨酒 |
English Name | Medicated Wine with Leopard Bone |
Function Description | 痹病 |
Indications | Arthritis, Rheumatoid arthritis |
Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
Human Tissues Associated with Indication | SkeletalMuscle, Blood |
Reference | Chinese Classical Prescriptions |
Reference Book/link | ISBN 7-5023-3930-2 |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH136 | Os pardi | 豹骨 | TCMH136 | |
TCMH2486 | Coix lacryma- jobi var. ma - yuen | 薏苡仁 | TCMH2486 | |
TCMH170 | Dioscorea hypoglauca | 萆薢 | TCMH170 | GBVU109-13, GBVT4961-13 |
TCMH2507 | Epimedium brevicornum | 淫羊藿 | TCMH2507 | AY362429 |
TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
TCMH1184 | Citrus reticulata | 橘皮 | TCMH1184 | ITSAA1245-14 |
TCMH2551 | Polygonatum odoratum | 玉竹 | TCMH2551 | ITSAM921-14 |
TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
TCMH2267 | Periploca sepium | 香加皮 | TCMH2267 | ITSAJ4400-14, GBVP4570-15 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT318 | HKDC1 | Putative hexokinase HKDC1 | Transferase | Q2TB90 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT61 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Unclassified | Q07820 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
TCMT666 | VCP | Transitional endoplasmic reticulum ATPase | Transporter | P55072 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT747 | ABCG2 | ATP-binding cassette sub-family G member 2 | Transporter | Q9UNQ0 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1174 | Mycobacterium bovis BCG |
TCMT1176 | Streptococcus pneumoniae |
TCMT1177 | Haemophilus influenzae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1184 | Mycobacterium fortuitum |
TCMT1185 | Mycobacterium phlei |
TCMT1187 | Enterococcus faecalis ATCC 29212 |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1192 | Bacteria |
TCMT1193 | Staphylococcus |
TCMT1194 | Shigella sonnei |
TCMT1196 | Salmonella |
TCMT1198 | Serratia marcescens |
TCMT1199 | Streptococcus sp. 'group A' |
TCMT1200 | Bacillus thuringiensis |
TCMT1201 | Staphylococcus epidermidis ATCC 12228 |
TCMT1202 | Mycoplasma hominis |
TCMT1203 | Mycoplasma pneumoniae |
TCMT1204 | Clostridium perfringens |
TCMT1207 | Legionella pneumophila |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1214 | Enterococcus faecium |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1216 | Vibrio cholerae |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1219 | Enterococcus |
TCMT1220 | Streptococcus pneumoniae R6 |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1224 | Proteus mirabilis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1237 | Mycobacterium kansasii |
TCMT1243 | Aspergillus flavus |
TCMT1244 | Staphylococcus saprophyticus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1251 | Candida albicans |
TCMT1252 | Alcaligenes faecalis |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1262 | Mycoplasma putrefaciens |
TCMT1266 | Mycobacterium abscessus |
TCMT1267 | Mycobacterium chelonae |
TCMT1271 | Shigella flexneri |
TCMT1272 | Campylobacter jejuni |
TCMT1273 | Pseudomonas putida |
TCMT1274 | Shigella boydii |
TCMT1276 | Klebsiella |
TCMT1277 | Serratia |
TCMT1278 | Pseudomonas |
TCMT1281 | Clostridium difficile |
TCMT1286 | Bacillus cereus |
TCMT1287 | Bacillus subtilis subsp. spizizenii ATCC 6633 |
TCMT1289 | Shigella dysenteriae |
TCMT1290 | Acinetobacter calcoaceticus |
TCMT1291 | Haemophilus parainfluenzae |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1299 | Morganella morganii |
TCMT1300 | Enterobacter |
TCMT1301 | Klebsiella sp. |
TCMT1303 | Bacillus |
TCMT1304 | Staphylococcus capitis |
TCMT1305 | Salmonella enteritidis |
TCMT1307 | Penicillium marneffei |
TCMT1309 | Aspergillus clavatus |
TCMT1310 | Enterococcus hirae |
TCMT1314 | Streptococcus viridans |
TCMT1315 | Streptococcus sp. |
TCMT1317 | Staphylococcus lentus |
TCMT1318 | Human T-lymphotropic virus 1 |
TCMT1321 | Staphylococcus hominis |
TCMT1322 | Streptococcus mitis |
TCMT1326 | Shigella |
TCMT1331 | Acinetobacter sp. |
TCMT1332 | Bacillus licheniformis |
TCMT1334 | Chlamydia trachomatis |
TCMT1340 | Staphylococcus faecalis |
TCMT1341 | Streptococcus oralis |
TCMT1342 | Streptococcus salivarius |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1345 | Prevotella loescheii |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1355 | Rhodococcus equi |
TCMT1356 | Campylobacter coli |
TCMT1358 | Bacteroides vulgatus |
TCMT1361 | Neisseria meningitidis |
TCMT1362 | Bordetella pertussis |
TCMT1363 | Peptostreptococcus anaerobius |
TCMT1366 | Prevotella bivia |
TCMT1370 | Prevotella melaninogenica |
TCMT1371 | Veillonella parvula |
TCMT1375 | Clostridium tetani |
TCMT1377 | Staphylococcus lugdunensis |
TCMT1378 | Acinetobacter haemolyticus |
TCMT1381 | Listeria innocua |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1383 | Streptomyces griseus |
TCMT1388 | Prevotella disiens |
TCMT1389 | Klebsiella oxytoca |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1393 | Vibrio sp. |
TCMT1394 | Mycobacterium aurum |
TCMT1395 | Staphylococcus sp. |
TCMT1396 | Fusobacterium |
TCMT1399 | Chlamydophila pneumoniae |
TCMT1400 | Mycobacterium mageritense |
TCMT1401 | Staphylococcus warneri |
TCMT1402 | Staphylococcus cohnii |
TCMT1403 | Streptococcus constellatus |
TCMT1404 | Streptococcus intermedius |
TCMT1406 | Mycobacterium leprae |
TCMT1407 | Aeromonas punctata |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1409 | Escherichia coli O157:H7 |
TCMT1410 | Listeria monocytogenes |
TCMT1411 | Vibrio parahaemolyticus |
TCMT1412 | Salmonella typhimurium |
TCMT1413 | Vibrio splendidus |
TCMT1414 | Vibrio vulnificus |
TCMT1415 | Vibrio fluvialis |
TCMT1416 | Plesiomonas shigelloides |
TCMT1417 | Aeromonas sobria |
TCMT1418 | Enterobacteriaceae |
TCMT1420 | Klebsiella pneumoniae subsp. ozaenae |
TCMT1421 | Vibrio mimicus |
TCMT1422 | Clostridium histolyticum |
TCMT1423 | Peptostreptococcus |
TCMT1424 | Haemophilus ducreyi |
TCMT1425 | Moraxella bovis |
TCMT1427 | Proteus inconstans |
TCMT1429 | Acinetobacter pittii |
TCMT1431 | Coxiella burnetii |
TCMT1432 | Serratia sp. |
TCMT1434 | Plesiomonas |
TCMT1435 | Corynebacterium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1460 | Mycobacterium intracellulare |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 12.5185 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.6019 |
