TCM Prescription: Heat Cooling Qi Enhancing Decoction



Prescription Description
Prescription IDTCMF2253
Pinyin NameQing Shi Yi Qi Tang
Chinese Name
English NameHeat Cooling Qi Enhancing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH814 Nelumbo nucifera 荷梗 TCMH814 ITSAI3109-14
TCMH1146 Oryza sativa 粳米 TCMH1146 GBVD4258-11, GBVD4257-11
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH2223 Exocarpium citrulli 西瓜皮 TCMH2223
TCMH2241 Panax quinquefolium 西洋参 TCMH2241 KY120319
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT926 LSS Lanosterol synthase Isomerase P48449
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1310 Enterococcus hirae
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 12.0088
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8535
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9347
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MAOB, MMP2, MMP9, PPARA, SRC, TYR 9.78133
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.49998
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 9.49998
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, GLO1, HMGCR, PDE5A, PIM1, PPARA, TYR, XDH 8.69146
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP2, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 8.4004
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, KDR, MAOB, MET, PPARA, SRC, TNKS, TNKS2, XDH 8.01065
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, PPARA, SRC, TYR 8.01065
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A 7.60878
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 7.4008
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, SRC, TYR 7.32823
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.31704
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, MAOB, SRC, TYR 7.31704
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 6.92053
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 6.87282
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 6.87282
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HMGCR, HTR1A, MAOB, TYR 6.87282
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, PPARA, SRC, TYR 6.66344
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.42288
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 6.38723
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 6.30884
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 6.2347
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MAOB, MMP2, PPARA, SRC 6.2308
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, MAOB, PPARA, SRC 6.22777
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TOP2A, TYR 6.22777
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 6.21259
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 6.16414
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, MAOB, SRC 6.10225
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH 6.09375
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.99726
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.92756
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.77832
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.66867
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.65617
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD11B2, KDR, MAOB, SRC 5.65617
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.57049
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 5.38387
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, MAOB, TYR 5.31065
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, HTR1A, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, SRC, TNKS2, TYR 5.31065
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.24124
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.20656
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA 4.89589
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 4.79592
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.69371
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 4.53628
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 4.4077
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.38579
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PPARA, PTPN1, SRC 4.37657
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PDE5A, PIM1, PTPN1, SRC, TNKS, XDH 4.31793
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 4.31793
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.28697
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.27261
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.26564
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TOP2A, TYR 4.23975
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 4.23974
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A, MAOB 4.10716
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 4.06983
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.03541
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 4.03541
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PDE5A, PIM1, PTPN1, SRC, TNKS, XDH 4.02735
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.91017
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.89787
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.89787
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.89787
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.86185
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIM1, PPARA, SRC, TYR 3.85064
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.78643
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.73504
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 3.70742
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.66818
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 3.64866
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2, TNKS, TNKS2 3.49682
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HMGCR, KDR, MET, PDE5A, PTPN1, SRC, XDH 3.48645
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48127
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.48127
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.45227
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.30498
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.30498
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.30498
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, MAOB 3.29845
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.27412
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.27412
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.25251
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.23987
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 3.2101
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PDE5A, PTPN1, SRC, XDH 3.18393
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 3.14629
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 3.07809
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.07245
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.07245
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 3.06698
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.06245
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05128
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 3.01831
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.97214
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.97214
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.97214
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.93689
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.92691
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, SRC, TOP2A 2.90775
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.84415
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.84039
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HMGCR, HSD11B2, MMP2, PPARA, SRC, TYR 2.79352
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.73323
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7324
[BP] GO:0009115 None AOX1, XDH 2.72685
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, SRC 2.7153
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.70399
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.69226
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.68394
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.67875
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65529
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.63576
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.63319
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.63319
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 2.60806
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC, TOP2A 2.60129
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.59044
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.58954
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, SRC 2.58954
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA 2.58374
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50607
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.50453
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC, TOP2A 2.49944
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.49944
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOB, PDE5A, XDH 2.49819
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, SRC, TOP2A 2.49447
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.45298
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44342
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.44022
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 2.41754
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.41754
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.40763
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.38016
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC 2.37373
[BP] GO:0046110 None AOX1, XDH 2.34883
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34883
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.34409
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.33963
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.33254
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.33254
[BP] GO:0042069 None DRD1, HTR1A, MAOB 2.33254
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33254
[BP] GO:0042053 None DRD1, HTR1A, MAOB 2.33254
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.31844
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, ESRRB, FLT3, HMGCR, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.31844
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.3138
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.30746
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, SRC 2.30746
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.30063
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.27291
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.23857
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.22383
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.2065
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.2065
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.2065
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.20137
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.18401
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.18401
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17623
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.17623
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.1732
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.16428
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, HCAR2, HMGCR, HTR1A, MAOB, MMP12, MMP9, PPARA, PTPN1, SRC 2.16428
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.16428
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.16054
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.15555
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, SRC 2.15555
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.1406
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.13854
[BP] GO:0070213 None TNKS, TNKS2 2.13854
[BP] GO:0006145 None AOX1, XDH 2.13854
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13854
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, SRC 2.11551
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.11551
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.11551
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2, MAOB, PDE5A, SRC, XDH 2.11279
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, FLT3, HMGCR, KDR, PDE5A, PTPN1, SRC, XDH 2.11279
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.09662
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.08612
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.08612
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.07457
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.01665
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.01665
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, MET, SRC, XDH 2.01665
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, HMGCR, IGF1R, MMP9, PDE5A, PTPN1, SRC, TNKS, XDH 2.01615
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, SRC, TNKS2, XDH 2.01493
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 2.01205
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOB, MMP2, MMP9, PDE5A, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.44022
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MAOB, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.2545
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.07331
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, IGF1R, KDR, MAOB, MET, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR 2.01784
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.88629
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 17.2584
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.2584
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 13.5787
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 13.4889
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1755
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9347
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 10.0956
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 9.14652
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.5362
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TYR, XDH 7.30556
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, TNKS, TNKS2, TOP2A, TYR, XDH 6.87282
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.16414
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.20434
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 5.04975
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.93206
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.45585
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B2, HSD17B1, MAOB, SRC, XDH 4.38069
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.19117
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.85704
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.69778
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.69778
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.58796
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.47139
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.33539
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.30498
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.30062
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.26426
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20286
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.17288
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.09363
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA 3.06575
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.97214
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.85362
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA 2.84039
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.84039
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.81355
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.72685
[MF] GO:0003845 None HSD11B1, HSD11B2 2.72685
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.60129
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.58954
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.53209
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA 2.50123
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.34883
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MAOB, MET, MMP9, TOP2A, TYR, XDH 2.30746
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.29797
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.13854
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.13854
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.13854
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, PDE5A, PIM1, SRC, TOP2A, XDH 2.13516
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, HTR1A, IGF1R, KDR, MET, PPARA 2.10613
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.02304