[BP] GO:0044281 | small molecule metabolic process | ABCG2, AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, PIM1, PPARA, XDH | 7.84735 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 | 7.84735 |
[BP] GO:0007215 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.16318 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.80342 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 | 6.51248 |
[BP] GO:0065008 | regulation of biological quality | ABCG2, ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, KDR, MCL1, MET, PPARA, SLC1A1, SRC, TRPV1, XDH | 6.45272 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HSD17B1, MET, PPARA, TRPV1 | 6.43608 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.49711 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH | 5.19119 |
[BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.19119 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH | 4.9457 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SRC, TRPV1 | 4.68824 |
[BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 | 4.41118 |
[BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.3963 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HCAR2, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH | 4.32215 |
[BP] GO:0060078 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 | 4.3038 |
[BP] GO:0042592 | homeostatic process | ABCG2, ADORA1, AKR1B1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MCL1, MET, SRC, TRPV1 | 4.20813 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 | 4.08955 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 | 4.08955 |
[BP] GO:0010033 | response to organic substance | AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MCL1, MMP2, PPARA, SRC, TRPV1 | 4.01075 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC | 3.90797 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GRIK5, GRM5, IGF1R, MMP2, MMP9, PPARA, SRC, TRPV1 | 3.89804 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 3.89804 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 3.88746 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, MET, PPARA | 3.88746 |
[BP] GO:0042221 | response to chemical | ABCG2, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, SRC, TRPV1 | 3.88746 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.88746 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1 | 3.76476 |
[BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.76476 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.73349 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC | 3.67517 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC | 3.63945 |
[BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, GRM1, GRM3, GRM5, GRM8 | 3.61816 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.57728 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.57728 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 3.48847 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH | 3.48385 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.41386 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 3.41386 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TRPV1, XDH | 3.41386 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH | 3.40787 |
[BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 | 3.37762 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 3.33182 |
[BP] GO:0007193 | None | ADORA1, GRM1, GRM3, GRM5, GRM8 | 3.18007 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1 | 3.17173 |
[BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.17152 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.17152 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC | 3.062 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MCL1, MMP2, MMP9, PTPN1, SRC, TRPV1 | 3.03957 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.94818 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.68652 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC | 2.67735 |
[BP] GO:0048878 | chemical homeostasis | ABCG2, AKR1B1, CA12, CA2, CA7, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 | 2.67735 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 | 2.67735 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.66437 |
[BP] GO:0006810 | None | ABCG2, ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, MCL1, MMP9, PPARA, SLC1A1, SRC, TRPV1, XDH | 2.59447 |
[BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC, TRPV1 | 2.57667 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 | 2.57667 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 | 2.57667 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.57667 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, AXL, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, PTPN1, SRC, XDH | 2.57618 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.57546 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH | 2.56197 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.55103 |
[BP] GO:0042391 | None | ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 | 2.55103 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1 | 2.55103 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC | 2.53819 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, CDC25B, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH | 2.53786 |
[BP] GO:0051234 | None | ABCG2, ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, MCL1, MMP9, PPARA, SLC1A1, SRC, TRPV1, XDH | 2.49283 |
[BP] GO:0071702 | None | ABCG2, ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, MCL1, PPARA, SLC1A1, TRPV1 | 2.43825 |
[BP] GO:0099566 | None | GRM1, GRM5 | 2.39395 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.39395 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC, TRPV1 | 2.39319 |
[BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1 | 2.38897 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 2.38528 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, CA2, CA7, KDR, SRC, TRPV1 | 2.38266 |
[BP] GO:0009987 | cellular process | ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TRPV1, XDH | 2.36846 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH | 2.32011 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, XDH | 2.28145 |
[BP] GO:0042493 | response to drug | ABCG2, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, SRC, TRPV1 | 2.27546 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.24314 |