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.482
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.5714
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7445
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH 6.0829
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.141
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.9458
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9458
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9458
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.5156
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.146
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8271
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.768
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.146
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.146
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.146
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.0987
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5311
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0987
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3639
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.298
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.0302
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, HTR1A, DRD1, DRD2 1.8784
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.3639
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.7474
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9974
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9957
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.806
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.5914
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9974
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 1.806
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, HTR1A 1.5887
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3777
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.4433
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5178
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2598
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.224
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.1968
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9889
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2734
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2688
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2418
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.022
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.217
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0195
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.983
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9076
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.2094
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0195
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0414
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9144
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9512
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8918
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2094
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2598
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1113
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0097
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2057
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8925
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8925
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8925
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8732
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8213
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8732
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8116
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8116
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8116
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6832
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6832
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6258
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4157
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6258
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2305
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2771
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3151
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3206
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3374
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3148
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3713
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3561
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3678
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3835
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3835
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.382
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3944
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3944
Platelet activation_Homo sapiens_hsa04611 SRC 0.4114
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6955
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4132
Axon guidance_Homo sapiens_hsa04360 MET 0.4036
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4114
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4406
Melanogenesis_Homo sapiens_hsa04916 TYR 0.468
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4679
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4719
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4763
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4896
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.476
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4757
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7115
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4887
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5002
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4896
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4896
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4892
Peroxisome_Homo sapiens_hsa04146 XDH 0.5002
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5331
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.511
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5319
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6529
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5887
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5452
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5599
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5599
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5599
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5467
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5672
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5599
Shigellosis_Homo sapiens_hsa05131 SRC 0.5599
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5632
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8697
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5899
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5632
Malaria_Homo sapiens_hsa05144 MET 0.6258
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6225
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6275
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6258
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6258
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6275
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6832
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6828
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6828
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7565
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7361
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.2082
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7788
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8116
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.803
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8213
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9076
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8489
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8925
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0335
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2226


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)