[BP] GO:0051179 | None | ABCG2, ACHE, ADORA1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, MCL1, MMP9, PPARA, SLC1A1, SRC, TRPV1, XDH | 2.21993 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC, TRPV1 | 2.19954 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1 | 2.19879 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.19879 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.14981 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.14981 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, KDR, SRC, TRPV1 | 2.12778 |
[BP] GO:1901652 | response to peptide | AKR1B1, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 | 2.11385 |
[BP] GO:0035235 | None | GRIA2, GRIA4, GRIK5 | 2.11122 |
[BP] GO:0032787 | None | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 2.11122 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH | 2.10672 |
[BP] GO:0050896 | response to stimulus | ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, PTPN1, SRC, TRPV1 | 2.09857 |
[BP] GO:0008152 | metabolic process | ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH | 2.09435 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC | 2.02702 |
[CC] GO:0098590 | plasma membrane region | ABCG2, ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 | 5.21223 |
[CC] GO:0005886 | plasma membrane | ABCG2, ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 | 3.54598 |
[CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.54598 |
[CC] GO:0097060 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 | 3.41386 |
[CC] GO:0044456 | None | ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 | 3.11399 |
[CC] GO:0044459 | plasma membrane part | ABCG2, ADORA1, ADORA3, AXL, CA2, CA4, CA9, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 | 2.94818 |
[CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 | 2.72255 |
[CC] GO:0016020 | membrane | ABCG2, ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MCL1, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 | 2.66727 |
[CC] GO:0014069 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.46065 |
[CC] GO:0099572 | None | ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC | 2.46065 |
[CC] GO:0044425 | membrane part | ABCG2, ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MCL1, MET, PTPN1, SLC1A1, SRC, TRPV1 | 2.40644 |
[CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 | 2.39395 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 18.1084 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.6331 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, XDH | 11.033 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.4997 |
[MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.62753 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.83747 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 6.83747 |
[MF] GO:0003824 | catalytic activity | ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, XDH | 6.29691 |
[MF] GO:0043167 | ion binding | ABCG2, ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TRPV1, XDH | 5.82678 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.30279 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH | 4.91387 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1 | 4.57308 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC | 4.32603 |
[MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, TRPV1 | 4.16823 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC | 4.16823 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 4.04175 |
[MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 | 4.01075 |
[MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, TRPV1 | 4.01075 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.89804 |
[MF] GO:0008144 | drug binding | ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 | 3.67517 |
[MF] GO:0004872 | receptor activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, TRPV1 | 3.62495 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.54598 |
[MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, TRPV1 | 3.48847 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TRPV1, XDH | 3.41386 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 3.17173 |
[MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, TRPV1 | 3.17173 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.13036 |
[MF] GO:0046872 | metal ion binding | ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TRPV1, XDH | 3.10251 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, XDH | 2.94818 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.94818 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH | 2.76995 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.73143 |
[MF] GO:0005231 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.66437 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.61315 |
[MF] GO:0030594 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 2.56955 |
[MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.44638 |
[MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.44638 |
[MF] GO:0099583 | None | GRM1, GRM5 | 2.39395 |
[MF] GO:0099094 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.27343 |
[MF] GO:0004971 | None | GRIA2, GRIA4 | 2.14981 |
[MF] GO:0005230 | None | GRIA2, GRIA4, GRIK5, TRPV1 | 2.07761 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 19.6979 |
Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 7.3497 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R | 6.8867 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, GRM1, GRIA4 | 6.8972 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.5931 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.5931 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | SRC, MMP2, KDR, MMP9, MET, IGF1R | 3.7089 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.4224 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.2605 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 | 2.8867 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.4327 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | SRC, MMP2, MMP9, GRM1 | 2.8867 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, GRM1, GRIA4 | 2.8831 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, GRIA2, ADORA1, PPARA, GRIA4 | 2.845 |
Pathways in cancer_Homo sapiens_hsa05200 | FLT3, MMP1, MMP2, MMP9, MET, IGF1R | 2.3783 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, GRM8, GRM1 | 2.399 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.8804 |
Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1, IGF1R | 2.4087 |
Metabolic pathways_Homo sapiens_hsa01100 | CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH | 2.0924 |
Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.3746 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.1217 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.3746 |
Focal adhesion_Homo sapiens_hsa04510 | SRC, KDR, MET, IGF1R | 2.0084 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | SRC, KDR, MET, IGF1R | 1.9559 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.341 |
Gap junction_Homo sapiens_hsa04540 | GRM5, SRC, GRM1 | 2.0831 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.71 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | KDR, MET, MCL1, IGF1R | 1.3835 |
Ras signaling pathway_Homo sapiens_hsa04014 | KDR, MET, IGF1R | 1.2218 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.4647 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4619 |
VEGF signaling pathway_Homo sapiens_hsa04370 | SRC, KDR | 1.4283 |
Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, GRIA4 | 1.3828 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | FLT3, MET | 1.3828 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.1059 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, PIM1 | 1.1504 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.4448 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.1999 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | SRC, TRPV1 | 1.1662 |
Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.1741 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B, IGF1R | 1.1662 |
Melanoma_Homo sapiens_hsa05218 | MET, IGF1R | 1.3746 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.3808 |
Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2 | 1.5643 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 1.1059 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.3787 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | SRC, MET | 1.3069 |
Bile secretion_Homo sapiens_hsa04976 | CA2, ABCG2 | 1.3746 |
Hepatitis B_Homo sapiens_hsa05161 | SRC, MMP9 | 0.923 |
Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, GRIA4 | 0.9965 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 1.0456 |
FoxO signaling pathway_Homo sapiens_hsa04068 | GRM1, IGF1R | 0.9805 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.0511 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.605 |
Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.71 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIM1, MCL1 | 0.8771 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.9535 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.852 |
Calcium signaling pathway_Homo sapiens_hsa04020 | GRM5, GRM1 | 0.8128 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9003 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7731 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.3007 |
ErbB signaling pathway_Homo sapiens_hsa04012 | SRC | 0.5248 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.3635 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | SRC | 0.3519 |
Taste transduction_Homo sapiens_hsa04742 | GRM1 | 0.5248 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.391 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.4876 |
Viral carcinogenesis_Homo sapiens_hsa05203 | SRC | 0.3623 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3818 |
Huntington's disease_Homo sapiens_hsa05016 | GRM5 | 0.3749 |
Prostate cancer_Homo sapiens_hsa05215 | IGF1R | 0.5248 |
Platelet activation_Homo sapiens_hsa04611 | SRC | 0.4756 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE | 0.4876 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.391 |
Apoptosis_Homo sapiens_hsa04210 | MCL1 | 0.4546 |
Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.4546 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | IGF1R | 0.5057 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.5248 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.4365 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | SRC | 0.3818 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.4546 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5085 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | SRC | 0.4769 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.4756 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8595 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | SRC | 0.4245 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.5248 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | IGF1R | 0.4546 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.4582 |
AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.4756 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4546 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | IGF1R | 0.5232 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.5248 |
Serotonergic synapse_Homo sapiens_hsa04726 | ALOX5 | 0.4876 |
Toxoplasmosis_Homo sapiens_hsa05145 | ALOX5 | 0.4769 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5248 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.4756 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.471 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5248 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | SRC | 0.5592 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.5248 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.5232 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5232 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5539 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5232 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | IGF1R | 0.583 |
Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.5248 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.565 |
Glioma_Homo sapiens_hsa05214 | IGF1R | 0.583 |
Renal cell carcinoma_Homo sapiens_hsa05211 | MET | 0.5827 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.583 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.583 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0831 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5 | 0.583 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6509 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6609 |
ABC transporters_Homo sapiens_hsa02010 | ABCG2 | 0.6988 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8306 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.852 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8771 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8684 |